Applications of Titration
Applications of Titration
Applications of Titration
Semester/Section: IV B
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Introduction of Titration
If you have ever worked in a chemistry lab, you are certainly familiar with the fact
that measurements are the key factor in doing chemistry. At its heart, chemistry
contains some very sophisticated methods that provide us with the products that
make our lives easier on daily basis. Specifically, analytical chemistry is the
branch of chemical sciences that mainly deals with two parts:
Qualitative Analysis: Reveals the identity of the chemical species in a
given sample.
Quantitative Analysis: The numerical determination of the absolute or
relative abundance of one, several, or all particular substance(s) present in a
sample.
Applications of Titration
Let’s take a look at few applications of how titration makes our lives easier
every day:
Food Industry:
Making delicious food is undoubtedly a complex task, which comes with a long
list of regulations to which the food and beverage industries are strictly subjected.
These regulations are fairly reasonable as contaminated food products can cause
serious problems to both consumers and producers. Titration is frequently used in
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the food industry to keep the acid, base, and salt content in the food products under
supervision. Some of the everyday food products, whose quality is determined by
titration are:
Acetic Acid in Vinegar, Mayonnaise, and Ketchup.
Citric Acid in Frozen Orange Juice Concentrate.
Malic Acid in Apple Juice.
Lactic Acid in Pickles.
Phosphoric Acid in Cola Beverages.
Salt in several food products such as Snacks, Chips, Meat Products, etc.
The alkalinity of Raw Water in the Beverage Industry.
The nitrogen content as per Kjeldahl (Protein) in meat products.
The codes of oils and fats, such as acid values, saponification
number, peroxide number, and iodine values.
In determining acidity by titration, the acid is neutralized by an alkaline
solution, most commonly, sodium hydroxide (NaOH). In a monoprotic acid
titration, equilibrium is reached at a particular pH, which can be detected
with a pH meter or visually by adding an indicator that changes its color at
the equilibrium pH. With the increase in competition, the level of volumetric
analysis in the food industry has reached similar heights to that of the
pharmaceutical industry.
Cosmetic Industry:
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Makeup has long been a part of human civilization, with the earliest known use of
cosmetic products dating back to 4000 BC (probably by Egyptians). The 21st-
century cosmetic industry worth $200 billion in business around the world, and
like many other chemical products of our daily use, this industry also depends on
titration to a great extent for the quality of their products. Since the product is to be
used by the consumer directly on their skin, cosmetic industries need to make sure
that the product should not cause any harm to the consumers. Titration facilitates
the appropriate concentration and amount of ingredients used in the manufacturing
of cosmetic products. Hair dyes, skin creams, shampoos, conditioners, cleansers,
and shaving creams all contain some mixtures of acids and bases. For instance,
bases like ammonium hydroxide are often used to adjust the pH in these products
via titration. Commercially available depilatory creams are of great concern to both
the producers and end consumers as they act by entering deep into the skin surface
and are most likely to cause allergic reactions such as rashes and bleeding burns. A
little misjudgment in the amounts of caustic chemicals can become a major
problem, and it can cause he companies to lose millions of dollars in lawsuits
Wine Industry:
From vineyards to glass, the process of making wine includes series of chemical
reactions and process that guarantees the elegant taste, color, and texture of the
wine. For winemakers, the quality of the wine is of paramount importance.
Mastering the art of making an exceptional wine comes with the science of
titration. For instance, it is essential to measure the concentration of several acids
such as tartaric, malic, or citric acid because the acid content impacts the taste,
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color, and microbial stability of the grape juice from which the wine is to be made.
In the wine industry, these acidic concentrations are known by the term “titratable
acidity.” The process includes titrating degassed wine with NaOH solution at
different paces until the endpoint of 8.2 pH is reached. Another most important
step in making wine is to evaluate and control the levels of sulfur dioxide content
in the wine. Sulfur dioxide is used as a microbial agent to control the spoilage of
wine by destroying bacteria that may cause unwanted secondary fermentation, both
during the vintage and winemaking and also during the storage. It also acts as an
antioxidant preserving the color of the wine. Sulfur dioxide in wine is traditionally
analyzed by Ripper titration using a color indicator. This technique uses iodine and
a starch indicator to titrate the solution and determine the concentration of
free {SO}_{2}SO2. Although advanced techniques such as gas chromatography or
liquid chromatography are usually available to most wineries for practical reasons,
titration is critical to ensure the consistency of the product quality.
Pharmaceutical Industry:
Like many other branches of chemistry, titration has long been a standard
method of analysis in the pharmaceutical industry. It facilitates the content
determination of active ingredients and raw materials for drug
manufacturing. From the formulation of a drug to its production, the role of
volumetric analysis can be categorized primarily in four different processes
as follow:
Purity Analysis of Pharmaceutically Active Ingredients: Titration is used to
determine the content of active ingredients in pharmaceutical products, e.g.
acetylsalicylic acid in Aspirin, or vitamin C in multivitamins tablets, and for
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the content determination and purity control of drug additives used for the
synthesis of medicinal compounds.
Content Analysis by Redox Titrations: Oxidation-reduction (redox) titrations
are also used for checking the purity of raw materials, fillers, and
preservatives. A good example of this is the bromatometric determination of
methyl- 4-benzoate, a p-hydroxybenzoic acid ester. This compound is used
as a preservative in ophthalmic preparations and ointments for external
application.
Precipitation Titrations: Based on their structure, some active ingredients
precipitate with a suitable titrant to form consumable medication. Examples
of this are benzalkonium chloride and clotrimazole.
pH-Stat Titrations: The pH-stat titration is performed to characterize drugs,
to check the purity of enzyme products, and to investigate the kinetics of
chemical reactions. pH-stat means the stationary pH value, i.e. the pH value
is held constant for a certain period of time. This technique is used in
particular for the determination of reaction kinetic parameters such as the
reactivity of enzymes.
Biodiesel Manufacturing:
Wastewater Management:
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Water is one of the essential components of our life, and its quality and
safety are of paramount importance for our well-being. Although water is a
renewable resource and is present in abundance on our planet, many
developing countries have inadequate access to clean drinking water. To
maintain a secure supply of drinking water, reliable testing of key variables
is necessary to support wastewater treatment and decontamination processes.
The contamination of water is monitored by analyzing the pH level of the
water with the help of simple titration methods. A significant change in pH
can also have repercussions on the other chemicals present in the water. For
instance, under normal conditions, the ammonia present in the water is not
regarded as harmful to aquatic life; however, if the pH increases, ammonia
becomes toxic and severely affects aquatic life. Besides, the solubility of
metals in water also depends upon the pH levels. If the water is more acidic
(low pH levels), it tends to dissolve the metals, thus increasing the chances
of toxicity. Another factor that titration allows us to analyze is the alkalinity
of water. In general terms, alkalinity is the measure of a water body’s ability
to neutralize the acid content. Alkaline compounds in the water such as
bicarbonates, carbonates, and hydroxides lower the acidity of water by
removing {H}^{+}H+ ions.
Medical Diagnosis: