Case Report: Hepatitis B

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Division of Gastroenterology-hepatology

Department of Internal Medicine


Hasanuddin University Medical School

CASE REPORT
Hepatitis B

Division of Gastroenterology-hepatology | Department of Internal Medicine | Hasanuddin University Medical School


PATIENT IDENTITY

• Name : Mr. M

• Date of Birth : 31 – 08 – 2003

• Gender : Male

• Address : Makassar

• Medical Report Number : 876121


HISTORY
• Chief complaint : Easily fatigue

• Present illness : 15 year old boy come to the hospital for control
with complaints of fatigue. There was no fever, no seizures, no coughing,
no chest tightness and no jaundice. The child is lost of appetite, defecation
is normal and brown in color, urination is normal and yellow in color.
History of jaundice was approximately 2 months ago. Hospitalized and the
screening test with reactive HBsAg result and HBV-DNA 9,6x104.
Patient has a history of mothers with Hepatitis B positive since 2016.
PHYSICAL EXAMINATION

• General examination : patient is in moderate pain, conscious


and cooperative (GCS15). He is in good nutritional status and
his hydration status is adequate.
Wight: 50kg, Height: 164cm.
VITAL SIGN

• Temperature : 36,8°C

• Blood pressure : 90/60mmHg

• Pulse rate : 84 beats/minute (regular rhythm)

• Respiratory rate : 20 breaths/minute (vesicular)


HEAD

• Shape : Normocephal

• Face : Symmetrical left and right

• Deformity : None

• Hair : Difficult to removed


EYES
• Eksoftalmus/Enoptalmus : (-)
• Movement : Normal
• Eyelids : Edema (-)
• Conjungtiva : Anemis (-)
• Sclera : Jaundice (-)
• Cornea : Clean
• Pupil : Isokor
EARS

• Tophi : (-)

• Hearing : Normal
NOSE

• Bleeding : (-)

• Mucus : (-)
MOUTH
• Lip : Cyanosis (-), Dry (-)

• Tooth : Caries (-)

• Gum : Bleeding (-)

• Tonsils : T1-T1 hiperemis (-)

• Farings : Hiperemis (-)

• Tounge : Dirty (-)


NECK

• Lymph node : No lymphadenopathy

• Thyroid : No enlargement thyroid

• Blood vessel : Normal

• Stiff neck : (-)


THORAX

• Inspection : Symmetrical left and right

• Palpation : Right focal fremitus is the same as left

• Percussion : Sonor

• Auscultation : Vesicular, rhonchi (-), wheezing (-)


HEART

• Inspection : No ictus cordis

• Palpation : No thrill

• Percussion : Normal

• Auscultation : Reguler, no murmur


ABDOMEN

• Inspection : Flat

• Auscultation : Peristaltik (+), normal

• Palpation : Tenderness (-), massa (-), hepar and lien not


palpable

• Percussion : Tympany (+)


BACK

• Inspection : Symmetrical

• Palpation : Right focal fremitus is the same as left,


tenderness (-)

• Percussion : Sonor, flank pain (-)

• Auscultation : Vesicular, ronchi (-), wheezing (-)


EXTREMITY

• Edema (-)

• Clubbing finger (-)

• Warm hand and feet (+)


LABORATORIUM
KIDNEY FUNCTOIN NORMAL
Ureum 12 10-50mg/dL
Creatinine 0,60 <1,3mg/dL
LIVER FUNCTION
SGOT/AST 32 <38U/L
SGPT/ALT 28 <41U/L
IMMUNOSEROLOGY
Albumin 4,3 3,5-5,0gr/dL
HBeAg 0,01/Non Reactive <0,1 COI
Anti-HBe 0,02/Reactive >=0,5/Non Reactive COI

SUPPORTING EXAMINATION : Fibroscan 5,5 F0-F1


ASSESSMENT

Hepatitis B Virus Infection


PLANNING
Treatment Curliv syrup 5ml/24H/oral

Blood routine, SGOT/SGPT,


Examination plan Ureum, Creatinine, HBeAg,
Bilirubin total and direct
PROGNOSIS
Depending on the patient's condition at the time of arrival, the
presence or absence of complications and treatment
Discussion
Hepatitis B Virus

HBV : liver infection caused by the hepatitis B virus. HBV can cause and liver
infections. Incubation period: 75 days (around 30-180 days). The hepatitis B virus
can survive outside the body for at least 7 days. During this time, the virus can still
cause infection if it enters the body of a person who is not protected by the
vaccine. The virus may be detected within 30 to 60 days after infection and can
persist and develop into chronic hepatitis B.
HBV Transmission
Infected blood products : Spread by percutaneous
recipient of blood products, or mucosal exposure to
hemodialysis (HD) patients, various body fluids:
health worker, job exposure saliva, menstrual,
to blood vaginal, and seminal
fluids

Sexual transmission

Infected items such as


needles, razor blades,
dental or medical
equipments.
Serological Markers of HBV infection
Classification
Symptoms
Icteric phase :
• weight loss
• Sclera icteric
Konvalesens :
Acute HBV • Dark urin
• Hepatomegali (+)
physical examination :
• Abnormal liver
• Hepatomegaly
chemical examination
• tenderness in the
right quadrant area
above the abdomen

• Asymptomatic
• Acute HBV
symptoms
• liver cirrhosis
Laboratory

• HBV serological test/imunoserologi (serological markers of HBV)


• Liver biochemistry test (SGOT, SGPT, bilirubin, albumin, globumin,PT,
GGT, alkali fosfatase) ;
• USG, liver biopsy, Fibroscan
Diagnosis
Acute Hepatitis Infection :
• History of HBV infection
• HBsAg (-)
• Serum HBV DNA is not
detected
• ALT normal
Treatment
Peg-Interferon:
• Peg-IFN-2a: 180 ug/SC
• Peg-IFN-2b: 1.15 ug/KgBB/week.SC
Analog Nukleosida:
• Lamivudin: 100 mg/day.PO
• Telbivudin: 600 mg/day.PO
• Entecavir: 0.5-1 mg/day.PO
Analog Nukleotida:
• Adefovir: 10 mg/day.PO
• Tenofovir: 300 mg/day.PO
Thankyou

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