FIGO Generic Protocols PPH April 2022
FIGO Generic Protocols PPH April 2022
FIGO Generic Protocols PPH April 2022
Haemorrhage Protocol
and Care Pathways
MSD for Mothers* through Concept Foundation (CF) and WACI Health are supporting ministries of
health in several African countries, to update their Essential Medicines List (EML) in line with World
Health Organization (WHO) PPH recommendations for the use of uterotonics including tranexamic
acid (TXA) and heat-stable carbetocin (HSC). FIGO, in partnership with ICM through the Improve
Access to essential medicines to reduce PPH morbidity and mortality Project (IAP), is contributing
to this work by partnering with national member societies and associations to update their
protocols/guidelines for PPH prevention and treatment, and to develop job aids for health facility-
based maternal care providers.
During the IAP project (2021 – 2022), we developed a generic PPH protocol and clinical pathway
using the WHO PPH recommendations. This provides examples of key definitions, early
identification of risk, estimation of blood loss, choice of uterotonics, prevention and treatment at
various levels of care, effective multidisciplinary teamwork, communication, and referral – all of
which can inform a systematic approach to developing policy for PPH management in health
facilities.
FIGO and ICM were supported by national obstetrics and gynaecology societies and midwives’
associations to engage with ministries of health and establish PPH expert working groups (EWG)
in each country. The focal persons from each professional society/association met virtually every 1
– 2 weeks with the international coordination team to plan for in-country activities.
Two virtual, multi-stakeholder workshops with the identified PPH EWG were facilitated. Workshop
1 aimed to raise awareness of the WHO PPH recommendations, discuss, and appraise current
national PPH guidelines and protocols, and develop a plan to adapt the FIGO generic PPH
protocol and clinical pathway to meet the needs of the context. Digital feedback forms were
developed, and comments were collected during, and two weeks following the workshop. FIGO
incorporated the recommendations into the generic PPH protocol and clinical pathway and
returned the document to the PPH EWG for review and validation by the Ministry of Health.
The objectives of workshop 2 were to present the country adapted PPH protocol, discuss the use
and dissemination of the adapted protocol and to agree on the content and format of job aids,
which could support maternity care providers better to prevent and treat PPH. The international
team encouraged national government health promotion departments and graphic designers to be
involved and contributed a FIGO design consultant for additional expertise. The PPH EWG gave
feedback following the same process as the first workshop. FIGO and ICM further supported their
member societies/associations to design and plan for dissemination of the job aids.
The design of the meetings and workshops ensured engagement and ownership of key maternal
health stakeholders involved with policy development, education, and clinical practice. Other
Combined with focused health system interventions, (procurement and supply of quality
uterotonics etc.), it is anticipated that the IAP project interventions will contribute to prevention of
PPH morbidity and mortality.
Charles Anawo Ameh PhD, MPH, FWACS (OBGYN), FRSPH, SFHEA, FRCOG
Reader/Associate Professor
FIGO Technical lead FIGO IAP
Head Emergency Obstetric Care and Quality of Care unit
Deputy Head International Public Health department
Liverpool School of Tropical Medicine
United Kingdom
*The activities in this publication were supported by funding from MSD, through its MSD for Mothers initiative and are
the sole responsibility of the authors. MSD for Mothers is an initiative of Merck & Co., Inc., Kenilworth, NJ, U.S.A.
Competent care providers can decrease PPH mortality by assessing for risk in the antenatal
period, monitoring progress of labour and active management of third stage of labour (AMTSL). It
is also vital to have a well-resourced and enabling environment and access to essential medicines.
In recent years, the World Health Organization (WHO) revised and published guidance to prevent
and manage PPH. These include:
For these recommendations to have a positive impact on PPH prevention and treatment, a system-
wide approach is needed.
MSD for Mothers have supported Concept Foundation (CF) and WACI Health during a two-year
project to update countries national policy/protocols in line with the WHO Recommendations
2017/18, as well as updating their EML to reflect the recommended use of TXA and heat-stable
carbetocin.
FIGO, in partnership with ICM, is joining CF and WACI Health to extend this effort for the next 18-
months through the Improve access to essential medicines to reduce PPH morbidity and mortality
(IAP) project from January 2021 to August 2022. FIGO and ICM will partner with their member
societies/associations in these countries to develop appropriate tools so that frontline clinicians are
able to implement the WHO Recommendations in health facilities.
