L5-Breast Diseases

Objectives :

Color Index: Slides & Raslan’s ( ) | Doctor’s Notes | Extra Explanation | Additional

This work is based on doctor’s Slides +Notes and Raslan’s only (Does not include the book)

2
Mind Map part (1)
part (2)

3
part (3)
 part (1)
Anatomy of the Breast
Breasts (mammary glands) are modified sebaceous glands.
The breast extends from the 2nd to the 6th ribs and transversely from the lateral border of
the sternum to the mid-axillary line
Breast Borders:
1. Upper border: collar bone
2. Lower border: 6th or 7th rib.
3. Inner border: edge of sternum.
4. Outer border: mid-axillary line
Breast :Divisions Each breast is divided into 5 segments.(Four quadrants & Tail of Spence )
A)Four quadrants:
By horizontal and vertical lines intersecting at the nipple
(upper outer quadrant, upper inner quadrant, lower outer quadrant, and lower inner quadrant)

Majority of benign or malignant tumors lie in the upper outer quadrant

B)Tail of Spence
(the axillary tail): an additional lateral extension of the breast tissue toward the axilla.
Breast Parts More details in the next slide

External Anatomy Musculature Related Internal Anatomy

Of The Breast To The Breast Of The Breast
A) External Anatomy Of The Breast:
1. Nipple: pigmented and cylindrical, lies at the 4th intercostal space (at age 18)
2. Areola: pigmented area surrounding the nipple.
3. Glands of Montgomery (Montgomery‟s Tubercles): sebaceous glands within the
areola, which act to lubricate the nipple during lactation
B)Musculature Related To The Breast:
The breast lies over the muscles that encases the chest wall.
The muscles involved include the
• pectoralis major (60%),
• pectoralis minor, serratus anterior (30%)
• external oblique, latissimus dorsi, subscapularis, and rectus abdominis fascia (10%).
Long Thoracic Nerve
- Serratus anterior
Nerve supply Thoracodorsal Nerve
- Latissimus Dorsi
Intercostalbrachial Nerve
- Lateral cutaneous
- Sensory to medial arm & axilla

Absence of the breast, also called amastia. Unilateral amastia (amastia just on one side)
is often associated with absence of the pectoral muscles (the muscles of the front of the chest)
C) Internal Anatomy Of The Breast:
The breast is composed of 3 different types of tissue:
1.Glandular tissue: It is the milk-producing tissue. Each mammary gland consists of 15-20
lobes. Each lobe is further divided into 20-40 lobules composed of clusters of milk-secreting
glands (alveoli/acini) and is drained by a lactiferous duct that opens onto the nipple.

2. Fibrous (supporting) tissue: Strands of connective tissue called the suspensory ligaments of
the breast (Cooper‟s ligaments) extend through the breast to the underlying muscle separating
the breast‟s lobes .
Benign or malignant lesions may affect these ligaments and cause (Skin retraction or dimpling)

any pathology that lead to blockage of the local lymphatic ducts causes →swelling of the breast
→lead to cooper’s ligaments becoming tight causing → Peau d'orange appearance

after surgery
dimpling may happen but remember infections are
because of malignancy
because of infections associated with
fever ,redness and tenderness

3. Fatty tissue: Subcutaneous and retromammary fat.

It gives the bulk of breast. There is No fat beneath areola and nipple.
 Lymphatic Drainage Of The Breast:
• Superficial lymphatic nodes drain the skin Axillary
drain the
• deep lymphatic nodes Infraclavicular
Supraclavicular mammary
parasternal (internal mammary) lobules.

Lymphatic drainage of the breast

The medial portion of the breast → to the internal mammary nodes

The central and lateral portions 75-80% →drain to the axillary lymph nodes

Axillary lymph nodes can be classified Anatomically into 5 groups and clinically into 3 levels

Anatomical classification of axillary lymph nodes: in the next slide

1. Anterior (pectoral) group: deep to pectoralis major.

2. Posterior (subscapular) group: along subscapular vessels.
3. Lateral group: along the axillary vein.
4. Central group: within the axillary pad of fat.
5. Apical group: which drains all of the other groups, lies behind the clavicle at the apex of axilla.
 very important
Clinical/surgical classification of axillary lymph nodes:
This surgical classification is used in axillary dissection.
It is based on the relationship of the lymph nodes to pectoralis minor.
There are 3 levels of axillary lymph nodes and options for dissection:
Level 1: any lymph node (lateral)= below pectoralis minor (first group involved in malignancy)
Level 2: any lymph node (posterior) =behind pectoralis minor. account for 80% of lymph nodes.
Level 3: any lymph node (medial ) =above pectoralis minor

Lymphatic channels are drained according to the blood supply that’s why some tumors
metastasize to the ribs and lungs
 Physiology Of The Breast
Normal physiological breast changes in females.
Puberty: need estrogen and progesterone
Estrogen→ growth and appearance, milk-producing system.
Progesterone→ lobes & alveoli, alveolar cells become secretory
Asymmetry is common

Menses:
o Progesterone: 3-7 days prior to menses, engorgement.
o Physiologic nodularity: retained fluid.
o Mastalgia= Breast pain

Pregnancy and lactation:

o Glandular tissue displaces connective tissue.
o Increases in size.
o Nipples prominent and darker.
o Mammary vascularization increases.
o Colostrum present.
o Attain Tanner stage V with birth.

