National Institute of Epidemiology

MSc. BIOSTATISTICS
PROSPECTUS

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 MSc Biostatistics Course
Eligibility criteria
 Bachelor Degree in Statistics
 Any Bachelor Degree with statistics as ancillary /allied subject

MSc. Biostatistics Course structure

 Two years programme with four semesters under CBCS regulations
 Odd semester July to November (90 working days)
 Even semesters January to May (90 working days)
 One month (approx) semester break each in December & June
 The duration for completion of the course is four semesters. The maximum allowed
period for completion is eight semesters
 75% attendance essential
Any candidate who has failed to obtain the prescribed 75% attendance for valid reasons,
on special permission from Director of NIE can be exempted and under any
circumstances the exemption should not be granted for attendance below 65%.

Requirements for proceeding to subsequent semesters

 Candidates shall register their names for the First semester examination after the
admission in the PG courses.
 Candidates shall be permitted to proceed from the First Semester up to the Final
Semester irrespective of their failure in any of the Semester examination subject to the
condition that the candidates should register for all the arrear subjects of earlier
semesters along with current (subject) Semester subjects.

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Choice Based Credit System (CBCS) Regulations

Credit refers to describe the quantum of syllabus in terms of hours of study. It indicates
differential weight-age given according to the contents & duration of the courses in the
curriculum design.
Core Courses are compulsory subjects offered.
Elective Courses are courses offered by NIE
Supportive courses are of intermediary & introductory level in nature; aimed at bridging
the gap in the curricula; Enabling improvement skills in computation & communication.
Human Rights is a compulsory credit course offered in the III semester.
The course is designed under lectures / practical work / Journal review/ Seminars /
dissertation work / viva-voce.
Application procedure
Online application - advertised thro NIE & ICMR website
Application submission fee of Rs 1000/-drawn in favour of Director NIE
Course fee Rs 60,000 for four semesters (non refundable)
Examination fees as University norms

Method of Selection
 Review/Scrutiny of application form
 Written test/ personal interview
Reservation of seats and concession for SC /ST/ differently abled student as per
Govt. norms.
Written test/ personal interview will be held at NIE
Course Subjects
1. No. of Core papers: 13
Practicals: 3
(Including Journal review/seminar)
2. Elective courses: 2 out of 4
3. Supportive courses: 2 out of 4
4. Dissertation/project work: 1
Total 21
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 Fee Structure for MSc. Biostatistics Studies

S.No Particulars Ist year IInd year

(Rupees) (Rupees)
1. Admission fee 1000
2. Registration fee 2000
3. Tuition fee 15000 15000
4. Library fee 1000 1000
5. Development of infrastructural 2000 2000
facilities
6. Internet/ Bar coded Identity 500 500
card/Calendar/Magazine
7. Laboratory fee 4500 4500
8. Computer facilities 4000 4000
9. Dissertation evaluation fee - 3000
Total Rs.30,000 Rs.30,000
Grand total Rs. 60000

Accommodation

On-campus limited hostel accommodation is available. Allotment will be based on the first
come first served basis.

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 MSc BIOSTATISTICS FRAME WORK

Elective courses

1. Data Management
2. Applied Spatial Statistics
3. Health informatics
4. Bayesian Statistics

Supportive courses

1. Scientific communication
2. Health Economics
3. Field Epidemiology
4. Health Systems
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Grading System
The term Grading system indicates a seven point scale of evaluation of the performance of
students in terms of marks, grade points, letter grade and class as given below.

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 Course Competencies

 Develop an efficient design for collecting, recording, and storing non spatial & spatial
data collected in the conduct of public health and medical research.
 Develop sample size and statistical power calculations for basic study designs including
those utilized in clinical trials.
 Produce edited data sets suitable for statistical analyses.
 Perform analyses of stated hypotheses using a variety of analytical tools including
analysis of variance, multiple regression, nonparametric statistics, logistic regression,
multivariate analyses, spatial data analysis and methods for analyzing rates and failure
time data.
 Interpret results of advanced statistical analyses and use these results to make relevant
inferences from data.
 Develop written presentations based on intermediate to advanced statistical analyses
for both public health professionals and educated lay audiences.
 Develop oral presentations based on intermediate to advanced statistical analyses for
both public health professionals and educated lay audiences.

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MSc. BIOSTATISTICS CURRICULUM

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 M_BS C01 5 hours/week 5 credits
Basic statistics
Unit 1 Types of Data
 Qualitative and quantitative data
 cross sectional and time series data
 discrete and continuous data
 Nominal, ordinal, ratio and interval scales
Unit 2 Presentation of Data
 Frequency distribution and cumulative frequency distribution
 diagrammatic and graphical presentation of data
 construction of bar, pie diagrams, histograms, frequency polygon,
frequency curve and ogives
Measures of central tendency
 Mean
 Median
 Mode

Unit 3 Measures of Dispersion

 Concept of dispersion, characteristics for an ideal measure of dispersion.
Absolute and relative measures based on
 Range, inter quartile range, quartile deviation
 coefficient of quartile deviation
 Mean deviation, coefficient of mean deviation
 standard deviation (σ), coefficient of variation
 Properties of these measures.
Moments, Skewness and Kurtosis
 Moments about mean and about any point
 derivation of their relationships
 effect of change of origin and scale on moments
 Coefficients of Skewness and Kurtosis with their interpretations.
Unit 4 Concepts in Probability

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  Random experiment/trial
 sample point, sample space, operation of events
 exhaustive, equally likely and independent events
 Definition of probability-classical, relative frequency
 statistical and axiomatic approach, conditional probability
 Addition & multiplication laws of probability
Unit5 Random Variable and Probability Functions
 Definition of random variable,
 discrete and continuous random variable,
 probability function,
 probability mass function
 probability density functions, distribution function and its properties
 functions of random variables
 Joint, marginal and conditional probability distribution function

Mathematical Expectation and Generating Functions

 Definition and its properties-moments, addition and multiplication
theorem of expectation. Conditional expectation and conditional variance.
 Moments generating function, cumulant generating function, probability
generating function along with their properties.

