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Essentials in Ophthalmology
Series Editor: Arun D. Singh
Jorge L. Alió
Joseph Pikkel Editors
Multifocal
Intraocular
Lenses
The Art and the Practice
Second Edition
Essentials in Ophthalmology
Series Editor
Arun D. Singh
Multifocal Intraocular
Lenses
The Art and the Practice
Second Edition
Editors
Jorge L. Alió Joseph Pikkel
Research & Development Department Department of Ophthalmology
and Department of Cornea Assuta Samson Hospital
Cataract, and Refractive Surgery Ashdod
VISSUM Corporation and Miguel Israel
Hernández University
Alicante Ben Gurion University
Spain School of Medicine
Beer-Sheva
Israel
This Springer imprint is published by the registered company Springer Nature Switzerland AG
The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
To our dear wives and children who follow us along the routes
of medicine, encourage, and support us – the reason for all that
we do and the joy of our lives, and to our patients from whom
we have received the inspiration and expertise to build up the
second edition of this book.
Jorge L. Alió and Joseph Pikkel
Alicante (Spain)/Safed (Israel)
Fall 2019
Preface
In our modern world, now on the first quarter of the twenty-first century,
medicine faces, more than ever before, the challenge of not only fighting
diseases and saving lives but also improving quality of life. While life expec-
tancy rises, patients’ activities remain at the same level that they were used to
being young and hence their visual demands keep being high. While in previ-
ous decades older people tended to lessen their activity, nowadays older peo-
ple do not reduce daily activities as driving, sport activities, and various
hobbies that require good visual acuity to different distances and are more
convenient if multifocality exists.
This evolution derived – among other things – new techniques and new
approaches of cataract surgery. The evolution of cataract surgery and IOL
implantation during the last decade has been, not surprisingly, focused on
improving the quality of vision and the quality of life of our patients.
Near vision and intermediate vision have been identified as one of the
reasons by which quality of life is really acknowledged by our patients.
Another trend in recent years is the tendency to operate younger patients than
before with better visual acuities, even with mild cataracts, which means that
patients are less tolerant to visual disabilities, and moreover the advances in
refractive surgery have educated them in their request for spectacle indepen-
dence. While usually we succeed in achieving good far vision without spec-
tacles or contact lenses, optimal multifocality for far, intermediate, and near
vision is still a challenge to be met.
Since multifocal lenses, by definition, divide light into different foci, using
multifocal intraocular lenses causes a dispersion of the energy of light enter-
ing into the eye and, consequently, distributing the light in different foci. This
causes a change in distribution of light and images at the level of the visual
function at the level of the retina. This is the reason why neuroadaptation,
which means the capability of the brain to adapt to changes, is necessary to
adjust neurophysiology to the changes that are induced in the quality of the
retinal image by dispersion of light. Moreover, the overlapping of different
foci is neither physiological nor normal in the human or animal evolution. To
the best of our knowledge, no visual system is multifocal in nature and it has
not existed in the human being throughout evolution. For this reason, neuro-
processing is the main challenge of multifocal intraocular lenses. The new
technologies emerging in recent years have aimed at smoothing the changes
in visual perception and to make a much more physiological division of light,
vii
viii Preface
but even in these conditions, their effectivity has to be demonstrated and con-
firmed by an improvement in the subjective quality of vision of the patient.
About four years ago we published the first edition of this book which was
welcomed by many ophthalmologists around the world. In recent years, a
tremendous advance in the field of multifocal intraocular has been made. In
this second edition, we bring the updated information on multifocal intraocu-
lar lenses techniques and about lenses available in the market today as well as
our personal experience on the subject. The main aims of this book are how
the practical ophthalmologist and ophthalmic surgeon can select an adequate
multifocal intraocular lens, how to differentiate them among the different
technologies, how to identify the best on the market, and how to use evidence
in favor of the selection of the best for the benefit of the patients.
We hope that the reader will find this book useful for the purpose for which
it was created, independent opinion, information, and credibility, and also
unbiased information on the subject of multifocal intraocular lenses, which is
constantly progressing and takes more and more part in our daily clinical
practice. If we achieve this goal, the time and work dedicated to this book will
be worthy.
ix
x Contents
xiii
xiv Contributors
When considering the latest innovations in oph- describe the current technologies and advances of
thalmology, there is no doubt that one of the lead- multifocal intra ocular lenses.
ing fields is multifocal intraocular lenses. The
quest of patients to be free from wearing glass or
using contact lenses meets the elongation of life 1.1 ow Can We Gain
H
expectancy as well as older people being more Multifocality in Lenses?
