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    Cardiovascular Pathology I

    Uploaded by

    Oyuka Oyuk
    This document contains 5 cases related to cardiovascular pathology. Case 1 describes the histology of a normal coronary artery and asks questions about identifying different layers. Case 2 involves a man with chest pain and describes pathology findings in the heart, asking questions about diagnosis and risk factors. Case 3 describes a woman with diabetes who collapsed and questions relate to histology of the heart and coronary artery. Case 4 involves a young man with shortness of breath and includes images of an endomyocardial biopsy for analysis. Case 5 is about a man with back pain and a pulsatile abdominal mass, asking questions about pathology findings and diagnosis.

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    Cardiovascular Pathology I

    Uploaded by

    Oyuka Oyuk
    78 views37 pages
    This document contains 5 cases related to cardiovascular pathology. Case 1 describes the histology of a normal coronary artery and asks questions about identifying different layers. Case 2 involves a man with chest pain and describes pathology findings in the heart, asking questions about diagnosis and risk factors. Case 3 describes a woman with diabetes who collapsed and questions relate to histology of the heart and coronary artery. Case 4 involves a young man with shortness of breath and includes images of an endomyocardial biopsy for analysis. Case 5 is about a man with back pain and a pulsatile abdominal mass, asking questions about pathology findings and diagnosis.

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    Cardiovascular Pathology I.ppt

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    This document contains 5 cases related to cardiovascular pathology. Case 1 describes the histology of a normal coronary artery and asks questions about identifying different layers. Case 2 involves a man with chest pain and describes pathology findings in the heart, asking questions about diagnosis and risk factors. Case 3 describes a woman with diabetes who collapsed and questions relate to histology of the heart and coronary artery. Case 4 involves a young man with shortness of breath and includes images of an endomyocardial biopsy for analysis. Case 5 is about a man with back pain and a pulsatile abdominal mass, asking questions about pathology findings and diagnosis.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    78 views37 pages

    Cardiovascular Pathology I

    Uploaded by

    Oyuka Oyuk
    This document contains 5 cases related to cardiovascular pathology. Case 1 describes the histology of a normal coronary artery and asks questions about identifying different layers. Case 2 involves a man with chest pain and describes pathology findings in the heart, asking questions about diagnosis and risk factors. Case 3 describes a woman with diabetes who collapsed and questions relate to histology of the heart and coronary artery. Case 4 involves a young man with shortness of breath and includes images of an endomyocardial biopsy for analysis. Case 5 is about a man with back pain and a pulsatile abdominal mass, asking questions about pathology findings and diagnosis.

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    Cardiovascular Pathology I

    Cardiovascular Pathology I
    Case 1
    Normal coronary artery
    H&E stain
    Elastin stain
    High power
    Q1. Describe the histology of a normal coronary
    artery.
    Be sure to describe all of the layers of the artery
    in your discussion.
    What is the arrow pointing to on the high power
    image?
    Case History

    A 57-year old man has experienced chest pain


    with exertion for the past year. For example,
    when he walks up a flight of 10 or more stairs he
    develops a pain in his chest which subsides
    within several minutes when he sits down and
    rests.
    Q1. Develop a clinical differential diagnosis.
    The image is that of the patient’s left
    anterior descending coronary artery
    Q2. Describe the histologic findings in this
    coronary artery.

    Q3. What is your pathologic diagnosis?


    Q4. Name at least 3 modifiable and 3 non-
    modifiable risk factors for the development of
    this condition.

    Q5. Correlate the clinical history with the


    pathology.
    Cardiovascular Pathology I
    Case 2
    History
    A 67-year old man presented to the emergency
    department with 10/10 crushing substernal
    chest pain. The pain was greatest over his left
    chest and radiated down his left arm.
    Q1. List 5 life-threatening causes of chest pain.
    *represents normal myocardium
    Cross sections of coronary artery
    Q2. Describe the gross morphologic findings of
    the heart. Be specific when describing the area
    to which the large arrow is pointing. What
    chambers of the heart are labeled A and B?
    Q3. What is your diagnosis?

    Q4. Based on the gross findings, when did this


    event occur? Discuss your rationale.
    Q5. Clinically, what lab tests would confirm the
    diagnosis? Why?

    Q6. Discuss potential complications of this


    disease process.
    Cardiovascular Pathology 1
    Case 3
    History
    A 45-year old woman with diabetes mellitus,
    type 1 complained of “not feeling well” for
    several days. She collapses from a cardiac arrest
    and cannot be resuscitated. An autopsy is
    performed. The light microscopic appearance of
    the left ventricle anterior wall and left anterior
    descending coronary artery are shown in the
    figures
    normal

    Low power

    High power
    Q1. Describe the histologic findings of the
    myocardium. Compare to normal.

    Q2. Describe the histologic findings of the


    coronary artery.
    Q3. What is your diagnosis?

    Q4. Based on the histologic findings, when did


    this event occur? Discuss your rationale.
    Q5. Are the patient’s symptoms typical of this
    disease process? Provide a rationale to your
    answer.

    Q6. Define the term “vulnerable plaque”.


    Cardiovascular Pathology
    Case 4
    History
    A 27-year old man presents with shortness of
    breath which developed 7 days prior and has
    been steadily worsening. He has no known
    medical problems and takes no medications.
    Physical exam reveals jugular venous distention,
    bilateral basilar lung crackles and lower
    extremity edema.
    Q1. Develop a clinical differential diagnosis.
    An endomyocardial biopsy is performed
    Low power

    High power
    Q2. Describe the histologic findings.

    Q3. What is your pathologic diagnosis?


    Q4. What is the most common cause of this
    entity in the United States?

    Q5. Correlate the clinical with the pathologic


    findings.
    Cardiovascular I
    Case 5
    History
    A 78-year-old man presents with sudden onset
    of low mid-back pain. His past history is
    significant for coronary artery disease and
    coronary artery bypass surgery. He has a 60-
    pack year smoking history. On examination, a
    pulsatile mass can be felt in the lower abdomen.
    On auscultation of the mass a bruit is
    appreciated.
    Q1. Describe the characteristic pathologic
    features of this specimen.

    Q2. Correlate the clinical findings with the pathology


    Q3. What is your diagnosis?

    Q4. What is/are risk factors for the


    development of this condition? How do they
    contribute to its development?

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