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    Development of Uroenital System

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    ERIAS TENYWA
    The document discusses the embryology of the urogenital system. It describes how the intermediate mesoderm forms the urogenital ridge containing the mesonephric ducts which give rise to the kidneys and urogenital system. The ureteric bud forms from the mesonephric duct and induces the metanephric blastema to form the kidney filtration units. The development of the kidneys, bladder, ureters, and external genitalia in both males and females is then outlined in detail over successive weeks of gestation under genetic signals influencing male versus female differentiation.

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    Development of Uroenital System

    Uploaded by

    ERIAS TENYWA
    17 views44 pages
    The document discusses the embryology of the urogenital system. It describes how the intermediate mesoderm forms the urogenital ridge containing the mesonephric ducts which give rise to the kidneys and urogenital system. The ureteric bud forms from the mesonephric duct and induces the metanephric blastema to form the kidney filtration units. The development of the kidneys, bladder, ureters, and external genitalia in both males and females is then outlined in detail over successive weeks of gestation under genetic signals influencing male versus female differentiation.

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    The document discusses the embryology of the urogenital system. It describes how the intermediate mesoderm forms the urogenital ridge containing the mesonephric ducts which give rise to the kidneys and urogenital system. The ureteric bud forms from the mesonephric duct and induces the metanephric blastema to form the kidney filtration units. The development of the kidneys, bladder, ureters, and external genitalia in both males and females is then outlined in detail over successive weeks of gestation under genetic signals influencing male versus female differentiation.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    17 views44 pages

    Development of Uroenital System

    Uploaded by

    ERIAS TENYWA
    The document discusses the embryology of the urogenital system. It describes how the intermediate mesoderm forms the urogenital ridge containing the mesonephric ducts which give rise to the kidneys and urogenital system. The ureteric bud forms from the mesonephric duct and induces the metanephric blastema to form the kidney filtration units. The development of the kidneys, bladder, ureters, and external genitalia in both males and females is then outlined in detail over successive weeks of gestation under genetic signals influencing male versus female differentiation.

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    You are on page 1of 44

    Embryology of Urogenital

    System
    KABSOM 2023

    Copyright © 2019 Wolters Kluwer • All Rights Reserved


    Intermediate Mesoderm Forms Much of the Urogenital System

    2
    3 Kidney Systems

    4.5 weeks
    3
    Intermediate Mesoderm Forms the Urogenital Ridge

    Urogenital Ridge
    (red box)

    5 weeks
    4
    The Ureteric Bud Forms as an Outgrowth from the Mesonephric Duct

    5.5 weeks
    5
    Collecting System Forms from the Ureteric Bud

    6-7 Weeks

    6
    The Ureteric Bud Induces the Metanephric Blastema to
    Form Filtration Units

    7
    Molecular Regulation of Kidney Development

    8
    Kidneys Develop in the Pelvic Region

    9
    Ascent of the Kidneys

    10
    Pelvic and Horseshoe Kidneys

    Ureter

    11
    Polycystic Kidney

    Recessive form: 1:5000; cysts from collecting tubules; renal failure in infancy
    Dominant form: 1:500-1000: cysts from anywhere; renal failure in adulthood

    12
    Duplications of the Ureters

    13
    Bladder Development

    6 Weeks 7 Weeks 8 Weeks

    14
    Bladder Development: Incorporation of the Mesonephric Duct

    15
    Possible Positions for Ectopic Ureters

    16
    Final Position of the Ureters and Mesonephric Duct (Vas Deferens)

    Ejaculatory duct

    17
    Urorectal Septal Defects and Imperforate Anus

    18
    Urachal Abnormalities

    19
    Relationship of the Genital Ridge to the Mesonephric System

    Cut Line

    20
    Migration of the Germ Cells

    4 Weeks (early) 6 Weeks

    21
    Relationship of Germ Cells to the Epithelium of the Genital Ridge

    6 Weeks

    22
    Formation of the Seminiferous Tubules

    8 weeks 16 weeks
    Sertoli cells: derived from epithelium; serve as nurse cells for sperm and
    produce antimüllerian hormone (AMH; also called müllerian-inhibiting
    substance [MIS])
    Interstitial cells (of Leydig): derived from mesenchyme of genital ridge;
    secrete testosterone (mesonephric ducts, tubules, etc.; dihydrotestosterone,
    external genitalia)
    23
    Male Tubules and Ducts

    16 Weeks 9 Months
    24
    Formation of Primary Oocytes and Follicular Cells

    7 Weeks 20 Weeks

    25
    Derivatives of the Paramesonephric Ducts

    8 Weeks 9 Months

    26
    Growth of the Urogenital Ridge Produces Fusion between the
    Paramesonephric Ducts

    27
    Formation of the Ovarian Ligaments

    28
    Induction of the Vagina by the Paramesonephric Ducts

    9 Weeks 12 Weeks Newborn

    29
    Vaginal Development

    30
    Uterine Abnormalities

    31
    Testis and Ovary Development

    32
    Genetic Signals: Male vs. Female

    33
    External Genitalia: Indifferent Stage

    4 Weeks 6 Weeks

    34
    Penis and Scrotal Development

    10 Weeks Newborn

    35
    Hypospadias

    Glandular Hypospadius Urethral and Glandular


    Hypospadias

    36
    Female External Genitalia

    37
    Female Pseudohermaphrodism (Adrenogenital Syndrome)

    38
    Androgen Insensitivity Syndrome (Testicular Feminization)

    39
    Signals for Sexual Differentiation

    SRY

    –SRY, +WNT4

    40
    Descent of the Testes
    8 Weeks 19 Weeks

    28 Weeks Newborn

    Cryptorchidism: Failure of the testes to reach the scrotal sac (3% of newborns)
    41
    Layers Covering the Testis

    42
    Indirect Inguinal Hernias and Hydroceles

    43
    Remnants of the Mesonephric Duct in Females

    44

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