State of Worlds Pharmacy
State of Worlds Pharmacy
State of Worlds Pharmacy
Stuart Anderson
London School of Hygiene and Tropical Medicine
Introduction
Today, therapeutic medicines are the cornerstone of much of health care throughout the world.
Indeed, they have been described as the ‘personal technology’ of our time (Davis, 1997). They play
a major part in the alleviation of suffering and the suppression of pain, and they offer the promise of
treatment or cure to millions of people. A vast global industry now exists to develop, produce and
market pharmaceuticals. There are, however, enormous variations between medicine use in
developed and developing countries. Whilst spending on pharmaceuticals represents less than ten
per cent of health spending in most developed countries, it represents between fifteen and thirty per
cent in transitional economies, and between twenty five and sixty six per cent in developing
countries (WHO, 2001a).
Responsibility for ensuring the safe, effective and rational use of medicines lies with pharmacists.
Pharmacists stand at the interface between the developer and producer of pharmaceuticals on the
one hand, and the consumer of their products on the other: they are society’s experts on medicines.
Pharmacy is the health profession concerned with therapeutic medicines. According to the 1968
Medicines Act, a therapeutic substance is ‘any substance or article (not being an instrument,
apparatus or appliance) administered to human beings or animals for a medicinal purpose’. Such a
purpose may include ‘the diagnosis, treatment or prevention of disease, and otherwise preventing or
interfering with the normal function of the body processes, either permanently or temporarily’. This
definition covers a broad range of items, including not only over the counter and prescription
medicines but also blood products and vitamins. It has recently been extended to include
homeopathic and herbal products.
The pharmacist’s involvement in therapeutic drugs extends from the initial development of new
chemical entities, their formulation into medicines, their testing, marketing and distribution, their
supply to patients, and ultimately to the monitoring of patients taking them.
Today, pharmacists practice in a situation of rapid development, where it is difficult for health
professionals to keep up with all the latest knowledge, where patients themselves increasingly go to
their doctor armed with information gleaned from the internet, and where the consequences of error
are increasingly great. Pharmacy, no less than medicine or nursing, is a profession in which lack of
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care can result in patient harm or death. This may result, for example, through failure to spot a
dosage error, or through the supply of the wrong drug (Barber, Smith and Anderson, 1994).
The developing clinical role of the pharmacist has been one of the most exciting and encouraging
developments in recent years. The pharmacist has shifted from a focus on the preparation and
supply of medicines to a focus on the sharing of pharmaceutical expertise and knowledge with
doctors, nurses and patients. This has placed greater emphasis on the clinical training of
pharmacists, and ensures that they make the greatest possible contribution to the rational use of
medicines. Developments in pharmaceutical care are occurring in both the hospital and community
settings. In some countries it is acknowledged that this responsibility is shared with other health
professionals, and the term ‘medicines management’ is preferred (Panton and Chapman, 1998).
Despite these developments, however, both pharmaceutical care and medicines management remain
largely aspirational in many parts of the world.
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their medicines in full, in part, or not at all. Countries differ widely as to who can own pharmacies.
Some allow corporate ownership, resulting in chains and multiples: some restrict pharmacy
ownership to pharmacists alone, and some allow individual pharmacists to own one pharmacy only.
Within these constraints the pharmacist’s contribution to health care in the community centres
around five broad themes (RPSGB, 1997). These are summarised in Table 1. In the management of
prescribed medicines, pharmacists work to help patients gain maximum benefit from their
medication, and are involved in every stage of the chain from drug development and manufacture to
providing medicines, information and support. In the management of long-term conditions, they not
only supply the medicines and support that patients need, but are increasingly involved in the
development of locally agreed shared care protocols, ensuring that patients use prescribed
medicines to best advantage, and helping them to improve the outcomes of treatment.
In the management of common ailments, pharmacists play a vital role in supporting responsible
self-medication, by giving people advice and re-assurance, supplying non-prescription medicines
when appropriate, and referring people to other health care professionals where necessary. In the
promotion and support of healthy lifestyles, they help people to maintain good health by providing
health screening, advice on healthy living, and other services. Pharmacists are now involved in a
range of such services, including blood pressure measurement, testing body fluids, cholesterol
testing, pregnancy testing, smoking cessation advice and diabetes guidance (RPSGB, 2001).
Finally, pharmacists contribute their expert knowledge of medicines and their use for the benefit of
other health care workers, including both doctors and nurses.
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clinical trials. The range of activities undertaken within hospital pharmacies in many countries is
illustrated in Table 2.
