Prostaglandins, LT, TH
Prostaglandins, LT, TH
Prostaglandins, LT, TH
Thromboxanes
EICOSANOIDS
Eicosanoids are produced from arachidonic acid, a 20-carbon polyunsaturated
fatty acid (5,8,11,14-eicosatetraenoic acid).
Hormones localized to tissues where they are produced.
prostaglandins, thromboxanes and leukotrienes.
derived from arachidonic acid
arachidonic acid from linoleic acid an essential fatty acid
Physiological functions of eicosanoids.
Eicosanoids Functions
prostaglandins inflammation, fever production, prevent
platelet aggregation (prevent clotting);
induce labor
thromboxanes produced by platelets to promote their
aggregation (blood clotting)
leukotrienes allergic reactions
Eicosanoids:
The Arachidonic Acid Derivatives
COOH
Membrane lipid
Corticosteroids
Phospholipase A2 -
Arachidonic acid
Cycloxygenase
Lipoxygenase
- NSAIDs
Hydroperoxides Endoperoxides
5-Hydroperoxyeicosatetraenoic acid
(5-HPETE) (PGG, PGH)
• (2) Because PGs are present in high concentration in semen and can
be rapidly absorbed when lodged in the vagina at coitus, it is
believed that they so coordinate movements of the female genital
tract that transport of sperms and fertilization is facilitated.