SAFETY DATA SHEET Version 6.

8
Revision Date 30.11.2021
according to Regulation (EC) No. 1907/2006 Print Date 16.03.2022
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : Formalin solution, neutral buffered, 10%
Product Number : HT501128
Brand : Sigma
UFI : UPX0-P6EG-W992-2FFE
REACH No. : This product is a mixture. REACH Registration Number see
section 3.

1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
Uses advised against : This product is not intended for consumer use.
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Pte Ltd
(Co. Registration No. 199403788W)
2 Science Park Drive
#05-01/12 Ascent Building
SINGAPORE 118222
SINGAPORE
Telephone : +65 6890 6633
Fax : +65 6890 6639
E-mail address : [email protected]
1.4 Emergency telephone
Emergency Phone # : 1-800-262-8200

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 4), H332
Skin sensitization (Category 1), H317
Germ cell mutagenicity (Category 2), H341
Carcinogenicity (Category 1B), H350
For the full text of the H-Statements mentioned in this Section, see Section 16.

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2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram

Signal word Danger

Hazard statement(s)
H302 + H332 Harmful if swallowed or if inhaled.
H317 May cause an allergic skin reaction.
H341 Suspected of causing genetic defects.
H350 May cause cancer.
Precautionary statement(s)
P201 Obtain special instructions before use.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection/ hearing protection.
P301 + P312 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel
unwell.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Call a POISON CENTER/ doctor if you feel unwell.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
Supplemental Hazard none
Statements
Restricted to professional users.
Reduced Labeling (<= 125 ml)
Pictogram

Signal word Danger

Hazard statement(s)
H317 May cause an allergic skin reaction.
H341 Suspected of causing genetic defects.
H350 May cause cancer.
Precautionary statement(s)
P201 Obtain special instructions before use.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection/ hearing protection.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

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SECTION 3: Composition/information on ingredients
3.2 Mixtures
Component Classification Concentration
formaldehyde
CAS-No. 50-00-0 Acute Tox. 3; Acute Tox. >= 3 - < 5 %
EC-No. 200-001-8 2; Acute Tox. 3; Skin Corr.
Index-No. 605-001-00-5 1B; Eye Dam. 1; Skin
Registration 01-2119488953-20- Sens. 1; Muta. 2; Carc.
number XXXX 1B; STOT SE 3; H301,
H330, H311, H314, H318,
H317, H341, H350, H335
Concentration limits:
>= 25 %: Skin Corr. 1B,
H314; 5 - < 25 %: Skin
Irrit. 2, H315; 5 - < 25 %:
Eye Irrit. 2, H319; >= 5
%: STOT SE 3, H335; >=
0,2 %: Skin Sens. 1,
H317;
Methanol
CAS-No. 67-56-1 Flam. Liq. 2; Acute Tox. 3; >= 1 - < 3 %
EC-No. 200-659-6 STOT SE 1; H225, H301,
Index-No. 603-001-00-X H331, H311, H370
Registration 01-2119433307-44- Concentration limits:
number XXXX >= 10 %: STOT SE 1,
H370; 3 - < 10 %: STOT
SE 2, H371;
For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with
water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact
lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.

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4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the
surrounding environment.
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Not combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Forms explosive mixtures with air on intense heating.
Ambient fire may liberate hazardous vapours.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
5.4 Further information
Remove container from danger zone and cool with water. Prevent fire extinguishing water
from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance
contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions
(see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb®). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.

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SECTION 7: Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary
measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands
and face after working with substance.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only
to qualified or authorized persons.
Storage class
Storage class (TRGS 510): 6.1C: Combustible, acute toxic Cat.3 / toxic compounds or
compounds which causing chronic effects
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters
Ingredients with workplace control parameters
8.2 Exposure controls

Personal protective equipment

Eye/face protection
Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact
with this product. Dispose of contaminated gloves after use in accordance with
applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU)
2016/425 and the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)
Splash contact

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 Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail
[email protected], test method: EN374
If used in solution, or mixed with other substances, and under conditions which
differ from EN 374, contact the supplier of the EC approved gloves. This
recommendation is advisory only and must be evaluated by an industrial hygienist
and safety officer familiar with the specific situation of anticipated use by our
customers. It should not be construed as offering an approval for any specific use
scenario.
Body Protection
protective clothing
Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following
standards: DIN EN 143, DIN 14387 and other accompanying standards relating to
the used respiratory protection system.
Recommended Filter type: Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory
protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure
Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
Color: colorless
b) Odor No data available
c) Odor Threshold No data available
d) pH 6,5 - 7,5 at 10%
e) Melting No data available
point/freezing point
f) Initial boiling point 100 °C at 1.013 hPa
and boiling range
g) Flash point 85 °CNot applicable
h) Evaporation rate No data available
i) Flammability (solid, No data available
gas)
j) Upper/lower Upper explosion limit: 70 %(V)
flammability or
explosive limits Lower explosion limit: 7 %(V)
k) Vapor pressure 53 hPa at 39 °C

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 l) Vapor density No data available
m) Density 1,080 g/cm3
Relative density No data available
n) Water solubility completely miscibleat 20 °C soluble
o) Partition coefficient: No data available
n-octanol/water
p) Autoignition Not applicable
temperature
q) Decomposition No data available
temperature
r) Viscosity Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
s) Explosive properties Not classified as explosive.
t) Oxidizing properties none

9.2 Other safety information

No data available

SECTION 10: Stability and reactivity

10.1 Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Violent reactions possible with:
The generally known reaction partners of water.

