Lipid Digestion and Absorption
Lipid Digestion and Absorption
Lipid Digestion and Absorption
absorption
Digestion of dietary lipids
• Diet contains about 60-150 g of fat
– On an average 80 g approximately/day
• Dietary lipids:
• pH optimum 4-6
• No emulsification in stomach
– Hence, insignificant in adults
• Both are important for the digestion
of milk fat
• Secretin
• Cholcystokinin:
FFA FFA
Isomerase
1 –Monoacyl glycerol
FFA + Glycerol
• Orlistat, an antiobesity drug inhibits gastric
and pancreatic lipases decreasing fat
absorption result in loss of weight
Cholesterol
Fatty +
acid FFA
Absorption of digested dietary
lipids
• Digested lipid products include:
– Used in hypercholesterolemia
Disorders
• Malabsorption
• Steatorrhea
• Cystic fibrosis
Malabsorption of lipids
• Steatorrhea
– Increased lipids (fats and fat soluble vitamins,
essential fatty acids etc.) in the feces
– Shortened bowel
Steatorrhea may be due to
• 1. A defect in the secretion of bile or
pancreatic juice into the intestine.
• 2. Impairment in the lipid absorption by the
intestinal cells
It is commonly seen in disorders associated
with pancreas, biliary obstruction, severe liver
dysfunction etc
• Colipase deficiency: patients suffers from
steatorrhea