BOOKS RECOMMENDED
1. Goon A.M., Gupta M. K., Dasgupta B (2008): Fundamentals of Statistics,
Published by Prentice Hall, 2nd edition.
2. Gupta S.C.& Kapoor V.K, (2000): Fundamentals of & Mathematical Statistics,
Sultan Chand Sons 10th edition.
3. Croxton F.E., Cowden D.J. & Kelin S, (1967): Applied General Statistics,
Prentice Hall.
4. Hogg and Craig, Introduction to Mathematical Statistics, (2013): Prentice
Hall, 7th edition.
5. Steel and J H Torrie, Principles and procedures of statistics, (2007): McGraw
Hill, 2nd edition.
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BOOKS FOR READING (FREE e-BOOKS)
1. http://www.e-booksdirectory.com/listing.php?category=15
2. http://www.analyticsvidhya.com/blog/2016/02/free-read-books-statistics-
mathematics-data-science/

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 M_BS C02 5 hours/week 5 credits
Statistical Inference I – Estimation Methods
Unit 1 Statistical Estimation
 Parameter and statistic
 Sampling distribution of statistic
 Point and interval estimate of a parameter
 Concept of bias and standard error of an estimate
 Standard errors of sample mean, sample proportion, standard deviation
Unit 2 Properties of a good estimator
 Unbiasedness
 Efficiency
 Consistency
 Sufficiency
(Definitions & Illustrations)
 Cramer Rao’s Inequality (statement-concept)
 Consistency and asymptotic efficiency
 Fisher’s Information Function
 Rao-Blackwell theorem (statement-concept)

Unit 3 Methods of Estimation (concepts only)

 Method of Moments
 Method of maximum likelihood and its properties
 Method of minimum Chi-square

Unit 4 Interval Estimation

 Confidence interval based on small and large samples (t, f, χ2,
distributions)
 Sufficiency and unbiased estimation
 Confidence interval for parameters of Normal distribution(s) (with
examples)

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Unit 5 Bayesian Inference
 Back ground
 Bayes theorem
 Prior and posterior distributions
 Interval estimation
 Fisher’s fiducial arguments

BOOKS RECOMMENDED
1. Daniel, W. W (2005): Biostatistics- A foundation for analysis in the Health
Sciences, John Wiley & Sons, 7th edition.
2. Hogg, R. V., McKean, J. W. and Craig, A. T. (2006): Introduction to
Mathematical Statistics, 6th edition, Pearson Education.
3. Rohatgi,V.K. and Saleh, A.K.(2001):An Introduction to Probability and
Statistics, John Wiley & Sons. (Chapter 8, Section 8.1 through 8.8)
BOOKS FOR REFERENCE
1. Casella, G. and Berger, R.L. (2002): Statistical Inference, Thomson Duxbury,
2nd edition.
2. Kale, B.K, (1999): A First Course on Parametric Inference, Narosa Publication ,
New Delhi, 2nd edition.
3. Pagano, M. and Gauvreau, K. (2000): Principles of Biostatistics, Duxbury, 2nd
edition.
4. Rao, C.R. (2002): Linear Statistical Inference and its applications, Wiley series
in Probability and Statistics, 2nd edition.

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 M_BS C03 5 hours/week 5 credits
Basic Epidemiology
Unit 1 Introduction to Epidemiology
 What is epidemiology?
 The historical context Origins
 Definition, scope, and uses of epidemiology

Unit 2 Measures of disease and death frequency

 Defining health and disease
 Definitions
 Diagnostic criteria
 Measuring disease frequency
 Population at risk
 Incidence and prevalence
 Case fatality
 Interrelationships of the different measures
Unit 3 Mortality and morbidity
 Death rates
 Infant mortality
 Child mortality rate
 Maternal mortality rate
 Adult mortality rate
 Life expectancy
 Age-standardized rates
 Morbidity
 Disability measures
Unit 4 Types of epidemiological studies
1. Observational studies
2. Experimental studies
3. Descriptive studies
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 4. Ecological studies
5. Cross-sectional studies
6. Case-control studies
7. Cohort studies
Unit 5 Potential errors in epidemiological studies
 Random error
 Systematic error
 Selection bias
 Measurement bias
 The control of confounding
 Validity

BOOKS RECOMMENDED:
1. R Bonita, R Beaglehole. T Kjellström, (2006): Basic Epidemiology 2nd Edition.
http://apps.who.int/iris/bitstream/10665/43541/1/9241547073_eng.pdf
2. Dicker, Richard, (2006): Principles of Epidemiology in Public Health Practice, 3rd
edition. http://www.cdc.gov/ophss/csels/dsepd/ss1978/ss1978.pdf
3. Altman D G, (2006): Practical Statistics for Medical Research, London: Chapman
and Hall, 2nd edition.
4. Leon Gordis M, (2004): Epidemiology, NA Saunders Company, 3rd edition.

BOOKS FOR READING

1. RC Brownson and DB Petittis (1998): Applied Epidemiology: Theory to Practice.
Oxford University Press, 2nd edition.
2. SM Teutsch and RE Churchill (1994): Principles and Practice of Public Health
Surveillance. Oxford University Press, 2nd edition.
3. CDC’s Morbidity and Mortality Weekly Reports (MMWR) .
Http://www2.cdc.gov/mmwr

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 M_BS C04 5 hours/week 5 credits
Sampling methods and Sample size determination
Unit 1 Introduction
 Advantages of sampling method
 Some uses of sample surveys
 The principal steps in a sample survey
 The role of sampling theory
 Probability sampling
 Alternatives to Probability sampling, Use of normal distribution, Bias and its
effects, The mean square error
Unit 2 Simple random sampling
 Simple random sampling, Selection of simple random sample, definitions
and notation, properties of the estimate, variance of the estimates
 The finite population correction, Estimation of the standard error from a
sample, confidence limits
 Random sampling with replacement
 Estimation of a ratio, Estimates of means over subpopulations, Estimates of
totals over subpopulations
 Comparisons between domain means, Validity of the normal approximation,
Linear estimators of the population mean
Unit 3 Sample size estimation
 A hypothetical example, Analysis of the problem, The specification of
precision
 The formula for n in Sampling for proportions, Rare items-Inverse sampling,
The formula for n with continuous data
 Advance estimates of population variances, Sample size with more than one
item
 Sample size when estimates are wanted for subdivisions of the population
 Sample size in decision problems
 The design effect
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Unit 4 Stratified random and Systematic sampling
 Description, Notation, Optimum allocation
 Estimation of sample size with continuous data, proportions
 Relative precision of stratified and simple random sampling
 Systematic sampling relative to cluster sampling
 Comparison of Systematic with stratified random sampling
 Stratified systematic sampling
Unit 5 Single stage cluster sampling: Clusters of equal and unequal sizes
 Reasons for cluster sampling, A simple rule
 Cluster sampling for proportions
 Cluster Units of unequal size
 Sampling with probability proportional to size
 Selection with unequal probabilities with replacement
 Probability proportional to its size measure

BOOKS RECOMMENDED
1. William G. Cochran, (1997): Sampling Techniques, , John Wiley & sons 3rd edition.
2. Murthy M N (2012): Sampling Theory and methods, Statistical publishing
Society, Calcutta 2nd edition.
3. Levy PS, Lemeshow S (1999): Sampling of Populations: Methods and
Applications, New York: Wiley Interscience, 3rd edition.
4. Lohr SL (2009): Sampling: Design and Analysis. Duxbury Press, 2nd edition.
5. Wayne Fuller (2009): Sampling Statistics, Wiley, 1st edition.
BOOKS FOR REFERENCE
1. Foundations of Inference in Survey Sampling (1997), Cassel, C.M., Sarndal, C.E.
and Wretman, John Wiley & Sons, 2nd edition.
2. Floyd J. Fowler (1995), Improving Survey Questions: Design and Evaluation, Sage
Publications, 2nd edition.

