MSDS Relugolix

**** MATERIAL SAFETY DATA SHEET ****
Relugolix
** SECTION 1- CHEMICAL PRODUCT AND COMPANY IDENTIFICATION**
Product Name: Relugolix
Synonyms: 1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin
-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea; TAK-385
Company Identification: Aurisco Pharmaceutical Co., Ltd,
Badu Industrial Park Zone, Tiantai, P.R.
Zhejiang Province, China
For Information: +86-0576-83177281
**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****

CAS #: 737789-87-6
Molecular formula: C29H27F2N7O5S
Molecular Weight: 623.63
**** SECTION 3 - HAZARDS IDENTIFICATION ****

3.1 Classification of the substance or mixture:
Not a hazardous substance or mixture.
3.2 GHS Label elements, including precautionary statements:
Not a hazardous substance or mixture.
3.3 Other Hazards: None.
**** SECTION 4 - FIRST AID MEASURES ****

4.1 Description of first aid measures
4.1.1 In case of Inhalation: Immediately relocate self or casualty to fresh air. If breathing is difficult,
give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation
4.1.2 In case of Skin contact: Rinse skin thoroughly with large amounts of water. Remove
contaminated clothing and shoes and call a physician.
4.1.3 In case of Eye contact: Remove any contact lenses, locate eye-wash station, and flush eyes
immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing.
Promptly call a physician.
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4.1.4 In case of Ingestion: Wash out mouth with water provided person is conscious. Never give
anything by mouth to an unconscious person. Get medical attention. Do NOT induce vomiting unless
directed to do so by medical personnel.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 3.2).
4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically.
**** SECTION 5 - FIRE FIGHTING MEASURES ****

5.1 Suitable extinguishing media
Use water spray, dry chemical, foam, and carbon dioxide fire extinguisher.
5.2 Special hazards arising from the substance or mixture
During combustion, may emit irritant fumes.
5.3 Advice for firefighters
As in any fire, wear self-contained breathing apparatus and protective clothing.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

6.1 General Measures: Use only as directed.
6.2 Personal precautions, protective equipment and emergency procedures
Use full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate
ventilation. Evacuate personnel to safe areas.
Refer to protective measures listed in sections 8.
6.3 Environmental Precautions:
Try to prevent further leakage or spillage. Keep the product away from drains or water courses.
6.4 Methods and Material for Containment and Cleaning Up
Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders);
Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material
according to Section 13.
**** SECTION 7 - HANDLING AND STORAGE ****

7.1 General Handling: Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol
formation. Use only in areas with appropriate exhaust ventilation.
7.2 Storage Conditions:
Storage Conditions: Preserve in tight light-resistant containers and kept at room temperature.
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7.3 Specific end use(s)
No data available.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

8.1 Control parameters
Components with workplace control parameters
Occupational exposure limit values: 1ug/m3.
8.2 Exposure controls

Engineering controls
Ensure adequate ventilation. Provide accessible safety shower and eye wash station.
Personal protective equipment
Eye protection: Safety goggles with side-shields.
Hand protection: Protective gloves.
Skin and body protection: Impervious clothing.
Respiratory protection: Suitable respirator.
Environmental exposure controls: Keep the product away from drains, water courses or the soil.
Clean spillages in a safe way as soon as possible.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Chemical formula: C29H27F2N7O5S
Molecular weight : 623.63
Appearance: Solid
Colour: Off-white to white
Boiling point [°C]: No data available
Solubility: No data available
Flash point [°C]: No data available
Relative density: No data available
**** SECTION 10 - STABILITY AND REACTIVITY ****

10.1 Reactivity: No data available.
10.2 Chemical stability: Stable under recommended storage conditions.
10.3 Possibility of Hazardous Reactions: Hazardous polymerization will not occur.
10.4 Conditions to Avoid: No data available
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10.5 Incompatible Materials: Strong acids / alkalis, strong oxidizing / reducing agents
10.6 Hazardous Decomposition Products: Under fire conditions, may decompose and emit toxic
fumes. Other decomposition products - no data available
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****

11.1 Information on toxicological effects
The toxicological effects of this product have not been thoroughly studied. For more details, see
section 3.
Carcinogenicity:
NTP? No IARC Monographs? No OSHA Regulated? No ACGIH? No
**** SECTION 12 - ECOLOGICAL INFORMATION ****

12.1 Toxicity:
Avoid release into the environment.
Runoff from fire control or dilution water may cause pollution.
12.2 Results of PBT and vPvB assessment
PBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****

13.1 Waste Treatment Methods:
Dispose substance in accordance with prevailing country, federal, state and local regulations.
Contaminated packaging
Conduct recycling or disposal in accordance with prevailing country, federal, state and local
regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****

DOT (US)
This substance is considered to be non-hazardous for transport.
IMDG
IATA
**** SECTION 15 - REGULATORY INFORMATION ****
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SARA 302 components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302.
SARA 313 components:
This material does not contain any chemical components with known CAS numbers that exceed the
threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 hazards:
No SARA Hazards.
Massachusetts Right to Know components:
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right to Know components:
No components are subject to the Pennsylvania Right to Know Act.
New Jersey Right to Know components:
No components are subject to the New Jersey Right to Know Act.
California Prop. 65 components:
This product does not contain any chemicals known to State of California to cause cancer, birth
defects, or any other reproductive harm.
**** SECTION 16 - ADDITIONAL INFORMATION ****

MSDS version date: January 24, 2022
Revision #: 1
The information above is believed to be accurate and represents the best information currently
available to us. However, we make no warranty of merchantability or any other warranty, express or
implied, with respect to such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the information for their
particular purposes. In no way shall the company be liable for any claims, losses, or damages of any
third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages,
howsoever arising, even if the company has been advised of the possibility of such damages.
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MATERIAL SAFETY DATA SHEET

SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS

SECTION 3 - HAZARDS IDENTIFICATION

SECTION 4 - FIRST AID MEASURES

SECTION 5 - FIRE FIGHTING MEASURES

SECTION 6 - ACCIDENTAL RELEASE MEASURES

SECTION 7 - HANDLING AND STORAGE

SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION

8.2 Exposure controls

SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES

SECTION 10 - STABILITY AND REACTIVITY

SECTION 11 - TOXICOLOGICAL INFORMATION

SECTION 12 - ECOLOGICAL INFORMATION

SECTION 13 - DISPOSAL CONSIDERATIONS

SECTION 14 - TRANSPORT INFORMATION

SECTION 15 - REGULATORY INFORMATION

SECTION 16 - ADDITIONAL INFORMATION

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