Corticosteroids
Corticosteroids
Corticosteroids
DR SEHRISH ZAFFAR
ASSISTANT PROFESSOR
PHARMACOLOGY
CMH LMC & IOD
Adrenal Steroids
GLUCOCORTICOIDS – CORTISOL
Regulates normal metabolism & resistance to stress.
ANDROGENS – DEHYDROEPIANDROSTERONE
Regulates anabolic functions
Cortisol Biosynthesis
Zona Fasiculata
Glucocorticoids
GLUCOCORTICOID
Synthesis and release
Circadian rhythm of cortisol secretion
Classification of Glucocorticoids
Short/medium Intermediate acting Long acting
acting
Prednisolone Fluprednisolone
Methylprednisolone
Meprednisolone
Pharmacokinetics
Daily secretion: 10-20 mg
Increase in gluconeogenesis
Increase in glycogen synthesis
Decreased uptake and utilization of glucose by muscle
Increased blood glucose > Stimulate insulin secretion
Both lipolysis and lipogenesis are stimulated
Net increase of fat deposition in certain areas (eg, the face
and the shoulders and back).
2. Catabolic effects
Muscle protein catabolism