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    The Microwave Multifunctional Tissue Processor You Were Waiting For. You Were Waiting For

    Uploaded by

    David Muñoz
    The document describes the KOS microwave tissue processor. It can perform histoprocessing, decalcification, special staining, fixation and gross hardening. It provides factory pre-set protocols to rapidly process tissues. It is a multifunctional and compact alternative to traditional tissue processors. It can process tissues, including bone marrow biopsies, in a fraction of the usual time while maintaining high quality slides.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    The Microwave Multifunctional Tissue Processor You Were Waiting For. You Were Waiting For

    Uploaded by

    David Muñoz
    102 views6 pages
    The document describes the KOS microwave tissue processor. It can perform histoprocessing, decalcification, special staining, fixation and gross hardening. It provides factory pre-set protocols to rapidly process tissues. It is a multifunctional and compact alternative to traditional tissue processors. It can process tissues, including bone marrow biopsies, in a fraction of the usual time while maintaining high quality slides.

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    KOS-CAT307EN-003

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    The document describes the KOS microwave tissue processor. It can perform histoprocessing, decalcification, special staining, fixation and gross hardening. It provides factory pre-set protocols to rapidly process tissues. It is a multifunctional and compact alternative to traditional tissue processors. It can process tissues, including bone marrow biopsies, in a fraction of the usual time while maintaining high quality slides.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    102 views6 pages

    The Microwave Multifunctional Tissue Processor You Were Waiting For. You Were Waiting For

    Uploaded by

    David Muñoz
    The document describes the KOS microwave tissue processor. It can perform histoprocessing, decalcification, special staining, fixation and gross hardening. It provides factory pre-set protocols to rapidly process tissues. It is a multifunctional and compact alternative to traditional tissue processors. It can process tissues, including bone marrow biopsies, in a fraction of the usual time while maintaining high quality slides.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 6

    KOS

    The microwave multifunctional tissue processor


    you were waiting for.

    Tissue processing Fixation


    Decalcification Gross hardening
    Special stains Antigen retrieval

    In a fraction of the time

    MILESTONE
    H E L P I N G
    P A T I E N T S
    KOS*Smart and Fast *KOS (Greek island).
    Home of Hippokrates,
    “Father of Medicine”.

    Histoprocessing Histoprocessing Bone Marrow Decalcification Special Stains


    (Transplant) Processing

    Time/Temperature Fixation Gross Hardening Favorites User Programs

    Notes Compliance Log BooK P.M. Help

    Rapid multifunctional microwave tissue processor.


    A state-of-the-art, multifunctional microwave tissue processor, the KOS is ideally suited as a
    complement to existing capabilities found in histology laboratories, where the multitasking nature of
    the instrument can enhance and accelerate many of the typical applications encountered.

    SMART. Icons driven.

    FAST. Factory prestored optimized, full documented protocols for rapid, microwave
    enhanced procedures. No calibrations required. Just plug-in and process.

    RELIABLE. Sensors controlled for protection of your precious specimens.


    FLEXIBLE. User defined customized programs can be created and added to a most used
    favorites list for quick access, as required for meeting the needs of each user laboratory.

    Multifunctional. One Unit. Six Major Applications

    Histoprocessing Decalcification Special Stains Time/Temperature Fixation Gross Hardening

    FULL COMPLIANCE TO CAP – C.L.S.I. GUIDELINES


    The KOS tissue processor will enable the laboratory manager to fulfill the requirements set by the C.L.S.I.
    and CAP inspection guidelines. The ideal substitute for the “kitchen type” microwave oven utilized in many histology laboratories.

    C.L.S.I. (FORMERLY N.C.C.L.S.) GUIDELINES.


    REFERENCE: Clinical and Laboratory Standards Institute. Microwave Device use in the Histology Laboratory; Approved Guideline.
    C.L.S.I. document GP28-A (ISBN 1-56238-563-1).
    CAP GUIDELINES. REFERENCE: Commission on laboratory accreditation. Anatomic pathology checklist - Rev. September 2007
    Rapid tissue processing
    Same day results for all tissue types.

    • From 1 to 45 cassettes • Safe. No xylene


    • Ideal for transplant centers • No proprietary reagents
    (Urgent biopsies) (Ethanol – isopropanol only)

    HIGH QUALITY SLIDES


    No compromise in regard to morphology and staining expression.
    Staining properties of microwave processed specimens are
    excellent for H&E routine staining, HC, IHC, FISH.
    In a fraction of the time.

    Colonic biopsy, Adenocarcinoma, Breast cells HER2 Breast cells HER2


    microwave processed microwave processed amplification amplification
    in 30 minutes. Cytokeratin CAM5.2, detection by FISH detection by
    H&E, x 400. x 400. processed by IHC, processed
    microwaves. by microwaves.
    Red-labeled HER2 Hematoxylin
    probe, x 800. counterstain, x 400.

    FAST. UNMATCHED TISSUE PROCESSING TIMES.