Aging:
o Perimenopause: decrease in glandular tissue, loss of lobular and alveolar tissue.
o Fatten, elongate, pendulous.
o Infra-mammary ridge thickens.
o Suspensory ligaments relax.
o Nipples flatten.
o Tissue feels “grainy”.
 Normal Variations of Breast
1- Accessory breast tissue
• Commonly occurs in three stages: puberty, pregnancy or lactation.
• Accessory breast is not well formed, there is no full duct or secretion or nipple
only accumulation of breast tissue.
• The patient is normal and a swelling occurs, it is due to increased glandular tissue in the axilla
which increases in size due to the effect of hormones.
• Treatment: nothing is done only reassurance.
2- Supernumerary nipples
Two deformity can occur in the nipple:
Retracted and deviated nipple presents in:
malignancy, inflammatory process, duct ectasia, or congenital
Accessory Nipples appear at birth as congenital abnormality.
if we are not sure which nipple is the accessory one we should do an ultrasound or a
ductogram to see the duct connections to the nipple.
3-Hair.
4-Asymmetry
is a common concern among female adolescents. Typically, the asymmetry is more noticeable
during puberty and eventually breast size evens out during development. If it was a major and
persistent asymmetry a breast augmentation or reduction surgical procedure may be considered
AFTER breast development/puberty is complete (NEVER interfere surgically during puberty).
but you should do an ultrasound to make sure there is no underlying pathology especially
in elderly.
 Normal Variations of Breast
Accessory Tissue

Biopsy

Accessory breast tissue Supernumerary nipple

Milk Lines
(Sites of Accessory Nipples and Breasts)
Breast Hair Breast asymmetry
Accessory Nipples and Breasts NEVER crosses below the umbilicus 11
 Clinical Approach Management of a patient with a breast lump:
1. History and examination
1. History 2. Ultrasound and mammogram if above 35 years old.
2. Clinical examination 3. FNAC or core biopsy or excision biopsy
3. Imaging Definitive treatment which is either:
4. Cytology and tissue diagnosis Observation, Excision, if malignant, along
the lines of cancer cases
Spectrum of complaints:
Women came to see a breast surgeons for the following reasons:

1. Breast lump (painful/painless) - 60%

2. Anxiety – 20%
3. Breast pain without a lump – 10%
4. Nipple discharge – 5%
5. Change in breast contour – 2%
6. Nipple-areolar complex disorder – 1% Triple assessment of a patient with a lump:
7. Axillary mass – 1% 1. History and examination
8. Screen detected lesion 2. Mammogram (99%) if above 35 years old
3. F.N.A

For history and Clinical examination you can go back to

Raslan’s (page 335) and read more about it
Breast presentation:
Skin dimpling:
carcinoma, aging, breast infection, previous breast surgery
Changes in nipple/areola:
Duct ectasia, carcinoma, paget‟s disease, eczema
Painless lump:
carcinoma, cyst, fibroadenoma, fibroadenosis
Painful lump:
cyst, periductal mastitis, abscess, sometimes carcinoma
Pain and tenderness (no lump):
cyclical, noncyclical, very rarely a carcinoma

The cardinal signs of a late cancer of the breast:

• hard
• non-tender
• irregular lump
• tethering or fixation
• palpable axillary lymph nodes
 Mammography
When to image?
Imaging Ultrasonography
• Investigation of a palpable lump or nipple discharge. Mammography
• Screening in appropriate groups (asymptomatic 40 y/o) Estimated reduction in mortality 15 – 25%
• Metastatic adenocarcinoma with an unknown primary 10% false positive rate
Densities and calcification
1-Mammography
Diagnostic mammography Screening mammography
performed in order to evaluate a breast complaint performed for asymptomatic
or abnormality detected by clinical examination. well‟ women to detect unsuspected lesions.
E.g. routine screening for women who are 40 years or older

Cardinal Mammographic Features Of Malignancy

• Speculated mass (stellate lesions)→check for the presence of a surgical scar. All other stellates are
presumed invasive carcinoma that requires work up and biopsy. If unexplained, don‟t be seduced by
stability.
• Architectural distortion without mass → should be treated as stellate lesion.
• MICRO-calcifications with casting or irregularity → 60% of localization biopsies are for
calcifications, but only 25% of these yield malignancy.
• Distribution (casting, linear, segmental, clustered) → segmental and clustered indicate malignancy.
• Morphology (pleomorphism).
• Relationship to parenchyma.
• Circumscribed density with distinct margins.
• Asymmetric density
Benign Vs. Malignant Imaging Characteristics In Breast Cancer:

Benign Vs. Malignant calcification :

Based on size Macrocalcification.(Large white dots) are always benign
and require no further follow-up.
Microcalcification.(Very fine white specks) mostly benign but can be
malignant.

