Elevating the

art of precision
for 30 years.

OUR PROMISE OUR LEGACY OUR EVIDENCE OUR LATEST INNOVATION

The only thing greater than
our legacy of innovation is
our vision for the future.
Your pursuit of optimal patient outcomes has always been our inspiration, and the HARMONIC™
brand continues to evolve to deliver the precise dissection and multifunctionality you need for an
efficient surgical flow. Together over the last 30 years, we have advanced surgery to improve
surgical outcomes.

Here’s to the next 30 years of collaboration and commitment to healing.

OUR PROMISE OUR LEGACY OUR EVIDENCE OUR LATEST INNOVATION

Honoring a legacy of firsts...

1992 1998 2000 2005

HARMONIC™ HARMONIC™ HARMONIC™ HARMONIC

LCS Shears LCS 5mm LCSC-5mm ACE™ Shears
10mm shafted shears and Shaft diameter reduced Blade curvature and ergonomic Improved ergonomics,
clamp arm to 5mm improvements clamp arm performance, and 5mm vessel
indication

First ultrasonic shears device First 5mm ultrasonic shafted shears for First to design curved ultrasonic First ultrasonic device with a 5mm
First to add clamp arm to control minimally invasive access blade for improved visualization and vessel indication
compression, improve hemostasis dissection capability
and cutting

Industry first Innovation

OUR PROMISE OUR LEGACY OUR EVIDENCE OUR LATEST INNOVATION

inspired by optimal patient healing...

2007 2011 2012

HARMONIC Generator HARMONIC Adaptive Tissue

FOCUS™ Shears GEN11 ACE™+ Shears Technology
First scissor-design shears for Combined modality generator Heat management and Intelligent feedback, thermal
open procedures improved blade design management, stronger seals,
and superior precision1-3

Pioneer in scissor-design shears for Combined ENSEAL™ and First ultrasonic device with thermal A foundational platform for future
open procedures HARMONIC™ generators into one unit management system to deliver more design and development
precise energy

1. vs. HARMONIC ACE® without Adaptive Tissue Technology. (044005-200826). 2. In a benchtop study, >99% of vessels sealed to over 240mmHg.
Industry first Innovation (049339-200427). 3. Based on a benchtop study with 5-7mm porcine carotid arteries, achieved burst pressure of 1878 mmHg. (140636-200801).

OUR PROMISE OUR LEGACY OUR EVIDENCE OUR LATEST INNOVATION

every step of the way.

2014 2016 2021

HARMONIC ACE™+7 HARMONIC HARMONIC™ HARMONIC™

Shears FOCUS™+ Shears HD 1000i Shears 1100 Shears
Advanced Hemostasis Mode Improved precision with finer tip Unique blade design and More precise dissection,
provides 7mm vessel indication and Adaptive Tissue Technology integrated transducer better tissue protection4,5
to minimize lateral thermal spread1

First ultrasonic device with up to 7mm First medical device to receive First ultrasonic device with integrated First active thermal management
vessel indication EARTHWARDS™ recognition for transducer, redesigned blade for system that controls blade heat for
reducing surgical waste enhanced precision, faster transection lower maximum blade temperature6
speed and reliable hemostasis2,3
1. As exhibited in a preclinical model (n=16), mean lateral thermal spread of 1.68mm. (012142-200109). 2. Based on benchtop metrology and porcine comparative studies vs. legacy HARMONIC® and LigaSure™ Maryland devices. (084839-210630). 3. In a benchtop study,
>99% of vessels sealed to over 240mmHg. (049339-200427). 4. Based on a PreClinical evaluation. (138469-200427). 5. Based on benchtop study that showed Harmonic 1100 had 35% faster transection speed and significantly lower maximum blade temperature post
Industry first Innovation transection than Harmonic ACE+7 Shears for shorter heat exposure. (140047-200512). 6. Compared to previous generations of Harmonic devices. (140049-210108).