    30 minutes 30 minutes 80 minutes


    for transplant for 1.5 mm biopsies. for 3 mm biopsies.
    biopsies Add 10 minutes Add 25 minutes
    including fixation. to include fixation. to include fixation.

    EASY. ICONS DRIVEN MENU.

    1) Select thickness 2) Select number of cassettes 3) Select reagents

    4) Press GO. 5) Press START. That’s all Time left will be shown on
    the terminal
    Bone Marrow processing
    Same-day diagnosis for bone marrow trephine biopsies.
    Will this help your patient?
    DECALCIFICATION + PROCESSING IN LESS THAN 3 HOURS !
    An ideal application of the technology and multifunctionality of the KOS.
    Optimized decalcification and processing protocols are factory stored.

    EDTA. FORMIC ACID (5%).


    Decalcification: 80 minutes Decalcification: 20 minutes
    Processing: 60 minutes Processing: 60 minutes
    Total time: 140 minutes Total time: 80 minutes

    FAST TURN AROUND TIME


    Minutes Temp.°C
    Fixation in formalin: 10 50
    Rinsing in tap water 10
    Decalcification (formic acid) 20 50
    Rinsing in ethanol 2
    Tissue processing (Prowave) 15
    Impregnation in Wax 23
    Bone marrow,
    Total time (minutes) 80 EDTA, H&E x 100

    Rapid Bone Decalcification


    Up to 45 cassettes.
    An excellent application for the KOS.
    The efficient stirring continuously keeps
    Hours, not
    the bone surface in contact with “fresh”
    decalcifier, positively influencing the days!
    equilibrium:
    (Bone) Ca ++ Ca ++ (Solution)

    conventional
    KOS

    Simply select the temperature,


    the number of cassettes and the
    decalcifying solution. EDTA pH 7,2 Formic 5% HCl
    acid (5%) 5% Formic acid
    Press GO CORE BIOPSY DECALCIFICATION TIMES (50° C)
    Special Stains
    Up to 76% time saving for histochemical staining protocols
    Several time consuming staining procedures are enhanced by microwave irradiation.
    Factory stored, optimized, step by step protocols for most common stains for 1-40 slides.
    Preset or customized programs guarantee operator independent, consistent results.
    • No splashing, constant pH conditions
    • Magnetic stiring for temperature uniformity along the entire length of the slides

    Stains Standard KOS Time Staining


    (minutes) (minutes) Saving % intensity

    GMS (Fungi) 130 25 76 Increased


    GRIMELIUS (Agryrophil) 65 13 72 Increased
    MASSON TRICHROME 120 32 70 Increased
    MASSON FONTANA 80 19 70 Increased
    PAS 50 21 50 Increased
    ALCIAN BLUE 34 13 61 Increased
    ZIEHL NIELSEN 39 11 61 Increased
    ELASTICA (ORCEIN) 30 7 62 Increased
    PEARLS IRON STAIN 21 8 46 Increased
    ^ Note: Times include non-microwave treatment steps

    Select stains menu Select specific stain Follow the step by step Microwave programs
    screen indications are pre-stored

    Alcian Blue: Grimelius Argyrophyl PAS,


    Bowel biopsy, cells in Duodenum, stomach gland,
    x 400. x 400. x 400.

    Time at temperature steps/Antigen retrieval


    1 Select
    temperature

    2 Select
    histomodule

    3 Select
    time

    4 Press GO.

    User’s programs can be easily set up and stored under “Favorites”


    for easy operation
    KOS Packed with the latest microwave and sensor technology.
    Controlled by the most advanced, intuitive software.

    USB port to upload- Touch-screen, Removable, stainless steel


    download data 8” color terminal tray for extra bench space

    High definition color monitor


    Connection to fume extraction
    system

    Built-in
    regenerable
    charcoal
    filter

    State-of-the-art safety
    Microwave power is switched off if:
    1 Cavity ventilation is compromised
    2 Solvent in cavity is above threshold
    3 Humidity in cavity exceeds set value
    4 Microwave leak is detected

    IR sensor with laser for


    temperature control

    High definition, pin-hole Software controlled stirring device


    TV camera, with autofocus

    In your country:
    MILESTONE MILESTONE Srl - Via Fatebenefratelli, 1/5 - 24010 Sorisole (BG) - Italy
    Tel: +39 035 4128264 - Fax: +39 035 575498
    www.milestonemedsrl.com - email: [email protected]
    UNI EN ISO 9001: 2008 / UNI EN ISO 13485:2012 CERTIFIED

    H E L P I N G MILESTONE MEDICAL TECHNOLOGIES, INC.


    P A T I E N T S 6475 Technology Avenue, Suite F, Kalamazoo, MI 49009 - USA
    Tel: 269-488-4950 - Toll-free: 866-995-5300 - Fax: 269-488-4949
    www.milestonemed.com - email: [email protected] CAT307EN-003

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