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 M_BS C05 4 hours/week 4 credits
Population Studies
Unit 1 Introduction to Demography
 Definition and uses of demographic data
 Source of vital statistics: census method - Registration method
 Sources of Demography Data: Secondary sources - SRS– Surveys
Unit 2 Mortality and Fertility
Mortality Measures
 Nature And Uses Of Mortality Statistics
 Mortality measures: Merits and demerits of Crude Death Rate (CDR) and
Age-Specific Death Rates, Infant Mortality Rate(IMR)
Fertility measures
 Basic terms and concepts used in the study of fertility
 Measures of fertility: Crude Birth Rate, Age specific fertility rate, General
fertility rate, Total fertility rate, Gross reproductive rate and Net reproductive
rate, Order-specific fertility rates.
 Life table and Abridged life table concepts
Unit 3 Standardization
 Need and importance of standardization
 Direct and indirect technique of standardization of rates and ratios in the
light of mortality/fertility rates
 Decomposition of Infant mortality rate and its sub-divisions
 Maternal Mortality Rate and Ratios
Unit 4 Population distribution and indices of dissimilarity
 Population classification - Urban-Rural international Standard definitions
 Rank size Rule for growth pattern
 Index of dissimilarity , Theil’s index, Isolation index ,Clustering
 Gini Concentration Ratio and Lorenz Curve
Unit 5 Mobility and Migration
 Concept of mobility and Migration
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  Types of migration, internal migration patterns and characteristics in
developing countries with a special focus on India.

BOOKS RECOMMENDED
1. Goon A.M., Gupta M. K., Dasgupta B (2008): Fundamentals of Statistics,
Published by Prentice Hall, 2nd edition.
2. Gupta S.C.& Kapoor V.K, (2000): Fundamentals of & Mathematical Statistics,
Sultan Chand Sons 10th edition.
3. Pathak, K.B. and F.Ram, (1998): Techniques of Demographic Analysis,
Mumbai,Himalaya Publishing House, Chapter 4
4. Jacob S. Siegel, David A. Swanson (2004): The methods and Materials of
Demography, Elsevier Inc.
BOOKS FOR REFERENCE:
1. Hinde, Andrew (1998), Demographic Methods, London: Edward Arnold, 1st
edition.
2. Cox, P. (1959): Demography, Cambridge University Press, 2nd edition.
3. Keyfitz, (1985): Applied mathematical Demography, Springer-Verlag, New York,
2nd edition.
4. Shrivastava, O.S. (1995): Demography and population Studies, Vikas Publishing
house private limited, 2nd edition.

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 M_BS C06 4 hours/week 4 credits
Statistical Inference II – Tests of Hypotheses
Unit 1 Introduction to Hypothesis Testing
 Null and alternative hypotheses- Simple and composite hypotheses,
 Critical region,
 Level of significance, one tailed and two tailed testing,
 Types of errors (I & II)
 Power and Sample size
 P- value interpretation and its associated misconceptions
Unit 2 Test of Hypotheses
 Neyman-Pearson Lemma,
 Tests based on Binomial, Poisson and Normal distribution(s)
Unit 3 Small and Large Sample Tests
Small Sample Tests
 Test for means and variances based on t, F, χ2 distributions.
Large Sample Tests:
Tests and Interval Estimation for
 Single mean, single proportion
 Two means, two proportions
 Fisher’s Z transformation
Unit 4 Nonparametric Tests
 Test of goodness of fit
 Chi square test
 Kolmogrov- Smirnov one sample test
 Sign test,
 Paired sample test
 Wilcoxon signed rank test
 Paired sample rank test
Unit 5 Two sample problems

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  Kolmogrov- Smirnov two sample test
 Mann- Whitney U test
 Wald-Wolfowitz runs test
Sequential Tests
 Sequential methods of drawing inferences
 Sequential probability ratio test (SPRT) – definition and basic concepts
 SPRT for testing simple hypotheses
 Operating Characteristic function
 Average Sample Number function
 Applications to binomial, Poisson and normal distributions

BOOKS RECOMMENDED
1. Conover, W. J. (2006): Practical Non-parametric Methods in Statistics, 2nd
edition, (Unit 5).
2. Daniel, W.W. (2006): Biostatistics: A foundation for analysis in the Health
Sciences, John Wiley & Sons, 7th edition (Unit 5).
3. Rohatgi,V.K. (1984): An Introduction to Probability Theory and Mathematical
Statistics, Wiley Eastern, 3rd edition ( Chapter 14-14.5 for SPRT).
4. Rohatgi, V.K. and Saleh, A.K. (2001): An Introduction to Probability and Statistics,
John Wiley & Sons, 3rd edition (Chapters 8 - 8.3, 9, 10- 10.1,10.2,10.6, 11 - 11.3).
BOOKS FOR REFERENCE:
1. S.C. Gupta and V.K. Kapoor (2008): Fundamentals of Applied Statistics, Sultan
Chand and Sons, 2008 4thedition.
2. G. Casella and R.L. Berger (2002): Statistical Inference, Thomson Duxbury, 2 nd
edition.
3. E.J. Dudewicz and S.N. Mishra (1988): Modern Mathematical Statistics, John
Wiley and Sons, 2nd edition.
4. A.M. Goon, M.K. Gupta and B. Dasgupta (2003): An Outline of Statistical Theory
(Vol. I), World Press, Kolkata, 4th edition.

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 M_BS C07 4 hours/week 4 credits
Longitudinal Data Analysis
Unit 1 One way classification
 Analysis of variance(ANOVA) : One Way, Two Way & generalization
 Single factor ANOVA
 Two-factor ANOVA with unequal and equal replication (with/without
interactions)- fixed and random effects models
 Multiple comparison tests-Tukey, Newman-Keul, Scheffe tests
Unit 2 Designs of Experiments
 Completely Randomized Designs (CRD)
 Randomized Block Designs (RBD)
 Latin Square Designs (LSD)
Unit 3 Advanced Designs for Analysis
 Repeated measures designs
 ANCOVA (for CRD and RBD)
 Factorial Designs (22,32)
Unit 4 Bioassay
 Introduction - Direct assays: the nature of direct assays, precision of
estimates and the design of direct assays.
 Dose Response Relations: Indirect assays, the dose response regression
 Standard curve estimation, slope estimation, and simultaneous trial
estimation
Unit 5 Response Surface Methodology (RSM)
 Concept of Response Surface Methodology
 Central Composite Designs (CCD)
 Box-Behnken Designs
 Missing Data

(Note: Emphasis on Definitions, Concepts, Applications and Interpretations)

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BOOKS RECOMMENDED
1. Das, M.N. and Giri N.C. (2006): Design and Analysis of Experiments Delhi. New
Age International (P) Ltd., New, 2nd edition.
2. Montgomery D.C (2006): Design and Analysis of Experiments, Wiley India 5th
Edition.
3. Zar, J.H. (2007): Biostatistical Analysis, Pearson Education 4th edition.
4. Govindarajulu, Z. (2000): Statistical techniques in Bioassay, Thomson Duxbury,
2nd edition.