Based on shape →Benign→ punctate, linear, spherical, popcorn, vascular, smoothly dense.
→Malignant→ mostly ductal, segmental and clustered.
Based on distribution → widespread bilateral distribution is suggestive of a benign process
2-Ultrasonography (Ultrasonographic Features ) for extra information about US
go back to Raslan’s (page 357-358)
Cysts:
• Contain no or few echoes
• Have smooth margins Fibrocystic changes
• Often compressible with ID
• Have posterior enhancement (increased echoes=whiter)

 Cysts can present as a palpable mass or a focal tender area within the breast
 A majority of cysts are found in asymptomatic women on their screening mammogram.
 On mammography: they appear as a mass and may have associated benign rim/eggshell calcifications.
 On ultrasound: it is the confirmatory diagnostic test, demonstrates a well-defined mass devoid of
internal echotexture (if any internal echoes are present, U/S guided FNA is recommended to fully exclude
malignancy)
Benign masses:
• Have smooth margins
• Have relatively uniform internal appearance
• Don‟t disturb surrounding tissues o Are usually wider than tall

Malignant masses:
• Have irregular or indistinct margins
• Have heterogeneous internal appearance
• Often cut across surrounding tissue planes
• Are often taller than wide or rounded (special types)
• The normal breast tissue appear as symmetrical waves under U/S. Malignant lesions disturb that
pattern but benign lesions follow that pattern.
1-Mammography
BI-RADS Features
Classification
0 Need additional imaging
1 Negative – routine in 1 year
2 Benign finding – routine in 1 year
3 Probably benign – 6 month follow-up
4 Suspicious abnormality – biopsy recommended
5 Highly suggestive of malignancy – appropriate action must be taken

2-Ultrasonography
Benign Malignant
Pure hyperechoic Hypoechoic, spiculated
Elliptical shape (wider than tall) Taller than wide
Lobulated Duct extension
Complete tine capsule Microlobulation
3-MRI

•High risk patients

oHistory of breast cancer High sensitivity
oLCIS, atypia o10 – 20% will have a biopsy
o1st degree relative with breast cancer
o Very dense breast
Cytology and Biopsy

 Fine-needle aspiration (cytology)

• Procedure description: a thin needle is inserted into the mass for sampling of cells that are later on
examined under a microscope.
• Fast, inexpensive
• 96% accuracy
• Institution dependent
• Unable to differentiate between in-situ vs CA

 Core biopsy → core and excisional biopsy give tissue

 Image guided
 Stereotactic
• Suspicious mammographic abnormalities
• Patients lay prone
• Biopsy under mammogram
 Excisional Biopsy
Atypical lesions
LCIS
Radial scar
Atypical papillary lesions
Radiologic-pathologic discordance
Phyllodes
Inadequate tissue harvesting
Nipple discharge
- 5% of women coming to the clinic complain of nipple discharge
- 95% of these complaints are benign.
Commonest causes in non-pregnant women:
• Carcinoma
• Intra-ductal papilloma (most common cause) most common cause of nipple discharge is lactation, most
common pathological cause is intra-ductal papilloma (bloody nipple discharge)
• Fibrocystic changes
• Duct ectasia
• Hypothyroid
• Pituitary adenoma (prolactin secreting adenoma, can present with galactorrhea)

Clinical characteristics:
1- Physiologic discharge (e.g. lactation)→ usually bilateral, multiple ducts, non-spontaneous, screen for
phenothiazine use (antipsychotic)
2- Pathologic discharge:→ Unilateral, spontaneous (without squeezing the nipple), single duct,
discolored discharge
Clinical Evaluation
-Most important points in history of nipple discharge are:
 Is it spontaneous or on pressure? Is it coming from single or multiple?
 Colors: Serous, serosanguinous, bloody, clear, milky, green, blue-black.
- R/O mass by clinical examination and mammogram.
- Identify source of discharge and test for presence of blood in discharge
- Consider ductography
- Cytology and biopsy: core biopsy
- Lab tests: thyroid, prolactin
Nipple discharge
For further evaluation of
spontaneous nipple discharge a
ductography can be performed.
Ductography is useful in detecting
the location of the lesion within the
duct and the extent of involvement.
This information can be extremely
helpful in presurgical planning.

