Musa Lawan Wida
Musa Lawan Wida
Musa Lawan Wida
ASSIGNMENT
BY
TO BE SUBMITED
TO THE
COURSE LECTURER
DR.ABUBAKAR EL-ISHAQ
JUNE, 2023
INTRODUCTION
Animal testing for toxicity is a controversial topic, and while it has been widely
used in the past, there has been a growing shift towards alternative testing
methods that do not involve animals. However, I can provide you with some
laboratory settings:
1. Rats: Laboratory rats, particularly the species Rattus norvegicus, have been
2. Mice: Mice, specifically the species Mus musculus, have been extensively
humans and have a short lifespan, making them convenient for experimental
studies.
3. Guinea pigs: Guinea pigs (Cavia porcellus) have been used in certain
evaluating eye and skin irritation. The Draize test, which assesses the irritancy
It's important to note that there is a growing push for alternatives to animal
testing, such as in vitro tests using cell cultures, computer simulations, and other
site of exposure into the bloodstream. In the case of guinea pigs, different routes
and cells depending on factors such as blood flow, solubility, and the
substance within the body. This process typically occurs in the liver, where
enzymes break down the substance into metabolites, which may be more or less
metabolites from the body. It can occur through various routes, including urine,
feces, breath, sweat, or milk (in the case of lactating animals). The kidneys,
liver, lungs, and gastrointestinal tract play crucial roles in the excretion process.
guinea pigs, specific toxicokinetic studies are conducted. These studies involve
These samples are then analyzed to quantify the concentration of the substance
Taylor, Katy; Alvarez, Laura Rego (2019). "An Estimate of the Number of
Animals Used for Scientific Purposes Worldwide in 2015". Alternatives
to Laboratory Animals. SAGE Publications. 47 (5–6): 196–
213. doi:10.1177/0261192919899853. ISSN 0261-1929. PMID 3209061
6. S2CID 211261775.
"U.S. Will No Longer Require Animal Testing for New Drugs". 13 January
2022.