Ed Harlow

Ed Harlow (born 1952) is an American molecular

biologist. Ed Harlow
Known for Retinoblastoma protein
Harlow received the Ph.D. degree from the Imperial Scientific career
Cancer Research Fund Laboratories in London.
Institutions Harvard Medical School
Harlow is professor of Biological Chemistry and
Molecular Pharmacology at Harvard Medical School.

He has been associate director of the Dana–Farber Cancer Institute as well as research director of the
Massachusetts General Hospital Cancer Center and the National Cancer Institute.

From 2009 to 2011 he was Chief Scientific Officer at Constellation Pharmaceuticals.

Among Harlow's discoveries was the demonstration that the retinoblastoma protein interacts with viral
transforming proteins, thereby linking tumor viruses with the cell cycle. He is also the author, with David
Lane, of "Using antibodies: a laboratory manual." (1999).[1]

Dr. Harlow has trained scientists in the field of molecular biology and oncology, including Nicholas
Dyson (Professor at Harvard Medical School and Scientific Director of the Massachusetts General
Hospital Cancer Center), Jacqueline Lees (Professor of Biology at MIT and associate director of the Koch
Institute), Joshua LaBaer (Virginia G. Piper Chair in Personalized Medicine at Arizona State University
and Director of the Biodesign Institute), Matthew Meyerson (Professor of Pathology at the Dana–Farber
Cancer Institute and Harvard Medical School and Senior Associate Member of the Broad Institute), Li-
Huei Tsai (Picower Professor of Neuroscience at MIT and Director of the Picower Center for Learning
and Memory), and Marc Vidal (Director of the Center for Cancer Systems Biology at the Dana–Farber
Cancer Institute).

Publications
Dyson, Nicholas, et al. "The human papilloma virus-16 E7 oncoprotein is able to bind to the
retinoblastoma gene product." Science 243.4893 (1989): 934–937.[2]
Whyte, Peter, et al. "Association between an oncogene and an anti-oncogene: the
adenovirus E1A proteins bind to the retinoblastoma gene product." (1988): 124–129.[3]
LaBaer, Joshua, et al. "New functional activities for the p21 family of CDK inhibitors." Genes
& development 11.7 (1997): 847–862.[4]
Buchkovich, Karen, Linda A. Duffy, and Ed Harlow. "The retinoblastoma protein is
phosphorylated during specific phases of the cell cycle." Cell 58.6 (1989): 1097–1105.[5]
van den Heuvel, Sander, and Ed Harlow. "Distinct roles for cyclin-dependent kinases in cell
cycle control." Science 262.5142 (1993): 2050–2054.[6]
Harlow, E. D., et al. "Monoclonal antibodies specific for simian virus 40 tumor antigens."
Journal of Virology 39.3 (1981): 861–869.[7]
 Tsai, Li-Huei, et al. "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase
5." (1994): 419–423.[8]
Meyerson, Matthew, et al. "A family of human cdc2-related protein kinases." The EMBO
Journal 11.8 (1992): 2909.[9]
Whyte, Peter, Nicola M. Williamson, and E. D. Harlow. "Cellular targets for transformation by
the adenovirus E1A proteins." cell 56.1 (1989): 67–75.[10]

Awards
National Academy of Sciences, Member[11]
Alfred P. Sloan, Jr. Prize[12]
American Academy of Arts and Sciences, Member[13]
Dickson Prize in Medicine[14]
National Academy of Medicine, Member
American Cancer Society, Medal of Honor[15]