Galactocele:
Def.: Cyst containing milk.
clinical presentation: dull aching pain with a well formed Management of Nipple discharge
lump Physiologic
Diagnosis: clinically or U/S o Treat cause if present
o Follow-up 6 months (observation)
Management: aspiration both therapeutic and diagnostic Pathologic
under full aseptic technique to prevent infection. If it o Biopsy and excise
appeared small on U/S there‟s no need to aspirate just (single duct excision or total duct excision(
reassure the patient.
If it accumulates again then aspirate again while reassuring
the patient that it‟ll resolve after lactation period
 part (2)
Common Benign Breast Disorders

1. Fibrocystic changes
2. Fibroadenoma '
3. Intraductal papilloma
4. Mammary duct ectasia
5. Mastitis
6. Fat necrosis
7. Phylloides tumor
8. Male gynecomastia
9. Galactocele
 1. Fibrocystic changes
 Characteristics:
o Most common breast pathology (No increased risk for cancer) “
o Lumpy, bumpy breasts
o 50-80% of all menstruating women
o Commonest incidence among age 30-50 (10% in women less than 21 )
o Caused by hormonal changes prior to menses
o Relationship to breast cancer doubtful.
o It may also present with pain, which may be cyclical
Three Morphologic Patterns seen in Fibrocystic Changes :
• Cysts formation and apocrine metaplasia
• Fibrosis of tissue
• proliferation of glands( Adenosis)Increase in the number of acini per lobule.
(Adenosis can be seen in pregnancy.)
Histology
 Signs And Symptoms - Adenosis
• Mobile cysts with well-defined margins - Apocrine metaplasia
• Singular or multiple - Fibrosis
• May be symmetrical - Duct ectasia
• Upper outer quadrant or lower breast border - Mild duct ectasia
• Pain, discomfort and tenderness
• Cysts may appear quickly and decrease in size
• Lasts half of a menstrual cycle
• Subside after menopause, if no HRT.
Fibrocystic Changes – Cont
 Investigations
Aspirate cyst fluid
o If bloody go for surgical biopsy.
o If non-bloody and disappear completely observe.
o If non-bloody and doesn’t resolve surgical biopsy.
Imaging for questionable cysts
o In young patients only U/S is performed show multiple cysts
o In 40 and above patients both U/S and mammogram are performed to exclude any underlying malignant
pathologies.
 Management
o Treatment based on symptoms
o Reassure patient
o ‟Atypical Hyperplasia  for more details about the management (go to the next slide)
o Comfort measures
 Eliminate Methylxantines (coffee, chocolate): may take 6 months for relief.
 Local heat/cold
 Wear a good supporting bra
 Low-Sodium diet
 Vitamin E: Antioxidant but do not take more than 1200/day
o Medications for mastalgia:(Breast pain)
 NSAIDS (simple analgesia)
 Monophasic oral contraceptive pills (to stabilize hormonal levels)
 Spironolactone
 Dopamine Agonists: Bromocriptine
 Rare or former use: Danazol (for severe cases, side effects include: acne and hirsutism, only 50%
respond to it, mostly not used), Tamoxifen, GnRH agonist (Luprolide)
Fibrocystic Changes – Cont
‟Atypical Hyperplasia” on pathology report indicates increased risk of breast cancer → must excise

 If simple (one layer of cells and fluid) → then just reassure the patient & conservative management

 Atypia or hyperplasia if atypia / hyperplasia / dysplasia changes were present → must EXCISE

 Complicated cyst (i.e. both solid and cystic components) → Biopsy is needed from solid component
to exclude malignancy (has malignancy potential).

 Constant cyst (i.e. doesn’t change with multiple imaging in different times) → must biopsy

Breast Pain In General

1-Cyclical pain – hormonal: this type is assuring . Secondary to hormonal influence.
Dull, diffuse and bilateral
Luteal phase
Treatment: Reassurance, NSAIDS, evening primrose oil
2. Non-cyclical pain:
Non-breast vs breast
Imaging
Treatment: Reassurance, NSAIDS, evening primrose oil
 2.Fibroadenoma '
 Characteristics
o Second most common breast condition (most common lump)
o Well circumscribed mass
o Most common in black women
o Late teens to early adulthood (15-30 years old of age) young age group
o Rare after menopause
o Totally benign, and NO malignancy potential
 Signs And Symptoms
o Firm, rubbery, round, mobile mass
o Painless, non-tender
o Solitary, 15-20% are multiple
o Well circumscribed
o Mostly located in upper-outer quadrant of the breast
o 1-5 cm or larger (if more than 5 cm it is called a giant fibroadenoma)
 Investigations And Treatment
o Triple assessment
o Imaging: U/S mostly used because its more common in young and mammogram
Popcorn microcalcification in mammogram
o Biopsy
o Excision and close follow-up
Fibroadenoma: To leave alone or to excise?
EXCISE if
- >3-4 cm or giant fibroadenoma = more than 5 cm
-localized
-painful
-rapidly growing
-a family history of malignancy (does NOT mean that fibroadenoma is pre-malignant but done
only to relieve the patient‟s worries)
-patient‟s preference
-Patient has no access for medical follow up
-indeterminate diagnosis(unclear pathology)
-if 35 y/o and older recommended (unusual age)
If left alone
it‟ll either remain the same or regress (some patients during pregnancy it regresses) or increase
in size or calcify

