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Best of Five MCQs for the Acute Medicine SCE
Best of Five MCQs
for the Acute Medicine SCE
Edited by
Nigel Lane
Consultant in Acute Medicine, North Bristol NHS Trust, UK
Louise Powter
Consultant in Acute Medicine, North Bristol NHS Trust, UK
Sam Patel
Consultant in Acute Medicine and Rheumatology,
Clinical Director, Medicine, North Bristol NHS Trust
Training Programme Director, General (Internal) Medicine, Severn Deanery, UK
1
1
Great Clarendon Street, Oxford, OX2 6DP,
United Kingdom
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First Edition published in 2016
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ISBN 978–0–19–968026–9
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CONTENTS
Abbreviations viii
Contributors xv
Introduction xvii
2 Gastroenterology
Questions 27
Answers 42
3 Respiratory
Questions 59
Answers 78
4 Cardiology
Questions 93
Answers 111
9 Musculoskeletal medicine
Questions 249
Answers 269
11 Haematology
Questions 301
Answers 306
15 Dermatology
Questions 395
Answers 400
Contents vii
16 Psychiatry
Questions 403
Answers 410
CF cystic fibrosis
CHM Commission on Human Medicines
CI-AKI contrast-induced acute kidney injury
CINV chemotherapy-induced nausea and vomiting
CIS clinically isolated syndrome
CJD Creutzfeldt-Jakob disease
CMAP compound muscle action potential
CMT core medical training (in the UK)
CMV cytomegalovirus
CNS central nervous system
COMT catecol-O-methyl transferase
COPD chronic obstructive pulmonary disease
CPC cerebral performance category
CRP C-reactive protein
CSII continuous subcutaneous insulin infusions
CTPA computed tomography pulmonary angiogram
CVID common variable immunodeficiency
CVP central venous pressure
CYP450 cytochrome P450
DESMOND Diabetes Education and Self Management for Ongoing and Newly Diagnosed
DEXA dual-energy X-ray absorptiometry
DIC disseminated intravascular coagulation
DIOS distal intestinal obstruction syndrome
DKA diabetic ketoacidosis
DSs dissociative seizures
DTs delirium tremens
DVLA Driver and Vehicle Licensing Agency
DVT deep vein thrombosis
EBV Epstein–Barr virus
ECG electrocardiogram
EGDT early goal-directed therapy
EGPA eosinophilic granulomatosis with polyangiitis (formerly known as Churg Strauss
Syndrome)
EMG electromyogram
EMR endomucosal resection
ENT ear, nose and throat
EPA Enduring Power of Attorney
ERCP endoscopic retrograde cholangiopancreatography
ESC European Society of Cardiology
ESR erythrocyte sedimentation rate
EULAR European League Against Rheumatism
x Abbreviations
Helen Alexander Consultant in General and Old Age Medicine, Gloucestershire Hospitals NHS
Foundation Trust, UK
Louise Beckham Specialty Registrar, Acute Medicine, Severn Deanery, UK
David de Berker Consultant Dermatologist, University Hospitals Bristol NHS Foundation Trust, UK
Begoña Bovill Consultant in Infectious Diseases and HIV, North Bristol NHS Trust, UK
Jeremy Braybrooke Consultant Medical Oncologist, University Hospitals Bristol NHS Founda-
tion Trust, UK
Andrew De Burgh-Thomas Consultant in Genito-urinary medicine and HIV, Gloucestershire
Hospitals NHS Foundation Trust, UK
Charlie Comins Consultant Clinical Oncologist, University Hospitals Bristol NHS Foundation
Trust, UK
Nerys Conway Speciality Registrar, Acute Medicine, Severn Deanery, UK
Ihab Diab Consultant Cardiologist, University Hospitals Bristol NHS Foundation Trust and
Weston Area NHS Trust, UK
Michelle Dharmasiri Consultant Stroke Physician, The Royal Bournemouth and Christchurch
Hospitals NHS Foundation Trust, UK
Sara Drinkwater Consultant Immunologist, Central Manchester University Hospitals NHS Foun-
dation Trust, UK
Tomaz Garcez Consultant Immunologist, Central Manchester University Hospitals NHS Founda-
tion Trust, UK
Matthew Hall Consultant Renal Physician, Nottingham University Hospitals NHS Trust, UK
Markus Hauser Consultant in Acute Medicine with an interest in Gastroenterology, Gloucester-
shire Hospitals NHS Foundation Trust, UK
Roland Jenkins Consultant in Respiratory Medicine, University Hospitals Bristol NHS Foundation
Trust, UK
Nigel Lane Consultant in Acute Medicine, North Bristol NHS Trust, UK
Rebecca Maxwell Consultant in Emergency Medicine, University Hospitals Bristol NHS Founda-
tion, Trust UK
Jim Moriarty Consultant Renal Physician, Gloucestershire Hospitals NHS Foundation Trust, UK
Fran Neuberger Specialty Registrar, Acute Medicine, Severn Deanery, UK
Anish Patel Consultant Liaison Psychiatrist, Avon and Wiltshire Mental Health Partnership NHS
Trust, UK
Sam Patel Consultant in Acute Medicine and Rheumatology, North Bristol NHS Trust, UK
xvi Contributors
The acute medicine specialty certificate examination (SCE) is the exit exam for acute medicine
higher specialty trainees in the UK, which needs to be passed before trainees are awarded a Cer-
tificate of Completion of Training. It should be taken towards the end of your registrar training. It
consists of two papers, each with 100 questions. The questions are in ‘best of five’ format. You are
given a question stem, which is usually a clinical scenario, and then five possible answers from which
you need to choose the most correct one. The exam is computer based, and questions can be
flagged for later review. For each paper you have three hours, giving you about 1 minute 45 seconds
per question plus 5 minutes for review. Both papers are done on the same day, with a break for
lunch.