BOOKS FOR REFERENCE

1. Morrison, 91990): Multivariate Statistical Methods, McGraw-Hill, 3rd edition.
2. Johnson, R.A. and Wichern, D.W. Applied Multivariate Statistical Analysis,
Pearson Education, Asia 5th edition.
3. Agresti, A. (2002): Categorical data analysis, John Wiley & Sons, 3rd edition.

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 M_BS C08 4 hours/week 4 credits
Applied Linear Regression Analysis
Unit 1 Simple linear regression
 Assumptions and Estimation of model parameters
 Standard error of estimators
 Testing of hypotheses on slope and intercept ( β’s)
 Coefficient of determination (R2 )
Unit 2 Multiple linear regressions
 Least square estimation of model parameters
 Variance covariance of least squares estimators
 Estimation of error variance
 Tests of hypotheses of regression parameters
 Significance of regression (ANOVA, R2and adjusted R2),
 Dummy variable regression- general concepts and uses
Unit 3 General linear Models (GLM)
 Introduction - Gauss Markov Setup
 Assumptions - Homoscedasticity & Hetroscedasticity
 Multicollinearity and it’s solutions
 Autocorrelation - Durbin – Watson test
 Variance stabilizing transformations to linearize the model
 Analytical methods for selecting a transform
Unit 4 Variable Selection
 Selection of Variables – forward selection, backward elimination and
stepwise regression (algorithms only)
 Weighted least squares
 Information Criteria
 Akaike Information Criteria
Unit 5 Introduction to Non-linear Regression
 Nonlinear regression – transformation to a linear model,
 Usefulness of the nonlinear regression method

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  Limitations of the nonlinear regression method
 Use of re-sampling procedures in regression

BOOKS RECOMMENDED
1. Montgomery, D. C., Peck, E. A. and Vining, G. G. (2003): Introduction to Linear
regression analysis, John Wiley and Sons, Inc. 3rd edition Chapters 2, 3, 4, 5, 6, 8
(8.1,8.2), 9, 10, 12 (12.1,12.3,12.4), 14 (14.1.2).
2. Zar, J.H. (2006): Biostatistical Analysis, Pearson education, 4th edition Chapter 18
(18.1, 18.2,18.4,18.5).

BOOKS FOR REFERENCE

1. Draper, N.R. and Smith, H. (2003): Applied Regression Analysis, John Wiley and Sons,
Inc. 3rd edition.
2. Johnston, J. (1984): Econometric methods, McGraw Hill International, 3rd edition.

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 M_BS C09 4 hours/week 4 credits
Categorical Data Analysis
Unit 1 Contingency table analysis
 Introduction - Nature of Categorical data - Statistical inference for a
proportion
 Contingency Tables and their distribution: Binomial and Multinomial
sampling
 Table structure comparing proportions - Comparing proportions in two-by-
two tables: Difference of proportions
 Relative risk - Odds Ratio - Properties of Odds Ratio - relationship between
Odds Ratio and Relative Risk
Unit 2 Measures of Association
 Nominal and Ordinal Measures of Association - Inference for Contingency
tables: Interval estimation for difference of proportions, odds ratio, log odds
ratio and relative risk
 Testing Independence in Two-Way tables: Pearson and Likelihood-ratio chi-
square tests - Yate’s correction for continuity-Residuals for cells in a
contingency table-Partitioning chi-squared
 Trend tests for 2 x J tables - Testing Independence for Ordinal Data-Fisher
Exact Test for 2 x 2 tables - Exact Inference for small samples - Association in
Three-Way Tables: Partial Tables - Marginal and conditional and Odds Ratios
- Homogeneous Association - Cochran-Mantel-Haenszel methods
Unit 3 Logistic regression
 Logit models for Binary data-Binomial GLM for 2 x 2 contingency tables
 Logistic regression: Interpreting logistic regression - Inference for logistic
regression
 Maximum likelihood estimate - test of overall regression and goodness of fit
 Deviance statistic, Wald test, LR test, Score test-Logistic regression
diagnostics
 Multiple Logistic Regression
Unit 4 Logit models for multinomial responses
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  Nominal Responses: Baseline-Category Logit Model
 Ordinal Responses: Cumulative Logit Models
 Ordinal Responses: Cumulative Link Models
 Alternative Models for Ordinal Responses
Unit 5 Loglinear models for contingency tables
 Loglinear Models for Two-Way Tables
 Loglinear Models for Independence and Interaction in
Three-Way Tables
 Inference for Loglinear Models
 Loglinear Models for Higher Dimensions

BOOKS RECOMMENDED
1. Agresti, A. (2002): Categorical data analysis, John Wiley & Sons, 3rd edition.
2. McCullagh, P. and Nelder, J.A. (1991): Generalized Linear Models, Chapman and hall,
London, 2nd edition.
3. Draper NR and Smith H (1981): Applied Regression Analysis, John Wiley & Sons, 3rd
edition.
4. Hosmer D., Lemeshow S., Sturdivant RX. Applied Logistic Regression, ISBN-13: 978-
0470582473ISBN-10: 0470582472, 3rd edition.
BOOKS FOR REFERENCE
1. Agresti, A. (1991): An Introduction to Categorical data analysis, John Wiley & Sons,
2nd edition.
2. Armitage, P. and Berry, G. (1987): Statistical methods in Medical Research, Blackwell
Scientific Publications, USA, 3rd edition.
3. Deshpande, J.V., Gore, A.P. and Shanubhogue, A. (1995): Statistical Analysis of Non
Normal Data, New Age International Publishers Ltd., New Delhi, 1st edition.
4. Hardin, J.W., and Hilbe, J.M. (1994): Generalized Estimating Equation, Chapman and
Hall, London, 2nd edition.
5. Hosmer, D.W. and Lemeshow, S.(1989): Applied Logistic Regression, John Wiley &
Sons Inc, 2nd edition.

