Structures and Functions of Protein
Structures and Functions of Protein
Structures and Functions of Protein
OF PROTEIN
Ika Yustisia
Department of Biochemistry
Faculty of Medicine UNHAS
2017
Definition
What is protein?
Definition
Myoglobin
Hemoglobin
Structure of Protein
Insulin
Structure of Protein
Protein Denaturation
• All proteins begin their existence on a ribosome
as a linear sequence of amino acid residues.
• This polypeptide must fold during and following
synthesis to take up its native conformation
• Modest changes in the protein’s environment
can bring about structural changes that can
affect function
Structure of Protein
Protein Denaturation
• Protein structures have evolved to function in
particular cellular environments
• Conditions different from those in the cell can
result in protein structural changes, large and
small
• A loss of three-dimensional structure sufficient
to cause loss of function is called denaturation
Structure of Protein
Protein Denaturation
• Three-dimensional structure of proteins
can be destroyed by heating, detergents,
nonpolar organic solvents, heavy metals,
and extreme pH.
• This process of denaturation leads to a
complete loss of the protein's biological
properties
Structure of Protein
Protein Denaturation
• Organic solvents, urea, and detergents act
primarily by disrupting the hydrophobic
interactions that make up the stable core of
globular proteins
• Extremes of pH alter the net charge on the
protein, causing electrostatic repulsion and
the disruption of some hydrogen bonding
Protein Function
• Proteins are the most versatile macromolecules
in living systems and serve crucial functions in
essentially all biological processes
Histidine
Tyrosine
Signaling Substances and Hormones
REFERENCES
• Meisenberg, G., Simmons, WH. Principles of
Medical Biochemistry, 2 ed. Mosby Elsevier, 2006
• Koolman, J.; Roehm, KH. Color Atlas of
Biochemistry, 2 ed. Thieme, 2004
• Devlin, TM. Textbook of Biochemistry with Clinical
Correlations, 6th ed., Wiley Liss, 2006
• Murray, RK., et al. Harper’s Ilustrated Biochemistry,
28th ed., Lange Medical Books/McGraw-Hill, 2009
• Nelson, DL, Cox, MM. Lehninger Principles of
Biochemistry, 5th ed., WHFreeman, 2009