Modelo Vírus Do HIV

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Build a Paper Model of HIV Capsid

pdb101.rcsb.org

Viruses come in many shapes and sizes, from simple protein shells filled with RNA or DNA to
membrane-enveloped particles that rival cells in complexity. HIV (shown on the right) is one of
these complex viruses, surrounded by a membrane and filled with a diverse collection of viral
and cellular molecules.
The genome of HIV, which is composed of two
strands of RNA, is packaged inside a
distinctive cone-shaped capsid,
which protects the RNA and
delivers it to the cells
that HIV infects.

capsid

viral enzymes and


accessory proteins

structural proteins
and membrane

#
g
.or
csb
1.r

To build an HIV capsid


b10
pd

at 1,000,000x magnifi-
cation, cut out the
model, fold along the
white lines, and tape or
glue the gray flaps.
Add two pieces of
string inside, each 3.3
meters long, to model
the RNA strands.

For an extra challenge,


try assembling the
model without creasing
on the lines to build a
rounder model that is
more similar to the
actual capsid.

& 6
n
t
y

Go to pdb101.rcsb.org to:
• read the Molecule of the
Month feature on
HIV Capsid
• download additional
copies of this model,
and watch a video
demonstration of how
Image created using data from the PDB archive to build it (Learn >
PDB ID: 3j3q Paper Models)
Mature HIV-1 capsid structure by cryo-electron microscopy
and all-atom molecular dynamics, G. Zhao, J.R. Perilla,
E.L. Yufenyuy, X. Meng, B. Chen, J. Ning, J. Ahn,
A.M. Gronenborn, K. Schulten, C. Aiken, P. Zhang
(2013) Nature 497: 643–646
PDB-101 is the educational portal of RCSB Protein Data Bank (rcsb.org)

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