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 M_BS C10 4 hours/week 4 credits
Time to event data analysis
Unit 1 Introduction and definition of time series analysis
 Components of time series, Trend, seasonal variations, cyclic variations,
irregular component
 Method of curve fitting by principle of least squares
 moving average method
 Analysis of seasonal fluctuations
 Construction of seasonal indices using method of simple averages
 ratio to trend method
 ratio to moving average method.
Unit 2 Introduction and terminology used in Survival analysis
 Survival functions- Concept of Time and event
 Censoring mechanism and truncations
 Order and Random Censoring
 Survival, hazard and density functions
 Mean and median residual life and their elementary properties
Unit 3 The shapes of hazard and survival functions
 Exponential
 Gamma
 Weibull
 Lognormal
 Preparing survival time data for analysis and estimation
Unit 4 Kaplan Meier methods
 Point estimation, Confidence Intervals, Scores, tests based on maximum
likelihood estimation
 Likelihood ratio, Partial likelihood estimation-log logistic distribution
 Kaplan Meier methods-Estimation of the hazard and survivor functions
 Kaplan-Meier life table and product-limit methods

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Unit 5 Nonparametric methods
 Log rank test
 Gehan Test
 Mantel - Haentzel Test
 Tarone - Ware tests
 Efron Tests

BOOKS RECOMMENDED
1. Klein, J.P. and Moeschberger, M.L. (2003): Survival Analysis- Techniques for
Censored and Truncated data. Springer Inc, 1st edition.
2. Miller, R.G. (1981): Survival Analysis, John Wiley and Sons, 1st edition.
3. Deshpande, J.V., Gore, A.P. and Shanubhogue, A. (1995): Statistical Analysis of Non
Normal Data, New Age International Publishers Ltd., New Delhi, 1st edition.
BOOKS FOR REFERENCE
1. Barlow, R. E. and Proschan, F. (1975): Statistical Theory of Reliability and Life testing,
Holt, Rinehart and Winston, New York, 2nd edition.
2. Johnson, E.R.E. and Johnson, N.L. (1980): Survival models and Data Analysis, John
Wiley and Sons, 3rd edition.
3. Lee, C.T. (1997): Applied survival analysis, John Wiley, 2nd edition.
4. Croxton F.E., Cowden D.J. &Kelin S (1973): Applied General Statistics, Prentice Hall,
1st edition.
5. Johnson RA and Wichern DW (1984): Applied Multivariate Statistical Analysis, John
Wiley & sons, 2nd edition.

29
 M_BS C11 4 hours/week 4 credits
Applied Multivariate Analysis
Unit 1 Multivariate Normal Distribution
 Definition, mean vector, variance-covariance matrix, properties
 Maximum likelihood estimators for mean vector, variance- covariance matrix
 Tests of hypotheses concerning mean vector, variance- covariance matrix
(one sample and two sample problems)

Unit 2 Principal component analysis

 Extraction of components - characteristics and properties of components
 Total variation, relative importance, standardization
 Covariance structures - interpretation of principal components
 Introduction to factor analysis
 Orthogonal factor model
 Estimation by maximum likelihood
 Principal component methods
 Factor scores - factor rotation
Unit 3 Canonical correlation analysis
 Extraction of canonical correlations and their variables
 Testing the significance of canonical correlations
 Interpretation of canonical variables
Unit 4 Classification and discrimination
 Classification problem
 Standards of good classification
 Procedures of classification into one of two populations with known
probability distributions
 Evaluation of classification function
 Fisher's linear discriminant function.
Unit 5 Cluster analysis
 Distance and similarity measures
 Agglomerative methods

30
  Single linkage
 average linkage
 complete linkage methods
Hierarchical clustering methods
 Introduction to Hierarchical clustering methods
 Non-hierarchical clustering methods
 Advantage and disadvantage of Hierarchical clustering methods
 K means method.

BOOKS RECOMMENDED
1. Johnson, R.A. and Wichern, D.W. (2007): Applied Multivariate Statistical Analysis,
Pearson Education, Asia, 6th edition.
2. Morrison (1990): Multivariate Statistical Methods, McGraw-Hill,.
3. Allen Agresti (1990) Categorical data analysis, 2nd edition.

BOOKS FOR REFERENCE

1. Anderson, T. W. (2003): An Introduction to Multivariate Statistical Analysis, , John
Wiley & Sons, 3rd edition
2. Hair, J.F., Anderson, R.E., Tatham. R.L. and Black, W.C. (2006): Multivariate Data
Analysis, Pearson Education, Asia, 5th edition.

31
 M_BS C12 5 hours/week 5 credits
Clinical Trials
Unit 1 Introduction to Clinical Trials
 Historical background – The need and ethics of clinical trials
 Organization and Planning ,Main features of the study protocol
 Selection of patients ,Treatment schedule ,Evaluation of patient response
 Follow-up studies
 GCP/ICH guidelines
Unit 2 Different Phases of clinical trials
 Phase I, II, III and IV trials
 Basic study designs: Randomized control study, Nonrandomized concurrent
control study
 Historical controls, cross-over design, withdrawal studies
 Group allocation design, hybrid designs
 Studies of equivalency
Unit 3 Methods of Randomization
 Fixed allocation randomization ,Stratified randomization,Adaptive
randomization ,Unequal Randomization
 Blinding and Placebos: Unblinded, Single blind and Double-blind
trials,conduct of double blind trials
 Crossover trials- Design, Analysis and interpretation
Unit 4 Statistical methods for determining Trial size
 Method for dichotomous response variable
 Continuous response variables
 Repeated measures
 Cluster randomization and equivalency of intervention
 Multicenter trials
Unit 5 Data management
 Interim analysis
 Case report form design

32
 Database design
 Data collection system for good clinical practice
 Terminologies used in Clinical research

BOOKS RECOMMENDED
1. Fundamentals of clinical trials (2010): Lawrence M. Friedman, Curt D.
Furberg, David L. DeMets. Springer; 4th edition.
2. Clinical Trials (2006): A practical guide to design, analysis and reporting.
Wang D, Bakhai A. Remedica; 1st edition.
3. SPIRIT 2013: New guidance for content of clinical trial protocols. Chan AW,
TetzlaffJM, Altman DG, Dickersin K, Moher D. Lancet. 2013 Jan 12;381(9861)
:91-2.
4. Pocock, S.J. (1991): Clinical Trials – A Practical Approach, John Wiley and
Sons.
http://onlinelibrary.wiley.com/doi/10.1002/0470842563.fmatter_indsub/pdf
BOOKS FOR REFERENCE
1. Fleiss, J.L. (1986): The design and analysis of clinical experiments John Wiley
& Sons.
2. Meinert, C.L. (1986): Clinical trials: Design, Conduct and Analysis, Oxford
university press.
http://samples.sainsburysebooks.co.uk/9781118031179_sample_388791.pdf
3. Piantadosi, S. (2005): Clinical Trials - A Methodological Perspective Wiley
series in probability and Statistics, 2nd edition.