10.4 Conditions to avoid

Strong heating.
10.5 Incompatible materials
Strong bases, Acids, Oxidizing agents, Alkali metals, Strong oxidizing agents, Amines,
Strong acids, Acid chlorides, Acid anhydrides, Reducing agents, Peroxides, Isocyanates,
Phenol, Aniline
10.6 Hazardous decomposition products
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Mixture
Acute toxicity
Oral: No data available

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 Acute toxicity estimate Inhalation - 4 h - 12,01 mg/l - vapor(Calculation method)

Dermal: No data available

Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitization
Mixture may cause an allergic skin reaction.
Germ cell mutagenicity
Evidence of genetic defects.
Carcinogenicity
No data available
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain
components considered to have endocrine
disrupting properties according to REACH Article
57(f) or Commission Delegated regulation (EU)
2017/2100 or Commission Regulation (EU)
2018/605 at levels of 0.1% or higher.
Methyl alcohol may be fatal or cause blindness if swallowed., Cannot be made non-
poisonous., Effects due to ingestion may include:, Nausea, Dizziness, Gastrointestinal
disturbance, Weakness, Confusion., Drowsiness, Unconsciousness, May cause convulsions.
Other dangerous properties can not be excluded.

This substance should be handled with particular care.

Handle in accordance with good industrial hygiene and safety practice.

Components
formaldehyde
Acute toxicity
LD50 Oral - Rat - 100 mg/kg
Remarks: (Lit.)

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 LC50 Inhalation - Rat - male and female - 4 h - < 0,57 mg/l - vapor
(OECD Test Guideline 403)
LD50 Dermal - Rabbit - 270 mg/kg
Remarks: (RTECS)
Skin corrosion/irritation
Skin - Rabbit
Result: Causes burns. - 20 h
(OECD Test Guideline 404)
Serious eye damage/eye irritation
Causes serious eye damage.
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: positive
(OECD Test Guideline 429)
Germ cell mutagenicity
Suspected of causing genetic defects.
Carcinogenicity
Presumed to have carcinogenic potential for humans
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available

Methanol
Acute toxicity
Acute toxicity estimate Oral - 100,1 mg/kg
(Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table
3.1/3.2)
Symptoms: Nausea, Vomiting
Acute toxicity estimate Inhalation - 4 h - 3,1 mg/l - vapor
(Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table
3.1/3.2)
Symptoms: Irritation symptoms in the respiratory tract.
Acute toxicity estimate Dermal - 300,1 mg/kg
(Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table
3.1/3.2)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation
Remarks: (ECHA)
Drying-out effect resulting in rough and chapped skin.

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 Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation
Remarks: (ECHA)
Respiratory or skin sensitization
Sensitisation test: - Guinea pig
Result: negative
(OECD Test Guideline 406)
Germ cell mutagenicity
Based on available data the classification criteria are not met.
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster lung cells
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male and female - Bone marrow
Result: negative
Carcinogenicity
Did not show carcinogenic effects in animal experiments.
Reproductive toxicity
Based on available data the classification criteria are not met.
Specific target organ toxicity - single exposure
Causes damage to organs. - Eyes, Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table
3.1/3.2)
Acute oral toxicity - Nausea, Vomiting
Acute inhalation toxicity - Irritation symptoms in the respiratory tract.
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available

SECTION 12: Ecological information

12.1 Toxicity
Mixture
No data available
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment

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 This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components
considered to have endocrine disrupting properties
according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.

12.7 Other adverse effects

No data available
Components
formaldehyde
Toxicity to fish static test LC50 - Morone saxatilis - 6,7 mg/l - 96 h
Remarks: (ECHA)

Toxicity to daphnia static test EC50 - Daphnia pulex (Water flea) - 5,8 mg/l - 48 h
and other aquatic (OECD Test Guideline 202)
invertebrates

Toxicity to algae static test EC50 - Desmodesmus subspicatus (green algae) -

4,89 mg/l - 72 h
(OECD Test Guideline 201)
Toxicity to bacteria static test EC50 - activated sludge - 19 mg/l - 3 h
(OECD Test Guideline 209)
Methanol
Toxicity to fish flow-through test LC50 - Lepomis macrochirus (Bluegill) -
15.400,0 mg/l - 96 h
(US-EPA)
Toxicity to daphnia semi-static test EC50 - Daphnia magna (Water flea) - 18.260
and other aquatic mg/l - 96 h
invertebrates (OECD Test Guideline 202)

Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green

algae) - ca. 22.000,0 mg/l - 96 h
(OECD Test Guideline 201)
Toxicity to bacteria static test IC50 - activated sludge - > 1.000 mg/l - 3 h
(OECD Test Guideline 209)

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and
containers, or contact us there if you have further questions.

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SECTION 14: Transport information
14.1 UN number
ADR/RID: - IMDG: - IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
14.4 Packaging group
ADR/RID: - IMDG: - IATA: -
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
Authorisations and/or restrictions on use
REACH - Restrictions on the manufacture, : formaldehyde
placing on the market and use of certain Methanol
dangerous substances, preparations and articles
(Annex XVII)

Other regulations
Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or
stricter national regulations where applicable.
Take note of Dir 94/33/EC on the protection of young people at work.
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H225 Highly flammable liquid and vapor.
H301 Toxic if swallowed.
H302 Harmful if swallowed.
H302 + H332 Harmful if swallowed or if inhaled.
H311 Toxic in contact with skin.
H314 Causes severe skin burns and eye damage.
H315 Causes skin irritation.
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 H317 May cause an allergic skin reaction.
H318 Causes serious eye damage.
H319 Causes serious eye irritation.
H330 Fatal if inhaled.
H331 Toxic if inhaled.
H332 Harmful if inhaled.
H335 May cause respiratory irritation.
H341 Suspected of causing genetic defects.
H350 May cause cancer.
H370 Causes damage to organs.
H371 May cause damage to organs.
Further information
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.

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