active than in previous years, with the improve-
ment of optical technologies and new inventions, A multifocal intraocular lens must incorporate
which results in a constant improvement of mul- some mechanism to focus light from distant
tifocal intraocular lenses. These new lenses and objects and light from near objects at the same
new technologies open a wide variety of solu- time. A redistribution of the light energy will hap-
tions for those who seek to get rid of visual aids pen, with no single focus receiving all the energy
as spectacles or contact lenses. Though a great as it happens in normal physiological accommo-
advancement has been made in recent years in dation. Unlike spectacle multifocal lenses, the
multifocal intraocular lenses designs and pro- multifocal intraocular lens refracts (or diffracts)
duction, there is still no perfect solution for all light from any object for both near and distance
distances, and there is still a lot to be achieved. vision at the same time. Thus there must always
Accommodative lenses might be a solution, and be some light that is not in focus with the light
this fascinating issue will be described and dis- that is in focus. For distant objects, for example,
cussed later in this book. In this chapter, we will the “add lens” steals some of the light that would
have been focused and instead distributes rela-
tively defocused light onto the retina, decreasing
J. L. Alió (*) image contrast and reducing contrast sensitivity.
Research & Development Department and Multifocal intraocular lenses can obtain multi-
Department of Cornea, Cataract, and Refractive
Surgery, VISSUM Corporation and Miguel focality in different ways:
Hernández University, Alicante, Spain
e-mail: [email protected] 1. A combination of two or more different ante-
J. Pikkel rior spherical refractive surfaces for distance
Department of Ophthalmology, Assuta Samson and near correction such as a combination of
Hospital, Ashdod, Israel an anterior spherical and an anterior aspheric
Ben Gurion University, School of Medicine, refractive surface for distance and near
Beer-Sheva, Israel correction
e-mail: [email protected]
the obstacle interfere and cause a diffractive later on this book, are trying to provide interme-
pattern. As the spacing between the diffractive diate vision by a redistribution of the diffracted
elements decreases, the spread in the diffrac- light to other foci.
tive pattern increases. By placing the diffrac- The diffractive models are composed by dif-
tive microstructures in concentric zones and fractive microstructures in concentric zones that
decreasing the distance between the zones as get closer to each other as they distance from
they get further from the center, a so-called the center. They generally provide good far and
Fresnel zone plate is produced that can produce near vision, but the intermediate vision may not
optic foci. Thus the distance power is the com- be satisfactory in some cases. They are not so
bined optic power of the anterior and posterior dependent of pupil dynamics and more tolerant
lens surfaces and the zero order of diffraction, to their centering, but they usually affect the con-
whereas the near power is the combined power trast sensitivity in a greater scale [4]. Although
of the anterior and posterior surfaces and the contrast sensitivity in patients with multifocal
first order of diffraction (Fig. 1.2). IOLs is diminished compared with those with
The diffractive multifocal lens implant pro- monofocal IOLs, it is usually within the normal
vides excellent reading vision and very good range of contrast [3].
distance vision. The intermediate vision is
acceptable but not excellent as the far and near
vision. However, multifocal diffractive intraocu- 1.2 DOF: Extended Depth
E
lar lenses are less pupil size defendant and are of Focus
more tolerant to differences of kappa angle.
Bifocal diffractive multifocal lenses only Extended depth of focus (EDOF), or extended
provide two focus points—far and near—and range of vision, is a new technology in the treat-
no intermediate foci; they have a high potential ment of presbyopia-correcting intraocular lenses.
of producing halos and glare due to more non- In contrast to multifocal intraocular lenses used in
transition area; and since they cause an equal the treatment of presbyopia, EDOF lenses work
distribution of light for both foci, they cause by creating a single elongated focal point rather
18% loss of light in transaction. These disadvan- than several focal points, to enhance depth of
tages may decrease quality of vision especially focus. The aim of these lenses is to reduce aber-
in mesopic and scotopic conditions when more rations, glare and halos, that are caused by the
zones affect the incoming light rays to the retina. exciting multifocal intraocular lenses (Fig. 1.3).
The modern trifocal diffractive IOLs, provided The SYMPHONY lens uses the described
by different mechanisms that will be explained technic to create EDOF; however, there are other
4 J. L. Alió and J. Pikkel
Elongated Focus
Focal distance
technologies that can be applied to enhance the Continuous Focus (WIOL-CF) (Medicem, Czech
range of vision without splitting light. Small Republic). This lens is a one-piece polyfocal
aperture designs and bioanalogic intraocular hyperbolic optics with no haptic elements. It is
lenses can also enhance the depth of focus. In a made from a biocompatible hydrogel 42% water
“nut shell,” there are three groups of design that hydrogel and mimics the properties of a natural
can enhance EDO: crystalline lens with a refractive index 1.43. The
lens enables a continuous range of focus.
