Yeasts Undergraduate Recording 2021
Yeasts Undergraduate Recording 2021
Yeasts Undergraduate Recording 2021
Introduction
Candida
Cryptococcus
Trichosporon
Saccharomyces
Candida
≈200 species
Epidemiology
Adhesins: colonisation
Secrete enzymes e.g. hydrolases: Nutrient acquisition
and degradation of host tissue
Yeast-to-hyphal transition: Δtemp, nutritional starvation,
alkaline PH
Biofilm formation- resistant to antifungals and host
immune defenses
Candidalysin- peptide toxin that promotes epithelial
damage, stimulates immune activation, and phagocyte
function Source: Alessandrada 2016 “Cell biology of Candida albicans–host interactions”
Clinical manifestations
Mucocutaneous
Cutaneous
Systemic
Mucocutaneous
infections
Source: https://www.semanticscholar.org/
Lab diagnosis
Source: https://microbiologyinfo.com/
Species identification
* Morphological characteristics on
ChromAgar
* Carbohydrate assimilation &
fermentation
* Chlamydospore production
Treatment
Source: https://www.keydiagnostics.com.au/
Lab diagnosis
Amphotericin B
Flucytosine – combined with
amphotericin B
Fluconazole