Banglia

ofcaudate
-Body
Nucleus

-
in i
Thalamus
wine
·

· extreme

/
⑧
capsule.
putamen

T
S

"
I
daustrum
->
=>

internal
↳ e
I
**
aI > external

apsule

·
-

-
*
=--
·subtualaic
5=-x
nucleus

externate substantia

pallicand
I

globes rail↳
of nigra
urdeus
↑globus pallides can date
-
 Basal
aglio

·
Caudate Nucleus
*

Striatum
*Motorfunction
t

Putamen

Basic:
Putamen
*

primary sensory
somato
t
Leutiform Basch Ganglic
↳ Lobus Nudens
-primary motor

Pallidkt
pre-motor
Thalamus
-ventral Anterior
-Ventral Lateral cortic spinal
Fract
Subthalamic
*

Mudens
substantia -
Zona Compacta voluntary
planned movement
x

->
Nigra Zona Reticlan's
DirectPath way ! Bartransmitter
Basal
lic
becain a motor
to
Antivity,

receptor 7. It
S
Path
way: :. GABA
I out
Glutaminergic
cliqued
GABA
Cortex -> strictum I Glos cliin
!
·

pallidus
⑦

gated)
⑰ sputament
I
a date Internes ↓
indent?

i
↓* GABA
VA, VL Hyperpolarization
note:
⑰
/IPSP:inhi·stay post-synaptic
GABA
Manginhibisi producti
potential
pada Globus Pallides Na "in
ligund
GABA
interna sehingga vA, VL
2. Glutamate ->

malah terinarie,I
gated castin
↓

Depolanzaln
~

Apart
↓
EPSP
↳
l L- threshold potential
(Excitatory tiz

I Lost Syna
potential I
 ·

Ganglia
2.
IndirectPathway

i
preventing
-

Pathway: unwantel
motor movement 3. High
Pathway
⑰
Glutamate
Cortex -> Striatum Function:Modulation of
(cardaten. perament
A

Directand IndirectPathway
* inhibition tr ⑦ GABA

VA, UL
G. palli des 1. How it
was
Direct pathway the

externs 449 GABA

4 ASABR I GARA cortex -> strictum -> 6. pallidus Internig

↓. AAAGABA
so
pallidus - subthalamus Dopaminereceptor)
Thalamus ->
cortex -> **4Motor
Internus
a glutamate substantia
ID:
istimulatory &848 stimulation
activity
ofwanted
. nigra pars C motor movement
E compacta. ampitty
i even more
C

to
i
Lesion
substantia -> Parkinson's Disease -> Difficulties in intiating
movement.
!
Migra
i
 S

"
DeReaptor Reaptor
i
:

D:
Dopamin + Reeptor
·Dopamin +
D2 Peaptor
I
4 stimulatory
6. Inhibitory

!
↓
↓
↑ C. AMP
indirectpathway ↓ cAMP
i. Amrence ↓
kinase L
a protein kinase
Wi
ion channel
A
protein
pathway: Glutamate ↓GARA
phostolivasi t

G pallidus
⑰44 increased ↓ fortolian channel

"
cortex -> strictur ->

X externus member and ↓

Dopamin
t
Da. receptor ↓ I GARA potential Less & You
fr
[Inhibitory subfalamic
Substantia ↓ ↓ cbfamate. Action sotential
( Harder to threshold
nigra p. comparte
-

6 pallidus internus ↓

↓ d GABA i Harder Action Potential

↓
I
cortex
I
Increase↑Motor activ
ty S

of unwanted motor
I
movement

!
Disease
Lesson: Hatington's
·
Wilson's Dicease
I

R. fever
extra pyramidal syndrome -> ist her antipsychotic I