• Lenses that use a pinhole effect Since it is not an accommodative lens, the
• Bioanalogic lenses lens has several zones that create different foci,
• Echelette technology lenses the refractive power is maximal in the center
and continuously decreases without steps to the
periphery. Observational studies indicated excel-
1.2.1 “Pinhole Lenses” lent visual acuity for far and intermediate vision
and reasonably good near vision with minimal
Lenses that use a pinhole effect are actually small optical phenomena [4].
lenses design like the IC-8 (AcuFocus, Inc., Irvine,
CA) and the KAMRA corneal inlay (Acu-Focus,
Inc.). These lenses are made with an embedded 1.2.3 Echelette Technology Lenses
opaque annular mask measuring 3.23 mm in total
diameter that blocks unfocused paracentral lightThis technic is actually used in the Symphony
lens and is based on a design that forms a step
rays while allowing paraxial light rays through its
structure whose modification of height, spacing,
1.36-mm central aperture. Actually, this creates a
pinhole effect that produces an elongated focal and profile of the echelette extends the depth of
range resulting in an extended and continuous focus. These designs in combination with achro-
range of functional vision. matic technology and negative spherical aberra-
The “pinhole lenses“like the IC-8 model tion correction improve simulated retinal image
may be suitable for post-refractive presbyopia, quality without compromising depth of field or
irregular corneas, and monofocal pseudophakic tolerance to decentration [5].
patients. The first intraocular lens that was approved by
the FDA was the TECNIS Symphony IOL (Abbott
Medical Optics, Inc. of Santa Ana, California).
1.2.2 Bioanalogic Intraocular This is a biconvex wavefront-designed anterior
Lenses aspheric surface and a posterior achromatic dif-
fractive surface with an echelette design. The
These lenses use different materials that mimic lens creates an achromatic diffractive pattern that
the properties of the natural young crystalline elongates a single focal point and compensates
lens. Such is the Wichterle Intraocular Lens- for the chromatic aberration of the cornea.
1 Multifocal Intraocular Lenses: What Do They Offer Today? 5
Overall, patients experience less glare and multifocality to all distances far intermediate and
halos with EDOF lenses; however, there is a need near is reachable and might be available to use in
of improving the near vision since the EDOF the near future.
lenses are good for far and intermediate range
and are less satisfactory for near-range vision. Compliance with Ethical Requirements Jorge L. Alió
One of the ways to compensate for the and Joseph Pikkel declare that they have no conflict of
interest. No human or animal studies were carried out by
decrease in near vision in patients with EDOF the authors for this article.
lenses is the mini-mono vision, or mix-and-
match strategies with diffractive low-add lenses
should be considered; however, using the mini- References
mono vision may cause decrease in far vision
and additional halos from the low myopia in the 1. Rosen E, Alió JL, Dick HB, Dell S, Slade S. Efficacy
contralateral eye [6]. and safety of multifocal intraocular lenses following
In any technique that is used to provide multi- cataract and refractive lens exchange: Metaanalysis of
peer-reviewed publications. J Cataract Refract Surg.
focality, the best visual result depends on patient 2016;42(2):310–28.
selection, accurate biometry, astigmatism correc- 2. Alió JL, Plaza-Puche AB, Fernandez-Buenaga R,
tion, and lens centration. These issues as well as Pikkel J, Maldonado M. Multifocal intraocular
others will be discussed in the next chapters of lenses: an overview on the technology, indications,
outcomes, complications and their management. Surv
this book; a pedantic preoperative approach is Ophthalmol. 2017;62(5):611–34.
necessary in order to succeed in multifocal intra- 3. Cochener B, Lafuma A, Khoshnood B, Courouve L,
ocular lenses implant and eventually causing the Berdeaux G. Comparison of outcomes with multifocal
patients to be happy [7]. intraocular lenses: a meta-analysis. Clin Ophthalmol.
2011;5:45–56.
Though, as said before, there is not a perfect 4. Studeny P, Krizova D, Urminsky J. Clinical experi-
solution yet for good vision in all distances, most ence with the WIOL-CF accommodative bioanalogic
of the patients who had a multifocal intraocular intraocular lens: Czech national observational regis-
lens implant are happy and satisfied with the out- try. Eur J Ophthalmol. 2016;26:230–5.
5. Pedrotti E, Bruni E, Bonacci E, Badalamenti R,
come. A recent meta-analysis of peer-reviewed Mastropasqua R, Marchini G. Comparative analysis
publications revealed evidence of high levels of of the clinical outcomes with a monofocal and an
patient’s satisfaction in general. The spectacle extended range of vision intraocular lens. J Refract
independence was 80% or more in 91.6% for Surg. 2016;32:436–42.
