Antipsychotics and Their Sars
Antipsychotics and Their Sars
Antipsychotics and Their Sars
SYMPTOMS
• Delusions SUBSTITUTION at POSITION 2-
• Hallucinations Substitution at the second position of the phenothiazine
• Disorganized thinking and speech nucleus with an electron-withdrawing substituent such as a
• Abnormal behavior halogen (e.g., fluorine, chlorine) or a nitro group has been
• Reduced ability to function daily in life shown to INCREASE the antipsychotic activity of
phenothiazines.
Psychoses can occur in different forms, such as:
• Schizophrenia Chlorpromazine
• Bipolar disorder
• Severe depression
The estimated prevalence of psychoses in the population is
approximately 1%.
THIOXANTHENE
FLUORINE ATOM IN PARA-POSITION OF ARYL
GROUP-
The presence of a fluorine atom in the para-position of the
aryl group of butyrophenones has been shown to
INCREASE their affinity for dopamine receptors.