One of the most significant events in the development of hospital pharmacy has been the shift in the
location of practice, from within the confines of the pharmacy, to the ward or clinic setting.
Pharmacists began visiting wards to check prescription sheets, and to initiate supply, to avoid the
need for prescriptions having to be sent to the pharmacy, and hence not being available at all times
on the ward. As pharmacists became more involved on the wards, in advising doctors on what
might be prescribed, and helping nurses with problems in drug administration, this ‘ward pharmacy’
evolved into a more patient-orientated ‘clinical pharmacy’. Indeed, pharmacy in virtually all
developed countries has progressively shifted from product-orientation to patient-orientation.
Most countries now have agencies dealing with drug safety and control, including licensing and
regulation. These include the Food and Drugs Agency in the United States, the Medicines Control
Agency in Great Britain, and multi-national agencies such as the European Medicines Evaluation
Agency. All employ substantial numbers of pharmacists. Indeed, the pharmacy degree provides a
sound training in medical science, and pharmacists are to be found scattered across a wide range of
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less obvious activities. These include medical publishing, such as journal and newsletters, as well as
national formularies and pharmacopoeias.
In recent years the period of study has tended to become longer, and the competencies required for
registration have become more rigorous. In the United Kingdom there are currently sixteen schools
of pharmacy. These now offer a four-year undergraduate degree course leading to the Master of
Pharmacy degree. The pre-registration year is now highly structured, and at the end of it candidates
sit a pre-registration examination. In the United States a professional doctorate qualification, the
Pharm.D. programme, has become the norm, and this qualification is now being offered by a
number of institutions within Europe. American students also undertake a period of pre-registration
training, which in the institutional setting is known as a residency programme. This is usually a
one-year programme of formal education and training in all aspects of pharmacy practice.
In Germany federal law regulates the pharmacy curriculum, and any change needs to be agreed by
all sixteen federal states. However, clinical pharmacy and pharmacotherapy have recently entered
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the curriculum, and pharmacists are being encouraged to develop critical thinking and clinical
problem solving skills. The Scandinavian countries, including Norway, Sweden and Finland, offer
two pharmaceutical qualifications. The master of pharmacy degree takes from five to six years to
complete, and includes six months of practical experience in a pharmacy (Mason, 2000). The other
qualification is the bachelor of pharmacy degree, which takes three years to complete. In Norway
and Sweden this is the qualification of prescriptionists. Pharmacists with masters and bachelors
degrees have the same responsibilities in relation to the dispensing of prescriptions and the giving
of advice to patients and customers, but those with the bachelor’s degree cannot own and run a
pharmacy.
Many developing countries now have the capacity to train their own pharmacists (WHO, 1997)). In
Indonesia, for example, the pharmacy undergraduate course has recently been reduced from five to
four years duration (Tan and Aslam, 2000). The course is followed by a year’s pre-registration
training. The pharmacy curriculum is heavily biased towards pharmaceutics (the preparation of
appropriate dosage forms), pharmacognosy (the study of medicinal substances of natural origin),
and laboratory work. Pre-registration trainees have to attend lectures as well as gaining experience
in all spheres of pharmacy practice, including hospital, community, industry, and with the ministry
of health. Indonesian pharmacists therefore tend to have a wide knowledge of all areas of pharmacy
practice but insufficient experience of any one branch of practice. Pre-registration trainees then
have to complete both written and oral examinations. There are sixteen faculties of pharmacy in
Indonesia, of which eight are part of private universities. Pharmacy education is regulated by the
ministry of education.
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Post-graduate and Continuous Education
Most countries now provide opportunities for the post-graduate education of pharmacists, leading to
a variety of higher qualifications such as certificates, diplomas, and master’s courses in clinical and
community pharmacy, as well as professional doctorates. Other specialist qualifications are
available for pharmacists choosing a specific area of practice such as information management,
production and quality control.
Continuing professional development has become a feature of pharmacy practice in most countries.
In Great Britain the Royal Pharmaceutical Society expects its members to undertake at least thirty
hours of continuing professional development per year (RPSGB, 2001). A College of Pharmacy
Practice was established in 1981 to promote the highest professional standards in pharmacy. The
College exists ‘to promote professional and personal development through education, examination,
practice and research, benefiting patients and health care provision’ (CPP, 2001).