6. Cochener B, Concerto Study Group. Clinical out-
distance vision, 100% for intermediate vision, comes of a new extended range of vision intraocu-
and 70% for near vision in the different groups lar lens: international multi-center concerto study. J
studied. The binocular uncorrected vision of 0.30 Cataract Refract Surg. 2016;42:1268–75.
log MAR was achieved in 100% for distance 7. Salerno LC, Tiveron MC Jr, Alio JL. Multifocal
intraocular lenses: types, outcomes, complica-
visual acuity, 96% for intermediate visual acuity, tions and how to solve them. Taiwan J Ophthalmol.
and 97.3% for near visual acuity of the patients 2017;7(4):179–84.
included in the study [8, 9]. 8. Alio JL, Plaza-Puche AB, Javaloy J, Ayala MJ,
So as described multifocal intraocular lenses Moreno LJ, Piñero DP. Comparison of a new refrac-
tive multifocal intraocular lens with an inferior
do provide a good (not perfect) solution for segmental near add and a diffractive multifocal intra-
patients who want to be spectacles free after cata- ocular lens. Ophthalmology. 2012;119:555–63.
ract surgeries. More important is the fact that new 9. de Vries NE, Nuijts RM. Multifocal intraocu-
techniques and new approaches are constantly lar lenses in cataract surgery: literature review of
benefits and side effects. J Cataract Refract Surg.
invented giving us the feeling that the goal of 2013;39(2):268–78.
Part I
Historical Background and Clinical
Indications
Multifocal Intraocular Lenses:
Historical Perspective
2
Kenneth J. Hoffer and Giacomo Savini
2.1 Introduction left eye since she was 3 days PO with sutures still
in. She corrected to 20/20 OD and 20/25
Our patients teach us many things [1]. Often it is OS. Since so much of the pupil was aphakic, out
humility, but on rare occasions, their clinical situ- of curiosity, I then refracted each eye in an apha-
ation can spark an idea that leads to analytical kic refraction range of about +10 diopters (D)
thinking and a totally new concept. Such a patient and was astounded that she was also refractable
appeared in my office over three decades ago on to a 20/20 level with a full aphakic refraction. I
November 18, 1982 (Fig. 2.1). She was referred couldn’t understand how this was possible?
to me by a colleague, John Hofbauer MD, for the Then I questioned this 65-year-old educated
necessity of IOL removal due to bilateral IOL and intelligent lady regarding glare, halos, rings,
dislocation. She had received a Shearing style and areas of blurred vision and she denied having
Iolab Hoffer Ridge posterior chamber intraocular any of these symptoms. I was astounded at how
lens (IOL) in each eye, and the implants had each unaffected she was by the dislocated lenses. I told
decentered so that one covered only 50% of the her that her eyes were perfect and sent her on her
pupil OD (right eye) and the other only one-third way. I told the referring surgeon that no interven-
of the pupil OS (left eye) (see hand-drawn dia- tion was necessary at least at this time.
grams in Fig. 2.1). In those days it was more dif-
ficult to get both stiff loops of the shearing lens in
the bag resulting in one loop out of the bag caus- 2.2 Inception of the Concept
ing decentration. I was evaluating her situation to
determine whether one or both of these IOLs That evening while enjoying a Guinness at Ye
should be removed. Olde King’s Head in Santa Monica with col-
After personally refracting each eye at dis- leagues, this lady’s remarkable condition kept
tance and near, there was a high cylinder in the haunting me. How could her distance vision be
20/20 with and without aphakic correction while
she was receiving only 50% of the IOL refracted
K. J. Hoffer (*) light (only 33% in the other eye) without aphakic
Stein Eye Institute, University of California, refractive aid and 20/20 while receiving 50%
Los Angeles, CA, USA
(66% in the other eye) of non-IOL refracted light.
St. Mary’s Eye Center, Santa Monica, CA, USA I analyzed the situation making the assumption
e-mail: [email protected]
that light was entering her pupils and being
G. Savini refracted by two different “lenses”
Studio Oculistico d’Azeglio, Bologna, Italy
this possibility if the concept had patent protec- theorized that the reason the bifocal IOL might
tion prior to their spending time and money on a work in a posterior chamber IOL better than it
new lens design. does in a contact lens was because the former is
fixed and stationary and, more importantly, that it
is located at the eye’s nodal point rather than on
2.3 Intellectual Property the front of the eye. I also considered and sketched
Protection as many possible configurations and combination
of ways to include more than one optical power
I organized my thoughts and wrote down my con- in the pupil (Fig. 2.4). Besides the simple Split
cept of multifocality for IOLs with the retina- Bifocal, one of the possibilities was a central bul-
brain selectivity of clearest image and submitted let for near or distance with the surrounding optic
it to my patent attorney Mr. Howard Silber on for the opposite. I didn’t feel this had much hope
May 3, 1983 (Fig. 2.3a, b). In the document I of success because of its dependence on pupil
location and size and the possibility of IOL
a decentration. With this design I couldn’t decide
whether to make the center bullet for near for
accommodative pupil constriction or distance
correction for outdoor light pupil constriction. A
trifocal triangular configuration was proposed
whereby one 33% segment was for distance, the
second for near, and the third for intermediate.
