TRANSDERMAL SESING ·

A NEW WINDOW ON THE BODY

IMPERIAL COLLEGE LONDON

Nine campuses

South and research

Kensington Teaching
- -

hospital word leading clincians and clinical cohorts and

6
teaching campuses with access to
-

samples
White
City innovation campus
- -

Academic strategy sustainable .

-

society
I
&
Smart
Healthy society
.
society
.

Continous (Molecular) Sensing -

Relevance
↓
Chronobiology : Both
healthy and disturbed biological systems are
dynamic
Continuous (Molecular)
sensing
↓

Environmental factors white

-Sydrome
Continous (Moleculae) Sensing
to
single Time point measurements :

only compared with conhost average

from this To this

E
↳M ④
To
L
·
·
·

Time Time

Chronobiology
Ultedian v
E 1
day
Gonadotrophin Releasing Hormons Infinizing
hormone
Cortisol ,

circadian eldayv =

Cortisol , Melatonin

Infradian v day
Luteinizing Hormone , Gestergen
 Personalized
Digital Health
reacking long form changes at an individual level
Exercise
- Phenotype
Genome
>
-

Environment
- X exigenome

Non /
Minimally Invasive Continuous
sensing
Capillary/Venous / Arteria Blood
Biofluids for sampling Urine

Dermal Interstitial fluid

Saliva / Nasopharyngeal fluids
sweet .

Exhaled Breath (VOC's 2 Aerosols)

faeces

SUBCUTANEOUS INTERSTITIAL FLUID .

-
Devices can be
for up
nonn to 14 days
-

Clinically validated for

type 1. diabetes management
-

Extensively supported.
Enabling Technologies
Smartphones and related electronics (NFC,
high resolution cameras cloud
Connectivity)
Precursor technologies
Home medical devices (BDM, Pulse Oximeters
, ... ]
DERMAL INTERSTITIAL FLUID
-

Superficial (1mm below skin surface)

fairly Readily sampled by microdialysis
-

-
In Equilibrium with Capillary Blood

composition well defined

-

Protein content is low

so
, what's Not Like about 1Sf ?
· You still have to cross the stratum corneum
 ↑

Device
Sterility
-

Foreign body/immuse response

-

Biocompatibility
and amplitude
Lag in respone D2/ Dt
-

SENSOR MATERIALS 2 FABRICATION ISSUES (

How devices
many for :

Lab
-

of concept
proof
-
Reproducibility assessment
-

Tissue phantom studies

.

-
First in man stuces
- first clinical trials

- . . . . .

OUR CHOICES AND REASONINGS -

Polycarbonate >
-
cheap and clean
Biocompatible

Injection Molded
Low-cost dies
rapidly machined
Excellent metal banding
Good adhension of medical adhesives

Lactate
Sensing During
Exercise
·
Lactate buildup Muscle
in
during Anaerobic exercise
Microneedle Oxidase
with Lactate
·

Amay
·

Good correlation with Venous Blood Levels

Skin Marks
Rapidly Disappeal
skin
Minimally marking
·

No invitation
·

Therapeutic Meng Monitoring <TDMY

those on
· Most
dengs ,
including treating Type 2 diabetes have a variable effect in patients
Continous TDM with
Bayesian Dose Optimisation theapy
·
can
improve
Inter-Individual
variability
Age Ethnicity comorbidities

Race
Gender Medications
 first in human Trials
Ten
·
volunteers took a close
of penicillin
· The sensor
outputs and blood levels were compared
·
Sensors in Ist track blood but with lower concentrations and about 1 home

LOOKING AT THE FUTURE .

-
still at the invites
stage -
1
Highly Nanoporous gold coatings for Dopamine
-

Developing sensing chemistries .

the Clinical consequences

of Altered LH (GRU) Pulsatily
Ultimate Embodiment -

A weanable LU senson

Please 1 :
Developing the molecular
recognition chemistry
Nucleic Acid aptamers :

Single Stranded DNA on RNA molecules selected to bind

to specific molecular targets with assinifes in the nM-pM lange