OUR PROMISE OUR LEGACY OUR EVIDENCE OUR LATEST INNOVATION

The evidence illustrating our clinical
and economic value continues to build.
Volumes of peer-reviewed clinical studies demonstrate the significant ways HARMONIC™ technology impacts patients, surgeons and hospitals.

2,000+ peer-reviewed clinical articles

More than any other advanced energy manufacturer1 33 +MILLION
patients served globally2

HARMONIC™ vs conventional/monopolar and/or advanced bipolar (P<0.05)3,4 HARMONIC™ may result in reduced annual costs compared to other
competitive advanced energy devices5
Reduced # of Studies
Blood loss
OR Time
86
141
$
600,000+ OR time costs
125,000+ hospital stay costs
Complications 48
Length of stay 36
$

1. As per literature searches for advanced energy devices in Embase/Medline, PubMed, and Google Scholar through May 2021. (112287-210609) 2. Global sales data and market share & insights for HARMONIC® as of October 2021. (062951-211202) 3. Based on a meta-analysis of HARMONIC
FOCUS® (HF) versus clamp, cut and tie, where HARMONIC FOCUS reduced operative time by 29 minutes (p<0.001), intra-operative blood loss by 45 ml (p<0.001), and length of stay by 0.68 days. Cheng et al., A systematic review and meta-analysis of Harmonic Focus in thyroidectomy
compared to conventional techniques. Thyroid Research. (2015) 8:15. (044268-210825) 4. Based on a meta-analysis of HARMONIC® technology (HT) versus conventional methods. Cheng et al., Breast Cancer (Dove Med Press). 2016 Jul 18;8:125-40. (058821-160824) 5. Budget Impact Model
analysis comparing portfolio-wide adoption of Ethicon energy devices versus other non-Ethicon manufactured energy devices in a typical hospital performing 8,000 annual electrosurgery procedures across five specialties (bariatric, colorectal, thoracic, gynecology, and general surgery).
Ferko, N., et al. A Device Category Economic Model of Electrosurgery Technologies Across Procedure Types: A U.S. Hospital Budget Impact Analysis. J of Med Eco. Jan-Dec 2021;24(1):524-535. (185706-220323)

OUR PROMISE OUR LEGACY OUR EVIDENCE OUR LATEST INNOVATION

More precise dissection, better tissue protection. 1,2

Introducing the HARMONIC™ brand’s latest innovation— HARMONIC™ 1100 Shears

HARMONIC™ 1100 Shears had a lower maximum blade
Unmatched precision temperature than HARMONIC ACE™+7 Shears and
Curved, tapered tip enables dissection HARMONIC™ HD 1000i Shears5
capabilities that surgeons rate as superior
to competitive advanced energy devices1,3 HARMONIC
ACE™+7 Shears

Maximum blade temperature

HARMONIC™
Faster transection HD 1000i Shears

35% faster than HARMONIC ACE™+7 HARMONIC™

with Advanced Hemostasis for shorter 1100 Shears

heat exposure4

Improved temperature control 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

Improved Adaptive Tissue Technology algorithm Transection number
actively controls blade heat for lower maximum
blade temperature4
And we’re just getting started.
1. Based on a PreClinical evaluation (138469-200427) 2. Based on bench top study with porcine vessels 3-5 mm in diameter. (138458-200427) 3. Based on user validation study where 81% of surgeons indicated that Harmonic HD 1000i
had dissection capability superior to other advanced energy devices. (057596-220317). 4. Compared to previous generations of Harmonic devices. (140049-210108). 5. Based on benchtop study that showed Harmonic 1100 had significantly
lower maximum blade temperature than Harmonic HD 1000i Shears after 15 tip bite transections. (140050-200512).

OUR PROMISE OUR LEGACY OUR EVIDENCE OUR LATEST INNOVATION

Here’s to the next 30 years of
collaboration and commitment
to healing.

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indications, contraindications, warnings, precautions, and adverse reactions, please reference full
package insert. ©2022 Ethicon, Inc. All rights reserved. 225318-220829

OUR PROMISE OUR LEGACY OUR EVIDENCE OUR LATEST INNOVATION