Annular rings of alternating powers were consid-
ered which, of course, could be a diffractive lens.
Other geometric shapes were considered but
most of them could be affected by IOL decentra-
tion. The patent was then applied for with all
b these ideas.
I decided to proceed experimentally with my
original concept of a simplistic Split Bifocal with
a diameter line through the optical center. With
this design the retina would always receive an
equal amount of light (50%) for both distance
and near, never compromising one over the other
regardless of the pupil size, accommodation, or
lighting conditions. In the patent application, I
specifically stipulated that the bifocal line be par-
allel to the axis of the loops. This was because the
primary cause of posterior chamber IOL decen-
Fig. 2.3 (a) Attorney work sheet for patent application
tration (one loop out of the bag, one loop crimped)
dated May 11, 1983. (b) First page of multifocal patent
application #1365 would cause the lens to decenter in the axis of the
Fig. 2.4 Diagrams of possible configurations for multifocal lenses submitted in the patent application: L-R split bifo-
cal, bullet bifocal, triangulate trifocal, and multiple rings
12 K. J. Hoffer and G. Savini
loops. Any minor to moderate decentration would to do this. I knew Mr. La Haye very well because
still maintain the bifocal line through the center of his willingness to sponsor the Welcome
of the pupil. On the other hand, if the bifocal line Reception at the Annual Meetings of the
was perpendicular to the axis of the loops, even a American Intra-Ocular Implant Society (now
minor decentration would shift one of the focal ASCRS) for which I was the Chairman. Mr. La
zones entirely out of the pupil leading to either a Haye had sold Iolab to Johnson & Johnson in
monofocal lens for distance or one for near. One 1980 but he was still in charge of the company for
unanswered question remained. Would the several years afterward. He told me it would be
patient notice the effect of the “line” through the extremely expensive to fabricate an injection
center of the visual axis? This could only be mold for this so I asked him to slice in half an 18
answered by patient clinical trials. I never imag- D and a 21 D IOL and then glue the opposite
ined in 1982 that it would take eight more years halves together. He promised me he would have
for me to accomplish it. it done in the company’s R&D department. I
recently learned for the first time (11/20/13) from
personal communication with Randall J. Olson
2.4 aking the First Split
M MD (Chair, Department of Ophthalmology and
Bifocal IOL Visual Sciences, John A. Moran Eye Center, Salt
Lake City, UT) that he clearly recalls Mr. La
With the legal protection the manufacturers Haye calling him in that year for advice as to
would need in the works, I proceeded to present whether to proceed with such a “wild idea.” Dr.
my idea to Mr. Peter La Haye (Fig. 2.5), the Olsen remembers telling him that he had no idea
President and CEO of Iolab Corporation (now whether it would work but that the only way it
Bausch & Lomb). Their IOLs were injection could be tested is to implant one in a patient’s
molded and I thought it might be easier for them eye. Perhaps if his advice were otherwise, La
Haye might not have proceeded.
After several months, Iolab finally produced
10 samples for me to look at under the slit lamp
(Fig. 2.6). Note in the figures that the split line is
in the axis of the loops. Also the “circle” that
appears in the center of the optic (Fig. 2.6a) is a
drop of water on the back of the lens sitting on a
flat surface and the peripheral curve of the water
meniscus can be seen as different in the two seg-
ments reflecting the different radius of curvature
of each segment. The lenses looked pretty good
but I was told categorically that these lenses
could not be implanted in a human patient since
it would need protocols and FDA submission.
Also the lenses were not clean or sterilized for
implantation. Not long after that, Mr. La Haye
was scheduled to leave the company as is often
the case in these buyouts and he no longer had
any influence over it anymore. This was not good
for me. I was soon to learn the corporate structure
at Johnson & Johnson was far different from that
of Iolab.
