Manual Book Cyclotron KIUBE
Manual Book Cyclotron KIUBE
Manual Book Cyclotron KIUBE
Production Guide
Technical Support If you cannot find information in this guide, you can contact us in several ways:
Otherwise:
Phone IBA Customer Services: +32 10 47 58 31
Phone the IBA switchboard: +32 10 47 58 11
Fax: +32 10 47 59 00
e-mail: [email protected]
Notices We have checked the contents of this manual for agreement with the hardware and/
or software described. Since deviations cannot be precluded entirely, we cannot
guarantee complete agreement, and IBA is not liable for incidental or consequential
damages in connection with use of this manual.
This document provides information for operating and/or maintaining the equipment,
however, experience with this type of equipment is required to use the document
effectively.
Only appropriately qualified personnel may operate the equipment or work in its
vicinity. Qualified personnel are persons familiar with the installation,
assembly, startup and operation of this product, and who possess the relevant
qualifications for their work in accordance with current standards in safety
technology.
ISO 9001 IBA is registered and certified in accordance with the ISO 9001 quality system
standards.
Contents
4. About Recipes
Overview .................................................................................................... 4-2
Recipe Parameters .................................................................................... 4-2
7. Tracking Productions
Overview .................................................................................................... 7-2
Operator-Confirmed Steps during Production ....................................... 7-2
Quick View Screen .................................................................................... 7-4
Production Tracking Screen .................................................................... 7-7
Production Summary Screen ................................................................... 7-8
9. Production Reports
Overview .................................................................................................... 9-2
Accessing Production Report Functions ................................................ 9-3
Displaying Production Reports ................................................................ 9-4
Printing Reports ........................................................................................ 9-5
Exporting Data to File ............................................................................... 9-5
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Cyclone®Kiube
Production Guide
Tables
Table 1-1: Cyclone®Kiube range................................................................ 1-2
Table 1-2: Typographic Conventions ......................................................... 1-3
Table 3-1: 18F- Conical Targets Specifications and Recommended
Parameters .............................................................................. 3-2
Table 3-2: Liquid Target Process ............................................................... 3-3
Table 4-1: Recipe Common Parameters Available to Authorized Users
in Production Mode.................................................................. 4-2
Table 4-2: Recipe Side (1or 2) Parameters Available to Authorized Users
in Production Mode.................................................................. 4-3
Table 8-1: Typical Exchanges Between ACS and User Systems .............. 8-2
In this chapter:
Scope and The Cyclone®Kiube is a radioisotope delivery system comprising the accelerator
(cyclotron) and a choice of targets.
Contents
The Cyclone®Kiube cyclotron produces and accelerates negative ions that are stripped of
their electrons by passing through a carbon foil (stripper) before hitting the target. This
method of extraction is nearly 100 % efficient and minimizes the activation of internal
cyclotron parts so that maintenance can be carried out shortly after system shutdown. The
Cyclone®Kiube can accommodate two proton sources. Particles accelerated can be
extracted at eight beam exit ports where targets are installed.
Nirta® Liquid for the production of 18F- is the most widely used target for the
Cyclone®Kiube and therefore the description of the 18F- target is included in the
description of the Cyclone®Kiube. However, a range of other targets are also available as
options: Nirta® Liquid targets for the production of 13NH3 and 68Ga; and Nirta® Gas
targets for the production of 15O, 11CO2, 11CH4.1, 2
Utility systems are mounted on the cyclotron, or in free standing cabinets in the power
supply or technical rooms.
The Zephiros® control system, with an application server providing the user interface with
the industrial programmable logic controller (PLC) that handles the control logic,
integrates all control and interlock functions including those for additional options that are
part of your Cyclone®Kiube configuration.
