Bayer CropScience

SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

PREMISE 350 SC 1/9

Version 1 / IND Revision Date: 23.09.2013
102000019218 Print Date: 23.09.2013

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE

COMPANY/UNDERTAKING
1.1 Product identifier
Trade name PREMISE 350 SC
Product code (UVP) 79227574
1.2 Relevant identified uses of the substance or mixture and uses advised against
Use Insecticide
1.3 Details of the supplier of the safety data sheet
Supplier Bayer CropScience Limited
Kolshet Road
400607 Thane (W)
Maharashtra
India
Telephone +91-22-25311030 / 25311234
Telefax +91-22-25455223

1.4 Emergency telephone no.

Indian Emergency Number 022-25311885 (24 hours/day)
Global Incident Response +1 (760) 476-3964 (Company 3E for Bayer CropScience)
Hotline

SECTION 2: HAZARDS IDENTIFICATION

2.1 Classification of the substance or mixture
Classification in accordance with Regulation (EC) No 1272/2008 on classification, labelling and
packaging of substances and mixtures, as amended.
Acute toxicity: Category 4
H302 Harmful if swallowed.
Acute aquatic toxicity: Category 1
H400 Very toxic to aquatic life.
Chronic aquatic toxicity: Category 1
H410 Very toxic to aquatic life with long lasting effects.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Xn Harmful, R22
N Dangerous for the environment, R50/53
2.2 Label elements
Labelling in accordance with Regulation (EC) No 1272/2008 on classification, labelling and
packaging of substances and mixtures, as amended.
Hazard label for supply/use required.
Hazardous components which must be listed on the label:
• Imidacloprid
Bayer CropScience
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

PREMISE 350 SC 2/9

Version 1 / IND Revision Date: 23.09.2013
102000019218 Print Date: 23.09.2013

Signal word: Warning

Hazard statements
H302 Harmful if swallowed.
H410 Very toxic to aquatic life with long lasting effects.
EUH401 To avoid risks to human health and the environment, comply with the instructions for
use.
Precautionary statements
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P501 Dispose of contents/container in accordance with local regulation.
2.3 Other hazards
No other hazards known.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS

3.2 Mixtures
Chemical nature
Suspension concentrate (=flowable concentrate)(SC)
Imidacloprid 350 g/l
Hazardous components
R-phrase(s) according to EC directive 67/548/EEC
Hazard statements according to Regulation (EC) No. 1907/2006
Name CAS-No. / Classification Conc. [%]
EC-No. EC Directive Regulation (EC) No
67/548/EEC 1272/2008
Imidacloprid 138261-41-3 Xn; R22 Acute Tox. 4, H302 30.50
428-040-8 N; R50/53 Aquatic Acute 1, H400
Aquatic Chronic 1, H410
Glycerine 56-81-5 Not classified Not classified > 1.00
200-289-5
Further information
Imidacloprid 138261-41-3 M-Factor: 10 (acute)
Substances which do not meet the classification criteria according to Directive 67/548/EEC as amended:
Glycerine (56-81-5): Substance with an EU indicative Occupational Exposure Limit value (OEL) below
the threshold value for reporting.
For the full text of the R-phrases/ Hazard statements mentioned in this Section, see Section 16.
Bayer CropScience
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

PREMISE 350 SC 3/9

Version 1 / IND Revision Date: 23.09.2013
102000019218 Print Date: 23.09.2013

SECTION 4: FIRST AID MEASURES

4.1 Description of first aid measures
General advice Move out of dangerous area. Place and transport victim in stable
position (lying sideways). Remove contaminated clothing immediately
and dispose of safely.
Skin contact Wash off thoroughly with plenty of soap and water, if available with
polyethyleneglycol 400, subsequently rinse with water. If symptoms
persist, call a physician.
Eye contact Rinse immediately with plenty of water, also under the eyelids, for at
least 15 minutes. Remove contact lenses, if present, after the first 5
minutes, then continue rinsing eye. Get medical attention if irritation
develops and persists.
Ingestion Call a physician or poison control center immediately. Rinse mouth.
Induce vomiting only, if: 1. patient is fully conscious, 2. medical aid is not
readily available, 3. a significant amount (more than a mouthful) has
been ingested and 4. time since ingestion is less than 1 hour. (Vomit
should not get into the respiratory tract.)
4.2 Most important symptoms and effects, both acute and delayed
Symptoms If large amounts are ingested, the following symptoms may occur:
Nausea, Vomiting, Abdominal pain, Dizziness
Symptoms and hazards refer to effects observed after intake of
significant amounts of the active ingredient(s).
4.3 Indication of any immediate medical attention and special treatment needed
Treatment Treat symptomatically. Monitor: respiratory and cardiac functions. In
case of ingestion gastric lavage should be considered in cases of
significant ingestions only within the first 2 hours. However, the
application of activated charcoal and sodium sulphate is always
advisable. There is no specific antidote.

