BT00323200039553614 RLS
BT00323200039553614 RLS
BT00323200039553614 RLS
Thyrocare
D-37/1,TTC MIDC,Turbhe,
Navi Mumbai-400 703
(Note: Average Blood Glucose value is calculated from HBA1c value and it indicates Average Blood Sugar level
over past three months.)
Method : Derived from HBA1c values
Please correlate with clinical conditions.
Method:
ICP - MASS SPECTROMETRY
Note:Reference range has been obtained after considering 95% population as cutoff.
Adult : < 30
Clinical Significance:
Homocysteine is linked to increased risk of premature coronary artery disease, stroke and thromboembolism.
Moreover, alzheimer’s disease, osteoporosis, venous thrombosis, schizophrenia, cognitive deficiency and pregnancy
complications also elevates Homocysteine levels.
High Values:
Elevated homocysteine levels might be due to increasing age, genetic traits, drugs, renal dysfunction and dietary
deficiency of vitamins or smoking. To lower your homocysteine, eat more green vegetables, stop smoking, alcohol.
Folic acid helps lowering elevated levels.
Please correlate with clinical conditions.
Method:- COMPETITIVE CHEMI LUMINESCENT IMMUNO ASSAY
Negative : < 25
Positive : > 25
Clinical Significance :
Anti-Cyclic-Citrullinated-Peptide (Anti-CCP) Antibodies hold promise for early and more accurate detection of
Rheumatoid Arthritis before the disease proceeds into an irreversible damage.
Analytical Specifications :
Anti-Cyclic-Citrullinated-Peptide (Anti-CCP) antibodies are detected using a solid phase enzyme immuno assay having
an analytical sensitivity of 25 RU/ml. Sensitivity of the method is 99% and specificity is 98.5%.
Please correlate with clinical conditions.
Method:- SOLID PHASE CAPTURE ENZYME IMMUNOASSAY
Interpretation:
Determination of LPA may be useful to guide management of individuals with a family history of CHD or with existing
disease. The levels of LPA in the blood depends on genetic factors; The range of variation in a population is relatively
large and hence for diagnostic purpose, results should always be assessed in conjunction with the patient’s medical
history, clinical examination and other findings.
Specifications:
Precision: Intra Assay (%CV): 3.4 %, Inter Assay (%CV): 2.0 %; Sensitivity: 0.002 gm/l
College of American Pathologists: General Chemistry and TDM; CAP Number: 7193855-01
Koschinsky ML, Marcovina SM. Lipoprotein A: Structural Implication for Pathophysiology. Int J Clin Lab Res, 1997; 27:
14-23.
Please correlate with clinical conditions.
Method:- LATEX ENHANCED IMMUNOTURBIDIMETRY
Vitamin D Total test is analyzed on Siemens ADVIA Centaur, standardized against ID-LC/MS/MS, as per Vitamin D
Standardization Program (VDSP).
Method : FULLY AUTOMATED CHEMI LUMINESCENT IMMUNO ASSAY
VITAMIN B-12 C.L.I.A 324 pg/ml
Reference Range :
Normal : 211 - 911 pg/ml
Clinical significance :
Vitamin B12 or cyanocobalamin, is a complex corrinoid compound found exclusively from animal dietary sources,
such as meat, eggs and milk. It is critical in normal DNA synthesis, which in turn affects erythrocyte maturation
and in the formation of myelin sheath. Vitamin-B12 is used to find out neurological abnormalities and impaired DNA
synthesis associated with macrocytic anemias. For diagnostic purpose, results should always be assessed in
conjunction with the patients medical history, clinical examination and other findings.
Interpretation:
High sensitivity C-reactive protein, when used in conjunction with other clinical laboratory evaluation of acute coronary
syndromes, may be useful as an independent marker of prognosis for recurrent events, in patients with stable coronary
disease or acute coronary syndromes. hsCRP levels should not be substituted for assessment of traditional
cardiovascular risk factors. Patients with persistently unexplained, marked evaluation of hsCRP after repeated testing
should be evaluated for non - cardiovascular etiologies
Clinical significance:
hsCRP measurements may be used as an independent risk marker for the identification of individuals at risk for future
cardiovascular disease. Elevated CRP values may be indicative of prognosis of individuals with acute coronary
syndromes, and may be useful in the management of such individuals.
References:
1. Chenillot O, Henny J, Steinmez J, et al. High sensitivity C-reactive protein: biological variations and reference limits.
Clin Chem Lab Med 2000;38:1003-11.
2. Hind CRH, Pepys MB. The role of serum C-reactive protein measurements in clinical practice. Int Med
1984;5:112-51.
Please correlate with clinical conditions.
Method:- FULLY AUTOMATED LATEX AGGLUTINATION – BECKMAN COULTER
Interpretation:
Lipemic Sera (Hypertriglyceridemia) may contain inhibitors, Which falsely depress results. About 20% of patients with
Acute Pancreatitis have abnormal lipids. Normal serum amylase may occur in Pancreatitis, Especially relapsing and
chronic pancreatitis. Moderate increases may be reported in normal pregnancy.
Clinical Significance:
Causes of high Serum Amylase include Acute Pancreatitis, Pancreatic Pseudocyst, Pancreatic Ascites, Pancreatic
Abscess, Neoplasm in or adjacent to Pancreas, Trauma to Pancreas, and common Duct Stones. Nonpancreatic Causes
include inflammatory salivary lesions (Eg, Mumps), Perforated Peptic Ulcer, Intestinal Obstruction, Biliary Tract
Disease, Peritonitis, Acute Appendicitis, Diabetic Ketoacidosis, and Extrapancreatic Carcinomas. Amylase levels more
than 25-fold the upper limit of normal are often found when metastatic tumors produce Ectopic Amylase.