Fig. 2.5 Mr. Peter La Haye, Founder and President of Those now in charge of such things at Iolab
Iolab Corporation (circa 1990) promised me it would be under consideration by
2 Multifocal Intraocular Lenses: Historical Perspective 13
a b
Fig. 2.6 Photographs of Hoffer Split Bifocal IOL made ent peripheral curvature due to the different radius of cur-
by Iolab in 1983 in their R&D department. (a) Note the vature of each half of the optic. Note the bifocal line is in
water meniscus at the back of the IOL (b) shows a differ- the axis of the loops and the lens has a Hoffer Laser Ridge
a committee, and so I waited many, many months. They did make some for me, but I could not find
I was told I had to be patient. After a year, I finally any specimens or photographs of these lenses.
pressured them for an answer I really didn’t want Delays by Cilco in further progress were similar
to hear. I was told they could not proceed with the to those by Iolab. I had also gone to Precision-
Hoffer Split Bifocal because funds and efforts Cosmet and most all IOL manufacturers includ-
were needed for other more important IOL devel- ing my friend William Link at AMO but they all
opment projects. I later learned that the main just turned me down completely. Things were at
project that took precedence over the bifocal was a standstill. I had a handful of bifocal IOLs but no
“partial depth holes.” For those too young to way to implant them.
remember, all IOLs had a series of two or four
peripheral through and through holes in the optic
to ease manipulating it in the eye with a hook. It 2.5 he First Bifocal IOL
T
was becoming evident that these holes were lead- Implantation
ing to glare and haloes especially with decentered
lenses. They were hoping to eliminate the prob- Then came the surprising day in 1986 when I
lem with holes that did not go completely through read a story in one of the throwaway ophthalmic
the optic. Eventually all positioning holes were newspapers that John Pierce MD had implanted
eliminated from all IOLs, so this was a real bifocal IOLs for the first time in England. The
wasted opportunity on their part. Because of my lenses were manufactured by Precision-Cosmet.
frustration and persistence, they told me that if I My initial reaction was ecstatic since I would
was that eager to do it I should take the lenses finally find out whether my theory of brain sup-
they had made for me and go to Mexico and pression was real. On the other hand, I was some-
implant them. I rejected that idea because I would what exasperated with Iolab and Cilco in that
not be able to explain to the patient appropriately they could have pioneered this in the USA 3 years
what the experiment was (informed consent) or earlier and FDA studies would have been nearing
carefully interrogate a postoperative patient in completion by then. What is most amazing is that
Spanish. I would also need to monitor the patient both companies had gained tremendous success
on a continual basis and was not planning to with their Hoffer Ridge lenses and you might
move to Mexico. I spent another 6 months plead- think they would consider that the inventor might
ing with them but it was to no avail. I then went also invent another reasonable idea.
to Cilco (now Alcon Surgical), who also pro- I was sorry to hear that the central near bullet
duced several prototypes in their R&D divisions (Fig. 2.7) concept was the design chosen to be
by lathe cutting rather than injection molding. implanted because of the inherent problems I
14 K. J. Hoffer and G. Savini
b
D
c d
predicted above. Soon thereafter, Johnson & degeneration? On the other hand, it is not subject
Johnson (Iolab) purchased Precision-Cosmet and to the vagaries of pupil size, position, or IOL
ironically inherited the mantle of the first bifocal decentration. All the other designs can be com-
IOL manufacturer. They ceased communicating promised by the pupil or IOL decentration and in
with me in any way after this. Not long after, 3 M the percentages of light available for each desired
presented a diffractive bifocal meniscus lens image position.
(Fig. 2.8) followed by several manufacturers try- My patent application was ultimately turned
ing variations on the bullet and annular ring down by the US Patent Office. They based their
themes (see below). The data looked promising at rejection on prior art based on an abandoned
that time but there were definite problems and bifocal contact lens patent application by Jack
compromises associated with all the various Hartstein MD of Missouri several years earlier. In
designs. I was pleased to see that my multifocal discussing a contact lens manufacturing process,
concept did seem to work. he mentioned “this could also be done with IOLs”
The diffractive bifocal causes a complete loss which had nothing to do with a bifocal IOL No
of almost 20% of the incoming light through the matter how much we protested their incorrect
pupil leaving about 40% of the light for distance reasoning, it was rejected. The cost to fight this
and 40% for near. Is this enough in contrast- was estimated at $200,000 ($486,720.63 in
compromised eyes such as those with macular 2019). Things again were not going so well.