SECTION 5: FIREFIGHTING MEASURES

5.1 Extinguishing media
Suitable Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Unsuitable High volume water jet
Hazchem Code 3Z

5.2 Special hazards arising In the event of fire the following may be released:, Hydrogen chloride
from the substance or (HCl), Hydrogen cyanide (hydrocyanic acid), Carbon monoxide (CO),
mixture Nitrogen oxides (NOx)
5.3 Advice for firefighters
Special protective In the event of fire and/or explosion do not breathe fumes. In the event
equipment for fire-fighters of fire, wear self-contained breathing apparatus.
Further information Contain the spread of the fire-fighting media. Do not allow run-off from
fire fighting to enter drains or water courses.
Bayer CropScience
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

PREMISE 350 SC 4/9

Version 1 / IND Revision Date: 23.09.2013
102000019218 Print Date: 23.09.2013

SECTION 6: ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions, protective equipment and emergency procedures
Precautions Avoid contact with spilled product or contaminated surfaces. Use
personal protective equipment.

6.2 Environmental Do not allow to get into surface water, drains and ground water.
precautions
6.3 Methods and materials for containment and cleaning up
Methods for cleaning up Soak up with inert absorbent material (e.g. sand, silica gel, acid binder,
universal binder, sawdust). Clean contaminated floors and objects
thoroughly, observing environmental regulations. Keep in suitable,
closed containers for disposal.
Additional advice Check also for any local site procedures.

6.4 Reference to other Information regarding safe handling, see section 7.

sections Information regarding personal protective equipment, see section 8.
Information regarding waste disposal, see section 13.

SECTION 7: HANDLING AND STORAGE

7.1 Precautions for safe handling
Advice on safe handling Use only in area provided with appropriate exhaust ventilation. For
personal protection see section 8.
Advice on protection No special precautions required.
against fire and explosion
Hygiene measures Avoid contact with skin, eyes and clothing. Keep working clothes
separately. Wash hands before breaks and immediately after handling
the product. Remove soiled clothing immediately and clean thoroughly
before using again. Garments that cannot be cleaned must be
destroyed (burnt).
7.2 Conditions for safe storage, including any incompatibilities
Requirements for storage Keep containers tightly closed in a dry, cool and well-ventilated place.
areas and containers Store in original container. Store in a place accessible by authorized
persons only. Keep away from direct sunlight. Protect from frost.
7.3 Specific end uses Refer to the label and/or leaflet.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control parameters

Components CAS-No. Control parameters Update Basis

Imidacloprid 138261-41-3 0.7 mg/m3 OES BCS*
(TWA)
*OES BCS: Internal Bayer CropScience "Occupational Exposure Standard"
8.2 Exposure controls
Bayer CropScience
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