Specifications:
Precision: Within run %CV has been recorded 1% and between run %CV of 1.5%. Analytical sensitivity (Lower
Detection Limit) 3 U/l
Tietz Nw, Huang WY, Rauh DF ET Al. Laboratory tests in the differential diagnosis of Hyperamylasemia. Clin Chem
1986;32: 301–307
Please correlate with clinical conditions.
Method:- ENZYMATIC PHOTOMETRIC TEST.
Interpretation:
For diagnostic purposes, the results should always be assessed in conjunction with the patient’s medical history,
clinical examination and other findings like serum amylase. Serum Lipase is usually normal in patients with elevated
serum amylase, having peptic ulcer, salivary adenitis, inflammatory bowel disease, intestinal obstruction, and
macroamylasemia. Lipemic sera may interfere with results.
Clinical Significance:
High serum Lipase is a specific marker for pancreatitis; after acute pancreatitis the Lipase activity increases within 4–8
hours, reaches a peak after 24 hours and decreases after 8 to 14 days. However, there is no correlation between the
Lipase activity determined in serum and the extent of damage to the pancreas.
Specifications:
Precision: Within run %CV has been recorded 1.16 % and between run %CV of 0.65 %. Analytical sensitivity (lower
detection limit) 3 U/l
Tietz Nw Et Al. Lipase In Serum - The Elusive Enzyme: An Overview. Clin Chem 1993; 39:746-756.
Please correlate with clinical conditions.
Method:- ENZYMATIC COLORIMETRIC ASSAY
Method:
ALKP - Modified IFCC method
BILT - Vanadate Oxidation
BILD - Vanadate Oxidation
BILI - DERIVED FROM SERUM TOTAL AND DIRECT BILIRUBIN VALUES
SGOT - IFCC* WITHOUT PYRIDOXAL PHOSPHATE ACTIVATION
SGPT - IFCC* WITHOUT PYRIDOXAL PHOSPHATE ACTIVATION
GGT - Modified IFCC method
PROT - BIURET METHOD
SALB - ALBUMIN BCG¹METHOD (COLORIMETRIC ASSAY ENDPOINT)
SEGB - DERIVED FROM SERUM ALBUMIN AND PROTEIN VALUES
A/GR - DERIVED FROM SERUM ALBUMIN AND PROTEIN VALUES
Method:
CHOL - CHOD POD METHOD
HCHO - ENZYME SELECTIVE PROTECTION METHOD
LDL - HOMOGENOUS ENZYMATIC COLORIMETRIC ASSAY
TRIG - ENZYMATIC COLORIMETRIC METHOD (GPO) [HIGHLY INFLUENCED BY LEVEL OF FASTING]
TC/H - DERIVED FROM SERUM CHOLESTEROL AND HDL VALUES
LDL/ - DERIVED FROM SERUM HDL AND LDL VALUES
VLDL - DERIVED FROM SERUM TRIGLYCERIDE VALUES
NHDL - Derived from serum Cholesterol and HDL values
*REFERENCE RANGES AS PER NCEP ATP III GUIDELINES:
BORDERLINE HIGH 200-239 HIGH >60 NEAR OPTIMAL 100-129 BORDERLINE HIGH 150-199
Alert !!! 10-12 hours fasting is mandatory for lipid parameters. If not, values might fluctuate.
Method:
CALC - ARSENAZO III METHOD, END POINT.
BUN - KINETIC UV ASSAY.
SCRE - CREATININE ENZYMATIC METHOD
B/CR - DERIVED FROM SERUM BUN AND CREATININE VALUES
URIC - Uricase / Peroxidase Method
SOD - ION SELECTIVE ELECTRODE
CHL - ION SELECTIVE ELECTRODE
Method :
T3 - COMPETITIVE CHEMI LUMINESCENT IMMUNO ASSAY
T4 - COMPETITIVE CHEMI LUMINESCENT IMMUNO ASSAY
TSH - ULTRA SENSITIVE SANDWICH CHEMI LUMINESCENT IMMUNO ASSAY
> = 90 : Normal
60 - 89 : Mild Decrease
45 - 59 : Mild to Moderate Decrease
30 - 44 : Moderate to Severe Decrease
15 - 29 : Severe Decrease
Clinical Significance
The normal serum creatinine reference interval does not necessarily reflect a normal GFR for a patient. Because mild
and moderate kidney injury is poorly inferred from serum creatinine alone. Thus, it is recommended for clinical
laboratories to routinely estimate glomerular filtration rate (eGFR), a “gold standard” measurement for assessment of
renal function, and report the value when serum creatinine is measured for patients 18 and older, when appropriate
and feasible. It cannot be measured easily in clinical practice, instead, GFR is estimated from equations using serum
creatinine, age, race and sex. This provides easy to interpret information for the doctor and patient on the degree of
renal impairment since it approximately equates to the percentage of kidney function remaining. Application of
CKD-EPI equation together with the other diagnostic tools in renal medicine will further improve the detection and
management of patients with CKD.
Reference
Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF, 3rd, Feldman HI, et al. A new equation to estimate glomerular
filtration rate. Ann Intern Med. 2009;150(9):604-12.
Please correlate with clinical conditions.
Method:- CKD-EPI Creatinine Equation
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