The FIGO/ICM collaboration will work with policy makers, health care providers and supply chain
experts to support increased availability of quality uterotonics and the anti-fibrinolytic drug,
tranexamic acid (TXA).
The IAP project aims to facilitate adoption of updated WHO PPH Recommendations (2017 &
2018), at a country level into practice through dissemination of updated clinical guidelines and
protocols. The expected outcomes of the project are:
To meet the ambitious maternal health targets of the Sustainable Development Goals, specifically
SDG 3.1: reduce the global maternal mortality ratio to less than 70/100,000 live births by 2030.
Practical steps are needed to scale up the implementation of evidence-based interventions to
prevent and treat PPH.
Following the publication of updated WHO PPH recommendations by the World Health
Organization in 2017 and 2018, there is limited application of these, as well as limited knowledge
of effective uterotonics for PPH prevention and treatment.
This clinical protocol for the prevention and management of post-partum haemorrhage has been
developed in line with the World Health Organization PPH guidelines, to improve awareness of
uterotonic options and a translation of the guidelines to facilitate evidence based clinical practice.
Purpose
The purpose of this guideline is to support Skilled Health Personnel in providing care based on
best practice and best available evidence to identify, prevent and manage PPH. Specifically, this
clinical protocol will increase the capacity for
These guidelines should be implemented along with current WHO guidelines that highlight women-
centred care to optimise the experience of labour and childbirth for women and their babies
through holistic, human rights and evidence based approach (WHO recommendations: Intrapartum
care for a positive childbirth experience and WHO labour care guide).7,8
Regular drills and skills training are essential in the management of PPH.
Trainees should be allowed dedicated and protected time for training.
Simulation of obstetric procedures and emergencies can only augment, not replace, the
learning that occurs by caring for actual patients.
In-house training is cheap and associated with improved outcomes.
Funding should be available for training to reduce the cost of medical litigation as a result of
substandard care.
Teamwork is essential for proper coordination of the management.
Above all, patients and their relatives must be kept fully informed at all stages of
management.
Definitions
Postpartum haemorrhage is defined as estimated blood loss of more than 500 ml* within 24
hours of a vaginal birth or 1000 ml after caesarean section, or any blood loss sufficient to
compromise haemodynamic stability. In women with lower body mass (less than 60kg), a lower
level of blood loss may be clinically significant. 11
PPH can be minor (500-1000 ml) or major (more than 1000 ml). A severe PPH following Lower
Segment Caesarean Section (LSCS) involves the loss of 1500 ml or more.
Massive PPH involves the loss of 2000 ml or more of blood from the genital tract within 24 hours
of the birth of the baby or when the woman is haemodynamically compromised or showing signs of
shock as a result of obstetric haemorrhage of any amount over 500 ml.
A blood loss can be considered a Massive Obstetric Haemorrhage in cases where either four
units of blood have been transfused and further units are required, regardless of blood loss or
there is a blood loss >2000 ml.
Secondary PPH is defined as excessive blood loss from the genital tract after 24 hours following
delivery, until six weeks post-delivery.
These clinical signs associated with specific blood loss volumes above are more reliable than
visual estimation. Swabs and clots can be weighed for a more accurate estimate of blood loss.
The main change in the 2012 WHO PPH guideline, is the use of tranexamic acid (indication,
timing, and dosing) - Table 1
Table 1: The main change in recommendation on TXA in the WHO 2012 PPH
recommendation.13
PPH Prevention
Minimising the risk of PPH starts during the antenatal period, by the identification and treatment of
anaemia, identify any women with increased risk of PPH (Table 2) and plan for their delivery. Risk
factors for developing PPH may present antenatally or intrapartum, so care plans should be
modified as these risks emerge. 11 Women with known risk factors should be delivered in health
facilities with capacity for blood transfusion and surgery.
During the 3rd stage of labour, one of the following uterotonics, carbetocin, misoprostol,
ergometrine/methylergometrine and oxytocin and ergometrine fixed-dose combination, should be
administered (Figure 1 and Figure 2). The characteristics of these uterotonics are provided in
Annex 1.
