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    Lectin Pathway

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    Laleth Mendoza Ojales
    The lectin pathway is similar to the classical pathway but uses mannose-binding lectin (MBL) instead of C1q. MBL binds to mannose residues on pathogens and activates MASP-1 and MASP-2, which can then cleave C4 and C2 into fragments. C4b and C2b bind together to form the C3 convertase. Historically, the larger fragment of C2 was called C2a but is now referred to as C2b. Immunology textbooks have used different naming conventions for the C2 fragments but there is a widely established convention to call the larger fragment C2b.

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    Lectin Pathway

    Uploaded by

    Laleth Mendoza Ojales
    73 views1 page
    The lectin pathway is similar to the classical pathway but uses mannose-binding lectin (MBL) instead of C1q. MBL binds to mannose residues on pathogens and activates MASP-1 and MASP-2, which can then cleave C4 and C2 into fragments. C4b and C2b bind together to form the C3 convertase. Historically, the larger fragment of C2 was called C2a but is now referred to as C2b. Immunology textbooks have used different naming conventions for the C2 fragments but there is a widely established convention to call the larger fragment C2b.

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    The lectin pathway is similar to the classical pathway but uses mannose-binding lectin (MBL) instead of C1q. MBL binds to mannose residues on pathogens and activates MASP-1 and MASP-2, which can then cleave C4 and C2 into fragments. C4b and C2b bind together to form the C3 convertase. Historically, the larger fragment of C2 was called C2a but is now referred to as C2b. Immunology textbooks have used different naming conventions for the C2 fragments but there is a widely established convention to call the larger fragment C2b.

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    © All Rights Reserved
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    73 views1 page

    Lectin Pathway

    Uploaded by

    Laleth Mendoza Ojales
    The lectin pathway is similar to the classical pathway but uses mannose-binding lectin (MBL) instead of C1q. MBL binds to mannose residues on pathogens and activates MASP-1 and MASP-2, which can then cleave C4 and C2 into fragments. C4b and C2b bind together to form the C3 convertase. Historically, the larger fragment of C2 was called C2a but is now referred to as C2b. Immunology textbooks have used different naming conventions for the C2 fragments but there is a widely established convention to call the larger fragment C2b.

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    Lectin pathway[edit]

    Main article: Lectin pathway


    The lectin pathway is homologous to the classical pathway, but with the opsonin, mannose-binding
    lectin (MBL), and ficolins, instead of C1q. This pathway is activated by binding of MBL to mannose
    residues on the pathogen surface, which activates the MBL-associated serine proteases, MASP-1,
    and MASP-2 (very similar to C1r and C1s, respectively), which can then split C4 into C4a and C4b
    and C2 into C2a and C2b. C4b and C2b then bind together to form the classical C3-convertase, as
    in the classical pathway. Ficolins are homologous to MBL and function via MASP in a similar way.
    Several single-nucleotide polymorphisms have been described in M-ficolin in humans, with effect on
    ligand-binding ability and serum levels. Historically, the larger fragment of C2 was named C2a, but it
    is now referred to as C2b.[17] In invertebrates without an adaptive immune system, ficolins are
    expanded and their binding specificities diversified to compensate for the lack of pathogen-specific
    recognition molecules.[citation needed]

    Complement protein fragment nomenclature[edit]


    Immunology textbooks have used different naming assignments for the smaller and larger fragments
    of C2 as C2a and C2b. The preferred assignment appears to be that the smaller fragment be
    designated as C2a: as early as 1994, a well known textbook recommended that the larger fragment
    of C2 should be designated C2b.[18] However, this was amplified in their 1999 4th edition, to say that:
    [19]
     "It is also useful to be aware that the larger active fragment of C2 was originally designated C2a,
    and is still called that in some texts and research papers. Here, for consistency, we shall call all large
    fragments of complement b, so the larger fragment of C2 will be designated C2b. In the classical
    and lectin pathways the C3 convertase enzyme is formed from membrane-bound C4b with C2b."[19]
    This nomenclature is used in another literature:[20] The assignment is mixed in the latter literature,
    though. Some sources designate the larger and smaller fragments as C2a and C2b respectively[21][22]
    [23][24][25][26][27][28][29]
     while other sources apply the converse.[18][19][30][31][32] However, due to the widely
    established convention, C2b here is the larger fragment, which, in the classical pathway, forms
    C4b2b (classically C4b2a). It may be noteworthy that, in a series of editions of Janeway's book, 1st
    to 7th, in the latest edition[28] they withdraw the stance to indicate the larger fragment of C2 as C2b.

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