Seat No.

Republic Df the Philippines

PROFESSIONAL REGULATION COMMISSION
Manila

BOARD OF MEDICAL ZZCHNOLCGY

MEDICAL TECHNOLOGISTS Licensure Examination

08:00 a.m. 10:00 a.m.
Saturday, September 21, 2019

CLINICAL CHEMISTRY SET A

INSTRUCTION: Select the correct answer for each of tne following

questions. Mark only one answe for each it.em by shading the box
responding to the letter of your choice on the answer sheet provided.
STRICTLY NO ERASURES ALLORED.

MULTIPLE CHOICE

1. Which statements refer to Type 1 diabetes?

A. Results from B-cell destruction and usually diagnosed in childre,

usually leads to absolute

B. Results from B.cel1 destmiction,
Insulin deficiency, and usually diagnosed in children,
C Usually leads co absolute insulin deficiency and usually
diagnosed in children
D. Results from B-cell destruction and umually leads to absolut
insulin deficiercy

Which analyte is SIGNIFICANTLY affecked by change in posture from

supine to a sitting or standing position?
A. Protein
B. Calcium D. Magnesium

Which are causes of random error ?

(1) Temperature of ana.yzer

(2) Reagent dispensing
(3) Instability of instrument
(4 Calibration differences
A. 1 and 4 3, and 4

B. 2 and D. 1, 2 , and 3

Electrolytes, glucose, BUN, cmeatinine, and osmolality examinations have

been performed on patient suspected of incesting ethanol. What can be
done to help reveal this condition without additional tests?
P.. Determine anion gap
Determine glycemi.c index
c. Compare measured and computed osmolalizy
D. Compute osmolality

5. Which protein is quantitied by standard protein electrophoresis? (1)

Fibrinogen
(3' C3
A, 1, 2 and 3 and 3

and 2 and

6. Which of the following refer to 13s?

4
(1) Range between t.wo observations in the gane run exceeds
(2) Detects Impregision CY systematic bias

(3) Not. recommended

(4) one observation exceeds 3 SD from the target. value
A. 2 and 4 C. and 3
B. and 3 D. 1 and 4

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MEDICAL TECHNOLOGISTS Licensure Examinat.ion
2019 08:00 a.m. 10:00 a.m. Page
Saturday, September 21,

SET A
CLINECAL CHEMISTRY

Which statement is Nor

Acts on Leydig cells whichiscaoulate the production of
A.
androgens
B. Involved i.n the development
of comous laceon, especially in
its secceting phase
C. Involved during she Somat.on of gametes
of primary
p. sas NO specifie function during the development
sex organs

C
D. Perforated duodeni ulcer

balance?
9.

(1) Bicarbonate
2. Calcium
Potassium
chloride
and 2
3 and 4.
D. and 3
B. 2, and 3

laboratory?
. which are acceptable dress code policy in the
(1) Comfortable foot
we.ar such as sandale and flip-flops
(2' Clean laboratory cats
(3) Minima use of favelry
(4) Shoulder-length bair culled back and socuzod
A. 1 t.o
3 and A

11. Which characterimes chronic clomerutar nophmitis?

(1) Sl.ow developing d.sease
(2 ) Gradual urem2.a
(3) LosS of functioning nephrons
( 2. and 3
and 2.
and
B. and 3

A. Phencyclidine
B. Cocaine
c. Opiates
D. Methylenediox mmethylamphetanine
with the previous
_ 3. Whichcompares the rosu t obtained for one sgecimen
results(s) obtained for the same patient?
A, Randomized diplicace specimens
B. Average normuls
C. Delta check
D. Pattern reccgmialon
is referred to?
14. Which Immuncassar Method for Thyroxine Testing
patient T4 for
Afluorogenic substrate-labeled thyroxine competing with only
antibody
unbound, leftover labeled 74
reacts with enzyme to form product
wreaction is directly

proportional
A. Microparticle Enzyme

3 rODS Ver 2.1

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EDICAL TECHNOLOGISTS Licensure Examination Page
08:00 a,m. - 10:00 a.m.
turday, September 21, 2019

SET A
INICAL CHEMISTRY

Fluorescent Substrate-Lapeled Ehhibition

D Fluorescent Polarization
is the MOST likely disease?

Increased
Increased
Increased
103 .. Increased
A. Secondary hypothyroidism
B. Secondary hyperthyroidism
c. Primary hyperthyroidism
D Primary hypothyroidism

16. Which inhibit. growth hormone secretion?

Glucose loading C. Thyroxine deficiency
A
Amino acids
Insulin deficiency

17. Which are causes of randon error?

(1) Sample evaporation

Electro-optical mechanism
(3) Variation in handling techniques
(4) Variation in operators
ard 4
and 2
D. and
B. 1 3, and

first responcers to stress by acting within seconds?