Oxytocin (10 IU, IM/IV) is the recommended uterotonic of choice (vaginal and caesarean birth). If
oxytocin is unavailable or the quality cannot be guaranteed, the other uterotonics above can be
used. The use of carbetocin (100 micrograms, IM/IV) is only recommended for the prevention of
PPH for all births in contexts where its cost is comparable to other effective uterotonics. It is
expected that heat-stable carbetocin (HSC) will be available in many low and lower-middle income
countries, this is likely to address the issues of effectiveness, quality and affordability.
Any uterotonic that contains ergometrine could be used in the absence of oxytocin in contexts
where hypertensive disorders can safely be excluded. Non Skilled Health Personnel should only
administer misoprostol (oral 400 or 600 microgram). 4
Injectable prostaglandins such as carboprost or sulprostone are not recommended for PPH
prevention.
Postpartum abdominal uterine tone assessment for the early identification of uterine atony is
recommended for all women.
Ergometrine / methylergometrine
(200 μg. IM/IV), in contexts
Is oxytocin available? where hypertensive disorders
No can be safely excluded prior to
Oxytocin is not available, or its use.
its quality cannot be
Yes guaranteed
No
OR
Is oxytocin of sufficient quality?
Fixed-dose combination of
oxytocin and ergometrine, in
contexts where hypertensive
Yes disorders can be safely excluded
prior to its use.
Misoprostol
(400 μg or 600 μg PO)
PPH Prevention
Birth personnel type
Yes No
Oxytocin 10IU, IV/IM (vaginal and caesarean births), Misoprostol (400 micrograms or
if unavailable or if quality cannot be guaranteed one 600 micrograms, orally)
of the following can be used following the decision
process above in figure 11, based on clinical eligibility
and availability:
Uterotonic
Birth asphyxia
Cord clamping
No Yes
Yes No
Placenta
The most senior skilled health personnel available should lead the management. The team leader
will be responsible for key procedures, clear communications, and allocation of tasks
(interventions, equipment and documentation, monitoring and communication with the family).
Clear information should be provided to the woman and her partner about what is happening from
the onset.
Look out for the Four T’s (Tone, Tissue, Trauma and Thrombin) and associated risk factors (Table
2). The most common cause of PPH is uterine atony with placenta site bleeding, genital tract
trauma or both. The initial evaluation is differential uterine atony from genital track lacerations.
Clinical considerations
Empty bladder – leave catheter in place and commence fluid balance chart
Assess uterine tone and perform uterine massage as necessary “rub up a contraction”,
bimanual compression if required.
Uterotonic medications see Figure 2. Note that dose of misoprostol for treatment is 800
micrograms sublingual.
Tranexamic acid (TXA) should be used in all cases of PPH, regardless of whether the bleeding
is due to genital tract trauma or other causes within 3 hours of birth.
TXA should be administered at a fixed dose of 1g in 10 ml (100 mg/ml) IV at 1ml per
minute(i.e., administered over 10 minutes), with a second dose of 1g IV if bleeding continues
after 30 minutes or if bleeding restarts within 24 hours of completing the first dose.14
TXA should be part of the standard comprehensive PPH treatment package, including
medical (uterotonics), non-surgical and surgical interventions in accordance with WHO
guidelines or adapted local PPH treatment protocols.
Early use of IV TXA (as early as possible after clinical diagnosis of PPH and only within 3
hours of birth) in addition to standard care is recommended for women with clinically
diagnosed PPH following vaginal birth or caesarean section.
The point estimates of effect of TXA use beyond 3 hours on death for trauma6 and for PPH
were both in the direction of harm, albeit not statistically significant for women with PPH. In
view of this evidence, WHO recommends against the use of TXA more than 3 hours after
birth.
Treatment delay in use of TXA appears to reduce benefit. The benefit appears to decrease
by 10% for every 15-minute delay, with no benefit seen after 3 hours.
TXA should be readily available at all times in the delivery and postpartum areas of facilities
providing emergency obstetric care.
TXA is relatively cheap in most contexts, easy to administer, often available in health care settings
due to its use in trauma and surgery, has a shelf life of 3 years, and can be stored at room
temperature (15–30C) in many places.
