Sympathetic Receptors and Their Responses: Nervous System

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08 L E C

SYMPATHETIC RECEPTORS AND THEIR RESPONSES


10
ANGELIQUE ANNE LOQUEZ, RN
21 O2
NERVOUS SYSTEM

OUTLINE - Whenever it is activated it triggers a fight or


I Nervous System flight response.
II Central Nervous System
III Peripheral Nervous System PARASYMPATHETIC NERVOUS SYSTEM
IV Autonomic Nervous System - Drugs under PNS are called
A. Sympathetic NS parasympathomimetic or Cholinergics.
B. Parasympathetic NS
V Sympathetic NS Receptors
SYMPATHETIC NERVOUS SYSTEM RECEPTORS
A. Alpha
B. Beta
C. Dopamine DIVIDED INTO THREE:

1) Alpha
NERVOUS SYSTEM

sensitive to epinephrine and
 Nervous system is your body's command
center. Originating from your brain, it controls norepinephrine (more sensitive to
your movements, thoughts and automatic Norepinephrine NE)
responses to the world around you.  DIVIDED INTO TWO:

 It is divided into two;


o CENTRAL NERVOUS SYSTEM
o PERIPHERAL NERVOUS SYSTEM

CENTRAL NERVOUS SYSTEM


CNS – CENTRAL NERVOUS SYSTEM

Consists of two parts

 Brain  Alpha 1
 Spinal cord
 post synaptic
PERIPHERAL NERVOUS SYSTEM  some location are in the liver, urinary
bladder, eyes, and acts upon your blood
PNS – PERIPHERAL NERVOUS SYSTEM
vessel
The peripheral nervous system is divided into two  generally, when you are in a fight or fight
main parts: response, your CNS is stimulated

 Somatic - consists of afferent (sensory) and CENTRAL NERVOUS SYSTEM SIMULATION


efferent (motor) nerves
 Vasoconstriction (alpha1 acts upon blood vessel
 Autonomic - comprises two antagonistic sets
of nerves, through this)
a. Sympathetic nervous system  Mydriasis (in the eyes/pupillary dilation)
b. Parasympathetic nervous systems.
 Urinary contraction (found in bladder; there is
AUTONOMIC NERVOUS SYSTEM urinary retention)
 Sympathetic nervous system or SNS  Glycogenolysis (in liver)
- Drugs under SNS are called
sympathomimetics or adrenergics.

BSN-2B TRANSCRIBED BY: GROUP 8 1


 Alpha 2 - Triggers the release of renin which has a part
in regulating or increasing the blood pressure
 pre-synaptic
 has inhibitory effects (when there is too
 Beta 2
much epinephrine, your alpha two
 Mainly seen in smooth muscles
inhibits)
 Ex. Of a smooth muscle is the lungs
CENTRAL NERVOUS SYSTEM SIMULATION  Helps with smooth muscle relaxation
 Causes:
 Inhibit NE release  Bronchodilation – expansion of the
 Decrease level of insulin (since you need glucose)
bronchial air passages
NOTES:  Vasodilation – widening of blood
vessels
Sympathetic Nervous System (Fight)  Inhibits labor – helps with uterus
 neurotransmitter: catecholamines (Epinephrine, relaxation
Norepinephrine, Dopamine)  Beta 3
- Mainly seen in adipose tissues (fats)
- Lipolysis (breakdown of fats)
DRUGS THAT MIMIC SNS EFFECTS:

a) Sympathomimetics or;
3) Dopamine Receptors
b) Adrenergics or; - Promotes dilation in:
c) Adrenergic agonists  Renal system
 Mesenteric (GI)
DRUGS THAT DOES THE OPPOSITE:  Cerebral/Cardiac/Coronary
a) Sympatholytics or;

b) Antiadrenergics or;

c) Adrenergic antagonists/blockers

CENTRAL NERVOUS SYSTEM (REST/DIGEST) REFERENCES


 neurotransmitter: acetylcholine
“PROF’S PPT ON QUIPPER AND LECTURE”
 DRUGS THAT MIMIC PNS RESPONSES:

a) Cholinergics or;

b) Parasympathomimetics or;

c) Cholinergic agonists

DRUGS THAT DOES THE OPPOSITE:

a) Anticholinergics or;

b) Parasympatholytics or;

c) Cholinergic antagonist/blockers

2) Beta
 Beta 1
- Mainly found in the heart
- Increased contractility of the heart
- Increased heart rate
- Increased blood pressure

BSN-2B TRANSCRIBED BY: GROUP 8 2


BSN-2B TRANSCRIBED BY: GROUP 8
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