PREMISE 350 SC 5/9

Version 1 / IND Revision Date: 23.09.2013
102000019218 Print Date: 23.09.2013

Personal protective equipment

In normal use and handling conditions please refer to the label and/or leaflet. In all other cases the
following recommendations would apply.
Respiratory protection Respiratory protection is not required under anticipated circumstances
of exposure.
Respiratory protection should only be used to control residual risk of
short duration activities, when all reasonably practicable steps have
been taken to reduce exposure at source e.g. containment and/or local
extract ventilation. Always follow respirator manufacturer's instructions
regarding wearing and maintenance.
Hand protection Wear CE Marked (or equivalent) nitrile rubber gloves (minimum
thickness of 0,4 mm). Wash when contaminated and dispose of when
contaminated inside, when perforated or when contamination on the
outside cannot be removed. Wash hands frequently and always before
eating, drinking, smoking or using the toilet.
Eye protection Wear goggles (conforming to EN166, Field of Use = 5 or equivalent).
Skin and body protection Wear standard coveralls and Category 3 Type 6 suit.
If there is a risk of significant exposure, consider a higher protective type
suit.
Wear two layers of clothing wherever possible. Polyester/cotton or
cotton overalls should be worn under chemical protection suit and
should be professionally laundered frequently.
If chemical protection suit is splashed, sprayed or significantly
contaminated, decontaminate as far as possible, then carefully remove
and dispose of as advised by manufacturer.

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties
Form liquid, suspension
Colour white
Odour weak, characteristic
pH 7.0 - 8.5 at 100 % (23 °C)
Density ca. 1.15 g/cm³ at 20 °C
Water solubility miscible
Partition coefficient: n- Imidacloprid: log Pow: 0.57
octanol/water
9.2 Other information Further safety related physical-chemical data are not known.

SECTION 10: STABILITY AND REACTIVITY

10.1 Reactivity
Thermal decomposition Stable under normal conditions.
10.2 Chemical stability Stable under recommended storage conditions.
Bayer CropScience
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

PREMISE 350 SC 6/9

Version 1 / IND Revision Date: 23.09.2013
102000019218 Print Date: 23.09.2013

10.3 Possibility of No hazardous reactions when stored and handled according to

hazardous reactions prescribed instructions.

10.4 Conditions to avoid Extremes of temperature and direct sunlight.

10.5 Incompatible materials Store only in the original container.

10.6 Hazardous No decomposition products expected under normal conditions of use.

decomposition products

SECTION 11: TOXICOLOGICAL INFORMATION

11.1 Information on toxicological effects
Acute oral toxicity LD50 (rat) > 300 - < 2,000 mg/kg
Test conducted with a similar formulation.
Acute inhalation toxicity LC50 (rat) > 2.743 mg/l
Exposure time: 4 h
Highest attainable concentration.
Determined in the form of a respirable aerosol.
Test conducted with a similar formulation.
Acute dermal toxicity LD50 (rat) > 2,000 mg/kg
Test conducted with a similar formulation.
Skin irritation No skin irritation (rabbit)
Test conducted with a similar formulation.
Eye irritation No eye irritation (rabbit)
Test conducted with a similar formulation.
Sensitisation Non-sensitizing. (mouse)
OECD Test Guideline 429, local lymph node assay (LLNA)
Test conducted with a similar formulation.
Assessment repeated dose toxicity
Imidacloprid did not cause specific target organ toxicity in experimental animal studies.
Assessment Mutagenicity
Imidacloprid was not mutagenic or genotoxic based on the overall weight of evidence in a battery of in
vitro and in vivo tests.
Assessment Carcinogenicity
Imidacloprid was not carcinogenic in lifetime feeding studies in rats and mice.
Assessment toxicity to reproduction
Imidacloprid caused reproduction toxicity in a two-generation study in rats only at dose levels also toxic
to the parent animals. The reproduction toxicity seen with Imidacloprid is related to parental toxicity.
Assessment developmental toxicity
Imidacloprid caused developmental toxicity only at dose levels toxic to the dams. The developmental
effects seen with Imidacloprid are related to maternal toxicity.
Further information
No further toxicological information is available.
Bayer CropScience
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

