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    Colistin

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    Mohammed Ibrahim
    The document provides guidelines for intravenous administration and dilution of colistimethate sodium including usual diluents, standard dilution amounts and rates, and alternative intermittent infusion methods. It also includes stability information for refrigerated and room temperature storage of the reconstituted drug.

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    © All Rights Reserved
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    Colistin

    Uploaded by

    Mohammed Ibrahim
    40 views1 page
    The document provides guidelines for intravenous administration and dilution of colistimethate sodium including usual diluents, standard dilution amounts and rates, and alternative intermittent infusion methods. It also includes stability information for refrigerated and room temperature storage of the reconstituted drug.

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    colistin

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    The document provides guidelines for intravenous administration and dilution of colistimethate sodium including usual diluents, standard dilution amounts and rates, and alternative intermittent infusion methods. It also includes stability information for refrigerated and room temperature storage of the reconstituted drug.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    40 views1 page

    Colistin

    Uploaded by

    Mohammed Ibrahim
    The document provides guidelines for intravenous administration and dilution of colistimethate sodium including usual diluents, standard dilution amounts and rates, and alternative intermittent infusion methods. It also includes stability information for refrigerated and room temperature storage of the reconstituted drug.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 1

    COLISTIMETHATE SODIUM (COLISTIN) - COLY-MYCIN®

    100 mg , 200 mg

    USUAL DILUENTS
    0.9% NaCl
    5% dextrose in 0.9% NaCl
    5% dextrose in water
    5% dextrose in 0.45% NaCl
    5% dextrose in 0.225% NaCl
    Lactated Ringer's solution
    Standard Dilution [Amount of drug] [Infusion volume] [Infusion rate]
    INTRAVENOUS ADMINISTRATION
    1. Direct Intermittent Administration - Slowly inject one-half of the total daily dose over a period of 3 to 5 minutes every
    12 hours.
    2. Continuous Infusion - Slowly inject one-half of the total daily dose over 3 to 5 minutes. Add the remaining half of the
    total daily dose of colistimethate for injection to one of the following:
    0.9% NaCl
    5% dextrose in 0.9% NaCl
    5% dextrose in water
    5% dextrose in 0.45% NaCl
    5% dextrose in 0.225% NaCl
    Lactated Ringer's solution

    There are not sufficient data to recommend usage of colistimethate for injection with other drugs or other than the above
    listed infusion solutions.

    Administer the second half of the total daily dose by slow intravenous infusion, starting 1 to 2 hours after the initial dose,
    over the next 22 to 23 hours. In the presence of impaired renal function, reduce the infusion rate depending on the degree of
    renal impairment.

    The choice of intravenous solution and the volume to be employed are dictated by the requirements of fluid and electrolyte
    management.

    Any infusion solution containing colistimethate sodium should be freshly prepared and used for no longer than 24 hours.

    3. Alternative method - not listed in package insert but available in specialized references: Intermittent infusion: [Prescribed
    dose] [50 - 100 ml] [30 minutes]
    ------------------------------------------------------------
    Colistin dosing calculator (beta) - output based on the latest guidelines located (July 2014). Package insert guidelines in
    many cases may lead to sub-therapeutic steady state concentrations (Css) based on the MIC for the target organism(s), and
    the site and severity of the infection.
    ------------------------------------------------------------

    STABILITY / MISCELLANEOUS
    STABILITY DATA:

    Stability Stability Reconstituted P-Insert


    Drug Refrigerated Room Temp. Vial/Powder Notes Updated
    Store between 20° to
    25°C (68° to 77°F).
    Store reconstituted
    Store reconstituted solution between 20°
    solution in refrigerator to 25°C (68° to 77°F),
    Colistimethate 2° to 8°C (36° to 46°F) and use within 7 days.

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