SAFETY DATA SHEET Version 8.

2
Revision Date 02.02.2021
according to Regulation (EC) No. 1907/2006 Print Date 22.02.2021
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : (S)-Lactic acid about 85% EMPROVE®
EXPERT Ph Eur,BP,E 270
Product Number : 1.00366
Catalogue No. : 100366
Brand : Millipore
REACH No. : This product is a mixture. REACH Registration Number see
section 3.
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Pharmaceutical production, Cosmetic raw material
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Chemical Pvt Limited
Industrial Area, Anekal Taluka
Plot No 12,
12 Bommasandra - Jigani Link Road
560100 BANGALORE
INDIA

1.4 Emergency telephone

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Skin irritation (Category 2), H315
Serious eye damage (Category 1), H318
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram

Signal word Danger

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 Hazard statement(s)
H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statement(s)
P264 Wash skin thoroughly after handling.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P362 + P364 Take off contaminated clothing and wash it before reuse.
Supplemental Hazard none
Statements

Reduced Labeling (<= 125 ml)

Pictogram

Signal word Danger

Hazard statement(s)
H318 Causes serious eye damage.
Precautionary statement(s)
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.2 Mixtures
Component Classification Concentration
lactic acid
CAS-No. 79-33-4 Skin Irrit. 2; Eye Dam. 1; >= 85 - <=
EC-No. 201-196-2 H315, H318 100 %

*
*A registration number is not available for this substance as the substance or its use are
exempted from registration according to Article 2 REACH Regulation (EC) No 1907/2006,
the annual tonnage does not require a registration or the registration is envisaged for a
later registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.

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SECTION 4: First aid measures
4.1 Description of first-aid measures
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with
water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
5.4 Further information
Prevent fire extinguishing water from contaminating surface water or the ground water
system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance
contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency
procedures, consult an expert.
For personal protection see section 8.

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6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions
(see sections 7 and 10). Take up with liquid-absorbent and neutralising material (e.g.
Chemizorb® H⁺, Merck Art. No. 101595). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed.
Store at +2°C to +30°C.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters
Ingredients with workplace control parameters
8.2 Exposure controls

Personal protective equipment

Eye/face protection
Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety
goggles
Skin protection
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:KCL 741 Dermatril® L
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please

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 contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:KCL 741 Dermatril® L
Body Protection
protective clothing
Respiratory protection
Recommended Filter type: Filter type P2
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory
protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure
Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Appearance Form: oily
Color: colorless
b) Odor odorless
c) Odor Threshold Not applicable
d) pH ca.2,8 at 10 g/l at 20 °C
e) Melting Melting point: 18 °C
point/freezing point
f) Initial boiling point 122 °C at 20 hPa
and boiling range

g) Flash point does not flash

h) Evaporation rate No data available
i) Flammability (solid, No data available
gas)
j) Upper/lower No data available
flammability or
explosive limits

k) Vapor pressure 0,1 hPa at 25 °C

l) Vapor density No data available
m) Relative density 1,21 g/cm³ at 20 °C
n) Water solubility at 20 °C soluble
o) Partition coefficient: log Pow: -0,62 - (refers to pure substance), Bioaccumulation is
n-octanol/water not expected.

p) Autoignition No data available

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 temperature
q) Decomposition No data available
temperature
r) Viscosity Viscosity, kinematic: No data available
Viscosity, dynamic: 20 - 40 mPa.s at 20 °C
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
No data available

SECTION 10: Stability and reactivity

10.1 Reactivity
No data available
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Oxidizing agents
Bases

10.4 Conditions to avoid

no information available
10.5 Incompatible materials
No data available
10.6 Hazardous decomposition products
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Mixture
Acute toxicity
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and
gastrointestinal tract.
Symptoms: Possible symptoms:, mucosal irritations
Skin corrosion/irritation
Mixture causes skin irritation.
Serious eye damage/eye irritation
Mixture causes serious eye damage.
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
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 IARC: No ingredient of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Acute oral toxicity - Irritations of mucous membranes in the mouth, pharynx, oesophagus
and gastrointestinal tract.
Acute inhalation toxicity - Possible symptoms:, mucosal irritations
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available

11.2 Additional Information

Not available

Other dangerous properties can not be excluded.

Handle in accordance with good industrial hygiene and safety practice.

Components
lactic acid
Acute toxicity
LD50 Oral - Rat - female - 3.543 mg/kg
(US-EPA)
LC50 Inhalation - Rat - male and female - 4 h - > 7,94 mg/l
(OECD Test Guideline 403)
LD50 Dermal - Rabbit - male and female - > 2.000 mg/kg
(US-EPA)
Skin corrosion/irritation
Skin - Rabbit
Result: Irritations
(OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - In vitro study
Result: Irreversible effects on the eye
Remarks:
(ECHA)
Respiratory or skin sensitization
Buehler Test - Guinea pig
Result: negative
(US-EPA)
Germ cell mutagenicity

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 Ames test
Escherichia coli/Salmonella typhimurium
Result: negative
Mutagenicity (mammal cell test): chromosome aberration.
Human lymphocytes
Result: negative
In vitro mammalian cell gene mutation test
Mouse lymphoma test
Result: negative
Carcinogenicity
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available

SECTION 12: Ecological information

12.1 Toxicity
Mixture
No data available
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Other adverse effects
Biological effects:
Harmful effect due to pH shift.
Discharge into the environment must be avoided.
Components
lactic acid
Toxicity to fish static test LC50 - Oncorhynchus mykiss (rainbow trout) - 130
mg/l - 96 h
(US-EPA)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 130 mg/l - 48
and other aquatic h

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 invertebrates (OECD Test Guideline 202)
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (algae) - ca.
3,5 mg/l - 72 h
(OECD Test Guideline 201)
Toxicity to bacteria static test EC50 - activated sludge - > 88,2 mg/l - 3 h
(OECD Test Guideline 209)

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and
containers, or contact us there if you have further questions.

SECTION 14: Transport information

14.1 UN number
ADR/RID: - IMDG: - IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
14.4 Packaging group
ADR/RID: - IMDG: - IATA: -
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user

Further information
Not classified as dangerous in the meaning of transport regulations.

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
REACH - Restrictions on the manufacture, :
placing on the market and use of certain
dangerous substances, preparations and articles
(Annex XVII)

National legislation
Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the
control of major-accident hazards involving dangerous substances.
Not applicable
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 Other regulations
Take note of Dir 94/33/EC on the protection of young people at work.

15.2 Chemical Safety Assessment

For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H315 Causes skin irritation.
H318 Causes serious eye damage.
Further information
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.

Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
for internal use only.
The branding on the header and/or footer of this document may temporarily not visually
match the product purchased as we transition our branding. However, all of the
information in the document regarding the product remains unchanged and matches the
product ordered. For further information please contact [email protected].

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