2 Multifocal Intraocular Lenses: Historical Perspective 15
d
D
Near Distance
Phase delays at steps
are not 1 wavelength
16 K. J. Hoffer and G. Savini
a b
Fig. 2.10 (a) Clinical photograph of the first implanted same day. Note that even under high power, there is no
Hoffer Split Bifocal dated October 18, 1990, labeled “PO bifocal line visible in this photo. It is obviously not visible
1 week OD” (Clannin.) (b) Another photograph taken the when photographed in aqueous
2 Multifocal Intraocular Lenses: Historical Perspective 17
November 7, 1990, I implanted the second one Bifocal”. Both lenses were a Shearing posterior
(Fig. 2.11a) in the right eye of 71-year-old Jessica chamber lens with a Hoffer Ridge: 18.0 D dis-
Antonucci (since deceased). The operations tance power and 21.0 D near power. [Those pow-
records from the operating room document the ers I chose before I ever did the calculations.] To
names and dates of the implants (Fig. 2.12) show- my great joy, both patients were able to see
ing implantations of IOLs labeled “Hoffer #002 clearly at distance with a mild over-refraction
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By the marriage of Ann Mortimer, sister of the Earl of March, with
Richard de Conysburgh, Earl of Cambridge, the manor fell to the
house of York, for their son, Richard Plantagenet, Duke of York,
succeeded them; and in 11 Henry VI., the King granted to Richard,
Duke of York, livery of Weymouth, and all the castles, manors, lands,
etc., which Ann, late wife of Edmund, Comes Marchiæ, held in dower
of the inheritance of the Duke.
The town is mentioned by Leland (1538), Coker (1630 circa), and
Camden. The first-named writes:
The Tounlet of Waymouth lyith strait agayn Milton
(Melcombe) on the other side of the haven, and at this
place, the Trajectus is by a bote and a rope, bent over the
haven, so that yn the fery-bote they use no ores.
In another part of the Itinerary we read:
Waiymouth Town rite agen Milton, on the other side of
the Haven yt is bigger than Miltoun ys now. The Est South
Est point of the Haven of Waymouth ys caulid St. Aldelm’s
point, being a litl foreland. Ther ys a Chapelle by on the
Hille. The Paroch Chirch ys a mile of—a Kay for shippes in
the town—the Haven Mouth almost at hand. Half a mile
and more to the New Castelle—an open Barbecane to the
Castelle. Weimouth is counted 20 miles from Pole.
Camden states that in the reign of Edward III., the King got
together a powerful army and fleet for the purpose of invading
France, and the town provided twenty ships and 264 mariners for the
siege of Calais; but these figures are disputed by Hackluit, who says
there were but fifteen ships and 263 mariners. In March, 1347, the
bailiffs of Weymouth seized all the goods, chattels, jewels, and
armour of Geoffry, Earl of Harcautly, who had joined the army of the
French King. In 1377 the town suffered considerably from the fleet of
Charles V., when great portions of the ports of Dartmouth, Plymouth,
Portsmouth, Hastings, and Weymouth were destroyed.
The next event of importance was the landing here, on April 14th,
1471, of Margaret of Anjou, the consort of Henry VI., on her return
from France with her son, Prince Edward.
So the tide of history swept on, with periodical ravages from
pirates and enemies, until the appearance off the harbour of a large
foreign fleet of eighty sail, which had voyaged from Middleburg on
January 10th, 1505, to escort Philip and Johanna to their Kingdom of
Castile; but a violent hurricane caused the ships to run to Weymouth
for shelter. The inhabitants, being unaware of the quality of their
visitors, and alarmed at so formidable an array of vessels, speedily
armed themselves, and sent word to Sir Thomas Trenchard, at
Wolfeton, who, with Sir John Carew, marched into the town at the
head of some hastily improvised troops. On the rank of the visitors
becoming known, Sir Thomas invited them to his house at Wolfeton
until he could advise the King, Henry VII., of the fortuitous
circumstance. As soon as Henry had notice of the arrival of these
royal visitors, he despatched the Earl of Arundel with a troop of 300
horse, carrying torches, to escort them to London.
There is much in the minor history of the town that one would fain
linger over, but we must confine ourselves to those larger and more
far-reaching historical events with which the old life of Weymouth
was so closely bound up.
In 1544 the bailiffs of Weymouth received the following letter from
the King, Henry VIII.:—
(By the King.)
Henr. R.
Trustie and well beloved, we greate you well. And
whereas betweene us and the Emperor upon provocation
of manyfolde injuries committed by the Frenche Kyng unto
us both particularlie; And for his confederation wyth the
Turke, against ye whole commonwealthe of
Christendome. It ys agreede that eche of us aparte, in
person, with his puissant Armie in several parties this
soommer, shall invade the Realme of Fraunce; and beyng
not yet furneyshed as to our honour appertayneth:—
We have appoynted you to send us the nombre of xv
hable fotemen, well furneyshed for the warres as
appertayneth, whereof iii to bee archers, every oone
furneyshed with a goode bowe in a cace, with xxiii goode
arrows in a cace, a goode sworde, and a dagger, and the
rest to be billmen, havyng besydes theyre bill, a goode
sworde, and a dagger, to be levyed of your owne servants
and tenants.
