Lesson: Synthesis

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CHAPTER 10 -

lesson 4
Protein synthesis
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Genes are segments of DNA in the chromosome that code hereditary character
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They direct the making of proteins through ribonucleic acid ( R NA)


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Transcription DNA acts as a template for RNA synthesis
:

in
Translation RNA :
dir c et s the assembly of protein

forming proteins based on DNA carried out by DNA is called protein synthesis
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Proteins protect the body & carry oxygen in red blood cells
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RNA structure & function


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It is a nucleic acid made up of nucleotides
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Dile re noes with DNA :

'
R NA has ribose instead of deoxyribose
'
URACIL instead OF THY mine

RNA
! DNA isis usually single stranded rather than double stranded
longer

Types of RNA
messenger RNA carries the genetic message from DNA in the nucleus
- :

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to the ribosome in cytosol
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ri bosom bat RNA part of the structure of ribosome ( where synthesis occurs) Bd
:

n
transfer RNA transefrs amino acids ribosome ¥¥f
: →
Transcription
I RNA polymerase catalyzes the RNA info with a DNA template & binds
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to a promoter a specific nucleotide sequence of DNA where RNA binds


The DNA Strands unwind & separate


1- Complementary to DNA RNA nucleotides are added
,
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The resulting chain is an RNA molecule


3- The termination signal is reached & the RNA polymerase releases DNA & RNA
The RNA made could be either tRNA mRNA or rRNA
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adenine +
URACIL ( replaced thymine)

guanine cytosine
+

€-2

The genetic code


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Rules that relate how a sequence of nitrogenous bases in nucleotides corresponds
to a particular amino acid
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3 nucleotides ( letters) specify an amino acid (word ) in a polypeptide
Each 3 letters are
codons
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a

start codon AUG :

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stop codons : UAA VA O UGA
, ,
Translation
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The making of protein

there are 20 different amino acids found in proteins
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The sequence of these amino acids determine the shape of the polypeptide in the protein
steps
I -

tRNA & mRNA join


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One end of tRNA will have an amino-acid & the other an anti codon
↳ me ti o nine

2- Peptide bonds form between amino acids


The ribosome moves the mRNA h tRNA
3- The polypeptide chain continues to grow
The first tRNA detaches
4- Ribosome reaches stop codon
New polypeptide falls off
5- Everything is complete & the translation
machinery leaves to repeat the process

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