33
 M_BS C13 (Compulsory subject) 3 hours/week 3 credits
Human rights
Unit 1 Background
 Introduction
 Meaning
 Nature and Scope
 Development of Human Rights
 Theories of Rights
 Types of Rights.

Unit 2 Human rights at various level

 Human Rights at Global Level UNO
 Human Rights – UDHR 1948 – UN Conventions on Human Rights:
 International Covenant on civil and Political Rights 1966
 International Convent on Economic,
 Social and Cultural Rights
 Racial Discrimination -1966 International.
 Instruments: U.N. Commission for Human Rights
 European Convention on Human Rights.

Unit 3 Human rights in India

 Development of Human Rights in India
 Human Rights and the Constitution of India
 Protection of Human Rights Act 1993-
 National Human Rights Commission
 State Human Rights Commission
 Composition Powers and Functions
 National Commission for Minorities, SC/ST and Woman

Unit 4 Human Rights Violations

 Human Rights Violations against Women,
 Human Rights Violations against Children,

34
  Human Rights Violations against Minorities, SC/ST and Transgenders
 Preventive Measures.

Unit 5 Political issues

 Political, Economic and Health Issues
 Poverty, Unemployment
 Corruption and Human Rights
 Terrorism and Human Rights
 Environment and Human Rights
 Health and Human Rights

BOOKS RECOMMENDED
1. Jagannath Mohanty, Teaching of Human sRights New Trends and Innovations, Deep
& Deep Publications, Pvt. Ltd., New Delhi,2009
2. Ram Ahuja: Violence Against Women, Rawat Publications Jewahar Nager,
Jaipur.1998.
3. Sivagami Parmasivam, Human Rights, Salem, 2008
4. Hingorani R.C.: Human Rights in India: Oxford and IBA, New Delhi.

35
 M_BS Elective Course 4 hours/week 4 credits
Data Management
Unit 1 Basics of computers
 Introduction,
 CPU
 I/O devices
 memory, storage
 working with files & folders
 system software
 application software
 virus/worms threat management.

Unit 2 Concept of data management

 Basic terminologies
 working with data base
 coding, data validation
 Data Quality
 Data cleaning
 Data dictionary
 Documentation
 Backups
 Introduction to RDBMS & SQL

Unit 3 Data Management & Analysis

 Designing Data Capture Interface with Entry/Edit/Delete Options
 data Matching/Compare
 File Handling
 Statistical Procedures
 Programming
 EpiInfo.

Unit 4 Large scale data management

 Data processing architectures,
 Parallel processing
 Distributed processing
 Online analytical processing
 Multi-query processing

Unit 5 Data Sharing and Re-Use Policies

36
  Why data-sharing policies matter?
 Overview of Scientific Data Sharing
 Legal and ethical matter consideration of Research data
 Plan for Archiving and Preservation of Data

BOOKS RECOMMENDED

1. Fred R McFadden, Jeffery A Hoffer, Mary B. Prescott, (2000): Modern Database

Management, Addison Wesley, 5th edition.
2. Andrew Vazsonyi, Richard 91980): Introduction to data processing,
ISBN 10: 0256023433 ISBN 13: 9780256023435 3rd edition.
3. Garcia-Molina, J. D. Ullman, J. Widom, Database Systems(2008): The Complete Book
Prentice Hall, 2nd edition.
4. T. Öszu, P. Valduriez, Principles of Distributed Database Systems (2011): Springer, 3rd
edition.
5. T. White, Hadoop (2012): The Definitive Guide, O’Reilly, 3rd edition.
6. J. Lin, C. Dyer (2010): Data-Intensive Text Processing with MapReduce, Morgan and
Claypool, 1st edition.
7. E. Redmond, J. R. Wilson (2012): Seven Databases in Seven Weeks: A Guide to
Modern Databases and the NoSQL Movement, Pragmatic Bookshelf, 1st edition.

Web pages for reading

1. Why data-sharing policies matter http://www.pnas.org/content/106/40/16894.full
2. Alan E. Guttmachera, Elizabeth G. Nabel and Francis S. Collin Data Sharing and
Consent March 2010 By Ciara Curtin http://www.genomeweb.com/data-sharing-
and-consent
3. Guidelines for Responsible Data Management in Scientific Research
http://ori.hhs.gov/education/products/clinicaltools/data.pdf pgs. 6-8
4. “Who Owns Research Data?”
http://ori.dhhs.gov/education/products/columbia_wbt/rcr_data/case/index.html#2
5. “Constructing Access Permissions”, University of Oregon Libraries:
http://libweb.uoregon.edu/datamanagement/sharingdata.html#three

37
 M_BS Elective Course 4 hours/week 4 credits
Applied Spatial Statistics
Unit 1 Introduction to Spatial Statistics
 Components of spatial data
 Geographical coordinates
 Map Projections
 Coordinate Systems
 Types of spatial data: Vector data and raster data
 Remotely sensed data
 Digitizing

Unit 2 Geographic Information Systems (GIS)

 What is GIS?
 GIS capabilities.
 Basic GIS Operations
 Visualization
 Types of Maps
 Exploratory spatial data analysis
Unit 3 Spatial clustering of health events
 Global indexes of spatial autocorrelation
 Moran’s I
 Geary’s C
 Spatial scan statistics
Unit 4 Geostatistics
 Fitting semivariogram models
 Variogram function,
 Interpolation techniques,
 Kriging
 Inverse distance weighting method

Unit 5 Models

38
  Introduction to spatial models
 Spatially correlated data
 Linear regression models for Spatially Autocorrelated data
 Interpretation and use with spatial data
 GeoDa software over view

BOOKS RECOMMENDED
1. Lance A. Waller and Carol A. Gotway (2004): Applied Spatial Statistics for Public
Health Data, John Wiley & Sons, 1st edition.
http://samples.sainsburysebooks.co.uk/9780471662679_sample_381451.pdf
2. Bailey, T.C. and A.C. Gatrell (1995): Interactive Spatial Data Analysis. Essex, England,
Prentice Hall 1st edition.
3. A. E. Gelfand, P. J. Diggle, M. Fuentes and P. Guttorp (2011) “Handbook of Spatial
Statistics edited by Gelfand, A. E., Diggle, P. J., Fuentes, M. and Guttorp, P.
4. N. Cressie (2015): Statistics for spatial data Wiley-Interscience; 2nd edition.
5. S. Banerjee, B. P. Carlin and A. E. Gelfand (2014): “Hierarchical modeling and analysis
for spatial data”, Chapman & Hall/CRC 6th edition.
BOOKS FOR READING
1. Wiley. Cressie, N. and Wikle, C. (2011): Statistics for Spatio-Temporal Data. Wiley 1st
edition.
2. Diggle, P. J. (2003) Statistical Analysis of Spatial Point Patterns 2nd edition.
3. Hodder Arnold. Diggle, P. J. and Ribeiro, R. J. (2007) Model-based Geostatistics.
Springer 2nd edition.

