Scribd Logo
Upload

Welcome to Scribd!

  • 6 views

    Pyrazinamide For Treatment of Tuberculosis 1

    Uploaded by

    William Imp

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Pyrazinamide For Treatment of Tuberculosis 1

    Uploaded by

    William Imp
    6 views2 pages

    Original Title

    Pyrazinamide-for-treatment-of-tuberculosis-1

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    6 views2 pages

    Pyrazinamide For Treatment of Tuberculosis 1

    Uploaded by

    William Imp

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    information for parents and carers

    Pyrazinamide for the treatment of tuberculosis


    This leaflet is about the use of pyrazinamide for the treatment of
    tuberculosis (TB for short). Your child will have to take up to four
    medicines for at least 3-6 months to cure their TB.

    This leaflet is for parents and carers about how to use this How should I give pyrazinamide?
    medicine in children. Our information sometimes differs f
    Tablets should be swallowed with a glass of
    rom that provided by the manufacturers, because their
    water, milk or juice. Your child should not chew
    information is usually aimed at adults. Please read this
    the tablets.
    leaflet carefully. Keep it somewhere safe so that you can
    read it again. You can crush the tablet and mix it with a small
    amount of soft food such as yogurt, jam or
    mashed potato. Make sure your child swallows
    It is essential that your child takes all their it all straight away, without chewing.
    medicines daily, as explained by the doctor, and
    continues until the doctor tells you to stop. Liquid medicine: Measure out the right amount
    using a medicine spoon or oral syringe. You
    can get these from your pharmacist. Do not use
    Name of drug a kitchen teaspoon as it will not give the right

    5.0 ml
    2.5 ml
    Pyrazinamide (PIR-a-ZIN-a-myde) amount.
    Brand names: Zinamide
    When should the medicine start working?
    Why is it important for my child to take this medicine? Your child should start to feel better and have fewer
    The bacteria that cause TB are hard to kill. Your child will symptoms after taking the TB medicines for about 2 weeks.
    have to take up to four medicines for at least 3-6 months. However, they must continue to take the medicine every
    Pyrazinamide is one of these key medicines. It is given for the day until the doctor says to stop treatment. This will be for 2
    first 2 months of treatment. months for pyrazinamide and at least 6 months for the other
    medicines.
    Your child should start to feel better and may not have
    any symptoms of TB soon after starting treatment. What if my child is sick (vomits)?
    However, you must continue to give the medicines until
    your doctor tells you to stop. If you stop too soon, or
    •• If your child is sick less than 30 minutes after having a
    dose of pyrazinamide, give them the same dose again.
    your child does not take the medicines as your doctor
    has told you to, the bacteria may not be killed and the •• your child is sick more than 30 minutes after having
    If
    TB may come back. It is also possible that the bacteria a dose of pyrazinamide, you do not need to give them
    will become resistant to the first drugs, which means another dose. Wait until the next normal dose.
    that the drugs will no longer work. This may mean that If your child is sick again, seek advice from your GP, TB nurse,
    other stronger drugs will have to be used, or the TB may pharmacist or hospital. They will decide what to do based on
    no longer be treatable. your child’s condition and the specific medicine involved.

    What is pyrazinamide available as? What if I forget to give it?


    •• Tablets: 500 mg If you forget to give your child a dose, give it as soon as
    possible on the same day. This should be at least 12 hours
    •• Liquid medicine can be ordered specially from your
    before the next dose is due.
    pharmacist

    When should I give pyrazinamide? What if I give too much?


