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    Interpretation of Full Blood Count

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    Clement
    The document provides an overview of interpreting a full blood count (FBC). It discusses the components of an FBC result, including red blood cells, white blood cells, platelets, hemoglobin, and other factors. It outlines potential causes and flags for low or high levels of various components. For example, low neutrophils can be caused by viruses or drugs, while high levels may result from infection. The document also covers classifying anemias based on mean corpuscular volume and hemoglobin concentration.

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    Interpretation of Full Blood Count

    Uploaded by

    Clement
    131 views25 pages
    The document provides an overview of interpreting a full blood count (FBC). It discusses the components of an FBC result, including red blood cells, white blood cells, platelets, hemoglobin, and other factors. It outlines potential causes and flags for low or high levels of various components. For example, low neutrophils can be caused by viruses or drugs, while high levels may result from infection. The document also covers classifying anemias based on mean corpuscular volume and hemoglobin concentration.

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    The document provides an overview of interpreting a full blood count (FBC). It discusses the components of an FBC result, including red blood cells, white blood cells, platelets, hemoglobin, and other factors. It outlines potential causes and flags for low or high levels of various components. For example, low neutrophils can be caused by viruses or drugs, while high levels may result from infection. The document also covers classifying anemias based on mean corpuscular volume and hemoglobin concentration.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    131 views25 pages

    Interpretation of Full Blood Count

    Uploaded by

    Clement
    The document provides an overview of interpreting a full blood count (FBC). It discusses the components of an FBC result, including red blood cells, white blood cells, platelets, hemoglobin, and other factors. It outlines potential causes and flags for low or high levels of various components. For example, low neutrophils can be caused by viruses or drugs, while high levels may result from infection. The document also covers classifying anemias based on mean corpuscular volume and hemoglobin concentration.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 25

    INTERPRETATION OF FULL

    BLOOD COUNT

    CLEMENT AWUAH

    03/06/2021 1
    Key points/purpose

     Provide an overview of the use of the FBC

     Discuss aspects of reduced and elevated


    results of some parameters in FBC

     Relate a few blood pictures to the FBC run

    03/06/2021 2
    Introduction 1/3

     FBC is probably the


    commonest test done
    (“full blood count”-
    how much of each
    type of cell).

    03/06/2021 3
    Introduction 2/3

    03/06/2021 4
    Introduction 3/3

    03/06/2021 5
    WHY FBC????

     To review your overall health. 

     To diagnose a medical condition.

     To monitor a medical condition.

     To monitor medical treatment. 

    03/06/2021 6
    Results Components 1/4

    03/06/2021 7
    Results Components 2/4

     WBC = White Blood Cells


     LYM = Lymphocyte
     MID = WBC not classified as LYM or GRA
     GRA = Granulocytes (neutrophil, basophil
    ,eosinophil)
     LYM% = (Lymphocyte)%
     MID % = Medicalese (WBC not classified as LYM
    or GRA)%
     GRA% = (Granulocytes)%
    03/06/2021 8
    Results Components 3/4

     RBC = Red Blood Cells


     HGB = Haemoglobin
     HCT = Haematocrit
     MCV = Mean Cell Volume
     MCH = Mean Cell Hemoglobin
     MCHC = Mean Cell Hemoglobin Concentration
     RDW = Red Cell Distribution Width

    03/06/2021 9
    Results Components 4/4
     PLT = Platelet
     P_LCC = Macro platelet count
     P_LCR = Macro platelet percentage
     PCT = Platelet percentage
     MPV = Mean platelet volume
     PDWcv = Platelet Distribution Width

    03/06/2021 10
    Neutrophils – Low

    Most common causes


     Viral
     Autoimmune/Idiopathic
     Drugs
    Red flags
     Person Particularly Unwell
     Severity
     Rate of change of Neutropenia
     Lymphadenopathy, Hepatosplenomegaly

    03/06/2021 11
    Neutrophils – High
    Most common causes
     Infection/Inflammation
     Necrosis/Malignancy
     Any Stress or Heavy Exercise
     Drugs
     Pregnancy
     CML (Chronic Myelogenous Leukemia)

    Red Flags
     Person particularly unwell
     Severity
    03/06/2021 12
    Lymphocytes
    Lymphocyte – Low
     Not usually clinically significant
     Could indicate hypo proliferative BM or suppression

    Lymphocyte – High
    Isolated elevated count not usually significant
     Acute Infection (Viral, Bacterial)
     Smoking
     Hyposplenism
     Acute Stress Response
     Autoimmune Thyroiditis
     CLL (Chronic Lymphocytic Leukemia)
    03/06/2021 13
    Monocytes
    Monocytes – Low
     Not clinically significant

    Monocytes – High
     Chronic infection
     An autoimmune or blood disorder
     Cancer
     Viral Infection
     Tuberculosis

    03/06/2021 14
    Eosinophil
    Eosinophil – Low
     No real cause for concern

    Eosinophil – High
     Allergy: Asthma
     Parasites

    Rarer causes
     Hodgkins Disease
     Myeloproliferative Disorders
     Churg-strauss Syndrome

    03/06/2021 15
    Basophils
    Basophils – Low
     Difficult to demonstrate

    Basophils – High
     Myeloproliferative disorders
     Allergies: food allergies, drug allergies, allergic
    rhinitis
     Infections: chickenpox, tuberculosis

    03/06/2021 16
    Platelets – Low
    Most common causes
     Viral Infection
     Idiopathic Thrombocytopenic Purpura
     Liver Disease
     Drugs
     Hypersplenism
     Autoimmune Disease
     Pregnancy

    Red Flags
     Bruising
     Petechiae
     Signs of bleeding
    03/06/2021 17
    Platelets – High
     Reactive conditions eg. infection, inflammation

     Pregnancy

     Severe Iron deficiency

     Post splenectomy

    03/06/2021 18
    Red Blood Cells
     ‘What is the size of RBC’ ?
     MCV indicates the Red cell volume (size)
     Both the MCH & MCHC tell Hb content of RBC.

    03/06/2021 19
    The Three Basic Measures
    A. RBC count

    B. Hemoglobin

    C. Haematocrit

    Check whether this holds good in given results


     A x 3 = ((B) x 3) = C (This is the rule of thumb)

    03/06/2021 20
    High haemoglobin
     Hb is often accompanied by PCV

     Can reflect decreased plasma volume (eg:


    dehydration, alcohol, cigarette smoking,
    diuretics) or

     Increased red cell mass (eg. polycythaemia)

    03/06/2021 21
    MCV

    03/06/2021 22
    Classification of Anaemia

    Using MCV to classify the anaemia


     Microcytic, MCV < 80 fl
     Normocytic, MCV 80 – 100 fl
     Macrocytic, MCV > 100 fl

    Using MCH to classify the anaemia


     •Hypochromic, MCH < 27 pg
     •Normochromic, MCH 27-34 pg
     •Hyperchromic, MCH > 34 pg

    03/06/2021 23
    What is your take?

    03/06/2021 24
    03/06/2021 25

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