Which serve as
A Cortisol C. Aldostercne
D. Catecholamine

ion when
19 A substance that can yield a hydrogen ion (H-) or hydronium
dissolved in water is a(r.)
C. acid excess
A. buffer
D.
B. alkali

20. Lithium is a(n)

A. CNS stimulant C. CNS depressant.
D antidepressant:
B. hallucinogen

NOT caused by increased

sodium lcss?
Which nyponatremia is
C. Reral failure
A Potassium
Diuretic use D. Severe burns

22. Which tes" conveys

information on hepatocellular damage and necrosis?
A. Transaminases
C. Bilirubin
D. Ammonia
B. Albumin

2.3 . Which is an indication of error ir the analysis, detected by a

5
one direction for at least
drift of control values in
progressive
consecutive runs?
Shift
P..
C. Dispersion
B. contraction E. Trend

substances approach may be

24. Glucose measurenent using the Meducing
erronecus_y higher by mg/dL compared to the enzymatic method.
C. 15 25
15 A ..
D. 10 20
B. 25 30

'TQDS Ver 2.1.9

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EDICAL TECHNOLOGISTS Licensure Examination
08:00 a.m. - 10:00 a.m. Page 4
aturday, September 21, 2019

SET A
SLINICAL CHEMISTRY

25 Which are acute phase reactants?

(1) Alphal-acid glycoprotein

(2) Alphal-antitrypsin
(3) C-reactive protein
A. and 3 and 3
B. 1, 2 and 3 D. 1 and

26. The major role of regulation of water balance in the body is attributed
to which cation?
A. Sodium C. Potassium
B. Calcium D. Chlorice

27. Which are considered a medical emergency?

(1) Ketoacidosis
(2) Glycosuria
3) Marked hyperkalemia
A. and c. 2 and 3
B. 1 and 2 and 3

institution in which all areas of

23. Acomprehensive program in an

operation are monitored to ensure quality with the aim of providing the

highest quality patient care is quality

A. assessment C. assurance
B. control D. systems

29. During drug administration, the read of drug via the circulatory
system to organs and tissues throughout the body is
elimination C. metabolism
B absorption D. distribution

30. Which is NOT attributed to Polycystic Ovarian Syndrome?

A. Hirsutism C. Obesity
B Infertiity

31. The 3-day old neonate, recently discharged from a delivery suite, had
inadequate protein feeding for the next 24 hours after discharge. What
will be the effect on the thyroxine levels compared to the normal
reference ranges?
A. Higher
B. Indeterminate Lower

32. Positive displacement pipet:

A. with no air cushion
B. all of the items
C. can pipette high density samples
D. aspiration force remains constant

33. Which is a COMMONLY used clearance test used as a rough estimate of

glomerular filtration rate?
C. CKD-EPI
B. D. Creatinine

34. What 1s the value of 200 mg/dL glucose in mmc1/L?

A. 8.5 C. 11.0
B. 10.50 D. 13.75

For 40 years old and above, there is moderate risk of developing

coronary heart disease when cholesterol is greater than mg/dL.
A. 240 C 200
B. 280 D. 260

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MEDICAL TECHNOLOGISTS Licensure Examination
saturday, September 2 1, 2019 08:00 a.m. - 10:00 a.m. Page

INICAL CHEMISTRY SET A

45. Violation of which rule does NOT incicate systematic error?

A C. 10: mean

B. 4:1s D.

46. The concept of treating all blood ard body fluids as capable of
ransmitting infectious diseases
A. safe practice standards C. universal precautions
B. infection control D. safety protocol

Thegram-molecular weight o: Nacl is 58.5 g.

What is the molarity of a solution containing 75 g of Nacl per liter ?
A. 1. 3 C. 1.0
B. 1.7 D. 1.6

18 The usual lipid studies require fasting for hours.

A. 12
B. 10

49 . Which formula is used to escimace osmolality?

A. Osmolality = [Na+l [ureal [glucose]
B. Osmolality =
[ureal + 2 X [glucose]
C. Osmolality [Na+ 2 x [urea + [glucose:
D. 2 x [Na+] + [urea' + [glucose:

50. Which does NOT refer to IDDM?

Age of onset- usually befcre 20 years of age
B. Serum insulin very low
C. NOne of the items
D. Presence of ketone bodies usually
Which Immunoassay Method for Thyroxine Testing is referred to?
fluorophorelabeled thyroxine competes with patient thyroxine for

antibody
antibodybound labelled thyroxine rotates slowly, emitting lower energy
light
*
reactions is inversely proportional
A. Microparticle Enzyme
Fluorescent Polarization
C. Fluorescent Substrate-Labelec Inhibition
D. Chemiluminescence
52,; Which measurement of uric acid Lacks specificity and has problems with
turbidizy?
Colorimetric : endpoint
A.. Enzymatic :
B. Colorimetric : kinetic D. Enzymatic : H202

