FASTA SEQUENCE DATABASE
ALDO LISI NAIL SPAHIJA KLEVIS XHYRA
Bio-Informatics is an upcoming field, comprising of application of Computer Science to Biological studyThe slides discusses the Search techniques used in FASTA
–
and
–
and
Example of FASTA database search
. The searching technique uses the Heuristicapproach for sequence alignment in FASTA.
INTRODUCTION
FASTA is a program for rapid alignment of pairs ofprotein and DNA sequences.Rather than comparing individual residues in the twosequences, FASTA instead looks for matching sequencepatterns or words, called k-tuples, and then attempts tobuild a local alignment based upon these word matches.Due to the relatively high speed and sensitivity of thealgorithm, FASTA is very useful.
FASTA
FASTA is comparable in algorithm and in reliability to BLAST but isconsiderably slower in speed.FASTA was found to be more sensitive at finding related proteinsequences than BLAST when using the blosum62 scoring matrixTwo studies have shown that both FASTA and BLAST are not as good atfinding protein families in sequence databases as exhaustive localhomology searches by dynamic programming.FASTA, BLAST and other searches may be performed on.The blocks database should be searched with test sequences to findproteins which share amino acid motifs with a test protein sequence.
FASTA vs BLAST