Antidepressants

Antidepressants
Antidepressant drugs are used to restore mentally depressed patients to an improved mental status. Depression results from a
deficiency of norepinephrine at receptors in the brain. Mechanisms that increase their effective concentration at the receptor sites
should alleviate depression. Antidepressant drugs act by one or more of the following stimulation type mechanisms:
1. Increase release of norepinephrine: Amphetamines and electroconvulsive therapy act by this mechanism. Amphetamines mimic
norepinephrine.
2. Prevent inactivation of norepinephrine:Monoamine oxidase (MAO) inhibitors are thought to act as antidepressant agents in part
by preventing the breakdown and inactivation of norepinephrine.
3. Prevent the re uptake of norepinephrine:The action of norepinephrine at the receptor site is terminated by the re uptake of
norepinephrine by the neuron from which it was originally released.
Tricyclic Antidepressants
The tricyclic antidepressants are the most effective drugs presently available for the treatment of depression. These act by
increasing the release of norepinephrine. Amphetamine and cocaine can also act in this manner. Imipramine, amitriptylin, and other
closely related drugs are among the drugs currently most widely used for the treatment of major depression.
imipramine (Tofranil)
desipramine (Norpramin)
The activity of the tricyclic drugs depends on the central ring of seven or eight atoms which confers an angled or twisted
conformation. The side chain must have at least 2 carbons although 3 appear to be better. The amine group may be either tertiary or
secondary. All tricyclic antidepressants block the re-uptake of norepinephrine at nerve terminals. However, the potency and
selectivity for the inhibition of the uptake of norepinephrine, serotonin, and dopamine vary greatly among the agents. The tertiary
amine tricyclics seem to inhibit the serotonin uptake pump, whereas the secondary amine ones seem better in switching off the NE
pump. For instance, imipramine is a potent and selective blocker of serotonin transport, while desipramine inhibits the uptake of
norepinephrine.
Serotonin
Serotonin (5-hydroxytryptamine or 5-HT) is a monoamine neurotransmitter found in cardiovascular tissue, in endothelial cells, in
blood cells, and in the central nervous system. The role of serotonin in neurological function is diverse, and there is little doubt that
serotonin is an important CNS neurotransmitter. Although some of the serotonin is metabolized by monoamine oxidase, most of the
serotonin released into the post-synaptic space is removed by the neuron through a re-uptake mechanism inhibited by the tricyclic
antidepressants and the newer, more selective antidepressant re uptake inhibitors such as fluoxetine and sertraline.
1 https://chem.libretexts.org/@go/page/412
Selective Serotonin Reuptake Inhibitors
In recent years, selective serotonin reuptake inhibitors have been introduced for the treatment of depression. Prozac is the most
famous drug in this class. Clomiprimine, fluoxetine (Prozac), sertraline and paroxetine selectively block the re uptake of serotonin,
thereby increasing the levels of serotonin in the central nervous system. Note the similarities and differences between the tricyclic
antidepressants and the selective serotonin re uptake inhibitors. Clomipramine has been useful in the treatment of obsessive-
compulsive disorders.
Monoamine Oxidase Inhibitors

Monoamine oxidase (MAO) causes the oxidative deamination of norephinephrine, serotonin, and other amines. This oxidation is
the method of reducing the concentration of the neurotransmitter after it has sent the signal at the receptor site. A drug which
inhibits this enzyme has the effect of increasing the concentration of the norepinephrine which in turn causes a stimulation
effect. Most MAO inhibitors are hydrazine derivatives. Hydrazine is highly reactive and may form a strong covalent bond with
MAO with consequent inhibition for up to 5 days.
These drugs are less effective and produce more side effects than the tricyclic antidepressants. For example, they lower blood
pressure and were at one time used to treat hypertension. Their use in psychiatry has also become very limited as the tricyclic
antidepressants have come to dominate the treatment of depression and allied conditions. Thus, MAOIs are used most often when
tricyclic antidepressants give unsatisfactory results.
Phenelzine is the hydrazine analog of phenylethylamine, a substrate of MAO. This and several other MAOIs, such as
isocarboxazide, are structurally related to amphetamine and were synthesized in an attempt to enhance central stimulant properties.
phenelzine (Nardil)
isocarboxazid (Marplan)
Contributors
Charles Ophardt (Professor Emeritus, Elmhurst College); Virtual Chembook
Antidepressants is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by LibreTexts.

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