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Inbound 7389658305523535294
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DISEASE
Cholecystitis is defined as gallbladder inflammation. It comes from the Greek word
"cholecyst" which means "gallbladder" and the suffix "itis" which indicates inflammation. It
happens when a digestive juice called bile gets trapped in your gallbladder. The gallbladder is a
small organ under your liver. It stores bile which is made in the liver. Normally bile drains out of
your gallbladder and into your small intestine. If the bile is blocked, it builds up in your
gallbladder. This causes inflammation and can cause infection. Cholecystitis can be sudden
(acute) or long-term (chronic).
Acute cholecystitis (AC) is a stone obstruction that leads to bile trapping, increased
intraluminal pressure, and an acute inflammatory process, typically presenting with RUQ (Right
upper quadrant) pain, leukocytosis, and fever. Chronic cholecystitis is defined as recurrence of
these events and is associated with fibrosis and mucosal atrophy. Acalculous cholecystitis is
considered in chronically debilitated patients, classically elderly patients in ICU on total parental
nutrition after sustained trauma or significant burn injury. Ascending (or acute) cholangitis is an
important complication of cholecystitis – a serious bacterial infection of the common bile duct. It
presents Charcot’s triad of fever, jaundice, and abdominal pain (Peach, 2021).
Gallstones affect 10 - 20% of Americans, and up to one-third of these persons get
cholecystitis. In contrast, Indian and Scandinavian individuals have the highest prevalence of
cholecystitis, which diagnosed 20.5 million people (about the population of New York) in 2012
and resulted in nearly 7,000 deaths. In the same year, there were up to 636,000 hospitalizations
and over 500,000 cholecystectomies. In 2011, the disease impacted 5,073, 040 persons in the
Philippines alone. In general, the frequency of cholecystitis rises with age, and females are 2-3
times more likely than males (Arch, 2015).
CAUSES
Cholecystitis happens when a digestive juice called bile gets trapped in your gallbladder.
In most cases, this happens because lumps of solid material (gallstones) are blocking a tube that
drains bile from the gallbladder. When gallstones block this tube, bile builds up in your
gallbladder. This causes irritation and pressure in the gallbladder. It can cause swelling and
infection. Other causes of cholecystitis include;
Bacterial infection in the bile duct system. The bile duct system is the drainage system
that carries bile from your liver and gallbladder into the first part of your small intestine
(the duodenum).
Tumors of the pancreas or liver. A tumor can stop bile from draining out of your
gallbladder. Reduced blood supply to the gallbladder. This may happen if you have
diabetes.
Gallbladder sludge. This is a thick material that can’t be absorbed by bile in your
gallbladder. The sludge builds up in your gallbladder. It happens mainly to pregnant
women or to people who have had a very fast weight loss.
In most cases, an attack of cholecystitis lasts 2 to 3 days. Each person’s symptoms may vary.
Symptoms may include;
Persons with gallbladder disease have few or no symptoms. Others, however, will
eventually develop one or more of the following symptoms:
(1) Frequent bouts of indigestion, especially after eating fatty or greasy foods, or certain
vegetables such as cabbage, radishes, or pickles,
(2) Nausea and bloating
(3) Attacks of sharp pains in the upper right part of the abdomen. This pain occurs when a
gallstone causes a blockage that prevents the gallbladder from emptying (usually by obstructing
the cystic duct).
(4) Jaundice (yellowing of the skin) may occur if a gallstone becomes stuck in the
common bile duct, which leads into the intestine blocking the flow of bile from both the gall
bladder and the liver. This is a serious complication and usually requires immediate treatment.
RISK FACTORS
Risk factors associated with development of gallstones include heredity, Obesity, rapid
weight loss, through diet or surgery, age over 60, Native American or Mexican American racial
makeup, female gender- gallbladder disease is more common in women than in men. Women
with high estrogen levels, because of pregnancy, hormone replacement therapy, or the use of
birth control pills, are at particularly high risk for gallstone formation, Diet-Very low-calorie
diets, prolonged fasting, and low-fiber /high-cholesterol/high- starch diets all may contribute to
gallstone formation.
PATHOPHYSIOLOGY
REFERENCES