The Cyclone®Kiube range includes the following models:
Table 1-1: Cyclone® Kiube range
ODP Vacuum 2 2 4 4
pumps
This guide describes functions for the Production Mode. Production Mode allows
operating the Cyclone®Kiube from a Recipe set up by the Supervisor (Administration
Mode). Members of the Regular Operator group can only use the Quick Start Production
whereas members of the Advanced Operator group can run the Manual Start Production
and can change some parameters of the recipe. Both groups are also able to
acknowledge alarms. Members of the Maintenance Technician group and Supervisor
groups also have access to both Production Mode options. Production Mode is
available on liquid targets only.
1. Optional Nirta® Liquid and Gas targets are covered in separate dedicated manu-
als.
2. Nirta® Solid is also compatible with the Cyclone® Kiube and also covered in a sep-
arate dedicated manual.
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Typographic
Conventions Table 1-2: Typographic Conventions
Typeset Usage
Text on the screen Name of a command button. Single click with the mouse.
Field labels.
Warnings and Before reading this manual, please read carefully the Cyclone®Kiube Safety and
Cautions Emergency Recommendations manual.
Additional warnings, cautions and notes are shown as follows:
WARNING
Warnings are used when an operating procedure, practice, etc., could result in
personal injury or loss of life, if not followed properly or the personnel may be
exposed to hazards when carrying out a task on the system.
CAUTION
Cautions are used when an operating procedure or practice, etc., if not followed
properly, could result in damage to the equipment.
IMPORTANT: (notes) are used for an operating procedure, a condition, etc., requiring
special attention.
NOTES: are used for technical tips, alternate method of performing a task or referrals to
other documents.
Illustrations Photos, drawings, and user interface screen representations are provided for illustration
purposes only and do not necessarily reflect the actual appearance of system hardware
or software or a realistic situation.
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Cyclone®Kiube
Production Guide
Related This Production Guide is part of a set of documents supplied with your Cyclone®Kiube.
Documents Cyclone®Kiube System Description
Cyclone®Kiube Safety and Emergency Recommendations
Cyclone®Kiube Manual Mode User Guide
Cyclone®Kiube Administration Guide
Cyclone®Kiube Maintenance Guide
If your system includes additional features (Nirta® Liquid or Gas options,
Nirta® Solid, Vectio® Beam Line, chemistry modules,...) each comes with its own
user manual.
As well as the above manuals, the documentation package contains the
Cyclone®Kiube product breakdown structure laid out as a Microsoft Excel spread-
sheet, with an outline feature that allows expanding or collapsing data. The spread-
sheet contains hyperlinks to assembly drawings, schematics and vendor
documentation.
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Cyclone®Kiube
Production Guide
In this chapter:
Overview
Logging On
Overview The User Interface application starts up when switching on the Thin Client module (WYSE)
module and displays the HOME screen:
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Cyclone®Kiube
Production Guide
The user group a user belongs to, determines the mode(s) that are authorized for this user
as shown on Fig.2-2
Logging On 1. Type your user name in the New Login Name field.
2. Press Enter.
3. Type your Password.
4. Press Enter.
5. Click Log on.
You will see your User Name and User Group shown as Actual login name and
Actual access level, respectively.
6. Click Production. One of the following is displayed according to which user group
you belong to
Quick Start only for Regular Quick Start and Manual Start
Operator group for other groups
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Cyclone®Kiube
Production Guide
In this chapter:
Conical 5 H218O 18
O (p, n)18F 18 -
F 17.5 45 120 1800 Never 235 5000
MeV exceed
Conical 8 (proton) 70 2300 35 235 8000
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Cyclone®Kiube
Production Guide
The valve used for loading and unloading the target is a double three-way valve rotated
by an actuator to one of three unique positions according to the target process:
The irradiated product is routed under helium flow to the shielded laboratory room and
should pass through suitable radioactivity measurement for Quality Analysis before use.
Options for An additional Syringe Drive module specially dedicated to the rinsing of the target is
Liquid Targets available. If this option is not present in your system, the rinsing process uses the
Load Syringe Drive.