Nigel and Louise have passed the SCE (in 2012 and 2011 respectively). When it came to revising,
it was clear there was a lack of appropriate revision material, hence the need for this book. The
book covers the acute internal medicine curriculum (2012) and at the end of each answer you are
given relevant additional reading—for instance, national guidelines—so you can easily find additional
information. The book is divided into chapters according to subject to make it easier to revise. Of
course, in the exam, the questions are random, so you don’t know that you are answering a ques-
tion about cardiology, for example. You can pick questions randomly from the book to more reflect
the exam if you choose.
All the questions and answers were correct at the time of writing. However, acute medicine is ever-
changing, which is what makes it so exciting, so very new guidance may not be included.
The editors had a lot of help in writing this book from a wide variety of specialists to ensure the
questions are accurate and up to date. The editors would like to thank all of the individual chapter
editors for their contribution, without which it would not have been possible.
We hope you find this book useful. All that remains is to say good luck!
6. A 55-year-old man was admitted to the acute medical unit with a four-
day history of increasing shortness of breath and cough productive of
green sputum. He was a smoker who took amlodipine for hypertension.
On examination his temperature was 35.8°C, pulse rate 85 beats per
minute, blood pressure 112/50 mmHg, and respiratory rate 26 breaths
per minute. Bronchial breath sounds were heard at the base of his right
lung. His capillary refill time was 4 seconds.
Investigations:
haemoglobin 143 g/L (130–180)
white cell count 13.9 × 109/L (4–11)
neutrophil count 10.1 × 109/L (1.5–7.0)
platelets 122 × 109/L (150–400)
serum sodium 144 mmol/L (137–144)
serum potassium 3.9 mmol/L (3.5–4.9)
serum urea 10.5 mmol/L (2.5–7.0)
serum creatinine 119 μmol/L (60–110)
arterial PO2 (air) 9.9 kPa (11.3–12.6)
arterial PCO2 4.5 kPa (4.7–6.0)
pH 7.33 (7.35–7.45)
lactate 3.3 mmol/L (0.5–1.6)
Which clinical syndrome does he have?
A. Acute kidney injury
B. Acute lung injury
C. Sepsis
D. Septic shock
E. Severe sepsis
4 CARDIORESPIRATORY ARREST AND SHOCK | QUESTIONS
8. A 60-year-old woman was admitted to the coronary care unit with acute
coronary syndrome for which she underwent percutaneous coronary
intervention. Her past medical history included type 2 diabetes mellitus,
hypertension, osteoarthritis, and a femoro-popliteal bypass six years
ago. She was taking metformin, ramipril, amlodipine, paracetamol,
codeine phosphate, and aspirin.
A urinary catheter was inserted during the procedure and over the next
12 hours she passed a total of 140 mL of urine.
On examination her pulse rate was 84 beats per minute, blood pressure
145/85 mmHg, jugular venous pressure 3 cm above the sternal notch,
respiratory rate 18 breaths per minute, and oxygen saturation 96%
on air. Auscultation of her chest revealed normal breath sounds with
occasional fine inspiratory crackles and heart sounds were dual with no
murmurs. There was no peripheral oedema and capillary refill time was
2 seconds.
A central venous catheter was inserted and the response to 250 mL of
0.9% saline was assessed:
Investigations:
Central venous pressure (mmHg):
Pre-treatment 5
Post-treatment 9
What is your action based on these results?
A. Insert arterial catheter
B. Repeat fluid challenge
C. Start dobutamine
D. Start furosemide
E. Take the central venous catheter out
6 CARDIORESPIRATORY ARREST AND SHOCK | QUESTIONS
Diastolic
Augmentation
Unassisted
Systole
Assisted Systole
Assisted Aortic
End Diastolic
Pressure
10. An 18-year-old woman was admitted to the acute medical unit after
having a generalized seizure. While on the ward, she continued to have
fits at least hourly despite treatment with lorazepam, phenytoin, and
levetiracetam. Between seizures her Glasgow Coma Score ranged from
9 (E2, V2, M5) to 13 (E3, V4, M6). Transfer to the intensive care unit via
the CT scanner was arranged.
Which one of the following would not be considered essential for safe
transfer of this patient?
