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    Necrosis Apoptocic Pathophysio

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    Somaia mohammed
    Apoptosis is a genetically programmed form of cell death that can occur under physiological or pathological conditions to eliminate cells. It is an energy-dependent process where the cell shrinks and its DNA and organelles fragment. The cell then breaks into fragments that are phagocytosed. In contrast, necrosis is a pathological process where cells die due to external pathogenic factors. It is not a programmed cell death. The cells swell and their organelles and membranes are damaged. The cells eventually lyse and release their contents.

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    Necrosis Apoptocic Pathophysio

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    Somaia mohammed
    6 views17 pages
    Apoptosis is a genetically programmed form of cell death that can occur under physiological or pathological conditions to eliminate cells. It is an energy-dependent process where the cell shrinks and its DNA and organelles fragment. The cell then breaks into fragments that are phagocytosed. In contrast, necrosis is a pathological process where cells die due to external pathogenic factors. It is not a programmed cell death. The cells swell and their organelles and membranes are damaged. The cells eventually lyse and release their contents.

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    Apoptosis is a genetically programmed form of cell death that can occur under physiological or pathological conditions to eliminate cells. It is an energy-dependent process where the cell shrinks and its DNA and organelles fragment. The cell then breaks into fragments that are phagocytosed. In contrast, necrosis is a pathological process where cells die due to external pathogenic factors. It is not a programmed cell death. The cells swell and their organelles and membranes are damaged. The cells eventually lyse and release their contents.

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    © All Rights Reserved
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    6 views17 pages

    Necrosis Apoptocic Pathophysio

    Uploaded by

    Somaia mohammed
    Apoptosis is a genetically programmed form of cell death that can occur under physiological or pathological conditions to eliminate cells. It is an energy-dependent process where the cell shrinks and its DNA and organelles fragment. The cell then breaks into fragments that are phagocytosed. In contrast, necrosis is a pathological process where cells die due to external pathogenic factors. It is not a programmed cell death. The cells swell and their organelles and membranes are damaged. The cells eventually lyse and release their contents.

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    © All Rights Reserved
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    of 17

    THE DIFFERENCE

    BETWEEN APAPTOSIS
    AND NECROSIS
    Introduction
    ◦ Initiating factor 
    ◦ Spreading
    ◦ Biochemical changes in cell
    ◦ Energy dependens 
    ◦ Plasmatic membrane
    ◦ Morphological changes in cell
    ◦ Elimintation of destructed cells 
    ◦ Nucleus
    Apoptosis

    Genatically determined for of cell death ,Can occur both in physiology and


    pathological states , Apoptosis as a physiological process ,Occurs
    throughout the life of living organism.It serves to clean tissues form cells
    that have completed their physiological function and have lost significance
    for the body (for example hemolysis of erythrocytes after 120
    days,apoptosis of intestinal epithelial cells ,etc).In pathological condetions,
    Apoptosis ensures the destruction of damaged and potentially harmful cells
    (for Example : apoptosis of viruses infected cell) 
    INITIATING
    FACTOR 
    Degeneration of DNA under
    influence of physiological and
    pathological factor
    SPREADING
    Single cell
    BIOCHEMICAL CHANGES IN
    CELL
    Activation of endonuclease
    MORPHOLOGICA
    L CHANGES
    Shrinkage of cell ,thickening of
    membrane condensation of
    granules
    ELIMENTATIO
    N OF
    DESTRUCTED
    CELLS

    Fragmentation of
    cell and
    phagocytosis
    Nucleus Fragmatation 
    Necrosis 
    The pathological process that result on the death of cells and tissue under the
    influence of the pathogenic factor ,There are several stages of necrosis :
    paranecrosis , necrobiosis, necrosis.
    Paranecrosis is the first stage of necrosis, lasts longest than other stages, and is
    accompained by reversible changes in the injured cell. If favorable condition
    occur, the life of a cell is restored. Necrobiosis is a short-term process, unlike the
    previous one. Necrobiosis is characterized by acceleration of catabolism and
    irreversible changes in the cells, during which cell injury deepens and results in
    necrosis.
    Necrosis means a complete cessation of cell life activity. 
    Initiating factor

    Destruction of plasma
    membrane under
    influence of pathogenic
    factors 
    SPREADING 
    Groub of cells 
    BIOCHEMICAL Activation of
    CHANGES IN lysosom
    enzyme
    CELL
    Morphological
    changes in cell 
    Increasing if cell size,
    swelling of cytoplasma ,
    destruction of membrane,
    swelling of mitochondria,
    lysis of granules.
    ELIMINATION OF Lysis of cells,
    DESTRUCTED CELLS  phagocytosis. 
    NUCLEUS
    Karyopyknosis, Karyorrhexis, Karyolysis. 
    THANKS FOR
    ATTENTION 
    By: Somaia Moahmmed Abdelatif 
    Groub number:421i-2c

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