Pathophysiology of PCOS: Alex Rotstein, Ragini Srinivasan, and Eric Wong
Pathophysiology of PCOS: Alex Rotstein, Ragini Srinivasan, and Eric Wong
Pathophysiology of PCOS Alex Rotstein, Ragini Srinivasan, and Eric Wong
Genetika Komorbiditas T2DM
Kegemukan Dislipidemia Penyakit
Gaya hidup menetap Jantung
Paparan androgen intrauterin (?)
Peningkatan pelepasan metformin
Resistensi insulin
pulsatil GnRH Akantosis nigrikans
Peningkatan rasio
Hyperinsulinemia
Melalui LH:FSH
pengurangan
penghambatan ↑ LH → theca cels Via ↑ androgenic and ↓ SHBG
umpan balik
hipotalamus
Kelebihan
Androgen
OCPs Penekanan pusat
Spironolactone
Hirsutisme Finasteride Blokade androgen
Depresi
Jerawat Flutamide perifer
komorbid Terhentinya
Alopecia
perkembangan memperburuk
folikel antral
Clomiphene citrate Ovarium polikistik
Metformin Anovulasi “untaian mutiara” di
U/S
tidak ada korpus luteum
Perkembangan oosit
Penurunan
Perdarahan yang terganggu, tingkat
pelepasan Subfertilitas keguguran yang tinggi
anovulasi
progesteron dan berbagai
komplikasi kebidanan
terobosan
Estrogen tanpa lawan (↑)
Siklus tidak Melalui hiperplasia endometrium
teratur
↑ risiko kanker endometrium
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