The cornerstone of the pharmacist’s professional status is educational attainment. Although there
remain considerable discrepancies between the educational attainment of pharmacists in different
countries, there is increasing mobility of pharmacists between them. There are, for example,
mobility agreements between the countries of the European Union, subject to competence in the
relevant language, although the actual number of pharmacists who have taken advantage of this
facility is so far low. Pharmacists who have qualified in other countries can apply for registration
with the Royal Pharmaceutical Society of Great Britain, for example, in order to work in the United
Kingdom. This usually involves attendance at a course lasting up to one year. There are also
reciprocal agreements operating between a number of countries, such as that between Great Britain,
Australia, New Zealand and Northern Ireland.
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Most countries now have written standards of practice for pharmacists, usually established by the
appropriate professional body. The Royal Pharmaceutical Society of Great Britain, for example,
issues such guidance to its members at regular intervals (RPSGB, 2001). Those who contravene
these standards may find themselves before the Statutory Committee, which has the power to
remove individuals from the Register of Pharmaceutical Chemists. Similar arrangements, including
registration and inspection of premises, exist in most other countries, although the extent to which
they are enforced is variable. Problems of enforcement tend to be greater in developing countries.
Less than one in three developing countries have fully functioning drug regulatory authorities, and
between ten and twenty per cent of sampled drugs fail quality control tests (WHO, 2001a).
WHO has also played an important part in emphasising the importance of pharmacy education,
ensuring that it is designed to equip pharmacists for their future roles in both hospital and
community settings. Their document on Good Pharmacy Practice (WHO, 1996) emphasised the
need for training of pharmacists in health promotion, disease prevention, the supply and use of
prescribed medicines, and skills in influencing prescribing and promoting the rational use of
medicines. WHO has been keen to emphasise that the potential contribution of pharmacists extends
far beyond simply the supply of medicines, to all levels of planning and provision of services.
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Pharmacy Practice in Europe
In their detailed review of the role and function of both community and hospital pharmacists in the
health care systems of Europe, Lunde and Dukes (1989) found large variations in both. In the
decade since, pharmacy practice in Europe has undergone rapid change. Current information about
the state of the pharmacy profession in all fifty-one countries of the WHO European Region is
available at the European Observatory on Health Care Systems (WHO, 2001b). The key drivers of
change have been commercial pressures, government policy, and therapeutic advances (van Mil,
2001). Governments are increasingly looking at ways of controlling the costs of medicines, and of
passing these onto the consumer. In the United Kingdom, foe example, several hundred medicines
have been deregulated from prescription-only status to pharmacy sale status in recent years. Patients
are now able to purchase for themselves items that were previously only available on a doctor’s
prescription. This policy has been repeated in most European countries. Its impact on the practice of
pharmacy has been substantial: patients are increasingly seeking advice from the pharmacist about
medical conditions where previously they would have visited the doctor.
The implementation of competition directives has also had an impact. In the UK, resale price
maintenance (which meant that medicines available without prescription had to be sold at the same
price through all outlets) has ended, with the result that many pharmacy chains and supermarkets
now offer ‘three for the price of two’ and related offers. Together with the fact that many general
sales list medicines can be sold through any retail outlet, this imposes a financial strain on small
independent pharmacies, and it is likely that the numbers of these will diminish. Other countries are
moving in a similar direction. From October 2001 a selected list of 250 medicines became available
in Denmark from a number of retail outlets, including petrol stations. Pharmacists in Germany are
fortunate in having a near monopoly in relation to the supply of medicines. Only three per cent of
medicine turnover is outside of pharmacies, and there are no dispensing doctors. However,
Germany operates a strict one-pharmacy one-pharmacist owner rule, so multiples are unlikely to
become established in the foreseeable future (Mason, 1999).
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from vending machines, by mail order, and from service stations. As in most countries, drugs such
as narcotics are controlled more stringently than others. Unlike some others, such as the UK, there
is no category of pharmacy only medicines, which can only be sold through registered pharmacies.
Nevertheless, US independent pharmacies continue to thrive.
Pharmacy is practised differently in every state of North America, reflecting different social,
political and economic characteristics, as well as differences in customs and traditions. There are
substantial differences in both regulation and efficiency, but there remains a firm commitment to
development of the role. Independent pharmacies on both sides of the Atlantic face similar
problems. Both find it hard to obtain payment for providing care rather than products, and both face
intense retail competition. Both face increasing costs and lower margins, making them less
profitable than other retail businesses. The challenge for all pharmacists is to meet the ever-
increasing expectations of the public everywhere, and to demonstrate a significant added value to
medicine usage.