A Target Output Switching system allows collecting the activity from any of your liquid
targets and routing it to any selected hot cell (maximum 8).
When these options are present in your system, the system is configured (by IBA) to
integrate their functions in the control system and you will have controls on your target
screens to operate them.
Target Preparation
Consumables H218O
Helium (grade 99.995)
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Cyclone®Kiube
Production Guide
4. About Recipes
In this chapter:
Overview
Recipe Parameters
Overview A Recipe is a set of parameters preset by a member of the Supervisor group to be used
in Production Mode. Members of the Regular Operator group can only select a recipe as
it is for the Quick Start Production, members of the Advanced Operator group can in
addition run the so-called Manual Start Production whereby they can make some changes
to the Recipe.
Recipes can only be set up for Liquid target productions.
Common
Parameters
Table 4-1: Recipe Common Parameters Available to Authorized Users in Production Mode
Full Auto: is the mode the control system takes all steps to
perform the production without message to the operator
except alarms. When not selected, the operator will have con-
firm some steps, for example, if the target is already filled, the
operator will be given the choice to use the filled target, to refill
the target or cancel the production. Click the box to select Full
Auto.
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Cyclone®Kiube
Production Guide
Side (1 and/or 2)
Parameters
Table 4-2: Recipe Side (1or 2) Parameters Available to Authorized Users in Production Mode
Target
Note: Only liquid targets are available for Production
Mode.
Note: Exit port, Requested Current and upper maxi-
mum pressure are shown here but are not part of the
recipe, these are target parameters not accessible in
Production modes.
a. The transfer always requires operator confirmation and can also be changed at that time.
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Cyclone®Kiube
Production Guide
In this chapter:
Overview
Running Quick Start
Overview Quick Start is intended for routine productions by selecting a Recipe set up by the
Supervisor in Administration Mode. The control system runs the complete production
according to the parameters of the Recipe. The minimum user access level for this option,
is Regular Operator.
3. From the QUICK START window, select the required recipe from the drop-down list.
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Production Guide
7. Click Test Cyclone© to start the pre-production tests to ensure that all devices required by
the selected recipe are ready. You can follow the progress of the tests on the PRODUCTION
CYCLONE© STATUS screen.
.
Note: elements not required by the selected recipe are not tested.
Note: if one of the tests fail, the Quick Start production cannot proceed. A maintenance
technician will need to investigate.
8. When the tests are successfully completed, Click Start Production on the QUICK
START window.
.
.
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Cyclone®Kiube
Production Guide
9. On production start, the following screen is displayed to follow the production of the
beam.
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Cyclone®Kiube
Production Guide
In this chapter:
Overview
Running Manual Start
Overview Manual Start allows for some adjustments to the Recipe. The minimum user access level
for this option, is Advanced Operator.
3. From the RECIPE SELECTION window, Select the required recipe from the drop-down
list.
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Cyclone®Kiube
Production Guide
5. Review and amend the now displayed recipe parameters, as needed. See Chapter 4
for more information on adjustable parameters.
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Cyclone®Kiube
Production Guide
8. Click Test Cyclone© to start the pre-production tests to ensure that all devices required by
the selected recipe are ready. You can follow the progress of the tests on the PRODUCTION
CYCLONE STATUS© screen.
Note: elements not required by the selected recipe are not tested.
Note: if one of the tests fails, the production cannot proceed, a maintenance techni-
cian will need to investigate.
9. When the tests are successfully completed, Click Start Production on the RECIPE
SELECTION window.
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Cyclone®Kiube
Production Guide
11. See Chapter 7 for ways of following and monitoring the production.
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Cyclone®Kiube
Production Guide
7. Tracking Productions
In this chapter:
Overview
Operator-Confirmed Steps during Production
Quick View Screen
Production Tracking Screen
Production Summary Screen
Overview The purpose of this section is to review specific screens1 available during the production
which allow the operator to follow different processes. Also described are steps during the
production process which require operator confirmation.
