A Review of Lumbar Radiculopathy, Diagnosis, and Treatment
A Review of Lumbar Radiculopathy, Diagnosis, and Treatment
A Review of Lumbar Radiculopathy, Diagnosis, and Treatment
1. Neurosurgery, Riverside University Health System Medical Center, Moreno Valley, USA 2. Neurology,
Alleghany Health Network, Pittsburgh, USA
Abstract
We review the epidemiology, etiology, symptomatology, clinical presentation, anatomy,
pathophysiology, workup, diagnosis, non-surgical and surgical management, postoperative
care, outcomes, long-term management, and morbidity of lumbar radiculopathy. We review
when outpatient conservative management is appropriate and "red flag" warning symptoms
that would necessitate an emergency evaluation. Diagnostic modalities, including magnetic
resonance imaging (MRI), computerized tomography (CT), contrast myelogram,
electromyogram (EMG), and nerve conduction velocity (NCV), are involved in the diagnosis and
decision-making are discussed. Treatment of lumbar radiculopathy requires a multimodal and
multispecialty team. We review indications for the involvement of other professionals,
including physical therapy (PT), occupational therapy (OT), physical and rehabilitation
medicine (PMR), and pain management.
FIGURE 1: Dermatomes
Anatomical map of the sensory dermatomes of the Lumbosacraloccygeal region
Image provided by the National University of Córdoba with permission for use.
L3 Knee Extension
L5 Ankle Eversion (peronous longus and brevis) Great Toe Extension Extensor Hallucis Longus
After a thorough physical exam, diagnostic imaging should be reviewed. The optimal imaging
modality for the evaluation of radiculopathy is MRI of the lumbar spine without contrast, which
can show compression of the nerve root (see Figure 2). Contrast-enhanced MRI may be useful or
indicated in cases where a tumor, infection, or prior surgery has occurred. In cases where MRI is
not available or possible, a CT myelogram is a reasonable alternative.
B. Axial T2 w/o contrast MRI lumbar spine; the same patient shows compression of the right exiting
S1 nerve root, which has caused this patient to experience right S1 radiculopathy.
Clinical Pearl
Ensure that you evaluate the MRI with the patient’s clinical exam in mind. Often, a far lateral
When there is a lack of correlation between the exam findings and imaging studies,
electrodiagnostic testing may be employed. Electromyography (EMG) and nerve conduction
velocities (NCV), as well as somatosensory evoked potentials (SSEP), can help differentiate
between radiculopathy and more diffuse disorders of the peripheral nervous system. It is
important to note that while EMG and NCV studies may be a useful diagnostic tool when
combined with a thorough history, clinical examination, and other diagnostic studies, they do
have limitations and potential pitfalls. EMG and NCV studies are affected by the patients’ level
of cooperation, which may be limited by pain, temperature of room, electrolyte and fluid
balance, pre-existing medical comorbidities, such as diabetes mellitus, thyroid disease, or renal
failure that can produce peripheral neuropathy, medications such as statins, which can produce
myopathy, movement disorders that produce tremors, prior surgeries, such as laminectomy,
which may give paraspinous muscle false-positives, body habitus with extreme obesity
preventing the full insertion of needles into muscle, congenital anatomical variations, for
example, Martin-Gruber nerve anastomosis, and subjective interpretation of the data by the
individual clinician [5]. Diagnostic nerve root blocks may also help to localize the symptomatic
level [6].
Treatment
Non-Surgical
The need for surgical intervention, the timing of surgery, and surgical approaches has been
extensively studied, yet, controversy still exists. Guidelines for approaching lumbar
radiculopathy favor an initial trial of conservative management, including patient education,
staying active/exercise, manual therapy (such as McKenzie exercises), and non-steroidal anti-
inflammatory drugs (NSAIDs) as first-line treatments [7-9]. The use of McKenzie exercises has
been demonstrated to provide some acute symptomatic relief in patients undergoing
conservative management for lumbar radiculopathy [10]. Oral corticosteroids prescribed as a
taper may benefit patients in the acute phase [11]. Often, the next step in treatment is pain
injections, which may include epidural steroid injections, facet injection, or transforaminal
injections, which have been shown to provide long-term relief of symptoms [12]. These
injections typically consist of a combination of an anti-inflammatory agent, such as a
glucocorticoid, and a long-lasting anesthetic such as Marcaine. In situations where the pain
generator is indeterminate, spinal injections can be both diagnostic and therapeutic. For
example, a patient with significantly low back pain and some numbness in her left foot who has
extensive arthritic changes throughout her spinal column receives an injection in her facets
with profound symptomatic relief. The injection into her lumbar spinal facet joints provided her
with significant symptomatic relief, demonstrating that arthritic changes in her facet joints,
not lumbar radiculopathy from a compressed nerve root, were her pain generator. However, a
patient with significant lower extremity pain in an L5 dermatomal pattern experiences
significant relief after an epidural injection, indicating the pain generator is likely the
compressed left L5 nerve root, not arthritic changes in the facet joints.