39
 M_BS Elective Course 4 hours/week 4 credits
Health Informatics

Unit 1 Challenges of Health informatics

 Introduction to Health informatics
 Reading & Writing patient records
 Creation of medical knowledge
 Access to medical knowledge
Unit 2 Principles of Health informatics – Part 1
 Representation
 Logic
 Clinical terms
 Knowledge representation
Unit 3 Principles of Health informatics – Part 2
 Standards in Health informatics
 Probability and decision making
 Probability and learning from data
Unit 4 Archiving Change
 Information Technology and Organizational transformation
 Archiving change through information
 Archiving change through information Technology
Unit 5 Public Health Policy
 Conceptual and theoretical foundations of health policy formulation
 Implementation and analysis in the health care sector with specific
applications to health informatics.

Book recommended
Taylor P, From Patient data to Medical knowledge – The principles and Practice of
Health Informatics (2006); Blackwell Publishing – BMJ Books.

40
 Books for Reading
1. Enrico Coiera Hodder Arnold , Guide to health informatics (2003) Second Edition.
2. Frank Sullivan, Jeremy C Wyatt, ABC of Health Informatics,(2006) Blackwell Publishing –
BMJ Books.

41
 M_BS Elective Course 4 hours/week 4 credits
Bayesian Statistics
Unit 1 Bayes law
 Background and introduction
 The differences between Bayesian verses non Bayesian approaches;
 Baye’s law for multiple events
Unit 2 Markov Chain Monte Carlo techniques
 Introduction
 Informative priors
 Non informative priors
 Simple Gibbs sampling
 Simple Metropolis Sampling
Unit 3 Specifying Bayesian Models
 Purpose
 Likelihood theory and estimation
 The Basic Bayesian Framework.
 Summarizing Posterior Distributions with intervals.
Unit 4 The Bayesian Prior
 The importance of priors
 Posterior distribution
 A Plethora of priors
 Conjugate priors
 Choice of priors
 Different posterior beliefs
Unit 5 Bayesian models
 Bayesian Hierarchical models
 Basic structure of the Bayesian Hierarchical Model
 A poison Gamma Hierarchical Model
 WinBUGS software
 OpenBUGS module

42
BOOKS RECOMMENDED
1. Jeff Gill, Bayesian methods: A Social and Behavioural Approach Chapman & Hall
(CRC)
2. P M Lee, Bayesian Statistics: An Introduction, Arnold
3. Andrew Gelman, John B. Carlin, H.S. Stern, and D.B. Rubin, Bayesian Data Analysis,
2nd Edition. Chapman & Hall (SFGEL)
4. G R Iverson, Bayesian Statistical Inference, Beverley Hills, CA: Sage (SF4 IVE)
5. J Albert, Bayesian Computation with R, Springer 2007
6. D V Lindley, An Introduction to Probability and Statistics from a Bayesian
Viewpoint (2 vols - Part I: Probability and Part II: Inference), Cambridge University
Press (S 9 LIN).
BOOKS FOR READING
1. Sivia, D. and skilling J (2006). Data analysis: A Bayesian tutorial. Oxford: Oxford
University Press, 2nd edition.
2. Bernardo, J. M., & Smith, M. F. A. (1994). Bayesian theory. New York: Wiley, 1st
edition.
3. Box, G. E. P., and Tiao, G. C. (1992). Bayesian inference in statistical analysis. New
York: Wiley, 1st edition.

43
 M_BS Supportive Course 4 hours/week 4 credits

Scientific communication
Unit 1 Science Communication overview

 What is Science Communication?

 History of Science Communication
 Goals for Science Communication
 Motivations for Science Communication

Unit 2 Oral presentation

 Single overriding communication objective (SOCO)
 Preparing a talk
 Visual aids
 Delivering a talk
Unit 3 Poster presentation
 Single overriding communication objective (SOCO)
 Preparing posters
 Visual aids
 Presenting a poster
Unit 4 Manuscript writing
 Argument matrix
 Writing style
 IMRD format
 Referencing
 Abstract writing
Unit 5 Communication through media
 Types of media
 Fundamentals of news media
 Role of news media in public health
 Soft skills for handling media

44
  Preparing message for print media, writing press release
 Preparing message and handling TV/radio media

BOOKS RECOMMENDED
1. Laura Bowater, Kay Yeoman, (2012): Science Communication: A Practical Guide for
Scientists. ©2013, Wiley-Blackwell.
2. Bucchi, M. & Trench, B. (Eds.) (2008). Handbook of Public Communication on Science
and Technology. London: Routledge.
3. Cheng, D., Claessens, M., Gascoigne, T., Metcalfe, J., Schiele, B., & Shi, S. (eds.)
(2008). Communicating Science in Social Contexts: New models, New Practices. New
York: Springer.
4. Joseph E. Harmon and Alan G. Gross, The Craft of Scientific Communication ©
2010 (Chicago Guides to Writing, Editing, and Publishing).
5. Schimel, Joshua (2011). Writing Science: How to Write Papers That Get Cited and
Proposals That Get Funded. Oxford University Press

BOOKS FOR READING

1. Marianne W. Zawitz, Bureau of Justice Statistics, Washington Statistical Society
Methodology Seminars. Data Presentation: A Guide To Good Graphics.
http://www.science.gmu.edu/~wss/methods/zawitzg.html
2. Phil Bartle. Report Writing. http://www.scn.org/ip/cds/cmp/modules/rep-int.htm
3. University of Wisconsin Cooperative Extension. Communicating Results: Tips and
Practices (Power Point presentation).
http://www.uwex.edu/ces/pdande/evaluation/powerpt/TipsRS.PPT
4. National Science Foundation. The 2002 User-Friendly Handbook for Project
Evaluation. http://www.nsf.gov/pubs/2002/nsf02057/start.htm

45
 M_BS Supportive Course 4 hours/week 4 credits

Health Economics
Unit 1 Tools for Health Economics
 Opportunity cost
 Demand and supply of health care, price elasticity of demand
 Utility functions
 Market structures, gross domestic product and inflation
 Equity and Efficiency
Unit 2 Economic evaluation in health care
 Concept and need of health care evaluation
 Concept of efficiency and its types
 Influence of economic evaluation in policy making
 Frameworks used to prioritise different programs
 Types of economic evaluation in health care -
 Perspective of Economic Evaluation
 Interpreting CER and ICER results of economic evaluation
 Methods of economic evaluation – RCT and Decision modeling
Unit 3 Costing and cost analysis
 Type of costs
 Perspectives of costing – Economic and financial
 Costing methods
 Designing a costing study
 Analysing cost data
Unit 4 Economic evaluation in health care
 Valuation of benefits – DALY, QALY, WTP
 Uncertainty analysis - Types of uncertainties, analysing uncertainties
 Decision rules and thresholds - Interpreting CER and ICER results,
Unit 5 League tables and threshold
 Introduction to league tables and thresholds