A. Adrenaline (epinephrine)
B. Intravenous access
C. Intubation
D. Pulse oximetry
E. Self-inflating bag
11. A 73-year-old man had a cardiac arrest. The rhythm was pulseless
electrical activity. Cardiopulmonary resuscitation was started at a rate
of 30 chest compressions to 2 ventilations.
What is the correct rate of chest compressions?
A. 80–100 per minute
B. 90–110 per minute
C. 100–120 per minute
D. 110–130 per minute
E. 120–140 per minute
12. A 64-year-old man had a cardiac arrest. The initial rhythm was pulseless
electrical activity. During cardiopulmonary resuscitation the rhythm on
the monitor was noted to change to VF.
What is the correct course of action?
A. Continue cardiopulmonary resuscitation until the two-minute period is completed
B. Deliver a DC shock then continue chest compressions until the two-minute period is
completed
C. Stop chest compressions and assess the rhythm
D. Stop chest compressions and check for a pulse
E. Stop chest compressions and deliver a DC shock
8 CARDIORESPIRATORY ARREST AND SHOCK | QUESTIONS
Investigations:
Arterial blood gas analysis (15 litres per minute oxygen via
face mask):
pH 7.19 (7.35–7.45)
PO2 8.5 kPa (11.3–12.6)
PCO2 2.9 kPa (4.7–6.0)
base excess –10.4 mmol/L (±2)
lactate 5.0 mmol/L (0.5–1.6)
oxygen saturation 91% (94–98)
ECG showed sinus tachycardia.
The appropriate course of action is:
A. Focused echocardiography and thrombolysis if right ventricular dysfunction
B. Give low molecular weight heparin and arrange urgent coronary angiography
C. Measure D-dimer and troponin and start intravenous heparin
D. Start intravenous heparin and arrange urgent CT pulmonary angiography
E. Thrombolysis pending CT pulmonary angiography
CARDIORESPIRATORY ARREST AND SHOCK | QUESTIONS 9
“No one here except the Emperor knows if the Berlin and Milan
Decrees be absolutely revoked or not; and no one dares inquire of
him concerning them. The general opinion of those with whom I have
conversed on the subject is that they are revoked. There are indeed
among those who entertain this opinion several counsellors of State;
but this is of little importance, as the construction which the Emperor
may choose to adopt will alone prevail.”
The Emperor’s will was law. The Council set itself accordingly to
the task of “leaving the principles of the matter a little obscure” until
the United States should declare war against England; while the
Emperor, not without reason, assumed that America had recognized
the legality of his decrees.
CHAPTER XIX.
The Emperor’s decision was made known to the American
government by a letter[313] from Bassano to Russell, dated May 4,
1811, almost as curt as a declaration of war:—
“I hasten to announce to you that his Majesty the Emperor has
ordered his Minister of Finance to authorize the admission of the
American cargoes which had been provisionally placed in deposit on
their arrival in France. I have the honor to send you a list of the
vessels to which these cargoes belong; they will have to export their
value in national merchandise, of which two thirds will be in silks. I
have not lost a moment in communicating to you a measure perfectly
in accord with the sentiments of union and of friendship which exist
between the two Powers.”
This was all. No imperial decree of repeal was issued or
suggested. President Madison cared little for the released ships; he
cared only for the principle involved in the continued existence of the
decrees, and Bassano’s letter announced by silence, as distinctly as
it could have said in words, that the principle of the decrees was not
abandoned. Such were Napoleon’s orders; and in executing them
Bassano did not, like Cadore or Talleyrand, allow himself the license
of softening their bluntness. Russell knew the letter to be fatal to
any claim that the French decrees were withdrawn, but he could do
nothing else than send it to London as offering, perhaps, evidence of
the “actual relations growing out of the revocation of the Berlin and
Milan Decrees.”[314] He wrote to Bassano a letter asking the release
of the American vessels captured and brought into French ports as
prizes since November 1, but he obtained no answer.[315] A month
afterward he wrote again, remonstrating against the excessive tariff
duties and the requirement that American vessels should take two
thirds of their return cargoes in French silks; but this letter received
as little notice as the other. Russell had the mortification of knowing,
almost as well as Bassano himself, the motives that guided the
Emperor; and July 13 he recited them to the President in language
as strong as propriety allowed:[316]—
“The temper here toward us is professedly friendly, but
unfortunately it is not well proved to be so in practice. It is my
conviction, as I before wrote you, that the great object of the actual
policy is to entangle us in a war with England. They abstain therefore
from doing anything which would furnish clear and unequivocal
testimony of the revocation of their decrees, lest it should induce the
extinction of the British orders and thereby appease our irritation
against their enemy. Hence, of all the captured vessels since
November 1, the three which were liberated are precisely those which
had not violated the decrees. On the other hand, they take care, by
not executing these decrees against us, to divert our resentment from
themselves. I have very frankly told the Duke of Bassano that we are
not sufficiently dull to be deceived by this kind of management. He
indeed pretends that they are influenced by no such motive; and
whenever I speak to him on the subject, he reiterates the professions
of friendship, and promises to endeavor to obtain the release of the
remainder of our vessels captured since November 1. I fear, however,
that he will not succeed.”
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