Operator- When started, the production will proceed according to the options selected in the Recipe
(See Chapter 4). During the course of the production, the operator may have to confirm
Confirmed Steps certain steps by way of message box displayed on the screen.
during
For example, if the target was already loaded prior to starting the production
Production
:
1. All manual mode screens can be displayed as well, this section only reviews the
screens more specifically related to Production mode.
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Cyclone®Kiube
Production Guide
Another example is to confirm the transfer before rinse, purge or unload steps:
If the recipe requests a manual beam stop, the operator needs to click Manual Beam
Stop when appropriate (the operator can watch the integrators and decide when the
irradiation should end).
Quick View Whether Quick Start or Manual Start is used to start the Production Mode, when the
production starts the system displays the following screen indicating that production is in
Screen progress
On the top is displayed the QUICK VIEW panel illustrating the three major phases;
preparation, beam and target unload. On the second half of the screen, are displayed
the target panel(s) (side 1 and/or side 2) for the target(s) used by the recipe.
IMPORTANT: The target pressure is monitored throughout the irradiation by the control
system. If the pressure strays outside the tolerance range for a given beam current, the
control system will stop beam acceleration.
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Cyclone®Kiube
Production Guide
Also shown here are summaries of different steps of the regulation loop, for example
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Cyclone®Kiube
Production Guide
Production During the Preparation phase, for example, the PRODUCTION TRACKING screen provides
way of following the accelerator start up and target preparation
Tracking Screen
This screen is also useful for following up end of beam and target unload.
You access this screen by clicking Production Tracking from the NAVIGATION PANEL to
the left of the QUICK VIEW screen.
Production This screen is accessed by clicking Prod.Summary at the top of the PRODUCTION
TRACKING screen and recaps the Recipe parameters.
Summary Screen
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Cyclone®Kiube
Production Guide
In this chapter:
Interlocks
System Alarms
Beam ON
Magnet ON
1. Refers to the Interface Control Document (ICD) for complete set of exchanged sig-
nals on your site.
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Cyclone®Kiube
Production Guide
Interlocks are listed in panels on each control screen (Fig. shows the ION SOURCE SYSTEM
control screen for example), listing the conditions required for operation. Conditions met
are indicated with a green tick mark (), conditions not met are shown with a red cross
( ).
System Alarms System alarms are abnormal conditions detected by the control system, some may be
blocking, some are just displayed to alert the user to the situation. Blocking alarms will
prevent a system, process or device to operate. A warning symbol in the interlock panel
of the system, process or device is shown when this is the case.
Alarms are recorded and displayed on the ALARMS screen.
Viewing Alarms This screen has two views; Real-time and Historical. You can switch view by clicking the
chosen display from the TYPE Panel on the left of the screen.
Alarms are listed in rows and use the following color convention:
ACK (blue): alarms that have been reset.
RTN (green): returned to normal.
UNACK (red): alarms not reset.
Together with a description of the alarm, the date and time of occurrence.
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Cyclone®Kiube
Production Guide
On the historical view, you can set the period you wish to display using the controls of the
QUERY panel.
Either click Last hour.
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Production Guide
9. Production Reports
In this chapter:
Overview
Accessing Production Report Functions
Displaying Production Reports
Printing Reports
Exporting Data to File
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Cyclone®Kiube
Production Guide
Displaying 4. Select the Batch id from the drop-down menu on the top left of the screen
Production 5. Click View Report.
Reports
Adjust display
size
Slide to view
up/down the
Use arrows to
page
see other pages
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Cyclone®Kiube
Production Guide
Printing Reports 7. With the report displayed on the screen, click the Printer icon to access the General
WINDOWSTM Print options.
Note: Page Setup icon gives access to the Page Setup options of the selected
printer.
Note: Print Layout icon displays a print preview of the report.
Exporting Data to 8. With the chosen report displayed on the screen, click the Export icon (disk).
File 9. Choose the file type from the drop-down list.
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