The clinical care pathway will depend on the type of facility where the diagnosis of PPH is made –
a primary care/facility with Basic Emergency Obstetric Care capacity (BEmOC) (Figure 3 and
Figure 4) or a hospital with Comprehensive Emergency Obstetric Care facility (CEmOC) (Figure 5).
Situation-Background-Assessment-Recommendation
The SBAR (Situation-Background-Assessment-Recommendation) technique provides a framework
for communication between members of the health care team about a patient's condition. 15,16
State the most recent vital signs: respiratory rate, heart/pulse rate, B/P, temperature,
oxygen saturations, AVPU (Alert, Voice/or new confusion, Pain or Unresponsive), Blood
sugar
RWhat
= Recommendation
is the state of the(action requested/recommended — what you want)
placenta?
What
State is
clearly
your assessment
what your recommendation
of lacerations? is or what do you want?
SBAR allows for an easy and focused way to set expectations for what will be communicated and
how between members of the team, which is essential for developing teamwork and fostering a
culture of patient safety.
There is moderate evidence for improved patient safety through SBAR implementation, especially
when used to structure communication over the phone16. A tool for SBAR implementation is
provided in Annex 3: SBAR communication and referral tool*.
No Yes
1 IVoxytocin peak onset of action is immediate and peak concentration after 30 minutes while IM oxytocin onset
of action is 3-7 minutes and duration of action is up to 1 hour (Annex 1).
2TXA should be avoided in women with clear contraindication to antifibrinolytic therapy such as a known
thrombotic event during pregnancy
Uterine packing is not recommended for the treatment of PPH due to uterine atony
Women should remain in the delivery suite for 24 hours after major PPH has been resolved or after transfer
from ICU/ITU
FIGO Postpartum Haemorrhage Clinical Protocol and Care Pathways 16
Figure 4: Flow chart for major PPH treatment at BEmOC facility
Estimated blood loss CALL for HELP! A multidisciplinary team
Most senior to lead care
>1000 ml should be alerted: Labour ward in-
charge/coordinator, first line obstetric Allocate tasks
Blood loss with change in
(medical intern/medical officer), obstetric
RR, PR and BP
No or
incomplete No tears Yes based on
on Yes
history. Prepare
inspection to refer to
Yes No
Repair CEmOC
If persistent bleeding/shock
Airway: Confirm airway open, patent and breathing Group and cross match 4 units of packed red
(RR) cells/fresh whole blood
If symptomatic: Oxygen 15L/min via facemask
Transfuse if bleeding is more than 1.5L and
Circulation: PR, BP bleeding is continuing
Establish venous access: 2 wide bore cannula
(14-16 G)
Repeat oxytocin and 800 micrograms misoprostol if
Fluid replacement: Warmed crystalloid infusion- unresponsive within 10 mins (uterus still atonic)1
2L fast, and transfuse as soon as possible
Administer TXA within 3 hours of birth: 1 g in 10 ml (100
Insert urethral catheter, empty the bladder, open
mg/ml) IV at 1 mL per minute2
fluid balance chart
Monitor vital signs (Pulse rate, respiratory rate Oxytocin 40 units in 500ml sodium chloride 0.9% /
and blood pressure) every 15 mins (MOEWS ringers lactate at 125 ml/hr
chart) Continuously assess blood loss
Secondary survey:
Bleeding stopped after 30 minutes?
Tissue: Check if placenta delivered and complete. CCT,
manual removal of placenta.
Non-surgical methods
No Yes
External aortic compression
Apply non-pneumatic anti-shock garment
2
TXA should be avoided in women with clear
Uterine Balloon Tamponade (UBT) contraindication to antifibrinolytic therapy such as a
known thrombotic event during pregnancy
Surgical methods
3
Examination under anaesthesia Involve experienced surgeons with vascular
expertise.
Repair tears
Apply brace sutures* 4
Resort to sub-total hysterectomy sooner rather than
Stepwise devascularisation and internal iliac artery ligation. 3
later
Hysterectomy.4
TXA should be administered IV ONLY
1
IV oxytocin peak onset of action is immediate and peak concentration after 30 minutes while IM oxytocin onset of action is 3-7
minutes and duration of action is up to 1hour (Annex 1).