    Pyrazinamide (along with other TB drugs) is usually given If you think you may have given your child too much
    once each day, this is usually in the morning. pyrazinamide, contact your doctor, TB nurse or local NHS
    services (details at end of leaflet). Have the medicine packet
    Give the medicine at about the same time each day so that
    with you if you telephone for advice.
    this becomes part of your child’s daily routine, which will help
    you to remember.
    Are there any possible side-eff ects?
    How much should I give? We use medicines to make our children better, but
    sometimes they have other effects that we don’t want
    Your doctor will work out the amount of pyrazinamide (the
    dose) that is right for your child. The dose will be shown on (side-effects).
    the medicine label. Side eff ects you must do something about
    It is important that you follow your doctor’s If your child has swelling of the face, lips or tongue,
    999
    instructions about how much to give. difficulty breathing or gets a rash or itching or fever, take
    them to your doctor or hospital straight away, as
    they may be allergic to pyrazinamide.
    If your child feels sick or is sick (vomits) for more than Is there anything else I need to know about this
    24 hours, or their skin or eyes gets a yellow tinge, or medicine?
    their urine (wee) is dark, contact your doctor straight •• Children with porphyria should not take pyrazinamide. If
    away, as there may be a problem with your child’s liver. your child has porphyria, or you have a family history of
    Do not give any more pyrazinamide. the condition, tell your doctor.
    If your child seems tired or short of breath or they seem •• Your doctor will take blood samples before your child
    to bruise more easily or bleeding doesn’t stop as quickly starts pyrazinamide and while they are taking it. This is
    as you would expect, contact your doctor straight away, to make sure that their liver is working properly, and that
    as there may be a problem with your child’s blood. pyrazinamide has not affected it.
    If your child develops pain or swelling in their joints, or Keep all your clinic appointments, as your doctor or TB
    they have difficulty or pain during urination (doing a nurse needs to check how your child is doing.
    wee), contact your doctor straight away.
    General advice about medicines
    Other side-effects you need to know about
    •• Give medicines at about the same times each day, to
    •• Your child’s skin may become more sensitive to sunlight. help you remember.
    Keep them out of strong sun. When outdoors, they
    should wear clothes that cover their skin, for example, a •• Only give this medicine to your child. Never give it to
    anyone else, even if their condition appears to be the
    long-sleeved top, trousers. They should also wear a hat
    same, as this could do harm.
    and use a high-factor sun screen (at least SPF 30).
    •• Your child may get an upset stomach or cramps when •• If you think someone else may have taken the medicine
    by accident, contact a doctor for advice.
    they first start taking pyrazinamide. Giving each dose
    with some food may help. They may also lose their •• Make sure that you always have enough medicine. Order
    appetite (feel less hungry). If this is still a problem after a new prescription at least 2 weeks before you run out.
    a week, contact your doctor. •• Make sure that the medicine you have at home has
    not reached the ‘best before’ or ‘use by’ date on the
    •• Your child may get headaches, feel dizzy or agitated or
    packaging. Give old medicines to your pharmacist to
    have trouble sleeping. If this is a problem, contact your
    doctor. dispose of.
    There may, sometimes, be other side-effects that are not listed Where should I keep this medicine?
    above. If you notice anything unusual and are concerned,
    contact your doctor. You can report any suspected side-effects
    •• Keep the medicines in a cupboard, away from heat and
    direct sunlight. It does not need to be kept in the fridge.
    to a UK safety scheme at http://yellowcard.mhra.gov.uk.
    •• Make sure that children cannot see or reach the
    Can other medicines be given at the same time as medicine.
    pyrazinamide? •• Keep the medicine in the container it came in.
    Pyrazinamide is normally given with rifampicin. The
    oral contraceptive pill does not work properly during Who to contact for more information
    treatment with rifampicin so your daughter should use Your child’s doctor, pharmacist or TB nurse will be able to
    other forms of contraception if she is sexually active. give you more information about pyrazinamide and other
    •• You can give your child medicines that contain medicines used to treat TB.
    paracetamol or ibuprofen, unless your doctor has told You can also get useful information from:
    you not to. England: NHS 111 - Tel 111 - www.nhs.uk
    •• Pyrazinamide should not be taken with some medicines Scotland: NHS 24 - Tel 111 - www.nhs24.scot
    that you get on prescription. Tell your doctor about
    Wales: NHS 111 Wales - Tel 111 - www.111.wales.nhs.uk
    all medicines your child is taking before starting
    pyrazinamide. Northern Ireland: NI Direct - www.nidirect.gov.uk
    •• Check with your doctor or pharmacist before giving any British Lung Foundation: 0845 850 5020 - www.lunguk.org
    other medicines to your child. This includes herbal or
    complementary medicines.

    www.medicinesforchildren.org.uk

    Version 2, September 2014. © NPPG, RCPCH and WellChild 2011, all rights reserved. Reviewed by: September 2017.
    The primary source for the information in this leaflet is the British National Formulary for Children. For details on any other sources used for this leaflet, please contact us through
    our website, www.medicinesforchildren.org.uk
    We take great care to make sure that the information in this leaflet is correct and up-to-date. However, medicines can be used in different ways for different patients. It is
    important that you ask the advice of your doctor or pharmacist if you are not sure about something. This leaflet is about the use of these medicines in the UK, and may not apply
    to other countries. The Royal College of Paediatrics and Child Health (RCPCH), the Neonatal and Paediatric Pharmacists Group (NPPG), WellChild and the contributors and
    editors cannot be held responsible for the accuracy of information, omissions of information, or any actions that may be taken as a consequence of reading this leaflet.

    You might also like