And that you put the saide nombre in such a redyness,
furnished with coats and hosen of such colours as is
appointed for the battel of our Armey.
As they faile not within oone houres warnyng to march
forward to such place as shall be appoynted accordinglie:
—
Yeven under our Sygnete at our palace of Westmr., the
vth daie of June, the xxxv yere of our reigne.
Henr. R.
Weymouth had been created a borough in the reign of Edward II.,
at the time that his nephew, Gilbert of Clare, Earl of Gloucester, was
lord of the manor (one of whose sisters had married Piers Gaveston,
and the other sister was the wife of Hugh le Despencer); and
although the town is styled a “burg” in several documents relating to
previous reigns, it was not until the nineteenth year of the reign of
Edward II. that it returned a representative to Parliament.
The borough of Weymouth and the adjoining one of Melcombe
(which together now make up modern Weymouth) had long viewed
each other with jealous eyes; and so many complaints being made
through their respective members, the Parliament prepared a
charter, at the suggestion of Cecil, it is said, which was approved by
Queen Elizabeth in the thirteenth year of her reign, which united
these two discordant elements into one borough.
The merchants of the town, like all those of our southern ports,
played a zealous and active part in fitting out ships to fight the
Armada; and from a MS. in the Cottonian Library we learn that the
following vessels set out from Weymouth in 1588, with instructions to
guard the coast and seek out the Invincible Armada:—
Name. Tonnage. Master. Men.
The Gallion 100 Richard Miller 50
The Catherine 60 30
The Heath Hen 60 30
The Golden Lion 120 60
The Sutton 70 Hugh Preston 40
The Expedition 70 50
Sidney Heath
Notwithstanding that their largest vessel was only of 120 tons, the
Weymouth contingent captured two of the galleons and brought
them as prizes into the harbour. The only other vessels sent by the
county on this occasion were two from Lyme Regis—The Revenge,
of 60 tons, and The Jacob, of 90 tons—and four from Poole. In the
Guildhall there is a memorial of the event in the shape of a massive
iron-bound chest (see illustration), believed to have been brought
from one of the captured galleons; and many other relics are
scattered over the county, as at Bingham’s Melcombe, where there is
a magnificent oval dining-table, of massive form and marvellous
workmanship, with the crest of a Spanish grandee in the centre, the
whole mounted on a sea-chest in lieu of legs. Many Spanish coins
have been washed ashore on the Chesil Bank, and it is possible that
others of the ill-fated ships sank in the vicinity of Portland, or that the
dons threw their money and valuables overboard rather than let
them fall into the hands of their captors.
Little is recorded during the next fifty years, save the building of a
wooden bridge of seventeen arches to unite the two towns, in 1594;
and thirteen years later the town was visited by one of those great
plagues which periodically swept over mediæval England.
The outbreak of the Civil War in 1642 found the county fairly
evenly divided in support of the rival parties, and Corfe Castle
became the headquarters of the Royalist, and Bingham’s Melcombe
that of the Parliamentary forces. In 1643 the Earl of Carnarvon
seized and held for the King, Weymouth, Melcombe, and Portland,
and left them in charge of Prince Maurice, whose troops are said to
have pillaged and ravaged the district. The following year the Earl of
Essex defeated the Royalist troops, and took the town for the
Parliament, when he was assisted by a fleet under the Lord High
Admiral, the Earl of Warwick. The towns proved a rich prize for the
captors, as, in addition to much ammunition, etc., no less than sixty
ships fell into their hands. The troubles of the inhabitants, however,
were far from over, as in 1645 Sir Lewis Dyves received orders from
the King to make an attempt to re-capture Weymouth, which, with
the help of Sir W. Hastings, the Governor of Portland, he succeeded
in doing, and drove the defenders across the harbour into
Melcombe. On June 15th, 1644, the town surrendered to the
Parliamentary Commander, Sir William Balfour, the final overthrow
being largely due to the Earl of Warwick, who appeared off the
harbour with a large fleet, originally mobilised for the relief of Lyme
Regis. The spoils of war which fell into the hands of the captors
included 100 pieces of ordnance, 2,000 muskets, 150 cases of
pistols, 200 barrels of powder, and 1,000 swords, in addition to sixty
ships of various tonnage lying in the harbour. The losses sustained
by the combined towns in the Civil War amounted to £20,000, as a
certificate from the Justices, in the Parliamentary Roll, testifies. The
town to-day shows no trace of the fierce bombardments it
underwent, but a house in Maiden Street has a “bogus” memento in
the shape of a cannon ball foolishly inserted in the masonry some
decades since.
Sidney Heath
Sandsfoot Castle