Surgical Decision-Making
A significant contribution from this study was that most patients improve given time, either
with or without surgery. At eight years after symptom onset, those patients who benefited most
from a surgical intervention were patients with sequestered disc fragments, symptom duration
of greater than six months, those with higher levels of low back pain, or who were neither
working nor disabled at baseline [4].
The ultimate timing of surgery is often based on the severity of the patient’s symptoms and
clinical experience. Overall, surgery has been shown to be of benefit to patients with more
severe symptoms [15].
Surgical Techniques
The gold standard surgical procedure for simple lumbar disc herniation remains a discectomy.
In 1939, Semmes presented a subtotal laminectomy and retraction of the dural sac to remove
the herniated disc [16]. Since then, many iterations of this procedure focussing on less invasive
techniques have been developed. In 1977 and 1978, Caspar and Williams reported refinements
in the approach with the use of a microsurgical technique [17]. In 1997, Foley introduced the
microendoscopic discectomy (MED) procedure [18-19].
Surgical options include open laminectomy with discectomy, the so-called “mini-open”
hemilaminectomy with a microdiscectomy, minimally invasive hemilaminectomy with
microdiscectomy via tubular retractors, and MED. Studies have shown MED to be superior to
open surgical techniques in producing less irritation of the nerve by intraoperative EMG studies
[20], less requirement of postoperative analgesia during the hospital stay, less mean operative
blood loss, and a lower mean number of rest days [21-22]. Less invasive methods may also
produce less joint destabilization due to less destructive techniques as well as decreased
surgical and hospital costs [22]. Minimally invasive techniques are not without limitations such
as a restricted cone field of vision for the surgeon and inability to approach pathology from
other angles. Minimally invasive techniques may be appropriate under the correct conditions
and should be evaluated on a case-by-case basis.
For traditional open discectomy, localization of the level is first obtained with fluoroscopy and
a midline incision is made at the level of the disc. The incision is then continued down in a
subperiosteal fashion to expose the lamina of the upper level and ligamentum flavum over the
interspace laterally. A retractor is then placed. The microscope is then brought in and a
hemilaminectomy and partial medial facetectomy is performed with a high-speed drill and
Kerrison Roungeurs. The ligamentum is then detached from the lamina and removed, exposing
the nerve root crossing over the disc. The root and thecal sac are retracted medially and the
annulus exposed. A box incision in the disc annulus is made and disc material removed. A
nerve hook can be used to sweep anterior to the thecal sac to retrieve any herniated fragments.
Loose fragments within the disc space can be flushed out from the disc space with
irrigation. The advantages of this approach are increased visualization, the ability to use a
wider variety of instruments, better visualization, and the ability to approach pathology from
multiple trajectories not limited to a specific trajectory such as minimally invasive surgery
(MIS) approaches.
Clinical Pearl
When using the MIS approach, it is essential to direct the trajectory of the tube perpendicular
to the disc of interest. An altered trajectory will limit the ability to fully visualize and surgically
decompress this nerve root. Confirm the trajectory with fluoroscopy.
Conclusions
Lumbar radiculopathy is one of the most common neurological complaints to be evaluated by a
neurosurgeon practicing in a rural environment. While the pathology has not changed, newer,
less invasive techniques are being developed to surgically treat these patients in the evolving
field of spine surgery. Intimate knowledge of the signs, symptoms, red-flag warning signs,
radiographic imaging, diagnostic tools, and conservative and surgical interventions is a
necessity. The red-flag warning signs that would prompt an emergent evaluation include saddle
anesthesia, incontinence to bowel or bladder, and sudden paresis in an extremity.
Additional Information
Disclosures
Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors
declare the following: Payment/services info: All authors have declared that no financial
support was received from any organization for the submitted work. Financial relationships:
All authors have declared that they have no financial relationships at present or within the
previous three years with any organizations that might have an interest in the submitted work.
Other relationships: All authors have declared that there are no other relationships or
activities that could appear to have influenced the submitted work.
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