Tablets are solid dosage forms consisting of active ingredients and excipients that may vary in size, shape, hardness, and other properties. They are classified as compressed or molded tablets based on the manufacturing method. Tablets offer large scale, low cost production and are easy for patients to use due to properties like precise dosing. However, some drugs are difficult to formulate into tablets. Tablet types include chewable, sublingual, effervescent, and implants. Excipients aid processing and protect the drug. Tablets are manufactured via wet or dry granulation and direct compression then may be film coated before ingestion and breakdown in the stomach and intestines.
Tablets are solid dosage forms consisting of active ingredients and excipients that may vary in size, shape, hardness, and other properties. They are classified as compressed or molded tablets based on the manufacturing method. Tablets offer large scale, low cost production and are easy for patients to use due to properties like precise dosing. However, some drugs are difficult to formulate into tablets. Tablet types include chewable, sublingual, effervescent, and implants. Excipients aid processing and protect the drug. Tablets are manufactured via wet or dry granulation and direct compression then may be film coated before ingestion and breakdown in the stomach and intestines.
Tablets are solid dosage forms consisting of active ingredients and excipients that may vary in size, shape, hardness, and other properties. They are classified as compressed or molded tablets based on the manufacturing method. Tablets offer large scale, low cost production and are easy for patients to use due to properties like precise dosing. However, some drugs are difficult to formulate into tablets. Tablet types include chewable, sublingual, effervescent, and implants. Excipients aid processing and protect the drug. Tablets are manufactured via wet or dry granulation and direct compression then may be film coated before ingestion and breakdown in the stomach and intestines.
Tablets are solid dosage forms consisting of active ingredients and excipients that may vary in size, shape, hardness, and other properties. They are classified as compressed or molded tablets based on the manufacturing method. Tablets offer large scale, low cost production and are easy for patients to use due to properties like precise dosing. However, some drugs are difficult to formulate into tablets. Tablet types include chewable, sublingual, effervescent, and implants. Excipients aid processing and protect the drug. Tablets are manufactured via wet or dry granulation and direct compression then may be film coated before ingestion and breakdown in the stomach and intestines.
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Presented By,
Muhammad Waleed & Shakir Jamal
Introduction: Tablets are solid dosage forms consisting of active ingredient(s) and suitable pharmaceutical excipients. They may vary in size, shape, weight, hardness, thickness, disintegration and dissolution characteristics, and in other aspects. They may be classified, according to the method of manufacture, as compressed tablets or molded tablets. Advantages: Production aspect: Large scale production at lowest cost Easiest and cheapest to package and ship High stability
User aspect: (doctor, pharmacist, patient)
Easy to handling Lightest and most compact Greatest dose precision & least content variability Disadvantages: Difficult swallow in case of children and unconscious patients. Some drugs resist compression into dense compacts. Drugs with poor wetting, slow dissolution, intermediate to large dosages may be difficult or impossible to formulate and manufacture as a tablet that provide adequate or full drug bioavailability. Bitter taste drugs, drugs with an objectionable odor, or sensitive to oxygen or moisture may require encapsulation or entrapment prior to compression or the tablets may require coating. Types of tablets: ( based on use ) Ingested orally Used in oral cavity • Compressed tablet Buccal tablet • Multiple compressed tablet Sublingual tablet • Enteric coated tablets Lozenges • Sugar coated tablet Dental cone • Film coated tablet Used to prepare solution • Chewable tablet • Targeted tablets Effervescent tablet
Administered by other Dispensing tablet
route Hypodermic tablet
• Implants • Vaginal tablet Chewable tablets : Tablets are to be broken and chewed in between the teeth before ingestion.
Implants : A small tablet that is prepared for
insertion under the skin by giving a small surgical cut into the skin which is stitched after the insertion of the tablet.
Dental cones: They are meant for placement in
the empty sockets after tooth extraction.
Effervescent tablet : The tablet that contains
acid substances and carbonate or hydrogen carbonate that react rapidly in the presence of water to release carbon dioxide. Excipients: (Additives ) Excipients are substances, other than the active drug substance, that have been appropriately evaluated for safety and are included in drug delivery systems:
To aid in the processing of the drug delivery system during its
manufacture. To protect, support, or enhance stability, bioavailability or patient acceptability. To assist in product identification Excipient functions: Compressed tablet manufacturing The classification of manufacturing methods :
wet granulation: suitable for drugs that are stable
to moisture and heat Granulation dry granulation: suitable for drugs that are sensitive to moisture and heat powder compression : suitable for drugs that are Direct sensitive to moisture and heat, fill material compression possessing, good flowability and compressibility crystal compression:suitable for drugs with proper crystal form and good flowability Tablet pressing: Single – punch press: Single punch tablet press also called eccentric press or single station press is the simplest machine for tablet manufacturing. Single punch tablet as the name implies employ single set of station tooling that is a die and a pair of upper and lower punches. The compaction force on the fill material is exerted by only the upper punch while the lower punch is static; such action equivalent to hammering motion and as a result, the single punch press is referred to as stamping process. The single punch tablet press produce about 60-85 tablets/min. Tablet coating: The reasons for tablet coating: 1) to protect the medicinal agent against destructive exposure to air and/or humidity. 2) to mask the taste of the drug. 3) to provide special characteristics of drug release. 4) to provide aesthetics or distinction to the product. 5) to prevent inadvertent contact by non-patients with the drug substance The general methods involved in coating tablets are as follows: sugarcoating tablets film-coating tablets fluid-bed or air suspension coating compression coating How tablet works in our body ? When you swallow a pill, it travels through the stomach and small intestine into the liver, which breaks it down and releases the remnants into the blood stream. Even though drugs travel in the blood throughout our body, each drug is designed to target certain protein molecules called receptors. They search out specific receptors generated by pain and inflammation as they course through the blood stream. Thank You