Important Note
we should make clear diagnosis from the beginning and we must
differentiate it from Phyllodes tumor because the Phyllodes tumors
has the potential to transform into malignancy.
 3.Intraductal papilloma
 Characteristics
o Slow-growing
o Overgrowth of ductal epithelial tissue
o Usually not palpable
o Cauliflower-like lesion
o Length of involved duct
o Most common cause of persistent bloody nipple discharge (IMPT) 40-50 years of age
 Signs And Symptoms
o Watery, serous, serosanguinous, or bloody discharge
o Spontaneous discharge (Without squeezing the nipple!)
o Usually unilateral
o Often from single duct  pressure elicits discharge from single duct 50% no mass palpated
 Investigations
o Test for occult blood
o Ductogram
Breast ducts is 2-3 cm and the growth is in the duct so it won’t be felt or be visible.
 On ultrasound and mammogram it will show normal breast tissue
 A ductogram is done which is a contrast material injected then an x-ray is taken
(mammogram) and filling defects are assessed
o Biopsy
 No pain
Intraductal papilloma No mass
Most common cause of bloody nipple discharge

Unilateral bilateral

spontaneous systemic cause not local cause

with squeezing
(without squeezing the nipple)

traumatic cause
Intraductal papilloma

 Treatment (Papilloma: To leave or to excise? )

o Excision of involved duct

 If single papilloma  can observe and see if it disappears

 If it doesn’t resolve  excise
 If presented with intraductal PAPILLAMATOSIS (appears as multiple filling defects on ductogram)
considered a pre-malignant condition must excise

In young by US or ductogram (filling defect),

o Exclude malignancy . if 40 and above by U/S, ductogram and mammogram
 4.Mammary duct ectasia dilatation of breast ducts
 Characteristics
• Inflammation and dilation of sub-areolar ducts behind nipples, completely benign
• May result in palpable mass because of ductal rupture
• Greatest incidence after menopause
• Etiology Unclear → Ducts become distended with cellular debris causing obstruction
• Predispose to periductal abscess or predictable mastitis diagnosed by ultrasound.
 Signs and symptoms
 Thick, pasty( like toothpaste)
• Multi-colored discharge
 White, green, greenish-brown or serosanguinous
Intermittent, no pattern
• Bilaterally from multiple ducts
• Nipple itching with drawing or pulling (burning) sensation

 Mammary Duct Ectasia versus Breast Cancer:

• Left breast (1)– slit-like nipple characteristic of mammary duct eclasia
• Right breast (2)– nipple retraction from carcinoma

(1) (2)
 The problems behind this condition:
1- Infection
Duct ectasia →stasis → risk of infection → higher chance of abscess (periductal mastitis) caused by mixed
organisms → broad spectrum antibiotics and abscess drainage
(nonlactating breast abscess or mastitis) →think of underlying duct ectasia)

2-Similar presentation to malignancy:

Inflammation → can retract nipple → patient is worried about malignancy → U/S and mammogram
according to age → reassure the patient, if 40 and above take aspiration for cytology

Dried Secretions from Yellow Breast Discharge Duct Ectasia Multi-colored Breast Discharge
Mammary Duct Ectasia
 Investigations And Treatment
Test for occult blood
Imaging →Mammogram and sonogram
Biopsy → Excision of ducts if mass present
Antibiotics
Close follow-up
 5.Mastitis
 Characteristics:
• Breast infection when bacteria enter the breast via the nipple
• Ducts infected
• Fluid stagnates in lobules
• Usually during lactation
• Penicillin resistant staphylococcus common cause
Lactating mothers are exposed to staph infection if they have cracked nipples or if the baby's mouth is
colonized by staph (mothers are instructed to clean areola and babies mouth before feeding)
 Signs And Symptoms
•Pain and tenderness
•Nipple discharge: -(Pus -Serum -Blood )
•Localized induration
•Fever and rigor
•Abscess: localized tenderness, severe fever and rigor
•Similar to cellulites .