References
1. Harlow, E (1998). Using antibodies: a laboratory manual. ISBN 0879695447.
2. Dyson, N (1989). "The human papilloma virus-16 E7 oncoprotein is able to bind to the
retinoblastoma gene product". Science. 243: 934–7. doi:10.1126/science.2537532 (https://d
oi.org/10.1126%2Fscience.2537532). PMID 2537532 (https://pubmed.ncbi.nlm.nih.gov/2537
532).
3. Whyte, P (1988). "Association between an oncogene and an anti-oncogene: the adenovirus
E1A proteins bind to the retinoblastoma gene product". Nature. 334: 124–9.
doi:10.1038/334124a0 (https://doi.org/10.1038%2F334124a0). PMID 2968522 (https://pubm
ed.ncbi.nlm.nih.gov/2968522).
4. LaBaer, J (1997). "New functional activities for the p21 family of CDK inhibitors" (https://doi.
org/10.1101%2Fgad.11.7.847). Genes Dev. 11: 847–62. doi:10.1101/gad.11.7.847 (https://d
oi.org/10.1101%2Fgad.11.7.847). PMID 9106657 (https://pubmed.ncbi.nlm.nih.gov/910665
7).
5. Buchkovich, K (1989). "The retinoblastoma protein is phosphorylated during specific phases
of the cell cycle". Cell. 58: 1097–105. doi:10.1016/0092-8674(89)90508-4 (https://doi.org/10.
1016%2F0092-8674%2889%2990508-4). PMID 2673543 (https://pubmed.ncbi.nlm.nih.gov/
2673543).
6. van den Heuvel, S (1993). "Distinct roles for cyclin-dependent kinases in cell cycle control".
Science. 262: 2050–4. doi:10.1126/science.8266103 (https://doi.org/10.1126%2Fscience.82
66103). PMID 8266103 (https://pubmed.ncbi.nlm.nih.gov/8266103).
7. Harlow, E (1981). "Monoclonal antibodies specific for simian virus 40 tumor antigens" (http
s://www.ncbi.nlm.nih.gov/pmc/articles/PMC171319). J Virol. 39: 861–9. PMC 171319 (http
s://www.ncbi.nlm.nih.gov/pmc/articles/PMC171319). PMID 6169844 (https://pubmed.ncbi.nl
m.nih.gov/6169844).
8. Tsai, L (1994). "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5".
Nature. 371: 419–23. doi:10.1038/371419a0 (https://doi.org/10.1038%2F371419a0).
PMID 8090221 (https://pubmed.ncbi.nlm.nih.gov/8090221).
 9. Meyerson, M (1992). "A family of human cdc2-related protein kinases" (https://www.ncbi.nl
m.nih.gov/pmc/articles/PMC556772). EMBO J. 11: 2909–17. doi:10.1002/j.1460-
2075.1992.tb05360.x (https://doi.org/10.1002%2Fj.1460-2075.1992.tb05360.x).
PMC 556772 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556772). PMID 1639063 (http
s://pubmed.ncbi.nlm.nih.gov/1639063).
10. Whyte, P (1989). "Cellular targets for transformation by the adenovirus E1A proteins". Cell.
56: 67–75. doi:10.1016/0092-8674(89)90984-7 (https://doi.org/10.1016%2F0092-8674%288
9%2990984-7). PMID 2521301 (https://pubmed.ncbi.nlm.nih.gov/2521301).
11. "Ed Harlow" (http://www.nasonline.org/member-directory/members/64201.html).
www.nasonline.org. Retrieved 2020-04-30.
12. "Four Researchers Garner Annual GM Foundation Prizes" (https://www.the-scientist.com/pr
ofession/four-researchers-garner-annual-gm-foundation-prizes-58422). The Scientist
Magazine®. Retrieved 2020-04-30.
13. "Edward Everett Harlow, Jr" (https://www.amacad.org/person/edward-everett-harlow-jr).
American Academy of Arts & Sciences. Retrieved 2020-04-30.
14. "Previous Winners of the Dickson Prize in Medicine | Dickson Prize in Medicine | University
of Pittsburgh" (http://www.dicksonprize.pitt.edu/recipients/). www.dicksonprize.pitt.edu.
Retrieved 2020-04-30.
15. "Advocate Lance Armstrong, Scientists Edward E. Harlow, Arnold J. Levine, and Marvin
Zelen to Receive American Cancer Society Highest Honor for Outstanding Contributions to
Cancer Fight - Nov 19, 2009" (http://pressroom.cancer.org/2009-11-19-Advocate-Lance-Arm
strong-Scientists-Edward-E-Harlow-Arnold-J-Levine-and-Marvin-Zelen-to-Receive-American
-Cancer-Society-Highest-Honor-for-Outstanding-Contributions-to-Cancer-Fight). American
Cancer Society MediaRoom. Retrieved 2020-04-30.

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