Basis Neurobiologi Depresi
Basis Neurobiologi Depresi
Basis Neurobiologi Depresi
Gangguan Mood
Oleh:
Dr. H. Jaya Mualimin,
SpKJ,Mkes.
Tumbuh-Kembang Otak
Gopnick et. al. (1999)hipotesis jaringan
kabel telepon
350 gr
1000 gr
2500
sinap/neur
on
15000
sinap/neur
on
1200-1400 gr
100 Milyar
neuron
Sinap ???
Transmisi
Impuls
saraf
Pembebasan
zat hantar saraf
Mekanisme-mekanisme neuroplastisitas
Prunning
Apoptosis
Sprouting
Collateral sprouting
Heterotypic
Homotypic
Seeman P. Brain development. Am J Psych
1999;156(2):168
Pathopsikologis Neuron
stressStressors(psychological, hormonal,
medication)
Ganggua
n mental
Genes
Multiple
susceptibility
alleles each of
small effect;
BDNF, Bcl-2,
diacylglycerolkina
seeta
Epigenetics
Gene and Protein
Expression,
e.g., BDNF levels
reduced during
depression,
mania,
Oxidative stress
Cells:
Multiple
glialand
neuronal
abnormalities;
mitochondrial
dysfunction
Systems:
Abnormal function and
information processing
In multiple, interacting
circuitsBipolarDisorder
s
Behavior:
Complex
interactions
affecting
emotional,
psychomotor,
cognitive,
visceromotor
function
First messenger:
Hipotesis
Celluler level:
neural survival >< apoptosis and mitochondrial dysfunction
BDNF (Brain-Derived Neurotrophic Factor) Bcl2 (B-cell Lymphoma)
NAA (N-Acetyl Aspartate)
myo-inositol
Neuroimmune:
cytokines (Interleukin, Tumor Necroting Factor,
Interferon)
Neurohormonal:
cortisol-estrogen-tyroid
DefisitKognitifpadaDepresiBipolar VS Unipolar
Fungsi
eksekutif
Memori
terimakasih