53. Which are considered when interpreting ABGs in the clinical setting?
1) Acid-base status
Alveolar ventilation
Oxygenation status ard 02 transport
Carboxyhemoglobin
A. 1, 2, and C. 2, 3, and
B. 1, 2, 3, and 4 D. and

54. Which is necessary for enzyme activity?

A. Coenzymes Activators
B. Cofactors

Continued on Page
MEDICAL TECHNOLOGISTS Licensure Examination
Saturcay, September 21, 2019 08:00 a.n 10:00 a.m. Page

CLINICAL CHEMISTRY SET A

55. Which a re causes of pseudohyperkalemia?

(1) In-Vitro hemolysis

2) Thrombocytosis
Prolonged tournicuet use
(4) Excessive fist clenching
A. 1, 2, 3, and 4 C. 1 and 2
B. 1, 3, and 4 D. 3 and 4

56. It interferes with protein sulfhydryl group in protein cceznyemes

reduces oxidative phosphorylation and ATP production. Which metal is
referred to?
A. Mercury C. Iron
B. Lead b. Arsenic

57. Practice of safety ir the laboratory involves

A. the heads and supervisors only
B. the laboratory aides handling the Laboratory wastes
c. everyone working in the laboratory
the medical technologists doing the tests
referred to?
58. Which Immunoassay Method for Thyroxine Testing is

*peroxidase-labeled antibody birds with ratient hormone (antigen) to

form complex (similar to ELISAL *addition

of acridium esters substrate forms an oxidizec product that emits light
for short time
A. Fluorescent Substrate-Labeled Inhibiticn
B. Microparticle Enzyme
C. Chemiluminescence
D. Fluorescent Polarization

59. Which is the result of urea being reabsorbed into the circulation due to
obstruction??
A. None of the items C. Pre-renal azotemia
B. Post-renal azotemia D. Renal azotemia

Which condition shows a low A/G ratio?

A. Multiple myeloma, Cirrhosis and Nephrotic syndrone
B. Nephrotic syndrome
C. Multiple myeloma and Cirrhosis
D. Cirrhosis

61. If blood was collected using an anticoagulant, how would the volume of
plasma be USUALLY described compared to bloo¢ collected without the
anticoagulant and serum is obtained instead?
A. Same C. Greater
B. Lower D. Indeterminate

(2. Which does NOT refer to neonatal primary hypothyroidism

A. Growth ceficiency C Thyroiditis
B Mental retardation D. Cretinism

63. The needle gauge used in pediatric venipuncture is

A, 20 C. 21
B 22 D. 19

64. Which class of enyzmes catalyze structural shifts in a molecule, causing

change
A.
B

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MEDICAL TECHNOLOGISTS Licensure Examination
08:00 a.m.
Saturday, September 21, 2019 10:00 a.m. Page

CLINICAL CHEMISTRY SET A

65 Which are antiasthmatic drugs?

(1) Theophylline
(2) Theobromine
(3) Digoxin
(4) Lithium
A. 2 and 4 C. and 3
B and 4 D. and

is decreased by least
66 BUN wil be significantly irareased when GFR at

25 C. 50
100 D. 75

67. When compared with circulating 73, levels of 'T4 are

A. the Same C. lower

B. variable D. higher

68. which condition cause cardiac arrest and can occur in the absence of any
warningclinical sympioms?
A. Hyponatremia C. Hypernatremia
B D. Hyperkalemia

What is the effect on draw volume i f evacuated tubes are stored at high

A. Decrease C Indeterminate
B. None D Increase

70. In the H-H equation, he numerator denotes the function.

liver heart
B. kidney D. lung

71 Eypernatremia is defined as a serum/plasma sodium level greater than

A 150 C. 160
3. 142 D. 155

72. What type of fire extinguishe. may be used on computer?

A. Halon C. Carbon dioxide
B Dry chemical D. Pressurized water

73. Which enzyme has a moderate specificity for liver, heart and skeletal
muscles:
A. AST C. CPK
B. ALT

74 . What is the value of 6.0 g/dL albumin in g/L?

A. 105 C. 40
B. 80 D. 50

75. Which assesses excretory function and synthetic capability of the liver?
Bilirubin C Prothrombin time
B. Albumin D. Transaminases

76. Which are non-proteir. mo. ecules used by enzymes to show full activity?
A. Ligands C. Sagars
Cofactors D. Fats

77. Which is a sensitive assay for renal tubular integrity?

A. B2 microglopulin C. Plasma creatinine
B. Plasma urea D. Creatinine clearance

Continued on Page 9 TODS Ver 2.1,

MEDICAL TECHNOLOGISTS Licensure 10:00 Page 9
September 21, 2019 08:00 a.m. a.m.
Saturday,
SET A
CLINICAL CHEMISTRY

Which refers tc Type 1. diabetes?