 Treatment
•Antibiotics
 Oxacillins →for PP mastitis(PP=postpartum=after childbirth)
 Cephalosporin for other abscesses → cephalexin, Keflex
•Empty breast if PP
•Incision and drainage of abscess
 Inflammatory carcinoma vs. mastitis
May have similar appearance, but completely different history
 Inflammatory carcinoma →non-lactating, nonfebrile, not as tender as mastitis
elderly, peaud’orange, must perform U/S, mammogram and biopsy.
 Mastitis → Lactating women presented with fever, painful and tender breasts

 Can a lactating female with abscess still breast feed her newborn?
YES, except if her baby appeared to be sensitive to antibiotic administered

 Note
Lactating women presented with fever, painful and tender breasts → most likely mastitis →
broad- spectrum antibiotics (cephalosporin 1st generation IV), warm sponges, if abscess must
drain it.

Puerperal Mastitis Puerperal Mastitis Inflammatory Carcinoma

Left Breast Erythema and peau d’orange
 6.Fat necrosis
 Cause:
•Trauma to breast (e.g. seat belt trauma in car accidents)
•Surgery
•Necrosis of adipose tissue Seat Belt Trauma Breast Hematoma

 Signs And Symptoms

•Pain or mass (Usually non-mobile mass)

 Treatment: no treatment
•Resolves over time without treatment
•may be excised

 Carcinoma vs. fat necrosis:

fat necrosis is important because both clinically and radiologically can appear very similar to
malignancy. In order to exclude cancer a biopsy should be performed.

• Patient presents with an irregular lump attached to the skin and doesn’t remember any
trauma.
• Upon clinical and radiological examination you can’t differentiate it from malignancy, on
ultrasound and mammogram speculation and calcification similar to malignancy .
• We differentiate between it and malignancy by core biopsy
 7.Phylloides tumor (cystosarcoma)
 Characteristics:
• Giant fibroadenoma (a variant of fibroadenoma) with rapid growth (patient presents with a
history of a rapidly growing mass)
• Malignant potential, lesions > 3 cm are more likely to be malignant
• Most are benign, 25% recur locally if incompletely excised
• The malignant form of this lesion mostly locally malignant (about 10%) can metastasize
hematogenously to the lungs and not to the axillary lymph nodes.
• Often occurs in women aged 40+

 Investigations:
Imaging: both mammography and ultrasound, they present as well-defined masses that are very
similar to a benign fibroadenoma.
The malignant forms are more likely to have cystic spaces on U/S

 Treatment:
Excision (mastectomy) is the only treatment!
Chemotherapy and radiotherapy are not effective.

Before Surgery After Surgery Cross Section of Giant Fibroadenoma

Malignant Phylloides Tumor
Giant Fibroadenoma
 8.Male Gynecomastia
 Characteristics
• Diffuse hypertrophy of breast
• 30-40% of male population
• Adolescence and older men
• Caused by imbalance of estrogen/testosterone
• Medical conditions (hepatitis, COPD, hyperthyroidism, TB)
• May be associated with genetic cancer families
• Must exclude testicular and adrenal malignancies (hormone producing tumors)

 Medications associated with gynecomastia:

o Marijuana
o Narcotics
o Phenothiazines
o Diazepams
o AnythingthataffectstheCNS

 Treatment
• If pre-puberty → wait to see if it resolves
• Change medication
• Treat underlying illness
• Occurs in families with genetic mutation → Colon , prostate cancer
 part (3)
Breast Cancer (for reading )
Facts about it:
• Killer of women • chance of dying from breast cancer by at
• USA1:8 least 30%
• KSA?1:15 • Women aged 50–69 who have a breast
• 187000 cases of cancer breast in one year screen every two years can reduce their
(USA) • chance of dying from breast cancer by at
• 45000 deaths due to it in one year (USA) least 30%
• Breast cancer is the most common cause of • The average age of diagnosis of breast
death from cancer in western women cancer in women is 45 - 55 years
• Every day in Australia, over 30 women • During the period 1994 to 1998, the five
discover they have breast cancer year survival rate for women diagnosed
• In Australia 11,400 people (11,314 women • with breast cancer was 85 %
and 86 men) were diagnosed with • Although we know of many factors that
• breast cancer in 2000. contribute to the risk of women getting
• 9 out of 10 women who get breast cancer • breast cancer, the cause remains unknown
do not have a family history of the • Most common type of breast cancer is
• disease ductal carcinoma.
• Age is the biggest risk factor in developing • Five year survival rates
breast cancer – over 70% of cases Stage at diagnosis Survival rates (%)
• occur in women over 50 years
Localized 96.8
• Women aged 50–69 who have a breast
screen every two years can reduce their Regional 75.9
Distant 20.6
Breast Cancer
Established risk factors for breast cancer in women
Relative risk <4 • Age (older age group higher risk)
• Country of birth (North America, Northern Europe)
• Mother and sister with history of breast cancer, especially at an early age
• Biopsy confirmed atypical hyperplasia and a history of breast cancer in a first
degree relative

