Stages of Gingival Inflammation

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Gingivitis

Dr G. Visithiriyan
2nd Year MDS
Introduction
 Inflammation - local response of living tissues to injury due to any agent

 Defense reaction of the body

 Infective agent, Immunological, Physical, Chemical


Signs of Inflammation :
RUBOR(redness),TUMOR(swelling),CALOR(heat),DOLOR(pain) and LOSS OF
FUNCTION
Events in Inflammation

VASCULAR CELLULA PHAGOCYTOSI


CHEMOTAXIS
EVENT R EVENT S
GINGIVAL INFLAMMATION
 Inflammation of the gingiva is termed as GINGIVITIS.

 It is associated with the presence of oral micro-organisms attached to the tooth and
perhaps in or near the gingival sulcus.
 These micro-organisms are capable of synthesizing products (COLLAGENASE,
HYALURONIDASE, PROTEASE, CHON DROITIN SULFATASE,
ENDOTOXIN)damage to epithelial and connective tissue cells, as well as to
intercellular constituents such as collagen, ground substance and glycocalyx.

 Widening of the spaces between the junctional epithelial cells by bacteria


themselves or their toxins to gain access to the connective tissue.
STAGES OF GINGIVITIS
 STAGE I : THE INITIAL LESION

 STAGE II : THE EARLY LESION

 STAGE III : THE ESTABLISHED LESION

 STAGE IV : THE ADVANCED LESION


STAGE I : THE INITIAL LESION ( 2-4 DAYS )

 Vascular changes - Dilated capillaries and increased blood flow

 Initial inflammatory changes due to microbial activation of resident leukocytes


(presence of PMNs) and stimulation of endothelial cells.

 Loss of perivascular collagen

 Increase in the flow of gingival fluid into the sulcus


STAGE II : THE EARLY LESION ( 4-7 DAYS )

 Evolves from initial lesion after the beginning


of plaque accumulation

 Clinical signs : ERYTHEMA [proliferation of


capillaries and increased formation of capillary
loops between rete pegs].

 Increase in gingival fluid flow and number of


trans migrating lymphocytes[ 75% of T lymphocytes]

 Amount of collagen destruction increases ( MMP-2, MMP-9 ) and Fibroblasts


show decreased capacity for collagen
STAGE III : THE ESTABLISHED LESION ( 14-21 DAYS )

 Predominance of plasma cells and B lymphocyte


( Ig G1, Ig G3 )

 Impaired venous return results ‘gingival anoxemia’

 Moderate to severe inflamed gingiva

 Increased collagenolytic activity

 Elevated levels of acid and alkaline phosphatase, cytochrome


oxidase,beta-glucuronidase,etc
STAGE IV : THE ADVANCED LESION

 Extension of the lesion into the alveolar bone.

 Phase of periodontal breakdown[bone loss].

 All types of inflammatory cells.

 More plaque accumulation, higher IL1beta


and lower IL-8 concentration at 28 days.

 Gingivitis progresses to periodontitis in individuals who are susceptible


Conclusion
Thank You …

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