From Table 6 it can be seen that least developed countries rarely have more than one or two
registered pharmacists per 100,000 population. However, these figures need to be treated with some
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caution. Firstly, the figures are taken from registration lists, and give no indication of the actual
number of practising pharmacists. Secondly, the numbers of pharmacists is no indication of the
numbers or distribution of pharmacies. Thirdly, in some countries pharmaceutical expertise is
substantially supported by pharmacists from other countries. The Gambia, for example, has recently
had the services of six Nigerian pharmacists providing technical support. Fifthly, the contribution
that pharmacists can make is largely determined by the availability of pharmaceuticals, and where
these are not available, for whatever reason, the need for pharmacists is reduced. Finally, many
countries make substantial use of traditional remedies, and have large numbers of traditional healers
involved with the making and supply of medicines. These are not of course reflected in figures for
numbers of registered pharmacists.
Poor people spend a higher proportion of their income on drugs than do other groups. In promoting
rational drug use by giving appropriate advice, pharmacists are able to reduce purchases of
unnecessary and inappropriate products. There has however, been criticism in the past of
pharmacists and their staff, both trained and untrained, for selling pharmaceuticals without
questioning or advising clients on the suitability of particular products. There is still some way to go
before the practice of the best becomes the practice of the majority.
Conclusions
Pharmacists are society’s experts on medicines. This paper has described some of the many
medicines-related activities with which pharmacists are involved. It has highlighted some of the
areas of divergence of pharmacy education and practice around the world, but has also
demonstrated the increasing convergence of pharmacy practice, education and training around the
rational use of drugs, medicines management and pharmaceutical care.
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Pharmacists have long occupied an indeterminate terrain in health and welfare, falling somewhere
between business and professionalism, and between professional care and lay care (Anderson and
Berridge, 2000) and this tension between business and profession continues today. The exact
location of pharmacists in the health care system continues to change, and varies from country to
country. In some they act as ‘gatekeepers’ to primary care: in others they are increasingly taking on
roles previously undertaken by general medical practitioners.
Patients in many countries are today exhorted to ‘ask the pharmacist’ in relation to a whole host of
minor conditions. In some countries medicines which were formerly available only on prescription
are now available from local pharmacies. This gradual transfer of responsibility for the prescribing
as well as the supply of medicines continues, and pharmacists are increasingly being given
prescribing rights in their own right. At the beginning of the twenty- first century the profession of
pharmacy faces many challenges, but there are also many opportunities. This paper has
demonstrated that pharmacy around the world is well placed to take them.
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Table 1: Range of Services and Activities; Community Pharmacy
Service Activity
The management of Many patients seek advice from pharmacists on how to take or
long-term conditions: use their medicine, and on avoiding unwanted side effects
The management of Many people make use of pharmacists for a wide variety of
common ailments: healthcare advice and help, as pharmacies are usually conveniently
located and pharmacists can usually be seen without an appointment.
The promotion and Both well and ill people visit pharmacies, so pharmacists are
support of healthy lifestyles: well placed to offer health information and advice, and to refer people
to specialist support and help when needed
Advice and support for other Pharmacists provide medicines information and advice to a wide
healthcare professionals: range of health care personnel
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Table 2: Areas of Specialist Practice; Hospital Pharmacy
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Table 3: Areas of Activity; Industrial Pharmacists
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Table 4: The Pharmacists’ Education; Core Pharmaceutical Subjects
Subject Description
Social and administrative pharmacy Study of the social, political and economic
aspects of the use of medicines
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Table 5: Number of Registered Pharmacists per 100,000 Population for
25 Higher Income Countries
Country number of population pharmacists
registered (000) per 100,000
pharmacists population
Sources: All population figures are from ‘World Population Prospects: The 2000 Revision’, United Nations
Population Division (2001). Figures for numbers of pharmacists or ratio of pharmacists to population are
taken from the OECD Data Base (2001); ‘The Compendium of Health Statistics’, thirteenth edition (2001),
Office of Health Economics; the WHO Europe ‘Health for All’ Data Base (2001); or from the registration
authorities of specific countries. Some figures relate to 1999.
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Table 6: Number of Registered Pharmacists per 100,000 Population
for 25 Middle and Lower Income Countries
Country number of population pharmacists
registered (000) per 100,000
pharmacists population
Sources: All population figures are from ‘World Population Prospects: The 2000 Revision’, United Nations Population
Division (2001). Figures for numbers of pharmacists or ratio of pharmacists to population are taken from the OECD
Data Base (2001); ‘The Compendium of Health Statistics’, thirteenth edition (2001), Office of Health Economics; the
WHO Europe ‘Health for All’ Data Base (2001); or from the registration authorities of specific countries. Some figures
relate to 1999.
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