Relative risk 2.1 • Nodular densities on mammogram occupying >75% of breast volume
• History of cancer in one breast
• Radiation to chest
• Mother or sister with history of breast cancer, diagnosed at an early age
• Biopsy-confirmed atypical hyperplasia without a family history of breast cancer
Relative risk 1.1 • Socioeconomic status (high)
• Place of residence (Urban
• Race/ethnicity (White >45 and Black <45)
• Religion (Jewish)
• Nulliparity, breast cancer >40 years of age
• Age at first full-term pregnancy, age at menarche, age at menopause
• History of primary cancer in endometrium, ovary
• Obesity (Obese breast cancer > 50 years, Thin breast cancer <50 years)
Staging Classification Of Breast Tumors

50 y/o female with a 2 cm tumor and liver metastasis-> stage 4

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 Screening Genetics
• Early age of onset
Prior breast cancer or atypia
• 2 breast primaries or breast & ovarian CA
- Annual mammography
Clustering of breast CA with:
- 6 month CBE
• Male breast CA
Family Hx • Thyroid CA
- 10 years younger than relative’s diagnosis • Sarcoma
- 6 month CBE • Adrenocortical CA
BRCA • Pancreatic CA
- 25 y.o, annual mammography • Leukemia/Lymphoma on same side of family
- 6 month CBE Family member with BRCA gene
Male breast CA
Ovarian CA

BRCA
•Account for 25% of early-onset breast cancers
•36 - 85% lifetime risk of breast cancer
•16 – 60% lifetime risk of ovarian cancer
•BRCA Management
 Monthly BSE – 18 y.o
 6 month CBE & annual mammo – 25 y.o
 Discuss risk reducing options
• Prophylactic Mastectomies
• Salpingo-oophorectomy upon completion of child bearing

 6 month transvaginal US & CA125 – 35. y.o

Histopathological Types Of Breast Cancer:
infiltrating (or invasive) Ductal Carcinoma (IDC) More details in the next slide
Starting in a milk passage, or duct, of the breast, this cancer breaks through the wall of the duct and invades the
breast‟s fatty tissue.
It can spread to other parts of the body through the lymphatic system and through the bloodstream.
Infiltrating or invasive ductal carcinoma accounts for about 80 percent of all breast cancers.
Most common type.

Infiltrating (or invasive) Lobular Carcinoma (ILC)

This type of cancer starts in the milk-producing glands. About 10 to 15 percent of invasive breast cancers are invasive
lobular carcinomas. These are multicenteric, and they can appear in the other breast as well (bilateral)

Medullary Carcinoma
This type of invasive breast cancer has a relatively well-defined distinct boundary between tumor tissue and normal
breast tissue. It accounts for about 5 percent of all breast cancers. The prognosis for medullary carcinoma is better
than that for invasive lobular or invasive ductal cancer

Colloid Carcinoma
This rare type of invasive disease, also called mucinous carcinoma, is formed by mucus-producing cancer cells.
Prognosis for colloid carcinoma is better than for invasive lobular or invasive ductal cancer.

Tubular Carcinoma
Accounting for about two percent of all breast cancers, tubular carcinomas are a special type of invasive breast
carcinoma. They have a better prognosis than invasive ductal or lobular carcinomas and are often detected through
breast screening

Adenoid Cystic Carcinoma

This type of cancer rarely develops in the breast; it is more usually found in the salivary glands. Adenoid cystic
carcinomas of the breast have a better prognosis than invasive lobular or ductal carcinoma
surgical treatment of breast cancer depending on stage:
Stage 1 and 2→WLE or mastectomy, axillary nodes then radiotherapy and chemotherapy
Stage 3 → neo-adjuvant chemotherapy then surgery
Stage 4 → no role of surgery

Imaging features which can be associated with ductal carcinoma in situ (DCIS):
- Micro-calcifications linear (75-90%) - Architectural distortion
- Circumscribed mass - Asymmetry
- Ill-defined mass - Sub-areolar mass
- Prominent duct or nodule

infiltrating (or invasive) Ductal Carcinoma (IDC)

Mammogram of DCIS with malignant microcalcifications. Note the fine, linear, heterogeneous
clustered calcifications associated with an ill-defined mass lesion. Although the hallmark
imaging feature for DCIS is the presence of microcalcifications, DCS can also present less
frequently without them.

