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    Oxygen PDF 2

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    khleima27
    How oxygen is transferred inside the blood stream

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    Oxygen PDF 2

    Uploaded by

    khleima27
    6 views10 pages
    How oxygen is transferred inside the blood stream

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    oxygen pdf 2

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    How oxygen is transferred inside the blood stream

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    6 views10 pages

    Oxygen PDF 2

    Uploaded by

    khleima27
    How oxygen is transferred inside the blood stream

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 10

    Roll No: 21101426

    B. Sc: 6th Semester


    KAMAKHYA PEMTON COLLEGE,
    HIYANGTHANG

    Oxygen Haemoglobin Dissociation Curve

    BY: Khaidem Leimahan Chanu Unit: 3


    To: Sir Rahul Sanjenbam
    Page:1

    ●
    INTRODUCTION
    ➢
    It is a graph which shows the relationship between the
    partial pressure of oxygen and oxygen saturation of
    haemoglobin.

    2
    Page:2

    Oxygen Haemoglobin Dissociation Curve

    3
    Page:3

    ●
    EXPLANATION
    ➢
    The O2 – Hb dissociation curve is a sigmoid curve.
    ➢
    It represents the relationship between O2 concentration and the saturation of Hb.
    ➢
    This curve describes the relationship between available oxygen and amount of oxygen carried by haemoglobin.
    ➢
    In this the partial pressure of SaO2 oxygen is on (X-axis) and the oxygen saturation is on (Y-axis) .
    ➢
    The horizontal axis is PO2, or the amount of oxygen available.
    ➢
    The vertical axis is SaO2, or the amount of haemoglobin saturated with oxygen.
    ➢
    Once the PO2 reaches 60mm Hg, the curve is almost flat. So, PO 2 of 60mm or more is usually considered
    adequate.
    ➢
    But, at less than 60mm Hg the curve is very steep and small changes in the PO 2 greatly reduce the SaO2.

    4
    Page: 4

    ●
    Traditionally the curve starts with:

    ➢
    pH at 7.4,

    ➢
    Temperature at 37o C, and

    ➢
    PaCO2 at 40.

    ●
    Changes from these values are called shifts.

    5
    Page: 5

    ●
    The term ‘affinity’ is used to describe oxygen attraction to
    haemoglobin binding sites. Affinity changes with:
    ➢
    Variation in pH

    ➢
    Temperature

    ➢
    CO2 and

    ➢
    2,3,-DPG.

    6
    Page : 6

    When the curve shifts to the left, haemoglobin has an increased affinity for oxygen and release less to the tissues. It is
    easier to load oxygen but difficult to unload.

    Conditions that caused the curve to shift left includes alkalosis, decreased
    PCO2, decreased temperature, low levels of 2,3-DPG, carboxy haemoglobin,
    Methaemoglobin, and abnormal haemoglobin.

    7
    Page : 7

    When the curve shifts to the right, haemoglobin has a


    decreased affinity for oxygen. It is difficult to load the oxygen, but
    easy to unload the oxygen.

    Conditions that caused the curve to shift right includes


    acute acidosis, high PCO2, increased temperature, high levels of
    2,3-DPG and abnormal haemoglobin.

    8
    Page :8

    FACTORS AND HOW THE CURVE IS AFFECTED:

    ●
    Variation of the hydrogen ion concentration
    ●
    Effects of carbon monoxide
    ●
    Effects of carbondioxide
    ●
    Effects of 2,3-DPG (Di phospho glycerate)
    ●
    Temperature
    ●
    Fetal haemoglobin

    9
    Page :9

    Thank you!

    10

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