FIGO
WomenPostpartum
should remain inHaemorrhage Clinical
the delivery suite for 24 hoursProtocol andhas
after major PPH Care
beenPathways
resolved or after transfer from ICU/ITU 18
Major PPH: Blood loss more than 1000 ml and ongoing bleeding or
clinical shock
The most senior skilled health personnel available should lead the management. The team leader
will be responsible for key procedures, clear communications, and allocation of tasks
(interventions, equipment and documentation, monitoring and communication with the family).
ABC: assess airway and breathing; oxygen 15L/min via face mask
Evaluate circulation
Position the patient flat
Give immediate clinical treatment:
o Uterine massage “rub up a contraction”, bimanual compression if required
o Empty bladder – leave catheter in place and commence fluid balance chart
o Uterotonic medications – see Figure 4
o Establish two 14-16g cannula, take bloods for full blood count, coagulation screen, renal
and liver baseline and cross match packed red cells (4 units).
o Volume replacement: involves restoration of both blood volume and oxygen carrying
capacity.
o As rapidly as possible give 2L of warmed Hartmann’s solution or normal saline, followed by
whole blood as soon as available.
o Blood transfusion as soon as blood is available, following blood transfusion clinical
protocol. Not that near patient estimation of Hb can be misleading.
o Controlled cord traction if placenta has not yet been delivered – remove any clots or
remaining tissue
o Continuously assess blood loss – weigh swabs and clots and keep a contemporaneous
estimate of blood loss.
o Monitor vital signs: pulse, respiratory rate, blood pressure every 15 minutes. A modified
early obstetric warning score (MEOWS) will aid monitoring, prompt action and escalating
promptly when abnormal scores are observed.17,18. Annex 5: Modified Early Obstetric
Warning score chart.
Care pathway
The B-Lynch suture allows for even tension, free drainage of the uterine cavity and facilitates
involution. With this technique it is easy to confirm haemostasis, that the uterine cavity is empty,
confirm no decidual tear/trauma.
Requirements19
After application, the uterus should be exteriorised and the surgeon demonstrates to the assistant
bimanual compression and ante version. The second assistant checks the vagina to ensure that
bleeding is controlled and the surgical technique will work.
Placenta percreta
Wrong technique causing uterine necrosis
Uncontrolled DIC
No pre-operative investigations done
Poor technique i.e. not properly applied
Delayed application
A pelvic ultrasound may help to exclude the presence of retained products of conception, although
the diagnosis of retained products is unreliable. Surgical evacuation of retained placental tissue
should be undertaken or supervised by an experienced clinician.
Oxytocin Synthetic cyclic peptide form of the naturally occurring posterior pituitary hormone
Has oxytocic properties, inhibits gastric acid and pepsin secretion, and enhances
gastric mucosal resistance to injury.
Ergometrine Ergometrine and methylergometrine are ergotalkaloids that increase uterine muscle
tone by causing sustained uterine contractions
Characteristics Pharmaco-kinetics(14,15)
Oxytocin Intravenous (IV): almost immediate action with peak Half-life: 1–6
concentration after 30 minutes minutes
Misoprostol Absorbed 9–15 minutes after sublingual, oral, vaginal or Half-life: 20–40
rectal use minutes
Ergometrine IM: onset of action within 2–3 minutes, lasting for about Half-life: 30–120
3 hours minutes
Efficacy and 1. The use of an effective uterotonic for the prevention Recommended
safety of of PPH during the third stage of labour is
uterotonics for recommended for all births. To effectively prevent
PPH PPH, only one of the following uterotonics should be
prevention used:
oxytocin (Recommendation 1.1)
carbetocin (Recommendation 1.2)
misoprostol (Recommendation 1.3)
ergometrine/methylergometrine
(Recommendation 1.4)
oxytocin and ergometrine fixed-dose combination
(Recommendation 1.5).
1.1 The use of oxytocin (10 IU, IM/IV) is recommended for Recommended
the prevention of PPH for all births.
Organisation of care
*This recommendation has been updated in the WHO 2018 updated recommendation on tranexamic acid for
the treatment of postpartum haemorrhage. 4
State clearly:
*If referral communication is via telephone, ask the receiver to repeat key information to ensure
understanding
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021-00309-z
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