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    Classification of Jaundice - UpToDate

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    Syed Akram Ali
    The document classifies jaundice into two main types: unconjugated and conjugated hyperbilirubinemia. It lists various causes that can lead to each type and provides examples of diseases and medical conditions associated with conjugated hyperbilirubinemia.

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    Classification of Jaundice - UpToDate

    Uploaded by

    Syed Akram Ali
    40 views2 pages
    The document classifies jaundice into two main types: unconjugated and conjugated hyperbilirubinemia. It lists various causes that can lead to each type and provides examples of diseases and medical conditions associated with conjugated hyperbilirubinemia.

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    Classification of jaundice - UpToDate

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    The document classifies jaundice into two main types: unconjugated and conjugated hyperbilirubinemia. It lists various causes that can lead to each type and provides examples of diseases and medical conditions associated with conjugated hyperbilirubinemia.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    40 views2 pages

    Classification of Jaundice - UpToDate

    Uploaded by

    Syed Akram Ali
    The document classifies jaundice into two main types: unconjugated and conjugated hyperbilirubinemia. It lists various causes that can lead to each type and provides examples of diseases and medical conditions associated with conjugated hyperbilirubinemia.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
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    8/19/23, 5:36 PM Classification of jaundice - UpToDate

    Official reprint from UpToDate®


    www.uptodate.com © 2023 UpToDate, Inc. and/or its affiliates. All Rights Reserved.

    Classification of jaundice according to type of bile pigment and mechanism

    Unconjugated hyperbilirubinemia Conjugated hyperbilirubinemia (continued)


    Increased bilirubin production* Extrahepatic cholestasis (biliary obstruction)

    Extravascular hemolysis Choledocholithiasis

    Extravasation of blood into tissues Intrinsic and extrinsic tumors (eg, cholangiocarcinoma,
    pancreatic cancer)
    Intravascular hemolysis
    Primary sclerosing cholangitis
    Dyserythropoiesis
    AIDS cholangiopathy
    Wilson disease
    Acute and chronic pancreatitis
    Impaired hepatic bilirubin uptake
    Strictures after invasive procedures
    Heart failure
    Certain parasitic infections (eg, Ascaris lumbricoides, liver
    Portosystemic shunts
    flukes)
    Some patients with Gilbert syndrome
    Intrahepatic cholestasis
    Certain drugs ¶  – Rifampin, probenecid, flavaspadic acid,
    Viral hepatitis
    bunamiodyl
    Alcohol-associated hepatitis
    Impaired bilirubin conjugation
    Non-alcohol-associated steatohepatitis
    Crigler-Najjar syndrome types I and II
    Chronic hepatitis
    Gilbert syndrome
    Primary biliary cholangitis
    Neonates
    Drugs and toxins (eg, alkylated steroids, chlorpromazine,
    Hyperthyroidism
    herbal medications [eg, Jamaican bush tea], arsenic)
    Ethinyl estradiol
    Sepsis and hypoperfusion states
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    8/19/23, 5:36 PM Classification of jaundice - UpToDate

    Liver diseases – Chronic hepatitis, advanced cirrhosis


    Infiltrative diseases (eg, amyloidosis, lymphoma,
    Conjugated hyperbilirubinemia sarcoidosis, tuberculosis)

    Defect of canalicular organic anion transport Total parenteral nutrition

    Dubin-Johnson syndrome Postoperative cholestasis

    Defect of sinusoidal reuptake of conjugated bilirubin Following organ transplantation

    Rotor syndrome Hepatic crisis in sickle cell disease

    Pregnancy

    End-stage liver disease

    AIDS: acquired immunodeficiency syndrome.

    * Serum bilirubin concentration is usually less than 4 mg/dL (68 mmol/L) in the absence of underlying liver disease.

    ¶ The hyperbilirubinemia induced by drugs usually resolves within 48 hours after the drug is discontinued.

    Graphic 55607 Version 13.0

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