PREMISE 350 SC 7/9

Version 1 / IND Revision Date: 23.09.2013
102000019218 Print Date: 23.09.2013

SECTION 12: ECOLOGICAL INFORMATION

12.1 Toxicity
Toxicity to fish LC50 (Rainbow trout (Oncorhynchus mykiss)) 211 mg/l
Exposure time: 96 h
The value mentioned relates to the active ingredient imidacloprid.
Toxicity to aquatic EC50 (Water flea (Daphnia magna)) 85 mg/l
invertebrates Exposure time: 48 h
The value mentioned relates to the active ingredient imidacloprid.
LC50 (Chironomus riparius (non-biting midge)) 0.0552 mg/l
Exposure time: 24 h
The value mentioned relates to the active ingredient imidacloprid.
Toxicity to aquatic plants EC50 (Desmodesmus subspicatus) > 10 mg/l
Growth rate; Exposure time: 72 h
The value mentioned relates to the active ingredient imidacloprid.
12.2 Persistence and degradability
Biodegradability Imidacloprid:
not rapidly biodegradable
Koc Imidacloprid: Koc: 225
12.3 Bioaccumulative potential
Bioaccumulation Imidacloprid:
Does not bioaccumulate.
12.4 Mobility in soil
Mobility in soil Imidacloprid: Moderately mobile in soils
12.5 Results of PBT and vPvB assessment
PBT and vPvB assessment Imidacloprid: This substance is not considered to be persistent,
bioaccumulative and toxic (PBT). This substance is not considered to be
very persistent and very bioaccumulative (vPvB).
12.6 Other adverse effects
Additional ecological No other effects to be mentioned.
information

SECTION 13: DISPOSAL CONSIDERATIONS

13.1 Waste treatment methods
Product In accordance with current regulations and, if necessary, after
consultation with the site operator and/or with the responsible authority,
the product may be taken to a waste disposal site or incineration plant.
Contaminated packaging Not completely emptied packagings should be disposed of as
hazardous waste.
Waste key for the unused 020108 agrochemical waste containing dangerous substances
product
Legal basis
Bayer CropScience
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

PREMISE 350 SC 8/9

Version 1 / IND Revision Date: 23.09.2013
102000019218 Print Date: 23.09.2013

Waste key in accordance with Schedule I of the Hazardous Waste Rules, 2008 as amended (India
- EP Act):
29.1Process wastes/residues
29.3Date-expired and off-specification pesticides

SECTION 14: TRANSPORT INFORMATION

ADR/RID/ADN
14.1 UN number 3082
14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID,
N.O.S.
(IMIDACLOPRID SOLUTION)
14.3 Transport hazard class(es) 9
14.4 Packing group III
14.5 Environm. Hazardous Mark YES
Hazard no. 90
Hazchem Code 3Z
Tunnel Code E

This classification is in principle not valid for carriage by tank vessel on inland waterways. Please
refer to the manufacturer for further information.

IMDG
14.1 UN number 3082
14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID,
N.O.S.
(IMIDACLOPRID SOLUTION)
14.3 Transport hazard class(es) 9
14.4 Packing group III
14.5 Marine pollutant YES

IATA
14.1 UN number 3082
14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID,
N.O.S.
(IMIDACLOPRID SOLUTION )
14.3 Transport hazard class(es) 9
14.4 Packing group III
14.5 Environm. Hazardous Mark YES

14.6 Special precautions for user

See sections 6 to 8 of this Safety Data Sheet.

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
No transport in bulk according to the IBC Code.

SECTION 15: REGULATORY INFORMATION

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
Further information
WHO-classification: II (Moderately hazardous)
Labeling according to Insecticide Rules 1971 as amended. (INDIA)
Bayer CropScience
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

PREMISE 350 SC 9/9

Version 1 / IND Revision Date: 23.09.2013
102000019218 Print Date: 23.09.2013

Class II: Highly toxic

Colour: bright yellow
Poison!
Keep out of the reach of children.

15.2 Chemical Safety Assessment

A chemical safety assessment is not required.

SECTION 16: OTHER INFORMATION

Text of R-phrases mentioned in Section 3
R22 Harmful if swallowed.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic
environment.
Text of the hazard statements mentioned in Section 3
H302 Harmful if swallowed.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.
The information contained within this Safety Data Sheet is in accordance with the guidelines established
by Regulation (EU) 1907/2006 and Regulation (EU) 453/2010 amending Regulation (EU) No 1907/2006
(and any subsequent amendments). This data sheet complements the user's instructions, but does not
replace them. The information it contains is based on the knowledge available about the product
concerned at the time it was compiled. Users are further reminded of the possible risks of using a
product for purposes other than those for which it was intended. The required information complies with
current EEC legislation. Addressees are requested to observe any additional national requirements.
Reason for Revision: New Safety Data Sheet. Safety Data Sheet according to Regulation
(EU) No. 453/2010.
Changes since the last version are highlighted in the margin. This version replaces all previous
versions.