46
  The problem of threshold in evaluating the cost
 The limits of cost effective analysis
 Using the Drummond checklist for critical appraisal of economic evaluation

BOOKS RECOMMENDED
1. Charles E. Phelp (2009), Health Economics, Prentice Hall , 4th edition.
2. Yasodha Shanmugasundaram (1994) Theory and Practice of Health Economics in
India Allied Publishers Ltd, 1st edition.
3. Government of India (1983) National Health Policy, New Delhi.
4. ICSSR AND ICMR (1981) Health for ALL 2000 A,D, ICSSR ,Delhi.
5. Naik J.P (1977) An alternative System of Health Care Services in India – Some
Prospects ICSSR Delhi.
6. Panchamukhi, P.R (1980), Economics of Health: A Trend Report, Volume – VII
Infrastructure, ICSSR Delhi.
BOOKS/WEB PAGES FOR READING
1. Health Economics Core Library Recommendations, 2011.
https://www.nlm.nih.gov/nichsr/corelib/hecon-2011.html
2. Introduction to Health economics
http://www.cartercenter.org/resources/pdfs/health/ephti/library/lecture_notes/health_sci
ence_students/LN_Intro_to_Health_Economics_final.pdf

47
 M_BS Supportive Course 4 hours/week 4 credits
Field Epidemiology
Unit 1 Public health situation analysis
 Framework of situation analysis
 Data sources
 Prioritization of public health problems
 SWOT analysis
Unit 2 Disease surveillance
 To manage and operationalise the disease surveillance system
 Conduct basic time, place and person analysis of surveillance data
 Use surveillance information for action
 Describe and evaluate a surveillance system
Unit 3 Outbreak investigations
 Conceptualize and undertake epidemiologic and laboratory investigations of
outbreaks
 Understand and undertake appropriate measures for preparation and
response to outbreaks
Unit 4 Public health programme evaluation
 Concept and purpose of evaluation
 Six steps of framework for public health programme evaluation
 Logic model
 Elements of description of health programme
 Evaluation design and tools
 Interpreting results of evaluation
Unit 5 Epidemiological Data
 Data Interpretation
 Validity
 Reliability

48
RECOMMENDED BOOKS
1. Michael Gregg (2008): Field Epidemiology, Oxford University Press, USA, 2nd edition.
2. ebook selected Chapters www.ciphi.ca/hamilton/Content/documents/fieldepi.pdf
3. Mark S. Dworkin (2011) Cases in Field Epidemiology: A Global Perspective. Publisher
Jones & Bartlett Learning.
4. Jones & Bartlett (2012): Learning, Methods of field Epidemiology. Publisher Michael
brown.
5. Anderson RM & May RM (1992) Infectious Diseases of Humans. Dynamics and
Control. Oxford Science Pubs., ISBN 0-19-854040-X.
RECOMMENDED FOR READING
1. Beaglehole R, Bonita R. (1997): Public Health at the Crossroads. Cambridge
University Press.
2. Breslow NE, Day NE, Davis W. Statistical methods in cancer research (1980) Vol 1.
Case-control studies. IARC Scientific Publications No 32. ISBN 9283211324
3. Clayton D, Hills M (1993). Statistical Models in Epidemiology. Oxford University
Press. ISBN 019852221-5.
4. Giesecke, J (2001); Modern Infectious Disease Epidemiology. Edward Arnold ISBN
034076423-6, 2nd edition.
5. Hennekens CH, Buring JE (1987): Epidemiology in Medicine. Little, Brown & Co., ISBN
0316356360

49
 M_BS Supportive Course 4 hours/week 4 credits
Health Systems
Unit 1 Organization and Structure of Health System in India
 Concept of six pillars of Health Systems - covering HS concepts, details of
each of the system blocks with reference to India's health care system
 Universal Health Coverage - what it is, what is happening in the country and
the issues related to it.
 Public health legislation - conceptual aspect of legislations, the various health
legislations in India
Unit 2 Health Policy
 Recognizing Policy – What is it? Who makes it? How is it made? What are its
impacts? How is it evaluated? – Introducing the policy triangle framework.
 Theories of policy making – introducing the main frameworks and theories of
the policy process.
Unit 3 Policy implementation
 Policy implementation and analysis – introducing various frameworks for the
analysis of policy
 Trends in the development of the health system in India. Over view of Indian
Health Policy - Introducing a critical analysis of health system development
Unit 3 Health service delivery in India
 National Health Mission
 National health programmes
 Quality systems - NABH, NABL, six sigma, ISO, Accreditation, Indian public
health standards
Unit 4 Health information systems
 HMIS and HMS
 ICD classification of diseases - Medical certification of deaths, ICD coding for
hospitalizations

50
  Data sources for health in India

BOOKS RECOMMENDED
1. Mark Britnell, In Search of the Perfect Health System, ISBN 9781137496614
Publication Date September 2015, Publisher Palgrave Macmillan.
2. LeighAnne Olsen, Dara Aisner, and J Michael McGinnis. The Learning Healthcare
System, Institute of Medicine (US) Roundtable on Evidence-Based Medicine;
Washington (DC): National Academies Press (US); 2007. ISBN-13: 978-0-309-10300-
8ISBN-10: 0-309-10300-2
3. OECD iLibrary, Health Care Systems Efficiency and Policy Settings ISBN
9789264094901 (PDF) ;
DOI :10.1787/9789264094901-en http://www.oecd-ilibrary.org/social-issues-
migration-health/health-care-systems_9789264094901-en
4. Corlien M. Varkevisser, Indra Pathmanathan, and Ann Brownlee Designing and
conducting Health Systems Research Projects. KIT, IDRC / 2003-01-01, SBN: Out of
print / 380 pg., e-ISBN: 1-55250-069-1

51
M_BS P01 6 hours/week 3 credits

Statistical Data Analysis I using EPI INFO/SPSS/SAS/STATA/ R

Exercise based on M_BS C01, M_BS C02, M_BS C03 and M_BS C04

M_BS P02* 6 hours/week 3 credits

Statistical Data Analysis II using EPI INFO/SPSS/SAS/STATA/ R

Exercise based on M_BS C05, M_BS C06, M_BS C07 and M_BS C08

M_BS P03* 6 hours/week 3 credits

Statistical Data Analysis II using EPI INFO/SPSS/SAS/STATA/ R

Exercise based on M_BS C09, M_BS C10, M_BS C11 and M_BS C12

*Elective subjects- in addition to the above EPI MAP/GEODA/WINBUGS will be used.

52