Bipolar Unipolar Dichotomy

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Bipolar – Unipolar Dichotomy

Dr Rupinder Gill
 He classified nonorganic ‘endogenous’ disorders into 2 main

Kraeplin’s groups:
1. Manic Depressive Psychosis (MDP)
Dichotomy 2. Dementia Praecox
Leonhard’s
classification of
endogenous
psychosis
 He was able to show that bipolar illness started on an average
Perris 15 years earlier than depression and recurred more frequently.
Classifications 1. ICD 11
used in clinical 2. DSM 5
practice
 It describes disorders with prominent primary mood symptoms:
1. Depressive

ICD 11 2. Manic
3. Mixed
4. Hypomanic
 Bipolar disorders

Block L2 – 6A6  6A60: Bipolar Type 1 disorder


 6A61: Bipolar Type 2 disorder
Bipolar Type I  Occurrence of 1 or more manic or mixed episodes
disorder
Bipolar Type II  Occurrence of 1 or more hypomanic episodes and at least 1
depressive episode
disorder
 Depressive disorders
 6A70: Single depressive disorder

L2 – 6A7  6A71: Recurrent depressive disorder


 6A72: Dysthymic disorder
 6A73: Mixed depressive and anxiety disorder
 Bipolar disorders are separated from depressive disorders
 Bipolar and related disorders include:
 Bipolar I disorder
 Bipolar II disorder

DSM 5  Cyclothymic disorder


 Substance/medication induced bipolar & related disorder
 Bipolar and related disorder due to another medical condition
 Other specified bipolar & related disorder
 Unspecifed bipolar and related disorder
1. St. Louis or Feighner criteria
2. CATEGO

Classifications 3. RDC

used in research 4. Leonhard’s system


5. Winokur’s familial system
6. Other systems: ICD & DSM for research
 bipolar and depressive disorders can be discriminated clinically
Dichotomy or and therapeutically

continuum?  clinical observations testify to a vast overlap between those


extremes
 50 percent of persons with major depressive disorder during
long- term prospective follow-up develop hypomanic or manic
episodes and should be reclassified as having bipolar disorder
 In some, if not many, instances, apparent switching of polarity
might simply be due to earlier misclassification of bipolar
disorder as major depressive disorder
 Heterogeneity undoubtedly exists among mood disorders.

 However, the classic unipolar–bipolar distinction might not be


the best way to capture it.

 The foregoing observations suggest that much of the recurrent


depressive terrain might be pseudo-unipolar (i.e., soft bipolar).
 The clinical significance of these considerations lies in the fact
that many DSM-5 subtypes of mood disorders are not pure
entities, and considerable overlap and switches in polarity take
place.
 They also provide some rationale, for instance, for why lithium
or other mood stabilizer augmentation may be effective in some
apparently unipolar depressions; such patients do not
necessarily experience brief spontaneous hypomanic episodes
but instead often exhibit a high baseline level of hyperthymic
traits.
 Finally, several studies have shown that bipolar patients with
cyclothymic premorbid adjustment and interepisodic
adjustment are at considerable risk of antidepressant-induced
rapid cycling, defined as a rapid succession of major episodes
with few or no intervals of freedom.
 As Kraepelin illustrated in his monograph, course is best
captured graphically. Kraepelin, after diagramming 18
illustrative patterns for the entire spectrum of manic-depressive
illness, declared that the illness pursued an indefinite number of
courses.
Thank You

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