Ductal Carcinoma In Situ Treatment

Depending on the degree of DCIS the options of treatment are
o Total mastectomy
o Lumpectomy
o Lumpectomy and radiationtherapy
DCIS does not spread to the axillary lymph nodes so these are usually not removed.
Lines Of Treatment
 Surgery (:Surgical Intervention: 1. Mastectomy 2. W.L.E (wide local excision))
• For Stage I and II WLE or mastectomy + axillary nodes
 Radiotherapy.
 Chemotherapy. (WLE ) = A wide local excision is a surgical
 Hormonal therapy. procedure to remove a small area of diseased
or problematic tissue with a margin of normal
 Ovarian ablation.
tissue. This procedure is commonly performed
 Reconstruction on the breast and to skin lesions, but can be
used on any area of the body

Chemotherapy
Chemotherapy for breast cancer is usually given in cycles every 3 or 4 weeks.
• The common schedules include:
 CMF (Cyclophosphamide, Methotrexate and 5-Flurouracil)
AC (Adriamycin,Cyclophosphamide)
 T axol or T axotere Prognostic Factors :
• Chemotherapy side effects: Size of tumor
o Fatigue Grade of tumor
o Anorexia Lymph nodes involvement
o Nausea and vomiting o Hairloss
o Effectsontheblood. o Mouth problems
o Skin problems
o Fertility
o Bowelproblems
 Radiotherapy
Side effects
 Tamoxifen
• Tamoxifen is a drug that has been used for the treatment of breast cancer.
It can increase survival for some women with breast cancer and reduce their risk of developing
cancer in the opposite breast. Tamoxifen is sometimes used whose breast cancer recurs.

• It is also being tested to see if it can prevent the development of breast cancer in unaffected
women who are at an increased risk because of a strong family history of the disease.

• Tamoxifen is taken by mouth. Tablets are either 10 mg or 20 mg.

• It is usually started after surgery or after the completion of radiation Rx
• Tamoxifen should take it at the same time each day.
• Currently the recommended length of Tamoxifen therapy is five years.

Side effects
Common side effects Uncommon side effects
• Hot flushes or sweats • Light-headedness, dizziness, headache or
• Irregular menstrual periods tiredness
(in women who have not gone through the • Rash
menopause) • Nausea
• Vaginal irritation, including vaginal
dryness or discharge
• Fluid retention and weight gain
 Lymphoedema
• Definition: Lymphedema is long-term swelling of the arm after axillary surgery or
radiotherapy to the axilla.
• Symptoms: include a general heaviness of the arm, a swelling of the fingers or sometimes
difficulty putting on a long sleeve.
• The earlier treatment is started the easier it is to achieve good results.
• Less than 1 in 10 women who have had either lymph glands removed or radiation to the
armpit will develop noticeable lymphedema.
• This risk increases to 1 in 3 if the pt. had both of these treatments.
• It can occur any time after the operation, even up to 10 years.
 Post-operative Breast Reconstructions
• The aim of breast reconstruction is to rebuild the breast shape and, if desired, the nipple
and the areola.
• Benefits:
• Reconstructionusuallydoesn‟trestrictanylatertreatments,nordoesit
• usually interfere with radiotherapy, chemotherapy or hormone therapy.
• The patient will not need to wear an external prosthesis.
• Follow-up after the operation is no more difficult and any recurrence of
• cancer in the area can still be detected.
• Some women feel more self-confident and feminine after reconstruction
• There are two main types of breast reconstruction:
• tissue or skin expander with breast implants
• flapreconstruction
 MCQs
Q5- the most likely diagnosis in a 34 year old smoker
Q1- It is advisable to remove a fibroadenoma if:
a. It is painful with a nipple piercing, painful breast and bloody
b. It is more than 3 cm in size nipple discharge:
c. There is a positive family history of breast cancer a- Duct ectasia
d. All of the above b-Phyllodes tumour
c-Lactation mastitis
d-Periductal mastitis
Q2- Which of the following factors increases the risk of breast cancer
among women?
a. Obesity and nulliparity
b. Age at menarche
c. Multiple pregnancies
d. Low-fiber diet

Q3- Failure to perform radiation after wide excision of an invasive cancer

risks which of the following outcomes?
a. Recurrence of cancer in the ipsilateral breast.
b. Shorter survival time.
c. Regional nodal recurrence.
d. Greater chance of breast cancer mortality.

Q4- A 21-year-old woman presents with an asymptomatic breast mass.

Which of the following statement(s) is/are true concerning her diagnosis
and treatment?

a. Mammography will play an important role in diagnosing the lesion

b. Ultrasonography is often useful in the differential diagnosis of this lesion
c. The mass should always be excised
46 1-D 2-a 3-a 4-b 5-d
d. The lesion should be considered pre-malignant
 Thank You..
Done By :
Falwah Alharthi
Norah Alnaeim
Revised By:
Turki Al-Otaibi

[email protected]

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