Title:-Re-entrant Ventricular Tachycardia in A Post-Operative Case of Tetralogy of Fallot - Ablated Successfully Under

Title:- Re-entrant Ventricular Tachycardia in a Post-Operative case of Tetralogy of
Fallot- Ablated successfully under three-dimensional (3D) mapping system.
Presentor:- Suresh Kumar Paidi MBBS,MD*
Co-Authors- Krishna Kumar Mohanan Nair MBBS,MD,DM1@, Narayanan Namboodiri MBBS,MD,DM2,
Sridhar Balaguru MBBS,MD,DM3, Ajitkumar Valaparambil MBBS,MD, DM2.
• * Senior Resident, SCTIMST, Thiruvananthapuram

•
•
@
1
Corresponding Author
Associate Professor, Dept. Of Cardiology, SCTIMST VIRTUAL IHRS 2020
• 2
Professor of Cardiology, SCTIMST
• 3
PDF, Dept. Of Cardiology, SCTIMST
Science, No Frontiers!
BACKGROUND
• There is increasing prevalence of repaired TOF among adults
because of improved surgical interventions [1,2].
• These people are at higher risk for sudden death on long
term follow up, related to progressive hemodynamic
problems and/or ventricular tachycardia [VT] or ventricular
fibrillation from surgical scar which accounts for one third to
half of late deaths [3].
• Most common mechanism of VT in these patients is macro-
rentry related to critical isthmuses surrounded by
unexcitable structures like surgical scars, valve annulus and
surgical patches[4,5].
• In 2007 landmark paper by Zeppenfeld et al. described
several anatomical isthmuses in surgical repaired ToF
patients[5].
• They were reported to be
• Between tricuspid annulus and right ventricular outflow tract (RVOT) patch/right
ventricular incision [isthmus 1]
• Between right ventricular incision site and pulmonary valve [isthmus 2]
• Between pulmonary valve and ventricular septal defect (VSD) patch [isthmus 3] – M/C
• Between VSD patch and tricuspid annulus [isthmus 4].
• In 2017 Kapel et al. on electrophysiological properties of
these anatomical isthmuses suggest that an anatomical
isthmus in the RVOT region of ToF will only support sustained
VT when it is long, narrow, slowly conducting, and low
voltage with low conduction velocity index appears to be the
most critical variable[6].
• The feasibility of catheter ablation, applying conventional
mapping techniques, has been reported [7].
• However, complex anatomy, hypertrophied myocardium,
broad isthmuses, hemodynamic instability, or non
inducibility of the VTs may explain ablation failure in 50% of
cases [8,9].
CASE REPORT
• 47-year-old lady underwent cardiac repair for TOF at the age
of 12 years. Subsequently she was asymptomatic on follow
up.
• Recently she presented elsewhere with palpitations and
presyncope with documented ventricular tachycardia [VT]
having left bundle branch block [LBBB] morphology with
inferior QRS axis and late precordial transition.
• Cardioverted and referred to our centre for EP study.
• EP study- Induced clinical VT which was hemodynamically
stable and the mechanism of VT was confirmed as reentry.
• With the help of 3D mapping system, VT circuit was
identified in the posterior RVOT region between the
pulmonary valve and upper end of VSD patch.
• Delivery of RF energy during VT terminated the tachycardia
with no further inducible VT despite aggressive pacing
protocols.
CONCLUSION
• Macro-reentrant mechanism
• Substrate- Anatomically defined isthmuses
• Amenable to RFA
REFERENCES
1. Marelli AJ, Mackie AS, Ionescu-Ittu R, Rahme E, Pilote L. Congenital heart disease in the general population: changing prevalence and age distribution.
Circulation 2007; 115:163–172.
2. Marelli AJ, Ionescu-Ittu R, Mackie AS, Guo L, Dendukuri N, Kaouache M. Lifetime prevalence of congenital heart disease in the general population from
2000 to 2010. Circulation 2014;130:749–756
3. Diller GP, Kempny A, Liodakis E, Alonso-Gonzalez R, Inuzuka R, Uebing A, OrwatS, DimopoulosK, SwanL, LiW, GatzoulisMA, BaumgartnerH.Left ventricular
longitudinal function predicts life-threatening ventricular arrhythmia and death in adults with repaired tetralogy of fallot.
Circulation 2012;125: 2440–2446.
4. KapelGF, ReichlinT, WijnmaalenAP, PiersSR, HolmanER, TedrowUB, SchalijMJ, StevensonWG, ZeppenfeldK. Re-entry using anatomically determined
isthmuses:acurable ventricular tachycardia in repaired congenital heart disease. Circ Arrhythm Electrophysiol 2015;8:102–109.
5. Katja Zeppenfeld , Martin J Schalij, Margot M Bartelings, Usha B Tedrow, Bruce A Koplan, Kyoko Soejima et al, Catheter ablation of ventricular tachycardia
after repair of congenital heart disease: electroanatomic identification of the critical right ventricular isthmus. Circulation 2007;116:2241–2252
6. Gijsbert F L Kapel, Frederic Sacher, Olaf M Dekkers, Masaya Watanabe, Nico A Blom, Jean-Benoit Thambo et al. Arrhythmogenic anatomical isthmuses
identified by electroanatomical mapping are the substrate for ventricular tachycardia in repaired Tetralogy of Fallot. Eur Heart J 2017;38 :268–276.
7. Furushima H, Chinushi M, Sugiura H, Komura S, Tanabe Y, Watanabe H, Washizuka T, Aizawa Y. Ventricular tachycardia late after repair of congenital heart
disease: efficacy of combination therapy with radiofrequency catheter ablation and class III antiarrhythmic agents and long-term outcome. J
Electrocardiol. 2006;39: 219–224.
8. Morwood JG, Triedman JK, Berul CI, Khairy P, Alexander ME, Cecchin F, Walsh EP. Radiofrequency catheter ablation of ventricular tachycardia in children
and young adults with congenital heart disease. Heart Rhythm. 2004;1:301–308.
9. JCS Joint Working Group Guidelines for non-pharmacotherapy of cardiac arrhythmias (JCS 2011) Circ J, 77 (2013), pp. 249-274.

Title:-Re-entrant Ventricular Tachycardia in A Post-Operative Case of Tetralogy of Fallot - Ablated Successfully Under

Uploaded by

Copyright:

Available Formats

Title:-Re-entrant Ventricular Tachycardia in A Post-Operative Case of Tetralogy of Fallot - Ablated Successfully Under

Uploaded by

Document Information

Original Description:

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Title:-Re-entrant Ventricular Tachycardia in A Post-Operative Case of Tetralogy of Fallot - Ablated Successfully Under

Uploaded by

Copyright:

Available Formats

Title:- Re-entrant Ventricular Tachycardia in a Post-Operative case of Tetralogy of

Fallot- Ablated successfully under three-dimensional (3D) mapping system.

Presentor:- Suresh Kumar Paidi MBBS,MD*

Co-Authors- Krishna Kumar Mohanan Nair MBBS,MD,DM1@, Narayanan Namboodiri MBBS,MD,DM2,

Sridhar Balaguru MBBS,MD,DM3, Ajitkumar Valaparambil MBBS,MD, DM2.

• * Senior Resident, SCTIMST, Thiruvananthapuram

You might also like