( 1 ) Usually diagnosed in children
(2) Results from B--cell.
destruction
insulin deficiency
(3) Usual leads to
and 2
A. 3
and
D. 2 and 3
B. 2 and 3

Which is bart of spectrometry?

C. Atomic absorpticn
A. Nephelometry
D. Gas chromatography
and T3?
80. Whiah stimulates the thyroid to release T4
A. DIT C. TSH
D. MIT

61. Which has the nighest protein content?

C.
B. D. Chylomicions

62 . Which is a nondestructive technique for determining the structure of

imited number of
orcanic compound and has been adapted for only
being lipoprotein
clinical laboratory analyses, the most popular
particle measurements?
A. Mass spectrometry
B. Matrix-assisted laser desorption ionization
c. scirtillation
D. Nuclear magnetic resonance spectroscopy

33. Which is NOT a macroenzyme?

D. ALP

Which centrifuge is used when rapid centrifugation of solution 13

needed?
A Horizontal-head c. Cytocentrifuge
D. None of the items
B. Fixed-angle head

85. If serum appears opaque and milky after a 12-hr

fast, triglyceride level

is probably mg/di
A c. greater than 300
less chan 20 c D. greater than 600

86. Which 1s a biochemical marker for bone resorption?

A. Cross-linked C-Telopeptides

B-Trace Protein
D. Myoglobin

87. Whicn is the steroid hormore produced by the corp1s luteum and placenta
that prepares the endometrium for blastocyst implantation arid maintains
pregnancy?
A. Progesterone
3, Estriol

visually detected in the Standing Plasma Test as a floating cream

38 It 15
layer, Which lipoprotein Le present?
C. LDL
D.

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 MEDICAL TECHNOLOGISTS Licensure Examination
Saturday, September 21, 2019 08:00 a.m. - 10:00 a.m. Page 10

CLINICAL CHEMISTRY SET A

89. Which analytic techniques do NOT measure the concentration of solute

particles in a solution?

(1) Osmometry
(2) Fluorometry
(3) Turbidimetry
(4) Nephelometry
A. and 4 C. 2, 3 and
B. and 4 D. and 3

90. The formula belcw is used to compute for expressed in

mg/dL.

[Total Cholesterol - HDL] [Triglycerides/5]

A. LDL C. IDL
D. Ip(a)

9.. Which is NOT a hazard associated with the use of liquid nitrogen?
A. Shock C. Explosion
B. Thermal burrs D. Asphyxiation

92. which analyte is affected by diurnal variation?

A. Thyroxine C. Calcium
B I ro n D.

93. Which is a major waste product of the prctein catabolism?

A. Creatinine C. Ammonia
B. Urea D. Uric acid

34 . Which.s NOT a catabolite of protein and nucleic acid metabolism?

A. Urea C. Glucose
B. Uric acid D. Creatinine

95. Which statistical calculation indicate the extent of variation of the

observations?
(1) Mode
(2 ) Range
3) Variance (4) Standard deviation
A.. 3 and 4 and
and 3 D. and 4

96. Which is a major protein constitutent of LD_?

A. ApoD
B. Apoc

97. Using the cutoff points for serum cholesterol, which are group,
expressed in years, matches the levels of risk for developing coronary
heart disease?

*
Moderate risk if cholesterol is greater than 240 mg/dL
* High risk if cholesterol is greater than 260 mg/dL
40 and over C. 30-39
B. 2-19 D. 20-29

8. Enzymes are involved in which of the following processes?

1 Anabolism
(2) Catabolism
(3) Energy generation
A. 1, 2 and C. 1 and
3. 2 and 3 D. 1 and

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MEDICALTECHNOLOGISTS Licensure Examination
Saturday, September 21, 2019 08:00 a.m. 10:00 a.m. Page 11

CLINICAL CHEMISTRY SET A

99. Which statement abcut chronic toxicity is NOT correct ?

A. Toxic effect: Always severe

B. Frequency of exposure: repeated
C. Dose: insufficient to cause immediate response
D. Duration of exposure: extended periods

100. Which performance characteristics of laboratory test are more relevant

for diagnosis of disease and therapeutic monitoring?
A Specificity and Precision
B Sensitivity anc Specificity
c Sensitivity and Accuracy
D. Accurancy and Precision

***END ***

WARNING: Failure to submit your Test Questions (Complete) set will

cause the cancellation of your Test-Results for the subject.