Targeted Drug Delivery System
Targeted Drug Delivery System
Targeted Drug Delivery System
SHUBHRAJIT MANTRY
D.Pharm, B.Pharm, M.Pharm, Ph.D
Associate Professor,
Department of Pharmaceutics
Sharadchandra Pawar College of Pharmacy,
Otur, Pune
INTRODUCTION
Target means specific organ or a cell or group of
cells, which in chronic or acute condition need
treatment.
components.
Targeted drug delivery implies for selective and effective
1. PASSIVE TARGETING
2. ACTIVE TARGETING
1. PASSIVE TARGETING
2. ACTIVE TARGETING
It refers to alteration of the natural disposition of the drug carrier, directing it to specific cells,
tissues or organs.
Example: Use of Ligands or monoclonal antibodies which can target specific sites.
AR RI E RS
C
OF R Y
G D EL IV E
E T ED D R U
TAR G
SYSTEM
Carriers
Carrier is one of the most important entities
essentially required for successful transportation
of the loaded drug.
B) Microparticulate Systems:
Microparticle, nanoparticle, Magnetic Microsphere, Albumin microsphere,
Nanocapsules.
2. CELLULAR CARRIERS
Resealed erythrocytes, Serum albumin, Antibodies, platelets, Leukocytes
3. SUPRAMOLECULAR DELIVERY SYSTEM
Polymeric carriers
5. MACROMOLECULAR CARRIERS
(AVE)
Antibodies
e) Lectins, Polysaccharides
VARIOUS CARRIERS USED IN
TARGETED DRUG DELIVERY SYSTEM
Liposomes 25nm-100μm
Niosomes 10 to 1000 nm
Aquasome 60-300nm
Nanoparticles 10-1000nm
(SLN)
EVENTS
AND
L P RO CE SS
BIOLOGICA
N DRUG TARGE T ING
INVO L VED I
Order involved in Drug targeting
A.First order targeting
It refers to DDS that delivers the drug to the capillary bed or
the active site or organ or tissue.
B. Second order targeting
It refers to DDS that delivers the drug to a special cell type
such as the tumor cells and not to the normal cells.
C.Third order targeting
It refers to DDS that delivers the drug to specific
intracellular compartments in the target cells e.g., Lysosomes.
Process involved in Drug targeting
3.Extravasation
4.Lymphatic uptake
1. Cellular uptake and processing
2. Transport across the epithelial barrier
3. Extravasation
4. Lymphatic uptake
THA N K Y O U